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Cited by 605Atrial Fibrillation Management and OutcomesHealth Promotion and Cardiovascular PreventionAcute Ischemic Stroke Management

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Mass Screening for Untreated Atrial Fibrillation: The STROKESTOP Study

Svennberg, Emma, Engdahl, Johan, Al-Khalili, Faris, Friberg, Leif, Frykman, Viveka, Rosenqvist, Mårten·2015·Circulation
DOI 10.1161/circulationaha.114.014343
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Abstract

BACKGROUND: The aims of the present study were to define the prevalence of untreated atrial fibrillation (AF) in a systematic screening program using intermittent ECG recordings among 75- to 76-year-old individuals and to study the feasibility of initiating protective oral anticoagulant (OAC) treatment. METHODS AND RESULTS: Half of the 75- to 76-year-old population in 2 Swedish regions were invited to a screening program for AF. Participants without a previous diagnosis of AF underwent intermittent ECG recordings over 2 weeks. If AF was detected, participants were offered OAC. During the 28-month inclusion period, 13 331 inhabitants were invited. Of these, 7173 (53.8%) participated. Of the participants, 218 (3.0%; 95% confidence interval [CI], 2.7-3.5) were found to have previously unknown AF, and of these, AF was found in 37 (0.5% of the screened population) on their first ECG. The use of intermittent ECGs increased new AF detection 4-fold. A previous diagnosis of AF was known in 9.3% (n=666; 95% CI, 8.6-10.0). Total AF prevalence in the screened population was 12.3%. Of participants with known AF, 149 (2.1%; 95% CI, 1.8-2.4) had no OAC treatment. In total, 5.1% (95% CI, 4.6-5.7) of the screened population had untreated AF; screening resulted in initiation of OAC treatment in 3.7% (95% CI, 3.3-4.2) of the screened population. More than 90% of the participants with previously undiagnosed AF accepted initiation of OAC treatment. CONCLUSIONS: Mass screening for AF in a 75- to 76-year-old population identifies a significant proportion of participants with untreated AF. Initiation of stroke prophylactic treatment was highly successful in individuals with newly diagnosed AF. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01593553.

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Crossref · 10.1161/circulationaha.114.014343

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Metadata

Authors
Svennberg, E., Engdahl, J., Al-Khalili, F., Friberg, L., Frykman, V., & Rosenqvist, M.
Affiliations
  • Danderyds sjukhus (SE)
  • From Karolinska Institutet, Department of Clinical Sciences, Cardiology Unit, Danderyd’s University Hospital, Stockholm, Sweden (E.S., F.A.-K., L.F., V.F., M.R.); Department of Medicine, Halland’s Hospital, Halmstad, Sweden (J.E.); and Stockholm Heart Center, Sweden (F.A.-K.).
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-06
Volume
131
Issue
25
Pages
2176-2184
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/circulationaha.114.014343
OpenAlex
W2020682484
Cited by
605
References
57
Citations by year
2026: 35 · 2025: 29 · 2024: 42 · 2023: 47 · 2022: 55 · 2021: 97 · 2020: 68 · 2019: 63 · 2018: 61 · 2017: 50 · 2016: 51 · 2015: 7
FWCI
40.91
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
atrial fibrillation, mass screening, oral anticoagulation, stroke prevention, prevalence, older adults, newly diagnosed atrial fibrillation, treatment initiation
MeSH terms
Aged, Atrial Fibrillation, Electrocardiography, Female, Humans, Male, Mass Screening, Prospective Studies, Risk Factors, Sweden, Stroke

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