Effect of statins on skeletal muscle function
Open accessAbstract
Background—: Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied. Methods and Results—: The Effect of Statins on Skeletal Muscle Function and Performance (STOMP) study assessed symptoms and measured creatine kinase, exercise capacity, and muscle strength before and after atorvastatin 80 mg or placebo was administered for 6 months to 420 healthy, statin-naive subjects. No individual creatine kinase value exceeded 10 times normal, but average creatine kinase increased 20.8±141.1 U/L ( P <0.0001) with atorvastatin. There were no significant changes in several measures of muscle strength or exercise capacity with atorvastatin, but more atorvastatin than placebo subjects developed myalgia (19 versus 10; P =0.05). Myalgic subjects on atorvastatin or placebo had decreased muscle strength in 5 of 14 and 4 of 14 variables, respectively ( P =0.69). Conclusions—: These results indicate that high-dose atorvastatin for 6 months does not decrease average muscle strength or exercise performance in healthy, previously untreated subjects. Nevertheless, this blinded, controlled trial confirms the undocumented impression that statins increase muscle complaints. Atorvastatin also increased average creatine kinase, suggesting that statins produce mild muscle injury even among asymptomatic subjects. This increase in creatine kinase should prompt studies examining the effects of more prolonged, high-dose statin treatment on muscular performance. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00609063.
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Among 420 statin-naïve subjects randomized to atorvastatin 80 mg daily or placebo for 6 months, 9.4% of statin-treated and 4.6% of control subjects met the study definition of myalgia (P = 0.054).
“Among the 420 statin-naïve subjects randomized to atorvastatin 80 mg daily or placebo for 6 months, 9.4% of the statin-treated and 4.6% of control subjects met the study definition of myalgia (P = 0.054)”
The STOMP study found no differences in measures of muscle strength or exercise performance between statin-treated and placebo subjects.
“The STOMP study also found no differences in the measures of muscle strength or exercise performance between statin-treated and placebo subjects.”
The STOMP study is the only randomized, double-blind, placebo-controlled study specifically designed to examine the effect of statins on skeletal muscle symptoms and performance.
“The Effects of Statins on Muscle Performance (STOMP) study is, to our knowledge, the only randomized, double-blind, placebo-controlled study specifically designed to examine the effect of statins on skeletal muscle symptoms and performance.22”
The incidence of muscle complaints due to statin is considerably less than that reported in observational trials.
“suggesting that the incidence of muscle complaints due to the statin is considerably less than that reported in observational trials.”
Discomfort and weakness typically occur early (within 4-6 weeks after starting statin therapy), but may still occur after many years of treatment.
“Discomfort and weakness typically occur early (within 4–6 weeks after starting statin therapy22), but may still occur after many years of treatment.”
One study designed specifically to study statin effects on muscle symptoms suggests that the frequency of muscle-related complaints is about 5%.
“One study, designed specifically to study the effects of statins on muscle symptoms, suggests that the frequency of muscle-related complaints is ≏ 5%. 217”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [217]
Statins may provoke muscle pain or weakness, which can be confused with normal post-exercise soreness, especially in individuals not accustomed to PRT.
“Medications such as statins may provoke symptoms such as muscle pain or weakness, which can be confused with normal post-exercise soreness, especially in individuals not accustomed to PRT [[588], [589], [590]].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [588]
Statins may provoke muscle pain or weakness that can be confused with normal post-exercise soreness.
“Medications such as statins may provoke symptoms such as muscle pain or weakness, which can be confused with normal post-exercise soreness, especially in individuals not accustomed to PRT [[588], [589], [590]].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [588]
One study designed specifically to study the effects of statins on muscle symptoms suggests that the frequency of muscle-related complaints is about 5%.
