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Chronic Cardiovascular and Renal Actions of Leptin: Role of Adrenergic Activity
Abstract
Abstract— This study was designed to determine the role of changes in adrenergic activity in mediating the chronic cardiovascular, renal, and metabolic actions of leptin. Male Sprague-Dawley rats were implanted with catheters for mean arterial pressure (MAP) and heart rate (HR) measurements and IV infusions of either vehicle (n= 7) or α- and β-adrenergic receptor antagonists, terazosin and propranolol (10 mg/kg/d; n= 8) throughout the study. After control measurements, murine leptin was infused IV (1.0 μg/kg/min) for 7 days along with vehicle or adrenergic antagonists, followed by a 7-day recovery period. Leptin infusion significantly reduced food intake in control rats from 22.6±0.8 to 10.6±0.4 g/d and, in adrenergic blockade rats, from 22.6±0.8 to 13.2±0.8 g/d. Fasting plasma insulin decreased from 48±10 to 5±2 μU/mL in control rats and from 51±9 to 9±2 μU/mL in adrenergic blockade rats during leptin infusion. Leptin infusion did not significantly alter glomerular filtration rate in either group. MAP and HR increased by 6±1 mm Hg and 23±7 bpm after 7 days of leptin infusion in control rats. However, in adrenergic blockade rats, leptin infusion did not significantly alter MAP (−1±1 mm Hg) and decreased, rather than increased, HR (−23±8 bpm). These results indicate that leptin-induced increases in blood pressure and tachycardia are mediated by increased adrenergic activity and support the concept that leptin may be an important link between obesity, increased sympathetic activity, and hypertension. However, the chronic effects of leptin on insulin and glucose regulation do not appear to be altered by α- and β-adrenergic receptor blockade.
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“Combined blockade of both a-adrenergic and β-adrenergic receptors abolished the chronic effects of leptin on BP in male rats, suggesting that these effects were mediated by the SNS128.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [128]
In the citing paper
“administration of α/β-adrenergic blockers or clonidine, which stimulates central α-2 adrenergic receptors and reduces SNS activity, prevents most of the obesity-induced rise in BP in obese animals10,62 and α/β-adrenergic blockade reduces ambulatory BP significantly more in obese than in lean hypertensive patients63”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [62]
In the citing paper
“The BP effects of leptin were completely abolished by combined α/β-adrenergic receptor blockade”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [62]
In the citing paper
“Leptin requires activation of POMC neurons and MC4R to mediate its effects on renal SNS activity and BP [28, 50, 51].”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [51]
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Cites
Receptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
van Heek, M., Compton, D. S., France, C. F., Tedesco, R. P., Fawzi, A. B., Graziano, M. P., Sybertz, E. J., Strader, C. D., & Davis, H. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119171 · Cited by 765
Chronic Leptin Infusion Increases Arterial Pressure
Shek, E. W., Brands, M. W., & Hall, J. E. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.409 · Cited by 686
Self-citationPathophysiological role of leptin in obesity-related hypertension
Aizawa-Abe, M., Ogawa, Y., Masuzaki, H., Ebihara, K., Satoh, N., Iwai, H., Matsuoka, N., Hayashi, T., Hosoda, K., Inoue, G., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8341 · Cited by 477
Obesity hypertension: role of leptin and sympathetic nervous system
Hall, J. E. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02077-5 · Cited by 361
Self-citationSympathetic and Cardiorenal Actions of Leptin
Haynes, W. G., Sivitz, W. I., Morgan, D. A., Walsh, S. A., & Mark, A. L. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.619 · Cited by 351
Leptin Receptors Expressed on Pancreatic β-Cells
Kieffer, T. J., Heller, R. S., & Habener, J. F. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1059 · Cited by 326
Pivotal role of nitric oxide in the control of blood pressure after leptin administration.
Frühbeck, G. (1999) · Diabetes · doi:10.2337/diabetes.48.4.903 · Cited by 319
Landsberg, L. (2001) · Journal of Hypertension · doi:10.1097/00004872-200103001-00001 · Cited by 312
Renal Denervation Attenuates the Sodium Retention and Hypertension Associated With Obesity
Kassab, S., Kato, T., Wilkins, F. C., Chen, R., Hall, J. E., & Granger, J. P. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.893 · Cited by 307
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Research works printed but not linked: 7
- 10.1161/hyp.33.1.548 · DOI
- 10.1161/hyp.25.4.893 · DOI
- 10.1161/hyp.30.3.619 · DOI
- 10.1161/hyp.31.1.409 · DOI
- 10.1161/hyp.37.3.936 · DOI
- 10.1161/hyp.37.2.670 · DOI
- Correia M, Mark AL, Morgan DA, Rahmouni K, Haynes WG. A new concept of selective leptin resistance: evidence from Agouti Yellow obese mice. J Hypertens. 2001; 19 (suppl 2): s95 (abstract).
