Cited by 501Lipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismMuscle Physiology and Disorders

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Effect of Statins on Skeletal Muscle Function

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Parker, Beth A., Capizzi, Jeffrey A., Grimaldi, Adam S., Clarkson, Priscilla M., Cole, Stephanie M., Keadle, Justin, Chipkin, Stuart, Pescatello, Linda S., Simpson, Kathleen, White, C. Michael, Thompson, Paul D.·2013·Circulation

DOI 10.1161/circulationaha.112.136101PMC PMC4450764

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Abstract

Background—: Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied. Methods and Results—: The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study assessed symptoms and measured creatine kinase, exercise capacity, and muscle strength before and after atorvastatin 80 mg or placebo was administered for 6 months to 420 healthy, statin-naive subjects. No individual creatine kinase value exceeded 10 times normal, but average creatine kinase increased 20.8±141.1 U/L ( P <0.0001) with atorvastatin. There were no significant changes in several measures of muscle strength or exercise capacity with atorvastatin, but more atorvastatin than placebo subjects developed myalgia (19 versus 10; P =0.05). Myalgic subjects on atorvastatin or placebo had decreased muscle strength in 5 of 14 and 4 of 14 variables, respectively ( P =0.69). Conclusions—: These results indicate that high-dose atorvastatin for 6 months does not decrease average muscle strength or exercise performance in healthy, previously untreated subjects. Nevertheless, this blinded, controlled trial confirms the undocumented impression that statins increase muscle complaints. Atorvastatin also increased average creatine kinase, suggesting that statins produce mild muscle injury even among asymptomatic subjects. This increase in creatine kinase should prompt studies examining the effects of more prolonged, high-dose statin treatment on muscular performance. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00609063.

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Authors: Parker, B. A., Capizzi, J. A., Grimaldi, A. S., Clarkson, P. M., Cole, S. M., Keadle, J., Chipkin, S., Pescatello, L. S., Simpson, K., White, C. M., & Thompson, P. D.
Affiliations: Hartford Hospital (US)
ORCID: Parker, Beth A.
Chipkin, Stuart
Pescatello, Linda S.
White, C. Michael
Thompson, Paul D.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-01
Volume: 127
Issue: 1
Pages: 96-103
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/circulationaha.112.136101
PMC: PMC4450764
OpenAlex: W1982914740
Cited by: 500
References: 27
Citations by year: 2026: 14 · 2025: 28 · 2024: 30 · 2023: 25 · 2022: 43 · 2021: 39 · 2020: 37 · 2019: 39 · 2018: 42 · 2017: 41 · 2016: 57 · 2015: 52 · 2014: 33 · 2013: 17
FWCI: 33.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL081893)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: statins, atorvastatin, skeletal muscle function, muscle strength, exercise capacity, creatine kinase, myalgia, statin-induced myopathy, high-intensity statin therapy, healthy volunteers
MeSH terms: Atorvastatin, Adult, Creatine Kinase, Double-Blind Method, Exercise Test, Female, Heptanoic Acids, Humans, Male, Middle Aged, Placebos, Pyrroles, Exercise Tolerance, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscle Strength, Young Adult, Musculoskeletal Pain

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