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Cited by 69Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlVestibular and auditory disorders

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Cerebral vasoconstriction in vasovagal syncope: any link with symptoms? A transcranial Doppler study

Lagi, Alfonso, Cencetti, Simone, Corsoni, Vanni, Georgiadis, Dimitrios, Bacalli, Stefano·2001·Circulation
DOI 10.1161/hc6172.099397
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Abstract

Background Cerebral vasoconstriction has been described previously in vasovagal syncope (VVS). This phenomenon appears paradoxical in view of the well-known decrease of systemic vascular resistances taking places during VVS. We aimed to assess (1) whether cerebral vasoconstriction in VVS is an independent paradoxical phenomenon and (2) whether cerebral vasoconstriction has any link with symptoms and/or VVS onsets. Methods and Results Seven young patients with recurrent VVS participated in the study. Each patient underwent monitoring of heart rate, blood pressure, cerebral blood flow velocity (by means of transcranial Doppler), end-tidal P co 2 , peripheral oximetry, respiratory rate, and tidal volumes both at rest and during head-up tilt. All the subjects experienced tilt-induced VVS. A significant increase of respiratory tidal volumes was observed in each subject ≥160 seconds before VVS. This deep breathing induced a P co 2 decrease and, consequently, also a decrease in cerebral blood flow velocity and increase in cerebrovascular resistance (expressed by the increase of the pulsatility index). Within 40 seconds, 5 subjects started complaining of discomfort, in the absence of any significant blood pressure drop. Conclusions Cerebral vasoconstriction is not a paradoxical phenomenon when it occurs before tilt-induced VVS but rather is only the physiological consequence of the hyperventilation-induced hypocapnia that occurs in habitual fainters. The large lag between the onset of syncope and cerebral vasoconstriction excludes the hypothesis that VVS is dependent on abnormal behavior of cerebral hemodynamics.

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Crossref · 10.1161/hc6172.099397

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4 of 4 references verified0 citation errors · 0 not checkable

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  • During phases of presyncope in orthostatic stress tests, probands appear to develop feelings described as distress or feeling uncomfortable in an ill-defined way.

    “At least during phases of presyncope in orthostatic stress tests, probands appear to develop feelings described as distress (Lagi et al., 2001) or “feeling uncomfortable in an ill-defined way” (Van Lieshout et al., 2003, p.835).”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Lagi et al., 2001

  • Lagi et al. found PCO2 falls to begin in an initial phase of irregular and deep breathing accompanied by reductions in cerebral blood flow; they proposed four phases leading up to syncope.

    “Lagi et al. (2001) found PCO2 falls to begin in an initial phase of irregular and deep breathing accompanied by reductions in CBF. They proposed four phases leading up to syncope; following the first phase of “deep breathing,” a second phase ensued during which patients complained of “discomfort,” followed by a third phase marked by the onset of falls in mean BP, and a fourth and final phase char”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Lagi et al. (2001)

  • Lagi et al. observed gradual and drastic falls in PCO2 starting 160 s before syncope, whereas blood pressure decreases began only 60 s after that point.

    “Gradual and drastic falls in PCO2 were also seen in a study by Lagi et al. (2001), starting 160 s before syncope, whereas BP decreases were observed to begin only 60 s after that point.”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Lagi et al. (2001)

Citations

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Metadata

Authors
Lagi, A., Cencetti, S., Corsoni, V., Georgiadis, D., & Bacalli, S.
Affiliations
Santa Maria Nuova Hospital (IT)
ORCID
Georgiadis, Dimitrios
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-11-27
Volume
104
Issue
22
Pages
2694-2698
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/hc6172.099397
OpenAlex
W2007911486
Cited by
69
References
4
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 5
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
vasovagal syncope, cerebral vasoconstriction, cerebral blood flow velocity, cerebrovascular resistance, hypocapnia, hyperventilation, head-up tilt, transcranial Doppler
MeSH terms
Adolescent, Adult, Blood Flow Velocity, Blood Gas Monitoring, Transcutaneous, Blood Pressure, Carbon Dioxide, Cerebrovascular Circulation, Diastole, Electrocardiography, Female, Heart Rate, Humans, Hyperventilation, Male, Plethysmography, Systole, Tidal Volume, Vasoconstriction, Hypocapnia, Ultrasonography, Doppler, Transcranial, Tilt-Table Test, Capnography, Syncope, Vasovagal

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