The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Periprocedural Stroke and Bleeding Complications in Patients Undergoing Catheter Ablation of Atrial Fibrillation With Different Anticoagulation Management: Results From the Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (COMPARE) Randomized Trial
Open accessAbstract
Background—: Periprocedural thromboembolic and hemorrhagic events are worrisome complications of catheter ablation for atrial fibrillation (AF). The periprocedural anticoagulation management could play a role in the incidence of these complications. Although ablation procedures performed without warfarin discontinuation seem to be associated with lower thromboembolic risk, no randomized study exists. Methods and Results—: This was a prospective, open-label, randomized, parallel-group, multicenter study assessing the role of continuous warfarin therapy in preventing periprocedural thromboembolic and hemorrhagic events after radiofrequency catheter ablation. Patients with CHADS 2 score ≥1 were included. Patients were randomly assigned in a 1:1 ratio to the off-warfarin or on-warfarin arm. The incidence of thromboembolic events in the 48 hours after ablation was the primary end point of the study. The study enrolled 1584 patients: 790 assigned to discontinue warfarin (group 1) and 794 assigned to continuous warfarin (group 2). No statistical difference in baseline characteristics was observed. There were 39 thromboembolic events (3.7% strokes [n=29] and 1.3% transient ischemic attacks [n=10]) in group 1: two events (0.87%) in patients with paroxysmal AF, 4 (2.3%) in patients with persistent AF, and 33 (8.5%) in patients with long-standing persistent AF. Only 2 strokes (0.25%) in patients with long-standing persistent AF were observed in group 2 ( P <0.001). Warfarin discontinuation emerged as a strong predictor of periprocedural thromboembolism (odds ratio, 13; 95% confidence interval, 3.1–55.6; P <0.001). Conclusion—: This is the first randomized study showing that performing catheter ablation of AF without warfarin discontinuation reduces the occurrence of periprocedural stroke and minor bleeding complications compared with bridging with low-molecular-weight heparin. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT01006876.
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Cites
Mehran, R., Rao, S. V., Bhatt, D. L., Gibson, C. M., Caixeta, A., Eikelboom, J., Kaul, S., Wiviott, S. D., Menon, V., Nikolsky, E., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.009449 · Cited by 4,476
Cappato, R., Calkins, H., Chen, S.-A., Davies, W., Iesaka, Y., Kalman, J., Kim, Y.-H., Klein, G., Natale, A., Packer, D., et al. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.859116 · Cited by 2,852
Calkins, H., Reynolds, M. R., Spector, P., Sondhi, M., Xu, Y., Martin, A., Williams, C. J., & Sledge, I. (2009) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.108.824789 · Cited by 847 · cited 6×
“Although ablation procedures performed without warfarin discontinuation seem to be associated with lower thromboembolic risk compared with other strategies discontinuing warfarin before ablation, no randomized study currently exists.2–6 This study aims at exploring the risk of periprocedural thromboembolic and hemorrh…”
BackgroundInfluentialPrevalence and Causes of Fatal Outcome in Catheter Ablation of Atrial Fibrillation
Cappato, R., Calkins, H., Chen, S.-A., Davies, W., Iesaka, Y., Kalman, J., Kim, Y.-H., Klein, G., Natale, A., Packer, D., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.022 · Cited by 584
Self-citationPacemaker or Defibrillator Surgery without Interruption of Anticoagulation
Birnie, D. H., Healey, J. S., Wells, G. A., Verma, A., Tang, A. S., Krahn, A. D., Simpson, C. S., Ayala-Paredes, F., Coutu, B., Leiria, T. L. L., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302946 · Cited by 579
Lakkireddy, D., Reddy, Y. M., Di Biase, L., Vanga, S. R., Santangeli, P., Swarup, V., Pimentel, R., Mansour, M. C., D'Avila, A., Sanchez, J. E., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.12.014 · Cited by 356
Self-citationDi Biase, L., Burkhardt, J. D., Mohanty, P., Sanchez, J., Horton, R., Gallinghouse, G. J., Lakkireddy, D., Verma, A., Khaykin, Y., Hongo, R., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.921320 · Cited by 294
Self-citationWazni, O. M., Beheiry, S., Fahmy, T., Barrett, C., Hao, S., Patel, D., Di Biase, L., Martin, D. O., Kanj, M., Arruda, M., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.727784 · Cited by 249
Self-citationNdrepepa, G., Schuster, T., Hadamitzky, M., Byrne, R. A., Mehilli, J., Neumann, F.-J., Richardt, G., Schulz, S., Laugwitz, K.-L., Massberg, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.060871 · Cited by 242
Lakkireddy, D., Reddy, Y. M., Di Biase, L., Vallakati, A., Mansour, M. C., Santangeli, P., Gangireddy, S., Swarup, V., Chalhoub, F., Atkins, D., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.039 · Cited by 177
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Cited by
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Calkins, H., Hindricks, G., Cappato, R., Kim, Y.-H., Saad, E. B., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,755
Self-citationSteffel, J., Verhamme, P., Potpara, T. S., Albaladejo, P., Antz, M., Desteghe, L., Haeusler, K. G., Oldgren, J., Reinecke, H., Roldan-Schilling, V., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy136 · Cited by 2,123
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403
Steffel, J., Collins, R., Antz, M., Cornu, P., Desteghe, L., Haeusler, K. G., Oldgren, J., Reinecke, H., Roldan-Schilling, V., Rowell, N., et al. (2021) · EP Europace · doi:10.1093/europace/euab065 · Cited by 1,132
Metadata
- Authors
- Di Biase, L., Burkhardt, J. D., Santangeli, P., Mohanty, P., Sanchez, J. E., Horton, R., Gallinghouse, G. J., Themistoclakis, S., Rossillo, A., Lakkireddy, D., Reddy, M., Hao, S., Hongo, R., Beheiry, S., Zagrodzky, J., Rong, B., Mohanty, S., Elayi, C. S., Forleo, G., Pelargonio, G., Narducci, M. L., Russo, A. D., Casella, M., Fassini, G., Tondo, C., Schweikert, R. A., & Natale, A.
- Venue
- Circulation
- Published
- 2014-06-24
- Volume
- 129
- Issue
- 25
- Pages
- 2638-2644
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1968678408
- Cited by
- 485
- References
- 18
- FWCI
- 38.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Periprocedural Stroke and Bleeding Complications in Patients Undergoing Catheter Ablation of Atrial Fibrillation With Different Anticoagulation Management: Results From the Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (COMPARE) Randomized Trial. https://app.cochat.ai/papers/10.1161/circulationaha.113.006426
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- Di Biase, L., Burkhardt, J. D., Santangeli, P., Mohanty, P., Sanchez, J. E., Horton, R., Gallinghouse, G. J., Themistoclakis, S., Rossillo, A., Lakkireddy, D., Reddy, M., Hao, S., Hongo, R., Beheiry, S., Zagrodzky, J., Rong, B., Mohanty, S., Elayi, C. S., Forleo, G., . . . Natale, A. (2014). Periprocedural Stroke and Bleeding Complications in Patients Undergoing Catheter Ablation of Atrial Fibrillation With Different Anticoagulation Management: Results From the Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (COMPARE) Randomized Trial. Circulation. https://doi.org/10.1161/circulationaha.113.006426
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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