The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017
Abstract
Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017. Methods: Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017. Results: Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700–107 900) and 35 700 (95% UI, 30 500–42 500) deaths, and 12.6 million (95% UI, 11.4 million–13.8 million) and 18.1 million (95% UI, 17.6 million–18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million–2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%–0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%–117%) and 35% (95% UI, 23%–47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries. Conclusions: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.
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Self-citationTranscatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients
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Self-citationBurden of valvular heart diseases: a population-based study
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Self-citationClinical Factors Associated With Calcific Aortic Valve Disease
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2021 ESC/EACTS Guidelines for the management of valvular heart disease
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Self-citationGlobal epidemiology of valvular heart disease
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2021 ESC/EACTS Guidelines for the management of valvular heart disease
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Metadata
- Authors
- Yadgir, S., Johnson, C. O., Aboyans, V., Adebayo, O. M., Adedoyin, R. A., Afarideh, M., Alahdab, F., Alashi, A., Alipour, V., Arabloo, J., Azari, S., Barthelemy, C. M., Benziger, C. P., Berman, A. E., Bijani, A., Carrero, J. J., Carvalho, F., Daryani, A., Durães, A. R., Esteghamati, A., Farid, T. A., Farzadfar, F., Fernandes, E., Filip, I., Gad, M. M., Hamidi, S., Hay, S. I., Ilesanmi, O. S., Naghibi Irvani, S. S., Jürisson, M., Kasaeian, A., Kengne, A. P., Khan, A. R., Kisa, A., Kisa, S., Kolte, D., Manafi, N., Manafi, A., Mensah, G. A., Mirrakhimov, E. M., Mohammad, Y., Mokdad, A. H., Negoi, R. I., Thi Nguyen, H. L., Nguyen, T. H., Nixon, M. R., Otto, C. M., Patel, S., Pilgrim, T., Radfar, A., Rawaf, D. L., Rawaf, S., Rawasia, W. F., Rezapour, A., Roever, L., Saad, A. M., Saadatagah, S., Senthilkumaran, S., Sliwa, K., Tesfay, B. E., Tran, B. X., Ullah, I., Vaduganathan, M., Vasankari, T. J., Wolfe, C. D. A., Yonemoto, N., Roth, G. A., & Collaborators, F. T. G. B. O. D. S. 2. N. V. D.
- Venue
- Circulation
- Published
- 2020-05-26
- Volume
- 141
- Issue
- 21
- Pages
- 1670-1680
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W3013380890
- Cited by
- 490
- References
- 29
- FWCI
- 29.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017. https://app.cochat.ai/papers/10.1161/circulationaha.119.043391
- The paper
- Yadgir, S., Johnson, C. O., Aboyans, V., Adebayo, O. M., Adedoyin, R. A., Afarideh, M., Alahdab, F., Alashi, A., Alipour, V., Arabloo, J., Azari, S., Barthelemy, C. M., Benziger, C. P., Berman, A. E., Bijani, A., Carrero, J. J., Carvalho, F., Daryani, A., Durães, A. R., . . . Collaborators, F. T. G. B. O. D. S. 2. N. V. D. (2020). Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990–2017. Circulation. https://doi.org/10.1161/circulationaha.119.043391
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
