Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary

Shah, Sanjiv J., Borlaug, Barry A., Kitzman, Dalane W., McCulloch, Andrew D., Blaxall, Burns C., Agarwal, Rajiv, Chirinos, Julio A., Collins, Sheila, Deo, Rahul C., Gladwin, Mark T., Granzier, Henk, Hummel, Scott L., Kass, David A., Redfield, Margaret M., Sam, Flora, Wang, Thomas J., Desvigne-Nickens, Patrice, Adhikari, Bishow B.·2020·Circulation

DOI 10.1161/circulationaha.119.041886

Cited by (436)

Items 101–200 of 436

Large animal models of heart failure with preserved ejection fraction
Chihiro Miyagi, Takuma Miyamoto, Taiyo Kuroda, Jamshid H. Karimov, Randall C. Starling, Kiyotaka Fukamachi · 2021 · Heart Failure Reviews
Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF)
María Valero‐Muñoz, Eng Leng Saw, Ryan Matthew Hekman, Benjamin C. Blum, Zaynab Hourani, Henk L. M. Granzier, Andrew Emili, Flora Sam · 2022 · Frontiers in Cardiovascular Medicine
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling
Hao Wu, Luxun Tang, Xuemei Wang, Liang-Peng Li, Xiaokang Chen, Yanji He, Dezhong Yang, Yu Shi, Jialing Shou, Zong-shu Zhang et al. · 2022 · Acta Pharmacologica Sinica
Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction
Danielle Rasooly, Claudia Giambartolomei, Gina Marie Peloso, Hesam Dashti, Brian R. Ferolito, Daniel J Golden, Andréa R. V. R. Horimoto, Maik Pietzner, Eric H. Farber‐Eger, Quinn Stanton Wells et al. · 2025 · Nature Cardiovascular Research
Machine learning to define phenotypes and outcomes of patients hospitalized for heart failure with preserved ejection fraction: Findings from ASCEND-HF
Evan M. Murray, Stephen John Greene, Vishal N. Rao, Jie‐Lena Sun, Brooke Alhanti, Vanessa L. Blumer, Javed Butler, Tariq Ahmad, Robert John Mentz · 2022 · American Heart Journal
Insights into the post-translational modifications in heart failure
Xudong Zhang, Yan Wang, Huaping Li, Dao Wen Wang, Chen Chen · 2024 · Ageing Research Reviews
Age and Sex Differences in Heart Failure With Preserved Ejection Fraction
Kamil Aleksander Kobak, Weronika Zarzycka, Ying Ann Chiao · 2022 · Frontiers in Aging
Clinical features, myocardial strain and tissue characteristics of heart failure with preserved ejection fraction in patients with obesity: a prospective cohort study
Jian He, Wenjing Yang, Weichun Wu, Xiaoxin Sun, Shuang Li, Gang Yin, Baiyan Zhuang, Jing Xu, Di Zhou, Yuhui Zhang et al. · 2022 · EClinicalMedicine
Prefrailty, impairment in physical function, and risk of incident heart failure among older adults
Matthew W. Segar, Sumitabh Singh, Parag Goyal, Scott L. Hummel, Mathew S. Maurer, Daniel E. Forman, Javed Butler, Ambarish Pandey · 2021 · Journal of the American Geriatrics Society
Hemodynamic Effects of SGLT2 Inhibitors in Patients with and Without Diabetes Mellitus—A Narrative Review
Roxana Daniela Brata, Andrei Vasile Paşcalău, Ovidiu Frățilă, Ioana Larisa Paul, Mihaela Mirela Muresan, Andreea Cămărășan, Tiberia Ioana Ilias · 2024 · Healthcare
Mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF)
Brandon Pecchia, Roy Samuel, Vacha Shah, Emily Newman, Gregory T. Gibson · 2025 · Heart Failure Reviews
Identification of patients with preclinical heart failure with preserved ejection fraction using the H2FPEF score
Katlyn E. Koepp, Yogesh N.V. Reddy, Masaru Obokata, Hidemi Sorimachi, Frederik Hendrik Verbrugge, Christopher Charles Jain, Alexander C. Egbe, Margaret M. Redfield, Thomas Patrick Olson, Barry A. Borlaug · 2022 · Nature Cardiovascular Research
Accelerating therapeutic discoveries for heart failure: a new public–private partnership
Sanjiv Jayendra Shah, Javed Butler, Svati Hasmukh Shah, Tania Nayak Kamphaus, Vandana Sachdev · 2022 · Nature Reviews Drug Discovery
