The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: CENTRAL Magnetic Resonance Imaging Randomized Controlled Trial
Open accessAbstract
Background: We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. Methods: We performed an 18-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to isocaloric low-fat or Mediterranean/low-carbohydrate (MED/LC) diet+28 g walnuts/day with/without added moderate physical activity (PA; 80% aerobic; supervised/free gym membership). Overall primary outcome was body fat redistribution, and the main specific end point was visceral adipose tissue (VAT). We further followed the dynamics of different fat depots (deep and superficial subcutaneous, liver, pericardial, muscle, pancreas, and renal sinus) by magnetic resonance imaging. Results: Of 278 participants (age, 48 years, 89% men, body mass index, 30.8 kg/m 2 ), 86% completed the trial with good adherence. The low-fat group preferentially decreased reported fat intake (−21.0% versus −11.5% for the MED/LC; P <0.001), and the MED/LC group decreased reported carbohydrates intake (−39.5% versus −21.3% for the low-fat group; P <0.001). The PA + groups significantly increased the metabolic equivalents per week versus the PA − groups (19.0 versus 2.1; P =0.009). Whereas final moderate weight loss was indifferent, exercise attenuated the waist circumference rebound with the greatest effect in the MED/LC PA+ group ( P <0.05). VAT (−22%), intrahepatic (−29%), and intrapericardial (−11%) fats declines were higher than pancreatic and femur intermuscular fats (1% to 2%) loss. Independent of weight loss, PA + with either diet had a significantly greater effect on decreasing VAT (mean of difference, −6.67cm 2 ; 95% confidence interval, −14.8 to −0.45) compared with PA − . The MED/LC diet was superior to the low-fat diet in decreasing intrahepatic, intrapericardial, and pancreatic fats ( P <0.05 for all). In contrast, renal sinus and femoral intermuscular fats were not differentially altered by lifestyle interventions but by weight loss per se. In multivariate models further adjusted for weight loss, losing VAT or intrahepatic fat was independently associated with improved lipid profile, losing deep subcutaneous adipose tissue with improved insulin sensitivity, and losing superficial subcutaneous adipose tissue remained neutral except for an association with decreased leptin. Conclusions: Moderate weight loss alone inadequately reflects the significant lifestyle effects on atherogenic and diabetogenic fat depots. The MED/LC diet mobilizes specific ectopic fat depots, and exercise has an independent contribution to VAT loss. Fat depots exhibit diverse responsiveness and are differentially related to cardiometabolic markers. Distinct lifestyle protocols may uniquely induce fat mobilization from specific anatomic sites. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01530724.
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“Interestingly, there is convincing evidence that reduction in visceral adipose tissue in response to exercise can be obtained in the absence of substantial weight loss.”
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1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
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Pathophysiology of human visceral obesity: an update
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Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
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Self-citationComparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates
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The cellular and signaling networks linking the immune system and metabolism in disease
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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972
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Ross, R., Neeland, I. J., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., Cuevas, A., Hu, F. B., et al. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0310-7 · Cited by 1,966
Self-citationAging and aging-related diseases: from molecular mechanisms to interventions and treatments
Guo, J., Huang, X., Dou, L., Yan, M., Shen, T., Tang, W., & Li, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01251-0 · Cited by 1,976
“Loomba et al. found that a set of 152 differentially methylated CpG islands in the peripheral blood-DNA of NASH patients correlate with the severity of hepatic fibrosis and that this DNA methylation signature is associated with the age-related acceleration of NASH in patients.74 However, demethylation of histone H3K9…”
BackgroundInfluentialVisceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement
Neeland, I. J., Ross, R., Després, J.-P., Matsuzawa, Y., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30084-1 · Cited by 1,603
Self-citationEslam, M., Sarin, S. K., Wong, V. W., Fan, J.-G., Kawaguchi, T., Ahn, S. H., Zheng, M., Shiha, G. E.-S., Yilmaz, Y. N., Gani, R. A., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10094-2 · Cited by 860
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674
“Using whole-body MRI, the investigators of the CENTRAL trial [284] found that the MEDD, rich in unsaturated fats and low in carbohydrates, is superior to the low-fat diet in mobilizing specific ectopic fat depots as hepatic, cardiac, and pancreatic fats.”
Method
Metadata
- Authors
- Gepner, Y., Shelef, I., Schwarzfuchs, D., Zelicha, H., Tene, L., Yaskolka Meir, A., Tsaban, G., Cohen, N., Bril, N., Rein, M., Serfaty, D., Kenigsbuch, S., Komy, O., Wolak, A., Chassidim, Y., Golan, R., Avni-Hassid, H., Bilitzky, A., Sarusi, B., Goshen, E., Shemesh, E., Henkin, Y., Stumvoll, M., Blüher, M., Thiery, J., Ceglarek, U., Rudich, A., Stampfer, M. J., & Shai, I.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Soroka Medical Center (IL)
- Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel (Y.G., H.Z., L.T., A.Y.M., G.T., N.C., N.B., M.R., D.S., S.K., O.K., R.G., H.A.-H., A.B., E.S., A.R., I.S.).
- Shaare Zedek Medical Center (IL)
- Shimon Peres Negev Nuclear Research Center (IL)
- Department of Medicine, University of Leipzig, Germany (M.S., M.B., J.T., U.C.).
- Leipzig University (DE)
- Brigham and Women's Hospital (US)
- Corresponding author
- Gepner, Yftach
- Shelef, Ilan
- Schwarzfuchs, Dan
- ORCID
- Venue
- Circulation
- Published
- 2018-03-13
- Volume
- 137
- Issue
- 11
- Pages
- 1143-1157
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W3016784104
- Semantic Scholar
- 09fc50175977a3f18864dc55ed917ee21fe2e738
- Cited by
- 279
- References
- 51
- Citations by year
- 2026: 32 · 2025: 27 · 2024: 30 · 2023: 43 · 2022: 47 · 2021: 45 · 2020: 26 · 2019: 18 · 2018: 11
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Circulation (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Funders
- Brigham and Women's Hospital
- Harvard T.H. Chan School of Public Health
- Deutsche Forschungsgemeinschaft
- Ben-Gurion University of the Negev
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adipose tissue redistribution, visceral adipose tissue, abdominal obesity, dyslipidemia, Mediterranean diet, low-carbohydrate diet, low-fat diet, Juglans regia, physical activity, intrahepatic fat, intermuscular fat, renal sinus fat, subcutaneous adipose tissue, weight loss, sedentary adults, workplace interventions, magnetic resonance imaging
- MeSH terms
- Healthy Lifestyle, Adipose Tissue, Adult, Aged, Female, Humans, Israel, Lipids, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Time Factors, Weight Loss, Exercise, Treatment Outcome, Diet, Fat-Restricted, Diet, Mediterranean, Risk Reduction Behavior, Adiposity, Dyslipidemias, Diet, Carbohydrate-Restricted, Obesity, Abdominal
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