Cited by
Sorted by citations
Items 101–200 of 290
(2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2019.07.012 · Cited by 46
Leptin, Obesity, and Hypertension: A Review of Pathogenetic Mechanisms
Lu, S., & Akanji, A. O. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2020.0065 · Cited by 46
Leptin and the clinical cardiovascular risk
Singh, M., Bedi, U. S., Singh, P. P., Arora, R. R., & Khosla, S. (2009) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.07.019 · Cited by 44
Sušić, D., & Varagić, J. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.008 · Cited by 45
Martin, W. P., Docherty, N. G., & le Roux, C. W. (2018) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2018.1518130 · Cited by 45
Lifestyle Modification with Diet and Exercise in Obese Patients with Heart Failure – A Pilot Study
Pritchett, A. M., Deswal, A. M., & Aguilar, D. A. (2012) · Journal of Obesity & Weight loss Therapy · doi:10.4172/2165-7904.1000118 · Cited by 42
Galletti, F., D’Elia, L., Palma, D. D., Russo, O., Barba, G., Siani, A., Miller, M. A., Cappuccio, F. P., Rossi, G., Zampa, G., et al. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.05.007 · Cited by 42
Hyperleptinemia Exacerbates High‐Fat Diet‐Mediated Atrial Fibrosis and Fibrillation
Fukui, A., Ikebe, Y., Kondo, H., Saito, S., Aoki, K., Fukunaga, N., Shinohara, T., Masaki, T., Teshima, Y., & TAKAHASHI, N. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13200 · Cited by 43
The complex interaction between overweight, hypertension, and sympathetic overactivity
Feldstein, C. A., & Julius, S. (2009) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2009.10.001 · Cited by 42
Role of the brain melanocortins in blood pressure regulation
do Carmo, J. M., da Silva, A. A., Wang, Z., Fang, T., Aberdein, N., Perez de Lara, C. E., & Hall, J. E. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.003 · Cited by 38
Self-citationD’Elia, L., & Strazzullo, P. (2017) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-017-0240-1 · Cited by 37
Soluble Prorenin Receptor Increases Blood Pressure in High Fat–Fed Male Mice
Gatineau, E., Gong, M. C., & Yiannikouris, F. B. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12906 · Cited by 37
Control of metabolic and cardiovascular function by the leptin–brain melanocortin pathway
do Carmo, J. M., da Silva, A. A., Dubinion, J., Sessums, P. O., Ebaady, S. H., Wang, Z., & Hall, J. E. (2013) · IUBMB Life · doi:10.1002/iub.1187 · Cited by 36
Self-citationLeptin expression affects metabolic rate in zebrafish embryos (D. rerio)
Dalman, M. R., Liu, Q., King, M. D., Bagatto, B. P., & Londraville, R. L. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00160 · Cited by 35
Factors Responsible for Obesity-Related Hypertension
Lim, K., Jackson, K. L., Sata, Y., & Head, G. A. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0750-1 · Cited by 35
Control of respiratory and cardiovascular functions by leptin
Bassi, M., Furuya, W. I., Zoccal, D. B., Menani, J. V., Colombari, E., Hall, J. E., da Silva, A. A., do Carmo, J. M., & Colombari, D. S. A. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.019 · Cited by 34
Self-citationZhang, Z., & Felder, R. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00504.2003 · Cited by 33
da Silva, A. A., Kuo, J. J., Tallam, L. S., Liu, J., & Hall, J. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000198458.70351.e0 · Cited by 33
Self-citationLeptin decreases heart rate associated with increased ventricular repolarization via its receptor
Lin, Y., Huang, J., Hileman, S., Martin, K. H., Hull, R. W., Davis, M., & Yu, H. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00623.2015 · Cited by 31
Obesity and renovascular disease
Zhang, X., & Lerman, L. O. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00547.2014 · Cited by 34
Blood Pressure and Vascular Effects of Leptin in Humans
Brook, R. D., Bard, R. L., Bodary, P. F., Eitzman, D. T., Rajagopalan, S., Sun, Y., & Depaoli, A. M. (2007) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2006.0023 · Cited by 31
Pausová, Z., Šedová, L., Bérubé, J., Hamet, P., Tremblay, J., Dumont, M., Gaudet, D., Pravenec, M., Křen, V., & Kuneš, J. (2003) · Hypertension · doi:10.1161/01.hyp.0000064347.49341.0b · Cited by 30
Pontiroli, A. E., Pizzocri, P., Paroni, R. C., & Folli, F. B. (2006) · Diabetes Care · doi:10.2337/dc06-1417 · Cited by 31
Gijón‐Conde, T., Graciani, A., Guallar‐Castillón, P., Aguilera, M. T., Rodríguez‐Artalejo, F., & Banegas, J. R. (2015) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2014.08.015 · Cited by 31
