Reproductive Risk Factors and Coronary Heart Disease in the Women’s Health Initiative Observational Study
Open accessAbstract
Background—: Reproductive factors provide an early window into a woman’s coronary heart disease (CHD) risk; however, their contribution to CHD risk stratification is uncertain. Methods and Results—: In the Women’s Health Initiative Observational Study, we constructed Cox proportional hazards models for CHD including age, pregnancy status, number of live births, age at menarche, menstrual irregularity, age at first birth, stillbirths, miscarriages, infertility ≥1 year, infertility cause, and breastfeeding. We next added each candidate reproductive factor to an established CHD risk factor model. A final model was then constructed with significant reproductive factors added to established CHD risk factors. Improvement in C statistic, net reclassification index (or net reclassification index with risk categories of <5%, 5 to <10%, and ≥10% 10-year risk of CHD), and integrated discriminatory index were assessed. Among 72 982 women (CHD events, n=4607; median follow-up,12.0 [interquartile range, 8.3–13.7] years; mean [standard deviation] age, 63.2 [7.2] years), an age-adjusted reproductive risk factor model had a C statistic of 0.675 for CHD. In a model adjusted for established CHD risk factors, younger age at first birth, number of still births, number of miscarriages, and lack of breastfeeding were positively associated with CHD. Reproductive factors modestly improved model discrimination (C statistic increased from 0.726 to 0.730; integrated discriminatory index, 0.0013; P <0.0001). Net reclassification for women with events was not improved (net reclassification index events, 0.007; P =0.18); and, for women without events, net reclassification was marginally improved (net reclassification index nonevents, 0.002; P =0.04) Conclusions—: Key reproductive factors are associated with CHD independently of established CHD risk factors, very modestly improve model discrimination, and do not materially improve net reclassification.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A query of sex and gender differences in heart diseases revealed that in women enhanced parasympathetic and decreased sympathetic tones appear to be greater and also defensive during cardiac stress, while key reproductive factors associated with coronary heart disease only modestly improve risk prediction.
“a query of sex and gender differences in heart diseases revealed that in women enhanced parasympathetic and decreased sympathetic tones appear to be greater and also defensive during cardiac stress61, while key reproductive factors associated with coronary heart disease only modestly improve risk prediction62.”
From Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare (2020) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536 · see citing works
Prediction of coronary heart disease using risk factor categories
Wilson, P. W. F., D’Agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H., & Kannel, W. B. (1998) · Circulation · doi:10.1161/01.cir.97.18.1837 · Cited by 9,581 · see citing works
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491 · see citing works
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879 · see citing works
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493 · see citing works
2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.005 · Cited by 4,945 · see citing works
Bellamy, L., Casas, J.-P., Hingorani, A. D., & Williams, D. J. (2007) · BMJ · doi:10.1136/bmj.39335.385301.be · Cited by 2,552 · see citing works
Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers
Pencina, M. J., D’Agostino, R. B., & Steyerberg, E. W. (2010) · Statistics in Medicine · doi:10.1002/sim.4085 · Cited by 2,478 · see citing works
Ridker, P. M., Buring, J. E., Rifai, N., & Cook, N. R. (2007) · JAMA · doi:10.1001/jama.297.6.611 · Cited by 1,814 · see citing works
Criteria for Evaluation of Novel Markers of Cardiovascular Risk
Hlatky, M., Greenland, P., Arnett, D., Ballantyne, C., Criqui, M., Elkind, M., Go, A., Harrell, F. E. J., Hong, Y.-L., Howard, B., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192278 · Cited by 1,153 · see citing works