“One study, designed specifically to study the effects of statins on muscle symptoms, suggests that the frequency of muscle-related complaints is ~5%.217”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [217]
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Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674 · see citing works
Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J. J., Gotto, A. M., Kastelein, J. J. P., Köenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344393.60303.0a · Cited by 3,641 · see citing works
Arky, R. A. (1994) · Cited by 2,632 · see citing works
Thompson, P. D., Clarkson, P., & Karas, R. H. (2003) · JAMA · doi:10.1001/jama.289.13.1681 · Cited by 1,463 · see citing works
Self-citationBruckert, E., Hayem, G., Dejager, S., Yau, C., & Bégaud, B. (2005) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-005-5686-z · Cited by 1,226 · see citing works
ACC/AHA/NHLBI Clinical Advisory on the Use and Safety of Statins
Writing Committee Members:, Pasternak, R. C., Smith, S. C., Bairey-Merz, C. N., Grundy, S. M., Cleeman, J. I., & Lenfant, C. (2002) · Circulation · doi:10.1161/01.cir.0000032466.44170.44 · Cited by 1,088 · see citing works
Cerivastatin and Reports of Fatal Rhabdomyolysis
Staffa, J. A., Chang, J. T., & Green, L. (2002) · New England Journal of Medicine · doi:10.1056/nejm200202143460721 · Cited by 627 · see citing works
Statin-associated myopathy with normal creatine kinase levels
Phillips, P. S., Haas, R. H., Bannykh, S., Hathaway, S., Gray, N. L., Kimura, B. J., Vladutiu, G. D., England, J. D. F., & and the Scripps Mercy Clinical Research Center* (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-7-200210010-00009 · Cited by 565 · see citing works
Pasternak, R. C., Smith, S. C., Merz, C. N. B., Grundy, S. M., Cleeman, J. I., & Lenfant, C. J. M. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02030-2 · Cited by 497 · see citing works
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
Hanai, J., Cao, P., Tanksale, P., Imamura, S., Koshimizu, E., Zhao, J., Kishi, S., Yamashita, M., Phillips, P. S., Sukhatme, V. P., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32741 · Cited by 281 · see citing works
Paolisso, G., Barbagallo, M., Petrella, G., Ragno, E., Barbieri, M., Giordano, M., & Varricchio, M. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00352-4 · Cited by 171 · see citing works
Association between statin-associated myopathy and skeletal muscle damage
Mohaupt, M. G., Karas, R. H., Babiychuk, E. B., Sanchez-Freire, V., Monastyrskaya, K., Iyer, L., Hoppeler, H., Breil, F., & Draeger, A. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.081785 · Cited by 166 · see citing works
Radi, Z. A., Koza‐Taylor, P., Bell, R. R., Obert, L., Runnels, H. A., BEEBE, J. S., Lawton, M. P., & Sadis, S. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.029 · Cited by 145 · see citing works
Skeletal muscle fatigue, strength, and quality in the elderly: the Health ABC Study
Katsiaras, A., Newman, A. B., Kriska, A. M., Brach, J. S., Krishnaswami, S., Feingold, E., Kritchevsky, S. B., Li, R., Harris, T. B., Schwartz, A. V., et al. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01276.2004 · Cited by 132 · see citing works
Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercise and Statins
Urso, M. L., Clarkson, P. M., Hittel, D. S., Hoffman, E. P., & Thompson, P. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000190608.28704.71 · Cited by 128 · see citing works
Self-citationStatin‐Associated Muscle‐Related Adverse Effects: A Case Series of 354 Patients
Cham, S., Evans, M. A., Denenberg, J. O., & Golomb, B. A. (2010) · Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.30.6.541 · Cited by 114 · see citing works
Effect of Statins on Creatine Kinase Levels Before and After a Marathon Run
Parker, B. A., Augeri, A. L., Capizzi, J. A., Ballard, K. D., Troyanos, C., Baggish, A. L., d’Hemecourt, P. A., & Thompson, P. D. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.08.045 · Cited by 98 · see citing works
Self-citationPrevalence and risk factors of muscle complications secondary to statins
El‐Salem, K., Ababneh, B., Rudnicki, S., Malkawi, A., Alrefai, A., Khader, Y., Saadeh, R., & Saydam, M. (2011) · Muscle & Nerve · doi:10.1002/mus.22205 · Cited by 83 · see citing works
