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Healthy Lifestyle Through Young Adulthood and the Presence of Low Cardiovascular Disease Risk Profile in Middle Age: The Coronary Artery Risk Development in (Young) Adults (CARDIA) Study
Open accessAbstract
Background—: A low cardiovascular disease risk profile (untreated cholesterol <200 mg/dL, untreated blood pressure <120/<80 mm Hg, never smoking, and no history of diabetes mellitus or myocardial infarction) in middle age is associated with markedly better health outcomes in older age, but few middle-aged adults have this low risk profile. We examined whether adopting a healthy lifestyle throughout young adulthood is associated with the presence of the low cardiovascular disease risk profile in middle age. Methods and Results—: The Coronary Artery Risk Development in (Young) Adults (CARDIA) study sample consisted of 3154 black and white participants 18 to 30 years of age at year 0 (1985–1986) who attended the year 0, 7, and 20 examinations. Healthy lifestyle factors defined at years 0, 7, and 20 included average body mass index <25 kg/m 2 , no or moderate alcohol intake, higher healthy diet score, higher physical activity score, and never smoking. Mean age (25 years) and percentage of women (56%) were comparable across groups defined by number of healthy lifestyle factors. The age-, sex-, and race-adjusted prevalences of low cardiovascular disease risk profile at year 20 were 3.0%, 14.6%, 29.5%, 39.2%, and 60.7% for people with 0 or 1, 2, 3, 4, and 5 healthy lifestyle factors, respectively ( P for trend <0.0001). Similar graded relationships were observed for each sex-race group (all P for trend <0.0001). Conclusions—: Maintaining a healthy lifestyle throughout young adulthood is strongly associated with a low cardiovascular disease risk profile in middle age. Public health and individual efforts are needed to improve the adoption and maintenance of healthy lifestyles in young adults.
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“Prevention is effective in reducing the impact of CVD”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [3]
In the citing paper
“the elimination of health risk behaviours would make it possible to prevent at least 80% of CVD and even 40% of cancers”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [3]
In the citing paper
“the elimination of health risk behaviours would make it possible to prevent at least 80% of CVD and even 40% of cancers, thus providing added value for other chronic diseases.3,4”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [3]
In the citing paper
“Findings from the Coronary Artery Risk Development in Young Adults (CARDIA) study demonstrate that young adults aged 18 to 30 years with healthy behaviors grow up to become older adults with lower biological risk.12”
From Better Population Health Through Behavior Change in Adults: A Call to Action (2013) · cites this paper as [12]
In the citing paper
“Moreover, highlighting the promise of behavior change, those who did not have a healthy lifestyle at baseline but began to practice healthy behaviors later still had higher rates of ideal cardiovascular biomarkers than those who never adopted healthy behaviors.”
From Better Population Health Through Behavior Change in Adults: A Call to Action (2013) · cites this paper as [12]
In the citing paper
“These results indicate that regardless of timing, the adoption of a healthy lifestyle has value for cardiovascular health.12”
From Better Population Health Through Behavior Change in Adults: A Call to Action (2013) · cites this paper as [12]
In the citing paper
“Among those who practiced all of 5 healthy lifestyle behaviors in young adulthood (nonsmoking, low or no alcohol use, healthy diet, physically active, maintenance of normal weight), 60% had all ideal cardiovascular biomarkers in middle age.”
From Better Population Health Through Behavior Change in Adults: A Call to Action (2013) · cites this paper as [12]
In the citing paper
“In contrast, of those who practiced none of these healthy behaviors in young adulthood, fewer than 5% reached middle age with all cardiovascular biomarkers at ideal levels.12”
From Better Population Health Through Behavior Change in Adults: A Call to Action (2013) · cites this paper as [12]
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The Influence of Time on Food Intake Patterns:
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“Another major finding based on CARDIA results was that maintaining a healthy lifestyle in young adulthood would promote better cardiovascular health into middle adulthood (Liu et al., 2012).”
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“…psychosocial consequences including discrimination and weight-based victimization, the disproportionate rate of obesity among Hispanic children is a public health issue that requires attention (Beck, 2016; Burke et al., 2008; K. Liu et al., 2012b; Morrison et al., 2015; Serdula et al., 1993).”
Nuevos enfoques en el riesgo cardiovascular residual. Introducción
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“33 The four scores were summed, and the higher 40 percentile was considered a healthier diet.”
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“In accordance with meta-analysis, based on an analysis of studies involving a total of more than 250,000 people, the risk of death due to CVD in the course of lifetime is approximately 30%, and taken into account the risk of death and all cardiovascular events dating back to it, 50% for both sexes, in each age group […”
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Secondary Prevention and Cardiac Rehabilitation
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Fat Sensing Using Low-Cost Near-Infrared Spectroscopy
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“978-1-7281-2800-9/19/$31.00 ©2019 IEEE Keywords—sensors, Near-Infrared (NIR), vibrational spectroscopy, chemometrics, Cardiovascular Disease (CVD), signal processing, Random Forest I. INTRODUCTION The goal of this project is to investigate the potential to develop a low-cost handheld spectroscopy-based instrument to e…”
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Metadata
- Authors
- Liu, K., Daviglus, M. L., Loria, C. M., Colangelo, L. A., Spring, B., Moller, A. C., & Lloyd-Jones, D. M.
- Affiliations
- Northwestern University (US)
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (K.L., M.L.D., L.A.C., B.S., A.C.M., D.M.L.-J.), and National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD (C.M.L.).
- ORCID
- Venue
- Circulation
- Published
- 2012-02-28
- Volume
- 125
- Issue
- 8
- Pages
- 996-1004
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3353808
- OpenAlex
- W2114377026
- Cited by
- 371
- References
- 46
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 24 · 2023: 30 · 2022: 28 · 2021: 46 · 2020: 28 · 2019: 23 · 2018: 30 · 2017: 22 · 2016: 26 · 2015: 22 · 2014: 18 · 2013: 23 · 2012: 14
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc95095-66-0-1, n01hc48047-55-0-1, n01hc48049-61-0-1)
- National Heart, Lung, and Blood Institute (N01 HC 95095, N01-HC-048049, N01 HC095095, N01 HC048047, N01-HC-480-47)
- National Center for Research Resources (UL1RR025741)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Lifestyle Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Keywords
- healthy lifestyle, early adulthood, middle age (human life stage), body mass index, alcohol consumption, healthy eating, physical activity, never smoking, untreated hypertension, CARDIA study, sex differences, racial differences
- MeSH terms
- Adult, Age Factors, Cardiovascular Diseases, Coronary Artery Disease, Female, Humans, Life Style, Longitudinal Studies, Male, Middle Aged, Risk Factors, Cohort Studies, Young Adult
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