Self-citationGoff, D. C., Lloyd‐Jones, D. M., Bennett, G. C., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D. A., O’Donnell, C. J., et al. (2014) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · Cited by 840 · see citing works
Menstrual cycle irregularity and risk for future cardiovascular disease
Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J. E., Stampfer, M. J., Willett, W. C., Speizer, F. E., & Manson, J. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8471 · Cited by 528 · see citing works
Increased Risk of Cardiovascular Disease in Young Women Following Gestational Diabetes Mellitus
Shah, B. R., Retnakaran, R., & Booth, G. L. (2008) · Diabetes Care · doi:10.2337/dc08-0706 · Cited by 489 · see citing works
Duration of Lactation and Risk Factors for Maternal Cardiovascular Disease
Schwarz, E. B., Ray, R. M., Stuebe, A. M., Allison, M. A., Ness, R. B., Freiberg, M. S., & Cauley, J. A. (2009) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000346884.67796.ca · Cited by 436 · see citing works
Self-citationLawlor, D. A., Emberson, J., Ebrahim, S. B. J., Whincup, P. H., Wannamethee, S. G., Walker, M., & Smith, G. D. (2003) · Circulation · doi:10.1161/01.cir.0000053441.43495.1a · Cited by 302 · see citing works
Age at Menarche and Risks of Coronary Heart and Other Vascular Diseases in a Large UK Cohort
Canoy, D., Beral, V., Balkwill, A., Wright, L., Kroll, M. E., REEVES, G. K., Green, J., & Cairns, B. J. (2014) · Circulation · doi:10.1161/circulationaha.114.010070 · Cited by 278 · see citing works
Cook, N. R., Paynter, N. P., Eaton, C. B., Manson, J. E., Martin, L. W., Robinson, J. G., Rossouw, J. E., Wassertheil-Smoller, S. W., & Ridker, P. M. (2012) · Circulation · doi:10.1161/circulationaha.111.075929 · Cited by 264 · see citing works
Self-citationParity and risk of later-life maternal cardiovascular disease
Parikh, N. I., Cnattingius, S., Dickman, P. W., Mittleman, M. A., Ludvigsson, J. F., & Ingelsson, E. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.11.017 · Cited by 234 · see citing works
Self-citationBirth Characteristics and Subsequent Risks of Maternal Cardiovascular Disease
Bonamy, A. E., Parikh, N. I., Cnattingius, S., Ludvigsson, J. F., & Ingelsson, E. (2011) · Circulation · doi:10.1161/circulationaha.111.034884 · Cited by 223 · see citing works
Self-citationFrontini, M., Srinivasan, S. R., & Berenson, G. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802422 · Cited by 218 · see citing works
Duration of lactation and incidence of myocardial infarction in middle to late adulthood
Stuebe, A. M., Michels, K. B., Willett, W. C., Manson, J. E., Rexrode, K., & Rich-Edwards, J. W. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.10.001 · Cited by 187 · see citing works
Gunderson, E. P., Chiang, V., Pletcher, M. J., Jacobs, D. R., Quesenberry, C. P., Sidney, S., & Lewis, C. E. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000490 · Cited by 182 · see citing works
Self-citationMaternal medical disease: Risk of antepartum fetal death
Simpson, L. L. (2002) · Seminars in Perinatology · doi:10.1053/sper.2002.29838 · Cited by 149 · see citing works
Kivimèki, M., Lawlor, D. A., Smith, G. D., Elovainio, M. J., Jokela, M. M., Keltikangas‐Järvinen, L., Vahtera, J., Taittonen, L. M., Juonala, M., Viikari, J. S. A., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1876 · Cited by 149 · see citing works
The epidemiology of stillbirth
Cnattingius, S., & Stephansson, O. (2002) · Seminars in Perinatology · doi:10.1053/sper.2002.29841 · Cited by 145 · see citing works
Colditz, G. A., Willett, W. C., Stampfer, M. J., ROSNER, B. A., Speizer, F. E., & Hennekens, C. H. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114723 · Cited by 143 · see citing works
Kharazmi, E., Dossus, L., Rohrmann, S., & Kaaks, R. (2010) · Heart · doi:10.1136/hrt.2010.202226 · Cited by 143 · see citing works
Stöckl, D., Meisinger, C., Peters, A., Thorand, B., Huth, C., Heier, M., Rathmann, W., Kowall, B., Stöckl, H., & Döring, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026076 · Cited by 117 · see citing works
Systematic Examination of the Updated Framingham Heart Study General Cardiovascular Risk Profile
Perak, A. M., & Lloyd‐Jones, D. M. (2009) · Circulation · doi:10.1161/circulationaha.108.835470 · Cited by 113 · see citing works
Menstrual irregularity and cardiovascular mortality.