Mullen, P. J., Zahno, A., Lindinger, P. W., Maseneni, S., Felser, A., Krähenbühl, S., & Brecht, K. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.07.019 · Cited by 76 · see citing works
Needed: Pragmatic Clinical Trials for Statin-Intolerant Patients
Maningat, P. D., & Breslow, J. L. (2011) · New England Journal of Medicine · doi:10.1056/nejmp1112023 · Cited by 74 · see citing works
Wu, J. S., Buettner, C., Smithline, H., Ngo, L. H., & Greenman, R. L. (2011) · Muscle & Nerve · doi:10.1002/mus.21847 · Cited by 61 · see citing works
Statin myotoxicity is associated with changes in the cardiopulmonary function
Phillips, P. S., Phillips, C. T., Sullivan, M. J., Naviaux, R. K., & Haas, R. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.06.014 · Cited by 59 · see citing works
The effects of statins on skeletal muscle strength and exercise performance
Krishnan, G. M., & Thompson, P. D. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833c1edf · Cited by 55 · see citing works
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Dobkin, B. H. (2005) · Neurorehabilitation and neural repair · doi:10.1177/1545968305277167 · Cited by 48 · see citing works
Thompson, P. D., Parker, B. A., Clarkson, P. M., Pescatello, L. S., White, C. M., Grimaldi, A. S., Levine, B. D., Haller, R. G., & Hoffman, E. P. (2010) · Preventive Cardiology · doi:10.1111/j.1751-7141.2009.00063.x · Cited by 37 · see citing works
Self-citationSerum Creatine Kinase in Patients with Rheumatic Diseases
Lee, Y. H., Choi, S. J., Ji, J. D., & Song, G. G. (2000) · Clinical Rheumatology · doi:10.1007/s100670070049 · Cited by 25 · see citing works
Observations From a Statin Myopathy Clinic
Phillips, P. S., & Haas, R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.11.1232-b · Cited by 12 · see citing works
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Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162 · see citing works
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Collins, R., Reith, C., Emberson, J., Armitage, J., Baigent, C., Blackwell, L., Blumenthal, R., Danesh, J., Smith, G. D., DeMets, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31357-5 · Cited by 1,857 · see citing works
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Self-citationNewman, C. B., Preiss, D., Tobert, J. A., Jacobson, T. A., Page, R. L., II, Goldstein, L. B., Chin, C. C., Tannock, L. R., Miller, M. J., Raghuveer, G., et al. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atv.0000000000000073 · Cited by 761 · see citing works
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Self-citationMancini, G. B. J., Baker, S. K., Bergeron, J., FITCHETT, D. H., Frohlich, J. J., Genest, J. J., Gupta, M., Hegele, R. A., Ng, D. S., Pearson, G. J., et al. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.01.003 · Cited by 253 · see citing works
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Cai, T., Abel, L., Langford, O., Monaghan, G., Aronson, J. K., Stevens, R., Lay-Flurrie, S. L., Koshiaris, C., McManus, R. J., Hobbs, R. F., et al. (2021) · BMJ · doi:10.1136/bmj.n1537 · Cited by 233 · see citing works
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Newman, C. B., Blaha, M. J., Boord, J. B., Cariou, B., Chait, A., Fein, H. G., Ginsberg, H. N., Goldberg, I. J., Murad, M. H., Subramanian, S., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa674 · Cited by 180 · see citing works
Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy
Vinci, P., Panizon, E., Tosoni, L. M., Cerrato, C., Pellicori, F., Mearelli, F., Biasinutto, C., Fiotti, N., Girolamo, F. G. D., & Biolo, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111687 · Cited by 180 · see citing works
Mora, J. C., & Valencia, W. M. (2018) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2017.08.007 · Cited by 196 · see citing works
Sex Differences in High-Intensity Statin Use Following Myocardial Infarction in the United States
Peters, S. A. E., Colantonio, L. D., Zhao, H., Bittner, V., Dai, Y., Farkouh, M. E., Monda, K. L., Safford, M. M., Muntner, P., & Woodward, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.032 · Cited by 173 · see citing works
Non-cardiovascular effects associated with statins
Desai, C. S., Martin, S. S., & Blumenthal, R. S. (2014) · BMJ · doi:10.1136/bmj.g3743 · Cited by 172 · see citing works
