The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events
Open accessAbstract
BACKGROUND: Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship. METHODS AND RESULTS: The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) enrolled 2580 pacemaker and defibrillator patients aged ≥65 years with a history of hypertension but without a history of atrial fibrillation. Pacemakers and implantable cardioverter-defibrillators precisely logged the time and duration of all episodes of SCAF and recorded electrograms that were adjudicated by experts. We examined the temporal relationship between SCAF >6 minutes in duration and stroke or systemic embolism. Of 51 patients who experienced stroke or systemic embolism during follow-up, 26 (51%) had SCAF. In 18 patients (35%), SCAF was detected before stroke or systemic embolism. However, only 4 patients (8%) had SCAF detected within 30 days before stroke or systemic embolism, and only 1 of these 4 patients was experiencing SCAF at the time of the stroke. In the 14 patients with SCAF detected >30 days before stroke or systemic embolism, the most recent episode occurred at a median interval of 339 days (25th to 75th percentile, 211-619) earlier. Eight patients (16%) had SCAF detected only after their stroke, despite continuous monitoring for a median duration of 228 days (25th to 75th percentile, 202-719) before their event. CONCLUSIONS: Although SCAF is associated with an increased risk of stroke and embolism, very few patients had SCAF in the month before their event. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00256152.
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“The detection of supraventricular tachycardia (SVT) may be important as well as it is associated with the development of AF and an increased risk of stroke even in patients without AF (4–6).”
From Diagnostic Yield of Extended Cardiac Patch Monitoring in Patients with Stroke or TIA (2015) · cites this paper as [5]
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“Strokes often occur without AHRE detected within 30 days before the event.143-147”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [143]
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Trueick, R., Shpigelman, J., Dabash, O., McCallig, J., Ashfaque, M. A., Quidwai, M., Donaghy, L., Guilfoyle, P., Saiva, L., O’Neill, J., et al. (2026) · Frontiers in Stroke · doi:10.3389/fstro.2026.1838151
Value of Cardiac Structural Metrics in Identifying Cardioembolic Stroke
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“However, no clear temporal relationship between AF and thromboembolic events has been reported, and no AF episodes were recorded during the 30 days preceding a thromboembolic event [24, 28].”
Thapa, S., Shah, S., Pratik, F. N. U., Ahmed, M., Wahid, A., Bujala, N., Thapa, A., Chand, S., Frishman, W. H., & Aronow, W. S. (2026) · Cardiology in Review · doi:10.1097/crd.0000000000001434
Godun, M.-M., Marcu, D. T. M., Morariu, P. C., Oancea, A. F., Apetrii, M.-C., Stefan, A.-E., Floria, D., Huiban, L., Todiraș, B., Tanasa, M. P., et al. (2026) · Diagnostics · doi:10.3390/diagnostics16193196
“Data from implanted devices show that episodes of subclinical AF lasting more than six minutes are rarely captured in the month before a stroke or systemic embolism occurs [13].”
The impact of sex and age in the treatment of atrial fibrillation
Bah, A. (2022) · UEF eRepo (University of Eastern Finland)
Photoplethysmography in algorithm-based detection of atrial fibrillation
Väliaho, E. (2023) · UEF eRepo (University of Eastern Finland)
Left Atrial Enlargement Identifies Risk of Stroke Independent of Atrial Fibrillation
Pedersen, J. J., Kühl, J. T., Pham, M. H. C., Sigvardsen, P. E., Fuchs, A., Nordestgaard, B. G., Køber, L., Lowes, M. M., Paulsen, R. R., & Kofoed, K. F. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.126.053248
Metadata
- Authors
- Brambatti, M., Connolly, S. J., Gold, M. R., Morillo, C. A., Capucci, A., Muto, C., Lau, C. P., Van Gelder, I. C., Hohnloser, S. H., Carlson, M., Fain, E., Nakamya, J., Mairesse, G. H., Halytska, M., Deng, W. Q., Israel, C. W., & Healey, J. S.
- Affiliations
- Goethe University Frankfurt (DE)
- From the Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (M.B., S.J.C., C.A.M., J.N., M.H., W.Q.D., J.S.H.); Clinica di Cardiologia, Università Politecnica delle Marche, Ancona, Italy (M.B., A.C.); Medical University of South Carolina, Charleston (M.R.G.); Cardiology Department, Loreto Mare, Napoli, Italy (C.M.); Queen Mary Hospital, Department of Medicine, University of Hong Kong, Hong Kong, China (C.P.L.); University of Groningen, University Medical Center...
- ORCID
- Venue
- Circulation
- Published
- 2014-05-27
- Volume
- 129
- Issue
- 21
- Pages
- 2094-2099
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2024497977
- Cited by
- 676
- References
- 31
- Citations by year
- 2026: 21 · 2025: 35 · 2024: 52 · 2023: 66 · 2022: 62 · 2021: 67 · 2020: 55 · 2019: 63 · 2018: 57 · 2017: 66 · 2016: 58 · 2015: 57 · 2014: 15
- FWCI
- 44.81
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- subclinical atrial fibrillation, stroke, systemic embolism, implantable cardioverter-defibrillator, cardiac pacemaker, temporal relations, asymptomatic atrial fibrillation, hypertension
- MeSH terms
- Aged, Aged, 80 and over, Atrial Fibrillation, Embolism, Female, Follow-Up Studies, Humans, Male, Pacemaker, Artificial, Prospective Studies, Risk Factors, Time Factors, Stroke
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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