Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure: ARIC Study
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Background: Higher physical activity (PA) is associated with lower heart failure (HF) risk; however, the effect of changes in PA on HF risk is unknown. Methods: We evaluated 11 351 ARIC study (Atherosclerosis Risk in Communities) participants (mean age 60 years) who attended visit 3 (1993–1995) and did not have a history of cardiovascular disease. Exercise PA was assessed using a modified Baecke questionnaire and categorized according to American Heart Association guidelines as recommended, intermediate, or poor. We used Cox regression models to characterize the association of 6-year changes in PA between the first (1987–1989) and third ARIC visits and HF risk. Results: During a median of 19 years of follow-up, 1750 HF events occurred. Compared with those with poor activity at both visits, the lowest HF risk was seen for those with persistently recommended activity (hazard ratio, 0.69; 95% confidence interval, 0.60–0.80). However, those whose PA increased from poor to recommended also had reduced HF risk (hazard ratio, 0.77; 95% confidence interval 0.63–0.93). Among participants with poor baseline activity, each 1 SD higher PA at 6 years (512.5 METS*minutes/week, corresponding to ≈30 minutes of brisk walking 4 times per week) was associated with significantly lower future HF risk (hazard ratio, 0.89, 95% confidence interval, 0.82–0.96). Conclusions: Although maintaining recommended activity levels is associated with the lowest HF risk, initiating and increasing PA, even in late middle age, are also linked to lower HF risk. Augmenting PA may be an important component of strategies to prevent HF.
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Long-term increases in physical activity and cardiorespiratory fitness are associated with a reduced risk of heart failure.
“Observational studies have also shown that long-term increases in PA and CRF are associated with a reduced risk of HF [ 114 , 117 ].”
From Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations (2022) · cites this paper as [117]
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Self-citationTimed synchronization of muscle contraction to heartbeat enhances muscle hyperemia
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Exploring the Mechanistic Link Between Obesity and Heart Failure
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Self-citationAssociation of Reduced Left Atrial Reserve With Exercise Intolerance and Outcome in Hypertension
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Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The ARIC Study
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Physical Activity, Cardiorespiratory Fitness, and Atherosclerotic Cardiovascular Disease: Part 2
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Nicotinamide Adenine Dinucleotide and Aging
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Effect of Exercise Program on Health Status of Heart Failure Patients: A Quasi-Experimental Study
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Hybrid HIIT/isometrics strength training programs: a paradigm shift for physical exercise
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Is “Normal for Age” a Legitimate Assessment?
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- Authors
- Florido, R., Kwak, L., Lazo, M., Nambi, V., Ahmed, H. M., Hegde, S. M., Gerstenblith, G., Blumenthal, R. S., Ballantyne, C. M., Selvin, E., Folsom, A. R., Coresh, J., & Ndumele, C. E.
- Affiliations
- Johns Hopkins University (US)
- Michael E. DeBakey VA Medical Center (US)
- Cleveland Clinic (US)
- Brigham and Women's Hospital (US)
- Baylor College of Medicine (US)
- University of Minnesota (US)
- ORCID
- Venue
- Circulation
- Published
- 2018-05-15
- Volume
- 137
- Issue
- 20
- Pages
- 2142-2151
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC6219377
- OpenAlex
- W2801904771
- Cited by
- 56
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 3 · 2017: 1
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (HHSN268201100008C, HHSN26820- 1100005C, HHSN268201100007C, 5u01hl096899-08, HHSN268201100011C, HHSN268201100010C, 5u01hl096902-08)
- National Heart, Lung, and Blood Institute (HHSN268201 100012C, HHSN268201100007C, HHSN2682 01100008C, HH-SN-268201100006C, HHSN268201100011C, HHSN268201100005C, HHSN268201100010C, K23HL122447, U01-HL-096899, HHSN26820 1100009C, U01-HL-096902, U01HL096917, U01HL096812)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK106414)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- physical activity, heart failure, incident heart failure risk, exercise intensity, heart failure prevention, middle-aged adults, Atherosclerosis Risk in Communities Study
- MeSH terms
- Female, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged, Peptide Fragments, Risk Factors, Biomarkers, Exercise, Incidence, Proportional Hazards Models, Natriuretic Peptide, Brain, Troponin T, Kaplan-Meier Estimate
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