Physical functioning and mental well-being in association with health outcome in patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial II
Abstract
The association of psychosocial and physical factors with health outcome in patients with congestive heart failure (CHF) has not been fully explored. The aim of this study was to assess the physical and mental health in relationship to health outcome in post-infarction patients with advanced left ventricular dysfunction. A total of 1058 patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) completed the Medical Outcome Trust Short Form (SF-12) at baseline. Physical component summary (PCS) and mental component summary (MCS) of SF-12 were analysed in relationship to survival, hospitalization due to CHF, and implantable cardioverter-defibrillator (ICD) therapy. Both baseline PCS and MCS were significantly associated with death (P < 0.001 and P < 0.016, respectively) and hospitalization due to CHF (P ≤ 0.001). After adjustment for significant clinical covariates and treatment group, low PCS and low MCS groups remained significant predictors of mortality and CHF hospitalization. Neither PCS nor MCS was associated with appropriate ICD therapy for ventricular tachyarrhythmias. Patients who experienced appropriate ICD shocks had a statistically significant deterioration of PCS but not MCS from baseline to 12 months. Lower baseline PCS and MCS are associated with unfavourable health outcome in MADIT II patients, but not with appropriate ICD therapy for ventricular tachyarrhythmias. Patients who experience ICD shock reported a decrease in PCS, but little or no changes in MCS.
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Poor QoL and poor patient-rated health status have been shown to predict poor prognosis and mortality in patients with an ICD, despite state-of-the-art treatment.
“Poor QoL and poor patient-rated health status have been shown to predict poor prognosis and mortality in patients with an ICD, despite state-of-the-art treatment [38].”
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- Authors
- Piotrowicz, K., Noyes, K., Lyness, J. M., McNitt, S., Andrews, M. L., Dick, A., Hall, W. J., Moss, A. J., & Zareba, W.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-28
- Volume
- 28
- Issue
- 5
- Pages
- 601-607
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2132797983
- Cited by
- 68
- References
- 24
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 12
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- physical function, psychological well-being, health-related quality of life, congestive heart failure, post-infarction patients, left ventricular dysfunction, implantable cardioverter-defibrillator, MADIT II, mortality, ICD shocks, ventricular tachyarrhythmia, SF-12
- MeSH terms
- Adult, Aged, Female, Heart Failure, Hospitalization, Humans, Male, Mental Health, Middle Aged, Survival Analysis, Treatment Outcome, Defibrillators, Implantable, Ventricular Dysfunction, Left
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