Wang, E., Cirillo, P. M., Vittinghoff, E., Bibbins-Domingo, K., Cohn, B., & Cedars, M. (2011) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2010-1709 · Cited by 109 · see citing works
Neighborhood Socioeconomic Status and Cognitive Function in Women
Shih, R. A., Ghosh‐Dastidar, B., Margolis, K. L., Slaughter, M. E., Jewell, A., Bird, C. E., Eibner, C., Denburg, N. L., Ockene, J. K., Messina, C. R., et al. (2011) · American Journal of Public Health · doi:10.2105/ajph.2011.300169 · Cited by 98 · see citing works
Subfertility and risk of later life maternal cardiovascular disease
Parikh, N. I., Cnattingius, S., Mittleman, M. A., Ludvigsson, J. F., & Ingelsson, E. (2011) · Human Reproduction · doi:10.1093/humrep/der400 · Cited by 97 · see citing works
Self-citationParker, D. R., Lü, B., Sands‐Lincoln, M., Kroenke, C. H., Lee, C.-C., O’Sullivan, M. J., Park, H. L., Parikh, N. I., Schenken, R. S., & Eaton, C. B. (2014) · The Annals of Family Medicine · doi:10.1370/afm.1668 · Cited by 81 · see citing works
Self-citationCavanaugh-Hussey, M. W., Berry, J. D., & Lloyd‐Jones, D. M. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2008.07.012 · Cited by 75 · see citing works
Excessive maternal weight gain patterns in adolescents
Howie, L. D., Parker, J. D., & Schoendorf, K. C. (2003) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2003.09.040 · Cited by 58 · see citing works
Hardy, R., Lawlor, D. A., Black, S., Mishra, G. D., & Kuh, D. J. (2008) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2008.076943 · Cited by 40 · see citing works
Celiac disease is not a risk factor for infertility in men
Zugna, D., Richiardi, L., Akre, O., Stephansson, O., & Ludvigsson, J. F. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.132 · Cited by 33 · see citing works
Gunderson, E. P., Schreiber, G. B., Striegel‐Moore, R. H., Hudes, M. L., Daniels, S. R., Biro, F. M., & Crawford, P. B. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.12.004 · Cited by 18 · see citing works
Abraham, J. M., Larson, J. C., Chung, M. K., Curtis, A. B., Lakshminarayan, K., Newman, J. D., Perez, M. V., Rexrode, K. M., Shara, N. M., Solomon, A. J., et al. (2013) · The American Journal of Medicine · doi:10.1016/j.amjmed.2013.05.023 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Parikh, N. I., Gonzalez, J. M., Anderson, C. A. M., Judd, S. E., Rexrode, K. M., Hlatky, M. A., Gunderson, E. P., Stuart, J. J., Vaidya, D., & On behalf of the American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, T. A. V. B. C. O. C. A. S. N. A. T. S. C. (2021) · Circulation · doi:10.1161/cir.0000000000000961 · Cited by 743 · see citing works
Self-citationSex and gender differences and biases in artificial intelligence for biomedicine and healthcare
Cirillo, D., Catuara-Solarz, S., Morey, C., Guney, E., Subirats, L., Mellino, S., Gigante, A., Valencia, A., Rementeria, M. J., Chadha, A. S., et al. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0288-5 · Cited by 553 · see citing works
Maas, A. H. E. M., Rosano, G. M. C., Cífková, R., Chieffo, A., van Dijken, D., Hamoda, H., Kunadian, V., Laan, E. T. M., Lambrinoudaki, I. V., Maclaran, K., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1044 · Cited by 361 · see citing works
Female infertility, infertility-associated diagnoses, and comorbidities: a review
Hanson, B. M., Johnstone, E. B., Dorais, J., Silver, B. M., Peterson, C. M., & Hotaling, J. M. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0836-8 · Cited by 296 · see citing works
Tschiderer, L., Seekircher, L., Kunutsor, S. K., Peters, S. A. E., O’Keeffe, L. M., & Willeit, P. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.022746 · Cited by 240 · see citing works
Women’s reproductive factors and incident cardiovascular disease in the UK Biobank
Peters, S. A. E., & Woodward, M. (2018) · Heart · doi:10.1136/heartjnl-2017-312289 · Cited by 226 · see citing works
Hypertensive Disorders of Pregnancy and 10-Year Cardiovascular Risk Prediction
Stuart, J. J., Tanz, L. J., Cook, N. R., Spiegelman, D., Missmer, S. A., Rimm, E. B., Rexrode, K. M., Mukamal, K. J., & Rich-Edwards, J. W. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.077 · Cited by 154 · see citing works
Markovitz, A. R., Stuart, J. J., Horn, J., Williams, P. L., Rimm, E. B., Missmer, S. A., Tanz, L. J., Haug, E. B., Fraser, A., Timpka, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy863 · Cited by 151 · see citing works
Pregnancy complications and later life women's health
McNestry, C., Killeen, S. L., Crowley, R. K., & McAuliffe, F. M. (2023) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.14523 · Cited by 142 · see citing works
Gunderson, E. P., Sun, B., Catov, J. M., Carnethon, M., Lewis, C. E., Allen, N. B., Sidney, S., Wellons, M., Rana, J. S., Hou, L., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.047320 · Cited by 117 · see citing works