An assessment by the Statin Intolerance Panel: 2014 update
Guyton, J. R., Bays, H. E., Grundy, S. M., & Jacobson, T. A. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.03.002 · Cited by 165 · see citing works
Banach, M., Rizzo, M., Toth, P. P., Farnier, M., Davidson, M. H., Al-Rasadi, K., Aronow, W. S., Athyros, V., Djuric, D. M., Ezhov, M. V., et al. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1039980 · Cited by 162 · see citing works
Moriarty, P. M., Jacobson, T. A., Bruckert, E., Thompson, P. D., Guyton, J. R., Baccara-Dinet, M. T., & Gipe, D. (2014) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2014.09.007 · Cited by 154 · see citing works
Self-citationPoly-ADP-ribosylation in health and disease
Bonicalzi, M.-È., Haince, J.-F., Droit, A., & Poirier, G. G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4505-1 · Cited by 150 · see citing works
Current and Emerging Uses of Statins in Clinical Therapeutics: A Review
Davies, J. T., Delfino, S., Feinberg, C. E., Johnson, M. F., Nappi, V. L., Olinger, J. T., Schwab, A., & Swanson, H. I. (2016) · Lipid Insights · doi:10.4137/lpi.s37450 · Cited by 148 · see citing works
Mechanisms of statin-associated skeletal muscle-associated symptoms
Bouitbir, J., Sanvee, G. M., Panajatovic, M. V., Singh, F., & Krähenbühl, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.010 · Cited by 146 · see citing works
The role of mitochondria in statin‐induced myopathy
Apostolopoulou, M., Corsini, A., & Roden, M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12461 · Cited by 142 · see citing works
Thompson, P. D., MacDougall, D. E., Newton, R. S., Margulies, J. R., Hanselman, J. C., Orloff, D. G., McKenney, J. M., & Ballantyne, C. M. (2016) · Journal of clinical lipidology · doi:10.1016/j.jacl.2015.12.025 · Cited by 142 · see citing works
Self-citationRosenson, R. S., Miller, K., Bayliss, M. S., Sanchez, R. J., Baccara‐Dinet, M. T., Chibedi-De-Roche, D., Taylor, B. A., Khan, I., Manvelian, G. Z., White, M. K., et al. (2017) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-017-6723-4 · Cited by 142 · see citing works
Statins and Musculoskeletal Conditions, Arthropathies, and Injuries
Mansi, I. A., Frei, C. R., Pugh, M. J., Makris, U. E., & Mortensen, E. M. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.6184 · Cited by 129 · see citing works
Cytokines: Roles in Atherosclerosis Disease Progression and Potential Therapeutic Targets
Moss, J. W. E., & Ramji, D. P. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0072 · Cited by 126 · see citing works
Li, P., Yin, Y., Guo, T., Sun, X., Ma, H., Zhu, M., Zhao, F., Xu, P. A., Chen, Y., Wan, G., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.017949 · Cited by 126 · see citing works
Writing Committee Members, Blumenthal, R. S., Morris, P. B., Gaudino, M., Johnson, H. M., Anderson, T. S., Bittner, V. A., Blankstein, R., Brewer, L. C., Cho, L., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001423 · Cited by 122 · see citing works
Warden, B. A., Guyton, J. R., Kovacs, A. C., Durham, J. A., Jones, L. K., Dixon, D. L., Jacobson, T. A., & Duell, P. B. (2023) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2022.09.001 · Cited by 111 · see citing works
Ahmad, Z. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.02.033 · Cited by 110 · see citing works
Diagnosis and Management of Statin Intolerance
Rodrigo Alonso, K., Cuevas, A. M., & Cafferata, A. (2019) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17030 · Cited by 109 · see citing works
Coming of Age: Considerations in the Prescription of Exercise for Older Adults
Zaleski, A. L., Taylor, B. A., Panza, G. A., Wu, Y., Pescatello, L. S., Thompson, P. D., & Fernández, A. B. (2016) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-12-2-98 · Cited by 107 · see citing works
Self-citationEssential amino acid supplementation in patients following total knee arthroplasty
Dreyer, H. C., Strycker, L. A., Senesac, H. A., Hocker, A. D., Smolkowski, K., Shah, S. N., & Jewett, B. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70160 · Cited by 101 · see citing works
Statins, Muscle Disease and Mitochondria
Ramachandran, R., & Wierzbicki, A. S. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6080075 · Cited by 91 · see citing works
Unmet Needs in LDL-C Lowering: When Statins Won’t Do!