Heart Failure with Preserved Ejection Fraction and Non-Alcoholic Fatty Liver Disease: New Insights from Bioinformatics
Anzhu Wang, Qiang Li, Zhuo Sun, Yifei Wang, Shuangqing Fu, Dawu Zhang, Xiaochang Ma · 2022 · ESC Heart Failure
Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure
Haipeng Wang, Na Zhang, Yu‐Jie Liu, Tian-Long Xia, Guo‐Chong Chen, Jing Yang, Furong Li · 2023 · Journal of Lipid Research
Hypertension as a Road to Treatment of Heart Failure with Preserved Ejection Fraction
Harry Hicklin, Olivia N. Gilbert, Fan Ye, Jeremy Brooks, Bharathi Upadhya · 2020 · Current Hypertension Reports
Sodium–glucose co‐transporter 2 inhibitors in heart failure with preserved ejection fraction: reasons for optimism
Stefan D. Anker, Muhammad Shahzeb Khan, Izza Shahid, Gerasimos S Filippatos, Andrew J.S. Coats, Javed Butler · 2021 · European Journal of Heart Failure
Biomarkers in HFpEF for Diagnosis, Prognosis, and Biological Phenotyping
Moemen Eltelbany, Palak Mayur Shah, Christopher R. deFilippi · 2022 · Current Heart Failure Reports
Cost-Effectiveness of Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction
Jennifer Zhou, Danny Liew, David M. Kaye, Sophia Zoungas, Dion A. Stub · 2022 · Circulation Cardiovascular Quality and Outcomes
Cardiac epigenetic changes in VEGF signaling genes associate with myocardial microvascular rarefaction in experimental chronic kidney disease
Alfonso Eirin, Alejandro Chade · 2022 · American Journal of Physiology-Heart and Circulatory Physiology
Reducing Pulmonary Capillary Wedge Pressure During Exercise Exacerbates Exertional Dyspnea in Patients With Heart Failure With Preserved Ejection Fraction
Bryce Nicholas Balmain, Andrew R. Tomlinson, James P. MacNamara, Linda Susan Hynan, Denis J. Wakeham, Benjamin D. Levine, Satyam Sarma, Tony G. Babb · 2023 · CHEST Journal
Diastolic heart failure: 20 years later. Сurrent issues of pathogenesis, diagnosis and treatment of heart failure with preserved LVEF
Fail T. Ageev, Artem G. Ovchinnikov · 2023 · Kardiologiia
Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis
L. Heger, Nicolas Schommer, Shoichi Fukui, S. Van Bruggen, Casey E. Sheehy, Long Chu, S. Rajagopal, D. Sivanandhan, B. Ewenstein, D. Wagner · 2023 · Life Science Alliance
Microvascular endothelial dysfunction in skin is associated with higher risk of heart failure with preserved ejection fraction in women with type 2 diabetes: the Hoorn Diabetes Care System Cohort
Elisa Dal Canto, L. van Deursen, Anna G. Hoek, Petra J. M. Elders, Hester M. den Ruijter, Jolanda van der Velden, Vanessa P. M. van Empel, Erik H. Serné, Etto C. Eringa, Joline W. J. Beulens · 2023 · Cardiovascular Diabetology
Independent and incremental prognostic value of semiquantitative measures of tricuspid regurgitation severity in heart failure with preserved ejection fraction
Tomonari Harada, Masaru Obokata, Kazunori Omote, Hiroyuki Iwano, Takahiro Ikoma, Kenya Okada, Kuniko Yoshida, Toshimitsu Kato, Koji Kurosawa, Toshiyuki Nagai et al. · 2020 · European Heart Journal - Cardiovascular Imaging
Current gaps in HFpEF trials: Time to reconsider patients' selection and to target phenotypes
Alberto Palazzuoli, Sergio Caravita, Stefania Paolillo, Stefano Ghio, Carlo Gabriele Tocchetti, Gaetano M. Ruocco, Michele Correale, Giuseppe Ambrosio, Pasquale Perrone Filardi, Michele Senni · 2021 · Progress in Cardiovascular Diseases
The sympathetic nervous system in heart failure with preserved ejection fraction
Joshua Wen-Han Chang, Rohit Ramchandra · 2024 · Heart Failure Reviews
Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure
Bradley J. Baranowski, Matti Douglas Allen, Jennifer N. K. Nyarko, R. Scott Rector, Jaume Padilla, Darrell D. Mousseau, Christoph D. Rau, Yibin Wang, M. Harold Laughlin, Craig A. Emter et al. · 2021 · JCI Insight
Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction
Alejandro Chade, Alfonso Eirin · 2022 · American Journal of Physiology-Heart and Circulatory Physiology
The grand challenge of discovering new cardiovascular drugs
Charles C. Hong · 2022 · Frontiers in Drug Discovery
Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype
Yijia Li, Hajime Kubo, Daohai Yu, Yijun Yang, Jaslyn P. Johnson, Deborah Eaton, Remus M. Berretta, Michael Foster, Timothy A. McKinsey, Jun Yu et al. · 2023 · American Journal of Physiology-Heart and Circulatory Physiology
Atrial Shunt Therapy for Heart Failure: An Update
Vikrant S. Jagadeesan, William A. Gray, Sanjiv Jayendra Shah · 2023 · Journal of the Society for Cardiovascular Angiography & Interventions
Integrated Systems Biology Identifies Disruptions in Mitochondrial Function and Metabolism as Key Contributors to HFpEF
Andrew Gibb, Kyle Brian LaPenna, Ryan B. Gaspar, Nadina R. Latchman, Yin Fei Tan, Carmen Choya-Foces, Jake E. Doiron, Zhen Li, Huijing Xia, Michael P. Lazaropoulos et al. · 2025 · JACC Basic to Translational Science
Left ventricular and atrial myocardial strain in heart failure with preserved ejection fraction: the evidence so far and prospects for phenotyping strategy
Mariane Higa Shinzato, Natasha Santos, Gustavo Nishida, Henrique Takachi Moriya, Jorge Eduardo Assef, Fausto Feres, Renato A. Hortegal · 2024 · Cardiovascular Ultrasound
Perspectives for Future Use of Cardiac Microtissues from Human Pluripotent Stem Cells
Ulgu Arslan, Valeria V. Orlova, Christine L. Mummery · 2022 · ACS Biomaterials Science & Engineering
What Role do Mitochondria Have in Diastolic Dysfunction? Implications for Diabetic Cardiomyopathy and Heart Failure With Preserved Ejection Function
Martin G. McCandless, Raffaele Altara, George W. Booz, Mazen Kurdi · 2022 · Journal of Cardiovascular Pharmacology
The potential of glucagon-like peptide-1 receptor agonists in heart failure
Frederik Flindt Kreiner, G. Kees Hovingh, Bernt Johan von Scholten · 2022 · Frontiers in Physiology
Are Arrhythmias the Drivers of Sudden Cardiac Death in Heart Failure with Preserved Ejection Fraction? A Review
Matthew Fomonyuy Yuyun, Scott Kinlay, Jagmeet P. Singh, Jacob Joseph · 2022 · ESC Heart Failure
Epigenetics in Heart Failure: Role of DNA Methylation in Potential Pathways Leading to Heart Failure with Preserved Ejection Fraction
Simon W. Rabkin, Chenille N. Wong · 2023 · Biomedicines
Peripheral Blood MicroRNA-21 as a Predictive Biomarker for Heart Failure With Preserved Ejection Fraction in Old Hypertensives
Maria E. Marketou, Joanna E. Kontaraki, Evangelos A. Zacharis, Spyros Maragkoudakis, Konstantinos Fragkiadakis, Emmanouil Kampanieris, Anthοula Plevritaki, Eirini Savva, Onoufrios Malikides, GREGORY I. CHLOUVERAKIS et al. · 2023 · American Journal of Hypertension
Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction
Elisabeth A. Jalink, Amber W. Schonk, Reinier Abraham Boon, Rio Putra Juni · 2024 · Frontiers in Cardiovascular Medicine
Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction
Chen Gao, Zhaojun Xiong, Yunxia Liu, Meng Wang, Menglong Wang, Tian Liu, Jianfang Liu, Shuxun Vincent Ren, Nancy Cao, Hai Yan et al. · 2024 · Circulation Research
Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: a renal-cardio axis
Alejandro Chade, Jason Edward Engel, Michael E. Hall, Alfonso Eirin, Gene Lee Bidwell · 2021 · American Journal of Physiology-Renal Physiology
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency
Mei Methawasin, Joshua G. Strom, Vito A. Marino, Jochen Gohlke, Julia Muldoon, Shelby Herrick, Robbert J. van der Pijl, John P. Konhilas, Henk L. M. Granzier · 2025 · American Journal of Physiology-Heart and Circulatory Physiology
