The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Vitamin C Inhibits Endothelial Cell Apoptosis in Congestive Heart Failure
Open accessAbstract
Background Proinflammatory cytokines like tumor necrosis factor-α and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced EC apoptosis and the development of endothelial dysfunction. Therefore, we investigated the effects of antioxidative vitamin C therapy on EC apoptosis in CHF patients. Methods and Results Vitamin C dose dependently suppressed the induction of EC apoptosis by tumor necrosis factor-α and angiotensin II in vitro as assessed by DNA fragmentation, DAPI nuclear staining, and MTT viability assay. The antiapoptotic effect of vitamin C was associated with reduced cytochrome C release from mitochondria and the inhibition of caspase-9 activity. To assess EC protection by vitamin C in CHF patients, we prospectively randomized CHF patients in a double-blind trial to vitamin C treatment versus placebo. Vitamin C administration to CHF patients markedly reduced plasma levels of circulating apoptotic microparticles to 32±8% of baseline levels, whereas placebo had no effect (87±14%, P <0.005). In addition, vitamin C administration suppressed the proapoptotic activity on EC of the serum of CHF patients ( P <0.001). Conclusions Administration of vitamin C to CHF patients suppresses EC apoptosis in vivo, which might contribute to the established functional benefit of vitamin C supplementation on endothelial function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Vitamin C has been found to reduce the cholesterol level in patients with hypercholesterolemia (Rossig et al. 2001)”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rossig et al. 2001
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 9,051
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Ascorbate is an outstanding antioxidant in human blood plasma
Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870
Dimmeler, S., Haendeler, J., Nehls, M. C., & Zeiher, A. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.601 · Cited by 806
Self-citationEndothelium-dependent vasodilation is attenuated in patients with heart failure.
Kubo, S. H., Rector, T. S., Bank, A. J., Williams, R. E., & Heifetz, S. M. (1991) · Circulation · doi:10.1161/01.cir.84.4.1589 · Cited by 775
Oxidant Signaling in Vascular Cell Growth, Death, and Survival
Irani, K. (2000) · Circulation Research · doi:10.1161/01.res.87.3.179 · Cited by 756
Keith, M. E., Geranmayegan, A., Sole, M. J., Kurian, R., Robinson, A., Omran, A., & Jeejeebhoy, K. N. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00101-6 · Cited by 560
Oxygen free radicals and congestive heart failure.
Belch, J. J. F., Bridges, A., Scott, N., & Chopra, M. (1991) · Heart · doi:10.1136/hrt.65.5.245 · Cited by 550
Katz, S. D., Biasucci, L. M., Sabbà, C., Strom, J. A., Jondeau, G., Galvao, M., Solomon, S. B., Nikolic, S. D., Forman, R. F., & LeJemtel, T. H. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90271-n · Cited by 395
Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure
Hornig, B., Arakawa, N., Kohler, C., & Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.97.4.363 · Cited by 389
Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Oxygen, oxidative stress, hypoxia, and heart failure
Giordano, F. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24408 · Cited by 1,515
Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404296 · Cited by 1,340
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007176.pub2 · Cited by 924
Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease
Fadeel, B., & Orrenius, S. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01570.x · Cited by 727
Metadata
- Authors
- Rössig, L., Hoffmann, J., Hugel, B., Mallat, Z., Haase, A., Freyssinet, J.-M., Tedgui, A., Aicher, A., Zeiher, A. M., & Dimmeler, S.
- Affiliations
- From Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany (L.R., J.H., A.H., A.A., A.M.Z., S.D.); INSERM U141, IFR “Circulation,” Hôpital Lariboisière, Paris, France (Z.M., A.T.); and Institut d’Hématologie et d’Immunologie, Faculté de Médecine, Université Louis Pasteur, Strasbourg, France (B.H., J.-M.F.).
- Goethe University Frankfurt (DE)
- Venue
- Circulation
- Published
- 2001-10-30
- Volume
- 104
- Issue
- 18
- Pages
- 2182-2187
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2170212513
- Cited by
- 182
- References
- 29
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 15 · 2013: 11 · 2012: 9
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Deutsche Forschungsgemeinschaft (SFB 553)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- vitamin C, congestive heart failure, endothelial cell apoptosis, endothelial dysfunction, TNF-α, angiotensin II, oxidative stress, systemic inflammation, cytochrome c release, caspase-9, antioxidant therapy
- MeSH terms
- Administration, Oral, Adult, Aged, Angiotensin II, Ascorbic Acid, Cell Survival, Cells, Cultured, Dose-Response Relationship, Drug, Drug Administration Schedule, Endothelium, Vascular, Enzyme Inhibitors, Female, Heart Failure, Humans, Injections, Intravenous, Male, Middle Aged, Prospective Studies, Tumor Necrosis Factor-alpha, Biomarkers, Apoptosis, Thiobarbituric Acid Reactive Substances, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