Krähenbühl, S., Pavik-Mezzour, I., & von Eckardstein, A. (2016) · Drugs · doi:10.1007/s40265-016-0613-0 · Cited by 89 · see citing works
NLA Task Force on Statin Safety - 2014 update
Jacobson, T. A. (2014) · Journal of clinical lipidology · doi:10.1016/j.jacl.2014.03.003 · Cited by 90 · see citing works
Statins and Physical Activity in Older Men
Lee, D. S. H., Markwardt, S., Goeres, L. M., Lee, C. G., Eckstrom, E., Williams, C. D., Fu, R., ORWOLL, E. S., Cawthon, P. M., Stefanick, M. L., et al. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.2266 · Cited by 89 · see citing works
Curing atherosclerosis should be the next major cardiovascular prevention goal
Robinson, J. G., & Gidding, S. S. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.04.009 · Cited by 87 · see citing works
Statin-associated muscle symptoms—Managing the highly intolerant
Backes, J. M., Ruisinger, J. F., Gibson, C., & Moriarty, P. M. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.01.006 · Cited by 88 · see citing works
Muscle- and skeletal-related side-effects of statins: tip of the iceberg?
Auer, J., Sinzinger, H. F., Franklin, B., & Berent, R. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314550804 · Cited by 85 · see citing works
Treatment Options for Statin-Associated Muscle Symptoms
Laufs, U., Scharnagl, H., Halle, M., Windler, E., Endres, M., & März, W. (2015) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2015.0748 · Cited by 83 · see citing works
Muntean, D. M., Thompson, P. D., Catapano, A. L., Stasiolek, M., Fabis, J., Muntner, P., Serban, M.-C., & Banach, M. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.001 · Cited by 82 · see citing works
Statin-Associated Muscle Disease: Advances in Diagnosis and Management
Taylor, B. A., & Thompson, P. D. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0670-z · Cited by 85 · see citing works
Self-citationPenson, P. E., Bruckert, É., MARAIS, D. P., Reiner, Ž., Pirro, M., Sahebkar, A., Bajraktari, G., Mirrakhimov, E. M., Rizzo, M., Mikhailidis, D. P., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12960 · Cited by 84 · see citing works
Statin Intolerance: A Literature Review and Management Strategies
Saxon, D. R., & Eckel, R. H. (2016) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2016.07.009 · Cited by 74 · see citing works
Brunham, L. R., Baker, S. K., Mammen, A. L., Mancini, G. B. J., & Rosenson, R. S. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy119 · Cited by 71 · see citing works
Statins for Primary Prevention in Older Adults—Moving Toward Evidence‐Based Decision‐Making
Singh, S., Zieman, S. J., Go, A. S., Fortmann, S. P., WENGER, N. K., Fleg, J. L., Radziszewska, B., Stone, N. J., Zoungas, S., & Gurwitz, J. H. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15449 · Cited by 67 · see citing works
Muscle Toxicity of Drugs: When Drugs Turn Physiology into Pathophysiology
Janssen, L., Allard, N. A. E., Saris, C. G. J., Keijer, J., Hopman, M. T. E., & Timmers, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00002.2019 · Cited by 67 · see citing works
Leblanc, A., Taylor, B. A., Thompson, P. D., Capizzi, J. A., Clarkson, P. M., White, C. M., & Pescatello, L. S. (2015) · SpringerPlus · doi:10.1186/s40064-015-1357-0 · Cited by 65 · see citing works
Self-citationPharmacogenomics for Primary Care: An Overview
Rollinson, V., Turner, R. M., & Pirmohamed, M. (2020) · Genes · doi:10.3390/genes11111337 · Cited by 64 · see citing works
An overview of statin-induced myopathy and perspectives for the future
Nikolić, D., Banach, M., Chianetta, R., Luzzu, L. M., Stoian, A. P., Diaconu, C. C., Citarrella, R., Montalto, G., & Rizzo, M. (2020) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2020.1747431 · Cited by 65 · see citing works
Perera, R., McFadden, E. C., McLellan, J., Lung, T. W.-C., Clarke, P., Pérez, T., Fanshawe, T. R., Dalton, A., Farmer, A. A., Glasziou, P., et al. (2015) · Health Technology Assessment · doi:10.3310/hta191000 · Cited by 63 · see citing works
Lalwani, N. D., Hanselman, J. C., MacDougall, D. E., Sterling, L. R., & Cramer, C. T. (2019) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2019.05.003 · Cited by 72 · see citing works
Statins and Their Effect on PCSK9—Impact and Clinical Relevance
Taylor, B. A., & Thompson, P. D. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0604-3 · Cited by 62 · see citing works