Self-citationCrump, C., Sundquist, J., McLaughlin, M. A., Dolan, S. M., Govindarajulu, U. S., Sieh, W., & Sundquist, K. (2023) · BMJ · doi:10.1136/bmj-2022-072112 · Cited by 115 · see citing works
Timpka, S., Fraser, A., Schyman, T., Stuart, J. J., Åsvold, B. O., Mogren, I., Franks, P. W., & Rich-Edwards, J. W. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0429-1 · Cited by 99 · see citing works
Sheiner, E., Kapur, A., Retnakaran, R. R., Hadar, E., Poon, L. C., McIntyre, D. H., Divakar, H., Staff, A. C., Narula, J., Kihara, A., et al. (2019) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12926 · Cited by 87 · see citing works
Wang, Y., Mínguez‐Alarcón, L., Gaskins, A. J., Missmer, S. A., Rich-Edwards, J. W., Manson, J. E., Pan, A., & Chavarro, J. E. (2021) · BMJ · doi:10.1136/bmj.n530 · Cited by 85 · see citing works
Perrino, C., Ferdinandy, P., Bøtker, H. E., Brundel, B. J. J. M., Collins, P. D., Davidson, S. M., den Ruijter, H. M., Engel, F. B., Gerdts, E., Girão, H., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa155 · Cited by 84 · see citing works
Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women’s Health Initiative
Hall, P. S., Nah, G., Howard, B. V., Lewis, C. E., Allison, M., Sarto, G. E., Waring, M. E., Jacobson, L. T., Manson, J. E., Klein, L., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.557 · Cited by 80 · see citing works
Self-citationHorn, J., Tanz, L. J., Stuart, J. J., Markovitz, A. R., Skurnik, G., Rimm, E. B., Missmer, S. A., & Rich-Edwards, J. W. (2018) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.15452 · Cited by 76 · see citing works
Gleason, J. L., Shenassa, E. D., & Thoma, M. E. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.009 · Cited by 72 · see citing works
Cardiovascular risk factors among women with self-reported infertility
Mahalingaiah, S., Sun, F. X., Cheng, J. J., Chow, E., Lunetta, K. L., & Murabito, J. M. (2017) · Fertility Research and Practice · doi:10.1186/s40738-017-0034-0 · Cited by 67 · see citing works
Rosendaal, N. T. A., & Pirkle, C. M. (2017) · BMC Public Health · doi:10.1186/s12889-017-4519-x · Cited by 60 · see citing works
Update on sex specific risk factors in cardiovascular disease
Nguyen, A. H., Hurwitz, M., Sullivan, S. A., Saad, A. F., Kennedy, J. L., & Sharma, G. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1352675 · Cited by 50 · see citing works
Ardissino, M., Slob, E. A. W., Carter, P., Rogne, T., Girling, J., Burgess, S., & Ng, F. S. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.027933 · Cited by 58 · see citing works
Cardiovascular risk prediction models for women in the general population: A systematic review
Baart, S. J., Dam, V., Scheres, L. J. J., Damen, J. A., Spijker, R., Schuit, E., Debray, T. P. A., Fauser, B. C. J. M., Boersma, E. H., Moons, K. G. M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210329 · Cited by 56 · see citing works
Parikh, N. I., Norberg, M., Ingelsson, E., Cnattingius, S., Vasan, R. S., Domellöf, M., Jansson, J.-H., & Bonamy, A. E. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08121 · Cited by 55 · see citing works
Self-citationInfertility and Risk of Cardiovascular Disease: A Prospective Cohort Study
Farland, L. V., Wang, Y., Gaskins, A. J., Rich-Edwards, J. W., Wang, S., Magnus, M. C., Chavarro, J. E., Rexrode, K. M., & Missmer, S. A. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.027755 · Cited by 51 · see citing works
Infertility and Risk of Heart Failure in the Women’s Health Initiative
Lau, E. S., Wang, D., Roberts, M. B., TAYLOR, C. N., Murugappan, G., Shadyab, A. H., Schnatz, P. F., Farland, L. V., Wood, M. J., Scott, N. S., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.020 · Cited by 50 · see citing works
Self-citationKyriacou, H., Al-Mohammad, A., Muehlschlegel, C., Foster-Davies, L., Bruco, M. E. F., Legard, C., Fisher, G., Simmons-Jones, F., & Oliver‐Williams, C. (2022) · European Heart Journal Open · doi:10.1093/ehjopen/oeac065 · Cited by 51 · see citing works
Cai, Y., Gong, D.-X., Tang, L.-Y., Cai, Y. H., Li, H., Jing, T.-C., Gong, M., Hu, W., Zhang, Z.-W., Zhang, X., et al. (2024) · Journal of Medical Internet Research · doi:10.2196/47645 · Cited by 48 · see citing works
The relationships between women’s reproductive factors: a Mendelian randomisation analysis
Prince, C., Sharp, G. C., Howe, L. D., Fraser, A., & Richmond, R. C. (2022) · BMC Medicine · doi:10.1186/s12916-022-02293-5 · Cited by 41 · see citing works
Hall, P. S., Nah, G., Vittinghoff, E., Parker, D. R., Manson, J. E., Howard, B. V., Sarto, G. E., Gass, M. L. S., Sealy-Jefferson, S. M., Salmoirago‐Blotcher, E., et al. (2019) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2019.02.012 · Cited by 40 · see citing works
Self-citationStem Cell Therapies for Human Infertility: Advantages and Challenges
Wu, J., Xia, T., She, L.-P., Lin, S., & Luo, X. (2022) · Cell Transplantation · doi:10.1177/09636897221083252 · Cited by 39 · see citing works