Grøntved, A., Steene‐Johannessen, J., Kynde, I., Franks, P. W., Helge, J. W., Froberg, K., Anderssen, S. A., & Andersen, L. B. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328346d787 · Cited by 30
Chronic hyperleptinemia results in the development of hypertension in pregnant rats
Palei, A. C., Spradley, F. T., & Granger, J. P. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00286.2014 · Cited by 32
Moraes‐Vieira, P. M., Bassi, Ê. J., Araújo, R. C., & Câmara, N. O. S. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.00997.x · Cited by 30
The heart in obesity-hypertension
Morse, S. A., Bravo, P. E., Morse, M. C., & Reisin, E. (2005) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.3.4.647 · Cited by 31
Association of Leptin Gene -2548 G/A Polymorphism with Obesity: A Meta-Analysis
Zhang, L., Yuan, L., Xiao, Y., Lu, M.-Y., Zhang, L., & Yin, W. (2014) · Annals of Nutrition and Metabolism · doi:10.1159/000363392 · Cited by 29
Hall, M. E., & Hall, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00005-6 · Cited by 36
Self-citationCombined amylin–leptin treatment lowers blood pressure and adiposity in lean and obese rats
Seth, R., Knight, W. D., & Overton, J. M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.262 · Cited by 28
PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin
Harlan, S. M., & Rahmouni, K. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.03.004 · Cited by 30
Bigford, G. E., Bracchi-Ricard, V. C., Keane, R. W., Nash, M. S., & Bethea, J. R. (2013) · ASN NEURO · doi:10.1042/an20130021 · Cited by 29
Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet
Dubinion, J. H., da Silva, A. A., & Hall, J. E. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328344280b · Cited by 27
Self-citationChen, H.-Y., Lu, F., Chang, C., Wang, R.-S., Yang, Y., Chang, Y., & Wu, J. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.09.029 · Cited by 26
Leptin Is Not Essential for Obesity-Associated Hypertension
von Schnurbein, J., Manzoor, J., Brandt, S., Denzer, F., Kohlsdorf, K., Fischer‐Posovszky, P., Weißenberger, M., Frank, S., Mahmood, S., & Wabitsch, M. (2019) · Obesity Facts · doi:10.1159/000501319 · Cited by 26
Adipocyte dysfunction and hypertension.
Zhou, J., & Qin, G. (2012) · PubMed Central · Cited by 28
Chronic cardiovascular and renal actions of leptin during hyperinsulinemia
Kuo, J. J., Jones, O. B., & Hall, J. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00480.2002 · Cited by 26
Self-citationNguyen, A., Khafagy, R. T. M., Gao, Y., Meerasa, A., Roshandel, D., Anvari, M., Lin, B., Cherney, D. Z. I., Farkouh, M. E., Shah, B. R., et al. (2023) · Diabetes · doi:10.2337/db22-0696 · Cited by 26
Kang, D. R., Yadav, D., Koh, S. B., Kim, J., & Ahn, S. V. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.2.339 · Cited by 25
Sex Differences in Leptin Control of Cardiovascular Function in Health and Metabolic Diseases
de Chantemèle, E. J. B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_6 · Cited by 27
Cardiovascular and Sympathetic Effects of Disrupting Tyrosine 985 of the Leptin Receptor
Harlan, S. M., Morgan, D. A., Dellsperger, D. J., Myers, M. G., Mark, A. L., & Rahmouni, K. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.166538 · Cited by 24
Gastric leptin: a novel role in cardiovascular regulation
Sartor, D. M., & Verberne, A. J. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00997.2009 · Cited by 24
The role of food intake regulating peptides in cardiovascular regulation
Mikulášková, B., Maletı́nská, L., Zicha, J., & Kuneš, J. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.021 · Cited by 25
Nguyen, L. V., Ta, Q. V., Dang, T. B., Nguyen, P. H., Nguyen, T. N., Pham, T. V. H., Nguyen, T., Baker, S. G., Tran, T. L., Yang, D. J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224674 · Cited by 24
Urinary sodium excretion after gastric bypass surgery
Docherty, N. G., Fändriks, L., le Roux, C. W., Hallersund, P., & Werling, M. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.04.002 · Cited by 22
Polyakova, E. A., Mikhaylov, E. N., Galagudza, M. M., & Shlyakhto, E. V. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08491 · Cited by 23
Leptin protects the cardiac myocyte cultures from hypoxic damage
Erkasap, N., İkizler, M., Shneyvays, V., Zinman, T., Mamedova, L. K., Uyar, R., & Shainberg, A. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.06.039 · Cited by 23
Obesity, Hypertension, and the Heart
Good, D., Morse, S. A., Ventura, H. O., & Reisin, E. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00011.x · Cited by 22
Antioxidant treatment normalizes renal Na+,K+-ATPase activity in leptin-treated rats.
