The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Improving the Diagnosis of Infective Endocarditis in Prosthetic Valves and Intracardiac Devices With 18 F-Fluordeoxyglucose Positron Emission Tomography/Computed Tomography Angiography: Initial Results at an Infective Endocarditis Referral Center
Abstract
Background—: The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) and 18 F-FDG PET/CT angiography (PET/CTA) was evaluated in this complex scenario at a referral center with a multidisciplinary IE unit. Methods and Results—: Ninety-two patients admitted to our hospital with suspected prosthetic valve or cardiac device IE between November 2012 and November 2014 were prospectively included. All patients underwent echocardiography and PET/CT, and 76 had cardiac CTA. PET/CT and echocardiography findings were evaluated and compared, with concordant results in 54% of cases (κ=0.23). Initial diagnoses with DC at admission, PET/CT, and DC+PET/CT were compared with the final diagnostic consensus reached by the IE Unit. DC+PET/CT enabled reclassification of 90% of cases initially classified as possible IE with DC and provided a conclusive diagnosis (definite/rejected) in 95% of cases. Sensitivity, specificity, and positive and negative predictive values were 52%, 94.7%, 92.9%, and 59.7% for DC; 87%, 92.1%, 93.6%, and 84.3% for PET/CT; and 90.7%, 89.5%, 92%, and 87.9% for DC+PET/CT. Use of PET/CTA yielded even better diagnostic performance values than PET/nonenhanced CT (91%, 90.6%, 92.8%, and 88.3% versus 86.4%, 87.5%, 90.2%, and 82.9%) and substantially reduced the rate of doubtful cases from 20% to 8% ( P <0.001). DC+PET/CTA reclassified an additional 20% of cases classified as possible IE with DC+PET/nonenhanced CT. In addition, PET/CTA enabled detection of a significantly larger number of anatomic lesions associated with active endocarditis than PET/nonenhanced CT ( P =0.006) or echocardiography ( P <0.001). Conclusions—: 18 F-FDG PET/CT improves the diagnostic accuracy of the modified DC in patients with suspected IE and prosthetic valves or cardiac devices. PET/CTA yielded the highest diagnostic performance and provided additional diagnostic benefits.
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Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493
Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009)
Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and by the International Society of Chemotherapy (ISC) for Infection and Cancer, Habib, G., Hoen, B., Tornos, P., Thuny, F., Prendergast, B., Vilacosta, I., Moreillon, P., de Jesus Antunes, M., Thilen, U., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp285 · Cited by 2,014
Self-citationRecommendations for the practice of echocardiography in infective endocarditis
Habib, G., (France), Badano, L., (Italy), Tribouilloy, C., (France), Vilacosta, I., (Spain), Zamorano, J. L., (Spain), et al. (2010) · European Journal of Echocardiography · doi:10.1093/ejechocard/jeq004 · Cited by 621
EANM/SNMMI Guideline for18F-FDG Use in Inflammation and Infection
Jamar, F., Buscombe, J., Chiti, A., Christian, P. E., Delbeke, D., Donohoe, K. J., Israel, O., Martin-Comin, J., & Signore, A. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.112524 · Cited by 577
Positron Emission Tomography/Computed Tomography for Diagnosis of Prosthetic Valve Endocarditis
Saby, L., Laas, O., Habib, G., Cammilleri, S., Mancini, J., Tessonnier, L., Casalta, J.-P., Gouriet, F., Riberi, A., Avierinos, J.-F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.01.092 · Cited by 503
Rudd, J. H. F., Myers, K. S., Bansilal, S., Machac, J., Rafique, A., Farkouh, M., Fuster, V., & Fayad, Z. A. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.05.024 · Cited by 423
Multislice Computed Tomography in Infective Endocarditis
Feuchtner, G. M., Stolzmann, P., Dichtl, W., Schertler, T., Bonatti, J., Scheffel, H., Mueller, S., Plass, A., Mueller, L., Bartel, T., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.077 · Cited by 422
Sarrazin, J.-F., Philippon, F., Tessier, M., Guimond, J., Molin, F., Champagne, J., Nault, I., Blier, L., Nadeau, M., Charbonneau, L., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.059 · Cited by 285
Infection imaging using whole-body FDG-PET
Stumpe, K. D. M., Dazzi, H., Schaffner, A., & von Schulthess, G. K. (2000) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590000277 · Cited by 266
Rouzet, F., Chequer, R., Benali, K., Lepage, L., Ghodbane, W., Duval, X., Iung, B., Vahanian, A., Le Guludec, D., & Hyafil, F. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.141895 · Cited by 230
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Blomström-Lundqvist, C., Traykov, V., Erba, P. A., Burri, H., Nielsen, J. C., Bongiorni, M. G., Poole, J., Boriani, G., Costa, R., Deharo, J.-C., et al. (2020) · EP Europace · doi:10.1093/europace/euz246 · Cited by 423
Characterization of 18 F-Fluorodeoxyglucose Uptake Pattern in Noninfected Prosthetic Heart Valves
Mathieu, C., Mikaïl, N., Benali, K., Iung, B., Duval, X., Nataf, P., Jondeau, G., Hyafil, F., Le Guludec, D., & Rouzet, F. (2017) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.116.005585 · Cited by 102
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Metadata
- Authors
- Pizzi, M. N., Roque, A., Fernández-Hidalgo, N., Cuéllar-Calabria, H., Ferreira-González, I., Gonzàlez-Alujas, M. T., Oristrell, G., Gracia-Sánchez, L., González, J. J., Rodríguez-Palomares, J., Galiñanes, M., Maisterra-Santos, O., Garcia-Dorado, D., Castell-Conesa, J., Almirante, B., Aguadé-Bruix, S., & Tornos, P.
- Venue
- Circulation
- Published
- 2015-09-22
- Volume
- 132
- Issue
- 12
- Pages
- 1113-1126
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2176021874
- Cited by
- 401
- References
- 26
- FWCI
- 27.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pizzi, M. N., Roque, A., Fernández-Hidalgo, N., Cuéllar-Calabria, H., Ferreira-González, I., Gonzàlez-Alujas, M. T., Oristrell, G., Gracia-Sánchez, L., González, J. J., Rodríguez-Palomares, J., Galiñanes, M., Maisterra-Santos, O., Garcia-Dorado, D., Castell-Conesa, J., Almirante, B., Aguadé-Bruix, S., & Tornos, P. (2015). Improving the Diagnosis of Infective Endocarditis in Prosthetic Valves and Intracardiac Devices With 18 F-Fluordeoxyglucose Positron Emission Tomography/Computed Tomography Angiography: Initial Results at an Infective Endocarditis Referral Center. Circulation. https://doi.org/10.1161/circulationaha.115.015316
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