Murugappan, G., Leonard, S. A., Farland, L. V., Lau, E. S., Shadyab, A. H., Wild, R. A., Schnatz, P. F., Carmichael, S. L., Stefanick, M. L., & Parikh, N. I. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.02.005 · Cited by 37 · see citing works
Self-citationHuang, C., Lin, B., Yuan, Y., Li, K., Xu, B., Zhang, P., Wei, X., Wang, W., Liu, W., Deng, Y., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.029020 · Cited by 35 · see citing works
Hormone therapy and cardiovascular disease: Benefits and harms
Maas, A. H. E. M. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101576 · Cited by 34 · see citing works
Naz, M. S. G., Sheidaei, A., Aflatounian, A., Azizi, F., & Tehrani, F. R. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.022349 · Cited by 35 · see citing works
Pregnancy complications and premature cardiovascular events among 1.6 million California pregnancies
Arnaout, R., Nah, G., Marcus, G. M., Tseng, Z. H., Foster, E., Harris, I. S., Divanji, P., Klein, L., Gonzalez, J. M., & Parikh, N. I. (2019) · Open Heart · doi:10.1136/openhrt-2018-000927 · Cited by 34 · see citing works
Self-citationRisk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study
Skåra, K. H., Åsvold, B. O., Hernáez, Á., Fraser, A., Rich-Edwards, J. W., Farland, L. V., Næss, Ø., Lawlor, D. A., Brumpton, B. M., & Magnus, M. C. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.05.038 · Cited by 30 · see citing works
Yang, S., Kwak, S., Kwon, S., Lee, H., Lee, H., Park, J., Lee, S., Kim, H., Han, K., Kim, Y.-J., et al. (2019) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007428 · Cited by 28 · see citing works
Lo, A., Lo, C. C. W., & Oliver‐Williams, C. (2023) · European Heart Journal Open · doi:10.1093/ehjopen/oead061 · Cited by 30 · see citing works
Zuo, R., Ge, Y., Xu, J., He, L., Liu, T., Wang, B., Sun, L., Wang, S., Zhu, Z., & Wang, Y. (2023) · BMC Public Health · doi:10.1186/s12889-023-17207-0 · Cited by 27 · see citing works
Contributions of the Women’s Health Initiative to Cardiovascular Research
LaMonte, M. J., Manson, J. E., Anderson, G. L., Baker, L. D., Bea, J. W., Eaton, C. B., Follis, S., Hayden, K. M., Kooperberg, C. L., LaCroix, A. Z., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.05.016 · Cited by 27 · see citing works
Self-citationThe risk of cardiovascular disease in women with a history of miscarriage and/or stillbirth
Asgharvahedi, F., Gholizadeh, L., & Siabani, S. (2019) · Health Care For Women International · doi:10.1080/07399332.2019.1566332 · Cited by 20 · see citing works
Cortés, Y. I., Catov, J. M., Brooks, M. M., Khoudary, S. R. E., Thurston, R. C., Matthews, K. A., Isasi, C. R., Jackson, E. A., & Barinas‐Mitchell, E. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.07.012 · Cited by 19 · see citing works
Doust, J. A., Baneshi, M. R., Chung, H., Wilson, L. F., & Mishra, G. D. (2024) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.123.010842 · Cited by 18 · see citing works
Yang, H., Chen, G., Zhou, M., Xie, L.-F., Jin, Y., Chen, H., Chen, Z., Kong, Y.-H., Yuan, C.-Z., & Li, Z. (2022) · Hepatology International · doi:10.1007/s12072-022-10429-1 · Cited by 18 · see citing works
Assessment of Cardiovascular Risk in Women: Progress so Far and Progress to Come
Tschiderer, L., Seekircher, L., Willeit, P., & Peters, S. A. E. (2023) · International Journal of Women s Health · doi:10.2147/ijwh.s364012 · Cited by 18 · see citing works
Pregnancy loss and risk of incident CVD within 5 years: Findings from the Women's Health Initiative
Wright, C. E., Enquobahrie, D. A., Prager, S., Painter, I. S., Kooperberg, C. L., Wild, R. A., Park, K. E., Sealy-Jefferson, S. M., & Kernic, M. A. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1108286 · Cited by 16 · see citing works
Cortés, Y. I., Catov, J. M., Brooks, M. M., Harlow, S. D., Isasi, C. R., Jackson, E. A., Matthews, K. A., Thurston, R. C., & Barinas‐Mitchell, E. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.007138 · Cited by 16 · see citing works
Chen, M., Wang, Z., Xu, H., Chen, X., Teng, P., & Ma, L. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01496-w · Cited by 15 · see citing works
Gender differences of cardiovascular risk
Борисовна, Ш. Э., Maksimov, S. A., & Artamonova, G. V. (2019) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2019-4-99-104 · Cited by 17 · see citing works
Tison, G. H., Avram, R., Nah, G., Klein, L., Howard, B. V., Allison, M., Casanova, R., Blair, R. H., Breathett, K. K., Foraker, R. E., et al. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.08.006 · Cited by 14 · see citing works
Self-citationHwang, S., Kang, S. W., Choi, K. J., Son, K. Y., Lim, D. H., Shin, D. W., Choi, D., & Kim, S. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-10088-0 · Cited by 12 · see citing works
Assisted reproductive technology: what are the cardiovascular risks for women?