Arterial stiffness and pulsatile hemodynamics in heart failure
Julio A. Chirinos · 2022 · Elsevier eBooks
High-intensity and moderate-intensity interval training in heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials
Ping Lai, Jinhua Xue, Mu-Jin Xie, Jin-Hua Ye, Ning Yang, Yiming Zhong, Yong-ling Liao · 2023 · Medicine
Chapter 2: Clinical and Mechanistic Potential of Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors in Heart Failure with Preserved Ejection Fraction
John W. Ostrominski, Muthiah Vaduganathan · 2023 · The American Journal of Medicine
High microvascular resistance and reduced left atrial strain in patients with coronary microvascular dysfunction: The micro-strain study
Daniëlle C. J. Keulards, Sjoerd Bouwmeester, Annemiek M.J. de Vos, Lukas Dekker, Nico H.J. Pijls, Patrick Houthuizen · 2021 · International Journal of Cardiology
Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities
Jens van de Wouw, Jarno J. Steenhorst, Oana Sorop, Ruben W. A. van Drie, Piotr A. Wielopolski, Alex KleinJan, Alexander Hirsch, Dirk Jan Duncker, Daphne Merkus · 2021 · Basic Research in Cardiology
Treatment of patients with heart failure and preserved ejection fraction: reliance on clinical phenotypes
Fail T. Ageev, Artem G. Ovchinnikov · 2022 · Kardiologiia
Go Red for Women Strategically Focused Research Network: Summary of Findings and Network Outcomes
Marie‐Pierre St‐Onge, Brooke Aggarwal, Matthew Allison, Jeffrey S. Berger, Sheila F. Castañeda, Janet M. Catov, Judith S. Hochman, Carl A. Hubel, Sanja Jelić, David A. Kass et al. · 2021 · Journal of the American Heart Association
Proteostatic Imbalance Drives the Pathogenesis and Age-Related Exacerbation of Heart Failure With Preserved Ejection Fraction
Kamil Aleksander Kobak, Weronika Zarzycka, Catherine J. King, Agnieszka Borowik, Frederick F. Peelor, Leslie M. Baehr, Mario Leutert, Ricard A. Rodríguez‐Mias, Judit Villén, Sue C. Bodine et al. · 2025 · JACC Basic to Translational Science
CCR2 + monocyte-derived macrophages drive cardiac hypertrophy in early HFpEF
Jana Raman, Steven J. Simmonds, Ellen Caluwé, Rick E.W. van Leeuwen, Caroline Walschap, Mathias Stroobants, Ümare Cöl, Petra Vandervoort, Stephane R B Heymans, Elizabeth A. V. Jones · 2025 · American Journal of Physiology-Heart and Circulatory Physiology
Aldehyde dehydrogenase 2 augments adiponectin signaling in coronary angiogenesis in HFpEF associated with diabetes
Bipradas Roy, Guodong Pan, Shailendra Giri, Rajarajan A. Thandavarayan, Suresh S. Palaniyandi · 2022 · The FASEB Journal
Targeting Efficacy of Spironolactone in Patients with Heart Failure with Preserved Ejection Fraction: The TOPCAT Study
Huimin Zhou, Rongjian Zhan, Xuanyu Chen, Yi-fen Lin, Shaozhao Zhang, Huigan Zheng, Xueqin Wang, Meng-ting Huang, Chaoguang Xu, Xinxue Liao et al. · 2022 · ESC Heart Failure
Skeletal muscle phenotypic switching in heart failure with preserved ejection fraction
Eng Leng Saw, Louis Dominic Werner, Payman L. Zamani, Julio A. Chirinos, María Valero‐Muñoz, Flora Sam · 2022 · Frontiers in Cardiovascular Medicine
CMR to characterize myocardial structure and function in heart failure with preserved left ventricular ejection fraction
Rojda Ipek, Jennifer Holland, Mareike Gastl, Oliver J. Rider · 2024 · European Heart Journal - Cardiovascular Imaging
Insight into the Pro-inflammatory and Profibrotic Role of Macrophage in Heart Failure With Preserved Ejection Fraction
Jinlian Shen, Xiao-jie Xie · 2020 · Journal of Cardiovascular Pharmacology
Understanding the Role of SERCA2a Microdomain Remodeling in Heart Failure Induced by Obesity and Type 2 Diabetes
