The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Nitric Oxide Regulates Local Arterial Distensibility In Vivo
Open accessAbstract
Background — Arterial stiffness is an important determinant of cardiovascular risk. Several lines of evidence support a role for the endothelium in regulating arterial stiffness by release of vasoactive mediators. We hypothesized that nitric oxide (NO) acting locally regulates arterial stiffness in vivo, and the aim of this experiment was to test this hypothesis in an ovine hind-limb preparation. Methods and Results — All studies were conducted in anesthetized sheep. Pulse wave velocity (PWV) was calculated by the foot-to-foot methodology from 2 pressure waveforms recorded simultaneously with a high-fidelity dual pressure-sensing catheter placed in the common iliac artery. Intra-arterial infusion of N G -monomethyl- l -arginine (L-NMMA) increased iliac PWV significantly, by 3±2% ( P <0.01). Infusion of acetylcholine and glyceryl trinitrate reduced PWV significantly, by 6±4% ( P =0.03) and 5±2% ( P <0.01), respectively. Only the effect of acetylcholine, however, was significantly inhibited during coinfusion of L-NMMA ( P =0.03). There was no change in systemic arterial pressure throughout the studies. Importantly, infusion of L-NMMA or acetylcholine distal to the common iliac artery (via the sheath) did not affect PWV. Conclusions — These results demonstrate, for the first time, that basal NO production influences large-artery distensibility. In addition, exogenous acetylcholine and glyceryl trinitrate both increase arterial distensibility, the former mainly through NO production. This may help explain why conditions that exhibit endothelial dysfunction are also associated with increased arterial stiffness. Therefore, reversal of endothelial dysfunction or drugs that are large-artery vasorelaxants may be effective in reducing large-artery stiffness in humans, and thus cardiovascular risk.
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Cites
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Self-citationThe velocity of pulse wave in man
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Cited by
The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome
Zhang, J., Bottiglieri, T., & McCullough, P. A. (2017) · Cardiorenal Medicine · doi:10.1159/000452283 · Cited by 1,080
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The Endothelium and Its Role in Regulating Vascular Tone
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Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease
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Metadata
- Authors
- Wilkinson, I. B., Qasem, A., McEniery, C. M., Webb, D. J., Avolio, A. P., & Cockcroft, J. R.
- Venue
- Circulation
- Published
- 2002-01-15
- Volume
- 105
- Issue
- 2
- Pages
- 213-217
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2068597752
- Cited by
- 502
- References
- 30
- FWCI
- 17.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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