Self-citationBeyond statins: New pharmacological targets to decrease LDL-cholesterol and cardiovascular events
Raschi, E., Casula, M., Cicero, A. F. G., Corsini, A., Borghi, C., & Catapano, A. L. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108507 · Cited by 66 · see citing works
Statin-Associated Myopathy: From Genetic Predisposition to Clinical Management
Vrablı́k, M., Zlatohlávek, L., Štulc, T., Adámková, V., Prusíková, M., Schwarzová, L., Hubacek, J. A., & Češka, R. (2014) · Physiological Research · doi:10.33549/physiolres.932865 · Cited by 59 · see citing works
Vaughan, R. A., Garcia-Smith, R., Bisoffi, M., Conn, C. A., & Trujillo, K. A. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.009 · Cited by 58 · see citing works
Statins Affect Skeletal Muscle Performance: Evidence for Disturbances in Energy Metabolism
Allard, N. A. E., Schirris, T. J. J., Verheggen, R. J. H. M., Rüssel, F. G. M., Rodenburg, R. J., Smeitink, J. A. M., Thompson, P. D., Hopman, M. T. E., & Timmers, S. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01561 · Cited by 59 · see citing works
Self-citationStatins, myalgia, and rhabdomyolysis
Tournadre, A. (2019) · Joint Bone Spine · doi:10.1016/j.jbspin.2019.01.018 · Cited by 59 · see citing works
Statin Intolerance: the Clinician’s Perspective
Štulc, T., Češka, R., & Gotto, A. M. (2015) · Current Atherosclerosis Reports · doi:10.1007/s11883-015-0552-3 · Cited by 59 · see citing works
The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins
Mo, H., Jeter, R., Bachmann, A., Yount, S. T., Shen, C., & Yeganehjoo, H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01515 · Cited by 56 · see citing works
Muscle-related side-effects of statins
Taylor, B. A., & Thompson, P. D. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000174 · Cited by 53 · see citing works
Self-citationNguyen, T. N., Ngangue, P., Haggerty, J. L., Bouhali, T., & Fortin, M. (2019) · Family Practice · doi:10.1093/fampra/cmz023 · Cited by 52 · see citing works
Graham, J., Sanchez, R. J., Saseen, J. J., Mallya, U. G., Panaccio, M. P., & Evans, M. A. (2016) · Journal of clinical lipidology · doi:10.1016/j.jacl.2016.10.003 · Cited by 49 · see citing works
Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study
Veronese, N., Koyanagi, A., Stubbs, B., Cooper, C. C., Guglielmi, G., Rizzoli, R., Schofield, P., Punzi, L., Al‐Daghri, N. M., Smith, L., et al. (2018) · Arthritis Care & Research · doi:10.1002/acr.23735 · Cited by 50 · see citing works
Expert opinion: the therapeutic challenges faced by statin intolerance
Patel, J., Martin, S. S., & Banach, M. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1197202 · Cited by 50 · see citing works
Mallinson, J. E., Marimuthu, K., Murton, A. J., Selby, A., Smith, K., Constantin‐Teodosiu, D., Rennie, M. J., & Greenhaff, P. L. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.285577 · Cited by 47 · see citing works
Drug‐related sarcopenia as a secondary sarcopenia
Kuzuya, M. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14770 · Cited by 46 · see citing works
- Authors
- Parker, B. A., Capizzi, J. A., Grimaldi, A. S., Clarkson, P. M., Cole, S. M., Keadle, J., Chipkin, S., Pescatello, L. S., Simpson, K., White, C. M., & Thompson, P. D.
- Affiliations
- Hartford Hospital (US)
- Venue
- Circulation
- Published
- 2013-01
- Volume
- 127
- Issue
- 1
- Pages
- 96-103
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4450764
- OpenAlex
- W1982914740
- Cited by
- 500
- References
- 27
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 30 · 2023: 25 · 2022: 43 · 2021: 39 · 2020: 37 · 2019: 39 · 2018: 42 · 2017: 41 · 2016: 57 · 2015: 52 · 2014: 33 · 2013: 17 · 2012: 1
- FWCI
- 33.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL081893)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- statins, atorvastatin, skeletal muscle function, muscle strength, exercise capacity, creatine kinase, myalgia, statin-induced myopathy, high-intensity statin therapy, healthy volunteers
- MeSH terms
- Atorvastatin, Adult, Creatine Kinase, Double-Blind Method, Exercise Test, Female, Heptanoic Acids, Humans, Male, Middle Aged, Placebos, Pyrroles, Exercise Tolerance, Muscle, Skeletal, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscle Strength, Young Adult, Musculoskeletal Pain
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