Guan, C. S., Rodriguez, C. P., Elder-Odame, P., Minhas, A., Zahid, S., Baker, V. L., SHUFELT, C. L., & Michos, E. D. (2023) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2023.2266355 · Cited by 12 · see citing works
Bertomeu‐González, V., Cordero, A., Ruiz-Nodar, J. M., Sánchez-Ferrer, F., López‐Pineda, A., & Quesada, J. A. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117372 · Cited by 12 · see citing works
Hossain, M. A., Amin, M. A., Hasan, M. I., Sohel, M., Ahammed, M. A., Mahmud, S. M. H., Rahman, M. R., & Rahman, M. H. (2022) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2022.100960 · Cited by 12 · see citing works
Markers of Cardiovascular Risk Associated with Pregnancy
Quesada, O., Scantlebury, D. C., Briller, J. E., Michos, E. D., & Aggarwal, N. R. (2023) · Current Cardiology Reports · doi:10.1007/s11886-022-01830-1 · Cited by 14 · see citing works
Identifying and managing younger women at high risk of cardiovascular disease
Srivaratharajah, K., & Abramson, B. L. (2019) · Canadian Medical Association Journal · doi:10.1503/cmaj.180053 · Cited by 12 · see citing works
Wang, M., Zhang, J., Yuan, L., Hu, H., Li, T.-Z., Feng, Y., Zhao, Y., Wu, Y., Fu, X., Ke, Y., et al. (2024) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2024.03.035 · Cited by 11 · see citing works
Preconception HbA 1c Levels in Adolescents and Young Adults and Adverse Birth Outcomes
McCarthy, K. J., Liu, S. H., Kennedy, J., Chan, H. T., Howell, F., Boychuk, N., Mayer, V., Vieira, L., Tabaei, B. P., Seil, K., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.35136 · Cited by 11 · see citing works
Parity, Job Strain, and Cardiovascular Risk in the Women’s Health Study
Durazo, E. M., de Baca, T. C., Slopen, N. B., Parikh, N. I., Buring, J. E., Glynn, R. J., & Albert, M. A. (2018) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-018-0571-z · Cited by 10 · see citing works
Self-citationMonseur, B. C., Morris, J. R., Hipp, H. S., & Berghella, V. (2019) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-019-01490-1 · Cited by 10 · see citing works
Gunnarsson, O. S., & Timpka, S. (2019) · Current Epidemiology Reports · doi:10.1007/s40471-019-00208-2 · Cited by 10 · see citing works
Chang, T., Zhao, Z., Liu, X., Zhang, Y., Liu, X., Zhang, Y., & Lu, M. (2025) · BMC Public Health · doi:10.1186/s12889-025-22012-y · Cited by 9 · see citing works
Quesada, J. A., Bertomeu‐González, V., Ruiz-Nodar, J. M., López‐Pineda, A., & Sánchez-Ferrer, F. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.08.008 · Cited by 9 · see citing works
Farland, L. V., Liu, C.-L., Diop, H., Cabral, H., Missmer, S. A., Coddington, C. C., Hwang, S. S., & Stern, J. E. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.11.012 · Cited by 9 · see citing works
Vermunt, J. V., Kennedy, S., & Garovic, V. D. (2020) · Current Hypertension Reports · doi:10.1007/s11906-019-1014-z · Cited by 8 · see citing works
Miller, E. C., Bello, N. A., Davis, R., Friedman, A. M., Elkind, M. S. V., Wapner, R. J., & Tom, S. E. (2021) · Journal of Women s Health · doi:10.1089/jwh.2021.0184 · Cited by 8 · see citing works
Emerging Medical Therapies for the Treatment of Obesity in Women with Cardiovascular Diseases
Behrooz, L., Lenneman, C. G., & Hamburg, N. M. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01961-z · Cited by 8 · see citing works
Fertility Histories and Heart Disease in Later Life in China
Wu, Y., Pang, J., Wang, J., Wu, J., Zhang, S., Zhang, S., Yao, Y., Cheng, S., Tao, Y., Shen, Z., et al. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.819196 · Cited by 7 · see citing works
Dakhil, Z. A., Gitti, S. A., & Kaddoura, R. (2026) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2026.1659244 · Cited by 6 · see citing works
Pregnancy Loss and Cardiovascular Diseases in Women: Recent Findings and Potential Mechanisms
Petersen, M. M. B. S., Hartwig, T. S., & Nielsen, H. S. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01065-z · Cited by 6 · see citing works
