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The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Intraaortic Balloon Pump in Cardiogenic Shock Complicating Acute Myocardial Infarction: Long-Term 6-Year Outcome of the Randomized IABP-SHOCK II Trial

Open access
Thiele, Holger, Zeymer, Uwe, Thelemann, Nathalie, Neumann, Franz-Josef, Hausleiter, Jörg, Abdel-Wahab, Mohamed, Meyer-Saraei, Roza, Fuernau, Georg, Eitel, Ingo, Hambrecht, Rainer, Böhm, Michael, Werdan, Karl, Felix, Stephan B., Hennersdorf, Marcus, Schneider, Steffen, Ouarrak, Taoufik, Desch, Steffen, de Waha-Thiele, Suzanne, On behalf of the IABP-SHOCK II Trial (Intraaortic Balloon Pump in Cardiogenic Shock II) Investigators, Alkisoglu, Zehra, Follath, Ferenc, Frey, Sonja, Haerting, Johannes, Huber, Kurt, Maisch, Bernhard, Messemer, Beate, Ourrak, Taoufik, Schuler, Gerhard, Vonderschmitt, Karin, Werdan, Karl·2019·Circulation

Abstract

Background: The role of intraaortic balloon counterpulsation (IABP) in cardiogenic shock is still a subject of intense debate despite the neutral results of the IABP-SHOCK II trial (Intraaortic Balloon Pump in Cardiogenic Shock II) with subsequent downgrading in international guidelines. So far, randomized data on the impact of IABP on long-term clinical outcomes in patients with cardiogenic shock complicating acute myocardial infarction are lacking. Furthermore, only limited evidence is available on general long-term outcomes of patients with cardiogenic shock treated by contemporary practice. Methods: The IABP-SHOCK II trial is a multicenter, randomized, open-label trial. Between 2009 and 2012, 600 patients with cardiogenic shock complicating acute myocardial infarction undergoing early revascularization were randomized to IABP versus control. Results: Long-term follow-up was performed 6.2 years (interquartile range 5.6–6.7) after initial randomization. Follow-up was completed for 591 of 600 patients (98.5%). Mortality was not different between the IABP and the control group (66.3% versus 67.0%; relative risk, 0.99; 95% CI, 0.88–1.11; P =0.98). There were also no differences in recurrent myocardial infarction, stroke, repeat revascularization, or rehospitalization for cardiac reasons (all P >0.05). Survivors’ quality of life as assessed by the EuroQol 5D questionnaire and the New York Heart Association class did not differ between groups. Conclusions: IABP has no effect on all-cause mortality at 6-year long-term follow-up. Mortality is still very high, with two thirds of patients with cardiogenic shock dying despite contemporary treatment with revascularization therapy. Clinical Trial Registration: URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00491036.

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Metadata

Authors
Thiele, H., Zeymer, U., Thelemann, N., Neumann, F.-J., Hausleiter, J., Abdel-Wahab, M., Meyer-Saraei, R., Fuernau, G., Eitel, I., Hambrecht, R., Böhm, M., Werdan, K., Felix, S. B., Hennersdorf, M., Schneider, S., Ouarrak, T., Desch, S., de Waha-Thiele, S., On behalf of the IABP-SHOCK II Trial (Intraaortic Balloon Pump in Cardiogenic Shock II) Investigators, Alkisoglu, Z., Follath, F., Frey, S., Haerting, J., Huber, K., Maisch, B., Messemer, B., Ourrak, T., Schuler, G., Vonderschmitt, K., & Werdan, K.
Venue
Circulation
Published
2019-01-15
Volume
139
Issue
3
Pages
395-403
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2913182240
Cited by
448
References
29
FWCI
15.92
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Intraaortic Balloon Pump in Cardiogenic Shock Complicating Acute Myocardial Infarction: Long-Term 6-Year Outcome of the Randomized IABP-SHOCK II Trial. https://app.cochat.ai/papers/10.1161/circulationaha.118.038201
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Thiele, H., Zeymer, U., Thelemann, N., Neumann, F.-J., Hausleiter, J., Abdel-Wahab, M., Meyer-Saraei, R., Fuernau, G., Eitel, I., Hambrecht, R., Böhm, M., Werdan, K., Felix, S. B., Hennersdorf, M., Schneider, S., Ouarrak, T., Desch, S., de Waha-Thiele, S., On behalf of the IABP-SHOCK II Trial (Intraaortic Balloon Pump in Cardiogenic Shock II) Investigators, . . . Werdan, K. (2019). Intraaortic Balloon Pump in Cardiogenic Shock Complicating Acute Myocardial Infarction: Long-Term 6-Year Outcome of the Randomized IABP-SHOCK II Trial. Circulation. https://doi.org/10.1161/circulationaha.118.038201

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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