Ping Lai, Viacheslav O. Nikolaev, Kirstie A. De Jong · 2022 · Journal of Cardiovascular Development and Disease
Emerging concepts in heart failure treatment and management: focus on SGLT2 inhibitors in heart failure with preserved ejection fraction
Andrea Beatriz De Lorenzi, Edgardo Kaplinsky, Marx Rivera Zambrano, Laia Tomas Chaume, Joan Monell Rosas · 2023 · Drugs in Context
Underweight Is Associated with Poor Prognosis in Heart Failure with Preserved Ejection Fraction
Yutaka Matsuhiro, Masami Nishino, Kohei Ukita, Akito Kawamura, Hitoshi Nakamura, Koji Yasumoto, Masaki Tsuda, Naotaka Okamoto, Akihiro Tanaka, Yasuharu Matsunaga‐Lee et al. · 2021 · International Heart Journal
Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection Fraction
Dalane W. Kitzman, Adriaan A. Voors, Robert John Mentz, Gregory D. Lewis, Shira Perl, Robin Myte, Grace Kaguthi, C. David Sjöström, Christian Källgren, Sanjiv Jayendra Shah · 2024 · JAMA Cardiology
Metabolomic profiling identifies novel metabolites associated with cardiac dysfunction
Kasen L. Culler, Arjun Sinha, Mallory E. Filipp, Pedro Giro, Norrina B. Allen, Kent D. Taylor, Xiuqing Guo, Edward Benjamin Thorp, Benjamin H. Freed, Philip Greenland et al. · 2024 · Scientific Reports
Epidemiology, Diagnosis, Pathophysiology, and Initial Approach to Heart Failure with Preserved Ejection Fraction
Theresa Anderson, Scott L. Hummel, Matthew C. Konerman · 2022 · Cardiology Clinics
Renal Denervation Helps Preserve the Ejection Fraction by Preserving Endocardial-Endothelial Function during Heart Failure
Sathnur Basappa Pushpakumar, Mahavir Singh, Yuting Zheng, Oluwaseun E. Akinterinwa, Sri Prakash Mokshagundam, Utpal Sen, Dinesh Kumar Kalra, Suresh C. Tyagi · 2023 · International Journal of Molecular Sciences
Myofilament dysfunction in diastolic heart failure
Anahita Aboonabi, Mark D. McCauley · 2023 · Heart Failure Reviews
Causal effect of central obesity on left ventricular structure and function in preserved EF population: A Mendelian randomization study
Yue Gao, Jiaxin Zeng, Fengwei Zou, Xinwei Zhang, Zhiyong Qian, Yao Wang, Xiaofeng Hou, Jiangang Zou · 2023 · Frontiers in Cardiovascular Medicine
Association of cardiac troponin T and growth differentiation factor 15 with replacement and interstitial cardiac fibrosis in community dwelling adults: The multi-ethnic study of atherosclerosis
Christopher R. deFilippi, Henry Tran, Raghav Gattani, Lori B. Daniels, Palak Mayur Shah, Leonard Ilkhanoff, Robert H. Christenson, João A.C. Lima, Stephen L. Seliger · 2023 · Frontiers in Cardiovascular Medicine
Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics
Axel J. Fenwick, Vivek Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle Brian LaPenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass et al. · 2024 · Journal of the American Heart Association
Statin administration improves vascular function in heart failure with preserved ejection fraction
Jarred J. Iacovelli, Jeremy K. Alpenglow, Stephen M. Ratchford, Jesse C. Craig, Jonah M. Simmons, Jia Zhao, Van R. Reese, Kanokwan Bunsawat, Christy L. Ma, John Jake Ryan et al. · 2024 · Journal of Applied Physiology
Novel insights into the pathobiology of pulmonary hypertension in heart failure with preserved ejection fraction
Vaishnavi Aradhyula, Rohit Vyas, Prabhatchandra R. Dube, Steven T. Haller, Rajesh Gupta, Krishna Rao Maddipati, David J. Kennedy, Samer J. Khouri · 2024 · American Journal of Physiology-Heart and Circulatory Physiology
Proteomics Identify Clinical Phenotypes and Predict Functional Outcomes in Heart Failure With Preserved Ejection Fraction: Insights From VITALITY-HFpEF
Christopher R. deFilippi, Palak Mayur Shah, Sanjiv Jayendra Shah, Wendimagegn Ghidey Alemayehu, Carolyn S.P. Lam, Javed Butler, Lothar Roessig, Christopher M. O’Connor, Cynthia M. Westerhout, Paul W. Armstrong et al. · 2024 · Circulation Heart Failure
Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta‐Analysis
Abolfazl Sam Daliri, Nima Goudarzi, Arshia Harati, Kourosh Kabir · 2025 · Clinical Cardiology
Exploring the Multi-Faceted Effects of Berberine in Ameliorating Diastolic Dysfunction in Rats with Heart Failure with Preserved Ejection Fraction
Yu Mu, Jing Geng, Chilu Liu, Shuang Jiang, Yanxing Han, Jian‐Dong Jiang, Yuhong Wang · 2025 · International Journal of Molecular Sciences
Association between the beta‐blockers, calcium channel blockers, all‐cause mortality and length of hospitalization in patients with heart failure with preserved ejection fraction: A meta‐analysis of randomized controlled trials
Mingming Wu, Dan Ni, Lin‐ling Huang, Shengjun Qiu · 2023 · Clinical Cardiology
Clinical Phenotypes and Age-Related Differences in Presentation, Treatment, and Outcome of Heart Failure with Preserved Ejection Fraction: A Vietnamese Multicenter Research
N.D. Nguyen, Tuan Diep Tran, Pham Lê An, Sy Van Hoang, Hoai-An Nguyen, Hoa Ngoc Chau · 2021 · Cardiology Research and Practice
Management of Heart Failure With Preserved Ejection Fraction: 2026 ACC Expert Consensus Decision Pathway
M D Kittleson, Gurusher Singh Panjrath, Katie Bates, Khadijah K Breathett, Dave L. Dixon, James L. Januzzi, Selma F. Mohammed · 2026 · Journal of the American College of Cardiology
Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential
Alexander Fuerlinger, Alina Stockner, Simon Sedej, Mahmoud Abdellatif · 2025 · Cardiovascular Diabetology
Comparison of the effects of metformin and empagliflozin on cardiac function in heart failure with preserved ejection fraction mice
Xiehong Liu, Huiqi Zhao, Sisi Liu, Siao Wen, Wenjuan Fan, Qiong Xie, Bo Cui, Lin Zhou, Jianqiang Peng, Hongwei Pan et al. · 2025 · Frontiers in Cardiovascular Medicine
Prognostic Models in Heart Failure: Hope or Hype?
Spyridon Skoularigkis, Christos Kourek, Andrew V. Xanthopoulos, Αlexandros Briasoulis, Vasiliki A. Androutsopoulou, Dimitrios E. Magouliotis, Thanos Athanasiou, John S. Skoularigis · 2025 · Journal of Personalized Medicine
Diagnostic and prognostic value of serum soluble suppression of tumorigenicity-2 in heart failure with preserved ejection fraction: A systematic review and meta-analysis
Yujiao Shi, Jiangang Liu, Chunqiu Liu, Shuang Xiong, Chenguang Yang, Wenbo Qiao, Guoju Dong · 2022 · Frontiers in Cardiovascular Medicine
Screening for Regenerative Therapy Responders in Heart Failure
Satsuki Yamada, Ryoung‐Hoon Jeon, Armin Garmany, Atta Behfar, André Terzic · 2021 · Biomarkers in Medicine
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)
Nisha Bhattarai, Iain Scott · 2024 · Current Opinion in Pharmacology
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction
Paola Cecilia Rosas, Liomar A. A. Neves, Nisha A. Patel, Duyen Tran, Carlos H. Pereira, Karina Bonilla, Jingjing Zheng, Jun Sun, Francisco J. Alvarado, Kathrin Banach · 2024 · American Journal of Physiology-Heart and Circulatory Physiology
Therapeutic potential of ketone bodies on exercise intolerance in heart failure: looking beyond the heart
Shubham Soni, Rachel J. Skow, Stephen Foulkes, Mark J. Haykowsky, Jason R.B. Dyck · 2025 · Cardiovascular Research
Impact of Multimorbidity on Mortality in Heart Failure With Mildly Reduced and Preserved Ejection Fraction
Mingming Yang, Toru Kondo, Pooja Dewan, Akshay Suvas Desai, Carolyn S.P. Lam, Martin P. Lefkowitz, Milton Packer, Jean Lucien Rouleau, Muthiah Vaduganathan, Michael R. Zile et al. · 2025 · Circulation Heart Failure
The Cardiomyocyte in Heart Failure with Preserved Ejection Fraction—Victim of Its Environment?