Maas, A. H. E. M. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.107970 · Cited by 5 · see citing works
Parity, infertility, age at first birth, and risk of atrial fibrillation: data from the HUNT study
Morooka, H., Haug, E. B., Malmo, V., Loennechen, J. P., Mukamal, K. J., Sen, A., Janszky, I., & Horn, J. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae215 · Cited by 6 · see citing works
Sex Differences in Cardiovascular Disease and Unique Pregnancy-Associated Risk Factors in Women
O’Kelly, A. C., & Honigberg, M. C. (2020) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-020-00860-8 · Cited by 6 · see citing works
Elevated cardiovascular disease risk in low-income women with a history of pregnancy loss
Tsulukidze, M., Reardon, D. C., & Craver, C. (2022) · Open Heart · doi:10.1136/openhrt-2022-002035 · Cited by 6 · see citing works
Moving Toward Sex-Specific Cardiovascular Risk Estimation
Dayan, N., & Udell, J. A. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.08.029 · Cited by 6 · see citing works
Miller, E. C., Miltiades, A., Soler, N. P., Booker, W. A., Landau-Cahana, R., Marshall, R. S., D’Alton, M. E., Wapner, R. J., Cleary, K. L., & Bello, N. A. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043052 · Cited by 5 · see citing works
Cortés, Y. I., Zhang, S., & Hussey, J. M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277320 · Cited by 5 · see citing works
Screening after hypertensive pregnancy disorders: She can do best
Maas, A. H. E. M. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317731207 · Cited by 5 · see citing works
Kaul, P., Barrett, O., Savu, A., Liyanage, V., Davidge, S. T., & Cooke, C. M. (2024) · American Heart Journal · doi:10.1016/j.ahj.2024.12.002 · Cited by 5 · see citing works
Szakun, N. A., Liva, S., Bodner, M. E., Wolff, A. C., Kim, M., & Coté, A. T. (2023) · CJC Open · doi:10.1016/j.cjco.2023.11.003 · Cited by 4 · see citing works
Cardiovascular disease family history and risk of pregnancy loss
Yeung, E. H., Park, H., Nobles, C. J., Mumford, S. L., Silver, R. M., & Schisterman, E. F. (2019) · Annals of Epidemiology · doi:10.1016/j.annepidem.2019.04.002 · Cited by 4 · see citing works
Gurbanova, A., Lombardi, A. E. M., Habets, D. H. J., Al‐Nasiry, S., Spaanderman, M. E. A., de Jonge, M. I., Meuleman, T., Wieten, L., & Molen, R. G. V. D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1602939 · Cited by 3 · see citing works
Sun, W., Hou, L., Wu, J., Shan, S., & Song, P. (2025) · International Journal of Stroke · doi:10.1177/17474930251365865 · Cited by 3 · see citing works
Xiao, J., Zhu, H., Fu, Q., Hu, Q., Li, W., Zhang, X., & Huang, S. (2025) · BMC Public Health · doi:10.1186/s12889-025-24297-5 · Cited by 3 · see citing works
The Role of Adverse Pregnancy Outcomes in Conventional Cardiovascular Risk Prediction
Reddy, S. M., Wiecha, N., Nguyen, C. T., & Barch, D. H. (2023) · Maternal and Child Health Journal · doi:10.1007/s10995-023-03725-1 · Cited by 3 · see citing works
Cardiovascular Disease Risk in Women: What Makes It Different from Men
Maas, A. H. E. M., & Merz, C. N. B. (2017) · Springer eBooks · doi:10.1007/978-3-319-54960-6_1 · Cited by 3 · see citing works
Kang, J., Kim, J., Yu, N., & Kang, H. (2020) · Korean Journal of Family Practice · doi:10.21215/kjfp.2020.10.3.182 · Cited by 3 · see citing works
Nemani, L., Garre, I., Jyotsna, M., & Garg, S. (2020) · Journal of Clinical and Preventive Cardiology · doi:10.4103/jcpc.jcpc_1_20 · Cited by 3 · see citing works
Pregnancy-related factors may signal additional protection or risk of future cardiovascular diseases
Reddy, S. M., Tsujimoto, T. H. M., Qaqish, B. F., Fine, J. P., & Nicholson, W. K. (2022) · BMC Women s Health · doi:10.1186/s12905-022-02125-x · Cited by 3 · see citing works
Boman, A., Kokkonen, H., Berglin, E. H., Alenius, G.-M., & Rantapää‐Dahlqvist, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010208 · Cited by 3 · see citing works
