Cited by 624Cardiac pacing and defibrillation studiesCardiac Health and Mental HealthCardiac electrophysiology and arrhythmias

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Quality of Life in the Antiarrhythmics Versus Implantable Defibrillators Trial: Impact of Therapy and Influence of Adverse Symptoms and Defibrillator Shocks

Schron, Eleanor B., Exner, Derek V., Yao, Qing, Jenkins, Louise S., Steinberg, Jonathan S., Cook, James R., Kutalek, Steven P., Friedman, Peter L., Bubien, Rosemary S., Page, Richard L., Powell, Judy, the AVID Investigators·2002·Circulation

DOI 10.1161/hc0502.103330

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Abstract

Background — Implantable cardioverter defibrillator (ICD) use reduces mortality in patients with serious ventricular arrhythmias compared with antiarrhythmic drug (AAD) use. However, the relative impact of these therapies on self-perceived quality of life (QoL) is unknown. Methods and Results — Three self-administered instruments were used to measure generic and disease-specific QoL in Antiarrhythmics Versus Implantable Defibrillators trial participants. Generalized linear models were used to assess the relationships between self-perceived QoL and treatment (AAD versus ICD) and adverse symptoms and ICD shocks. To minimize the impact of missing data, only patients surviving 1 year were included in the primary analyses. Baseline characteristics among QoL participants (n=905) and nonparticipants (n=111) were similar, but participants who survived 1 year (n=800) were healthier at baseline than nonsurvivors (n=105). Of the 800 patients in the primary analysis, characteristics of those randomized to AAD (n=384) versus ICD (n=416) were similar. Overall, ICD and AAD use were associated with similar alterations in QoL. The development of sporadic shocks and adverse symptoms were each associated with reduced physical functioning and mental well-being and increased concerns among ICD recipients, whereas development of adverse symptoms was associated with reduced physical functioning and increased concerns among AAD recipients. Conclusions — ICD and AAD therapy are associated with similar alterations in self-perceived QoL over 1-year follow-up. Adverse symptoms were associated with reduced self-perceived QoL in both groups, and sporadic shocks were associated with reduced QoL in ICD recipients.

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Authors: Schron, E. B., Exner, D. V., Yao, Q., Jenkins, L. S., Steinberg, J. S., Cook, J. R., Kutalek, S. P., Friedman, P. L., Bubien, R. S., Page, R. L., Powell, J., & the AVID Investigators
Affiliations: University of Maryland, Baltimore (US)
ORCID: Exner, Derek V.
Yao, Qing
Steinberg, Jonathan S.
Cook, James R.
Kutalek, Steven P.
Page, Richard L.
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-02-05
Volume: 105
Issue: 5
Pages: 589-594
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/hc0502.103330
OpenAlex: W2101541776
Semantic Scholar: 216ffa4eb6d0222f0b0b6ea03afb7c4d6d95a1c3
Cited by: 624
References: 39
Citations by year: 2026: 5 · 2025: 8 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 26 · 2020: 19 · 2019: 26 · 2018: 17 · 2017: 27 · 2016: 31 · 2015: 36 · 2014: 24 · 2013: 27 · 2012: 39
FWCI: 13.52
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Funders: Fondation pour la Recherche Médicale
National Institutes of Health (n01hc025117-014)
Canadian Institutes of Health Research
National Heart, Lung, and Blood Institute (N01-HC-25117)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: quality of life, implantable cardioverter-defibrillator, antiarrhythmic drugs, ventricular arrhythmias, ICD shocks, adverse symptoms, physical function, psychological well-being, patient concerns
MeSH terms: Aged, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Demography, Electric Countershock, Electrocardiography, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Treatment Outcome, Defibrillators, Implantable

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Quality of Life in the Antiarrhythmics Versus Implantable Defibrillators Trial: Impact of Therapy and Influence of Adverse Symptoms and Defibrillator Shocks

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