Angela Rocca, Ruud B. van Heeswijk, Jonas Richiardi, Philippe Meyer, Roger Hullin · 2022 · Cells
A rat model of metabolic syndrome-related heart failure with preserved ejection fraction phenotype: pathological alterations and possible molecular mechanisms
Yujiao Shi, Chunqiu Liu, Chenguang Yang, Wenbo Qiao, Yongcheng Liu, Siyu Liu, Guoju Dong · 2023 · Frontiers in Cardiovascular Medicine
A network medicine approach to study comorbidities in heart failure with preserved ejection fraction
Jan D. Lanzer, Alberto Valdeolivas, Mark E. Pepin, Hauke Hund, Johannes Backs, Norbert Frey, Hans‐Christoph Friederich, Jobst‐Hendrik Schultz, Julio Sáez-Rodríguez, Rebecca T. Levinson · 2023 · BMC Medicine
Preload dependence in an animal model of mild heart failure with preserved ejection fraction ( HFpEF )
Jens Christian Jacobsen, Irene H. Schubert, Karin Larsen, Dijana Terzic, Louise Thisted, Morten Bækgaard Thomsen · 2024 · Acta Physiologica
Inhibition of activin receptor 2 signalling ameliorates metabolic dysfunction–associated steatotic liver disease in western diet/L-NAME induced cardiometabolic disease
Julia Swan, Zoltán Szabó, Juliana Peters, Outi Kummu, Anna Kemppi, Lea Rahtu‐Korpela, Anja Konzack, Jukka Hakkola, Arja H. Pasternack, Olli Ritvos et al. · 2024 · Biomedicine & Pharmacotherapy
Sex-specific cardiometabolic multimorbidity, metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank
Ambre Bertrand, Xin Zhou, Andrew Lewis, Thomas Monfeuga, Ramneek Gupta, Vicente Grau, Blanca Rodríguez · 2025 · Cardiovascular Diabetology
Hydrogen Sulfide Deficiency and Therapeutic Targeting in Cardiometabolic HFpEF
Jake E. Doiron, Mahmoud H. Elbatreek, Huijing Xia, Xiaoman Yu, Natalie Gehred, Tatiana Gromova, Jingshu Chen, Ian H. Driver, Naoto Muraoka, Martin Borch Jensen et al. · 2025 · JACC Basic to Translational Science
Updates for the diagnosis and management of cardiac amyloidosis
Piotr Gościniak, Tomasz Baron, Sławomir Milczarek, Magdalena Kostkiewicz, Bogusław Machaliński · 2022 · Advances in Clinical and Experimental Medicine
Key Phenotypes of Heart Failure with Preserved Ejection Fraction
Kazuki Kagami, Tomonari Harada, Hideki Ishii, Masaru Obokata · 2022 · Cardiology Clinics
A narrative review of heart failure with preserved ejection fraction in breast cancer survivors
Vidhushei Yogeswaran, Elena Wadden, Warren Szewczyk, Ana Barac, Michael Steven Simon, Charles B. Eaton, Richard Kar-Hang Cheng, Kerryn W. Reding · 2023 · Heart
Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardiometabolic heart failure
Kleiton Augusto Santos Silva, Emily V. Leary, T. Dylan Olver, Timothy L. Domeier, Jaume Padilla, R. Scott Rector, Craig A. Emter · 2020 · American Journal of Physiology-Heart and Circulatory Physiology
Current Understanding of Circulating Biomarkers in Pulmonary Hypertension Due to Left Heart Disease
Noah Todd, Yen‐Chun Lai · 2020 · Frontiers in Medicine
Automatic fault detection of sensors in leather cutting control system under GWO-SVM algorithm
Ke Luo, Yingying Jiao · 2021 · PLoS ONE
Salutary Acute Effects of Exercise on Central Hemodynamics in Heart Failure With Preserved Ejection Fraction
Masaru Obokata, Yogesh N.V. Reddy, Katlyn E. Koepp, Glenn M. Stewart, Thomas Patrick Olson, Vojtěch Melenovský, Daniel Burkhoff, Barry A. Borlaug · 2021 · Journal of Cardiac Failure