van Os, H. J. A., Kanning, J. P., Ferrari, M. D., Bonten, T. N., Kist, J. M., Vos, H. M. M., Vos, R. C., Putter, H., Groenwold, R. H. H., & Wermer, M. J. H. (2023) · Neurology · doi:10.1212/wnl.0000000000207513 · Cited by 3 · see citing works
López‐Pineda, A., Maldonado, C. S., Arrarte, V., Sánchez-Ferrer, F., Bertomeu‐González, V., Ruiz-Nodar, J. M., Quesada, J. A., & Cordero, A. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11090287 · Cited by 2 · see citing works
Xing, Z., Kirby, R. S., Chen, H., Cain, M. A., & Alman, A. C. (2025) · O&G Open · doi:10.1097/og9.0000000000000063 · Cited by 2 · see citing works
Female infertility and long-term cardiovascular risk: a systematic review and meta-analysis
Polymeropoulou, C., Mili, N., Armeni, E., Siliogka, E., Augoulea, A., & Lambrinoudaki, I. V. (2026) · Endocrine · doi:10.1007/s12020-025-04543-x · Cited by 2 · see citing works
Xu, N., Hu, P., Shi, W., Zhou, Z., Zhou, X. W., Chen, S., Zhu, L., Huang, H., & Xu, C. (2026) · Reproductive Toxicology · doi:10.1016/j.reprotox.2026.109226 · Cited by 2 · see citing works
Al-Lami, R. A., Taha, S. A., Jalloul, R. J., & Taylor, H. S. (2021) · F&S Reports · doi:10.1016/j.xfre.2021.12.003 · Cited by 2 · see citing works
Nasr, N. M. G., Soltész, B., Sándor, J., Ádány, R., & Fiatal, S. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9090295 · Cited by 3 · see citing works
Tsulukidze, M., Reardon, D. C., & Craver, C. (2024) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2024.200260 · Cited by 2 · see citing works
Cardiovascular risks in infants born with reproductive technologies
Александровна, Г. И., Omelchenko, M. Y., Sokolova, L. A., & Бондаренко, Б. Б. (2020) · Translational Medicine · doi:10.18705/2311-4495-2020-7-6-29-38 · Cited by 1 · see citing works
- Authors
- Parikh, N. I., Jeppson, R. P., Berger, J. S., Eaton, C. B., Kroenke, C. H., LeBlanc, E. S., Lewis, C. E., Loucks, E. B., Parker, D. R., Rillamas-Sun, E., Ryckman, K. K., Waring, M. E., Schenken, R. S., Johnson, K. C., Edstedt-Bonamy, A.-K., Allison, M. A., & Howard, B. V.
- Affiliations
- Kaiser Permanente (US)
- From Division of Cardiology, University of California San Francisco (N.I.P.); Fred Hutchinson Cancer Research Center, Seattle, WA (R.P.J., K.K.R.); Cardiology, Hematology, Vascular Surgery, NYU School of Medicine, New York (J.S.B.); Departments of Family Medicine and Epidemiology, Brown University, Providence, RI (C.B.E., D.R.P.); Kaiser Permanente Division of Research, Oakland, CA (C.H.K.); Kaiser Permanente Center for Health Research, Portland, OR (E.S.L.); University of Alabama at Birmingham (C.E...
- ORCID
- Venue
- Circulation
- Published
- 2016-05-31
- Volume
- 133
- Issue
- 22
- Pages
- 2149-2158
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4889516
- OpenAlex
- W2341028609
- Cited by
- 134
- References
- 39
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 15 · 2023: 24 · 2022: 21 · 2021: 12 · 2020: 9 · 2019: 13 · 2018: 8 · 2017: 9 · 2016: 1
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@UMassChan (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- American Heart Association
- National Institutes of Health (UL1TR001453, UL1TR001409, HHSN268201100004C, HHSN268201100001C, HHSN268201100002C, KL2TR000160, HHSN268201100003C)
- National Heart, Lung, and Blood Institute (R21HL115398, U01HL105268, HHSN2682011-00001I, HHSN2682011-00002I, L30 HL097670, HHSN2682011‐00004I, HHSN268201100046C, HHSN2682011-00003I)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities (U54MD007584)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- coronary artery disease, reproductive risk factors, women, age at first birth, stillbirth, miscarriage, infertility, breastfeeding, risk stratification, model discrimination
- MeSH terms
- Adult, Aged, Coronary Artery Disease, Female, Humans, Longitudinal Studies, Middle Aged, Pregnancy, Reproduction, Risk Factors, Women's Health, Pregnancy Rate, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