Bełtowski, J., Jamróz-Wiśniewska, A., Borkowska, E., Nazar, J., & Marciniak, A. (2005) · PubMed · Cited by 21
Renal effects of long-term leptin infusion and preventive role of losartan treatment in rats
Gündüz, Z., Dursun, N., Akgün, H., Öztürk, F., Okur, H., & Koç, N. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.09.017 · Cited by 20
The ‐2548G/A LEP polymorphism is associated with blood pressure in Tunisian obese patients
Ali, S. B., Kallel, A., Ftouhi, B., Sédiri, Y., Feki, M., Slimane, H., Jemaa, R., & Kaabachi, N. (2008) · Blood Pressure · doi:10.1080/08037050802488960 · Cited by 20
Does leptin cause an increase in blood pressure in animals and humans?
Simonds, S. E., Pryor, J. T., & Cowley, M. A. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000287 · Cited by 20
Renal denervation ameliorates the risk of ventricular fibrillation in overweight and heart failure
Yamada, S., Lo, L., Chou, Y., Lin, W.-L., Chang, S., Lin, Y., Liu, S.-H., Cheng, W., Tsai, T., & Chen, S. (2019) · EP Europace · doi:10.1093/europace/euz335 · Cited by 19
Leptin reduces plasma ANP level via nitric oxide-dependent mechanism
Yuan, K., Yu, J., Shah, A., Gao, S., Kim, S., Kim, S. Z., Park, B., & Kim, S. H. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00598.2009 · Cited by 19
do Carmo, J. M., da Silva, A. A., Gava, F. N., Moak, S. P., Dai, X., & Hall, J. E. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00077.2019 · Cited by 19
Self-citationRudyk, O., Makra, P., Jansen, E. H. J. M., Shattock, M. J., Poston, L., & Taylor, P. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025250 · Cited by 19
Insights into the emerging cardiometabolic prevention and management of diabetes mellitus
Lastra‐González, G., Manrique, C. M., Govindarajan, G., Whaley‐Connell, A. T., & Sowers, J. R. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.13.2209 · Cited by 19
Ryan, M. J., Coleman, T., Sasser, J. M., Pittman, K. M., Hankins, M. W., & Stec, D. E. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00336.2015 · Cited by 18
Tallam, L. S., Kuo, J. J., da Silva, A. A., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000148993.47498.b2 · Cited by 18
Self-citationSabi, E. M., Dahman, L. S. B., Mohammed, A. K., Sumaily, K. M., & Al‐Daghri, N. M. (2022) · Medicina · doi:10.3390/medicina58030346 · Cited by 18
Park, Y. C., Lee, S., Kim, Y., Park, J. M., Han, K., Lee, H., Hong, K., Kim, J.-K., Cho, E. S., Chung, T., et al. (2022) · BMC Nephrology · doi:10.1186/s12882-022-02795-7 · Cited by 17
Autonomic activity and leptin in Africans and whites
Pieterse, C., Schutte, R., & Schutte, A. E. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000110 · Cited by 16
Pathophysiology of Obesity—Induced Hypertension and Target Organ Damage
Hall, J. E., da Silva, A. A., Brandon, E. L., Stec, D. E., Ying, Z., & Jones, D. W. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-03961-1.50041-6 · Cited by 18
Self-citationRole of SOCS3 in POMC neurons in metabolic and cardiovascular regulation
Wang, Z., do Carmo, J. M., da Silva, A. A., Bailey, K. C., Aberdein, N., Moak, S. P., & Hall, J. E. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00163.2018 · Cited by 19
Self-citationMatuszak, O., Banach, W., Pogorzały, B., Muszyński, J., Mengesha, S. H., Bogdański, P., & Skrypnik, D. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102062 · Cited by 16
Esteghamati, A., Zandieh, A., Zandieh, B., Khalilzadeh, O., Meysamie, A., Nakhjavani, M., & Gouya, M. M. (2011) · Endocrine · doi:10.1007/s12020-011-9447-4 · Cited by 16
Different pathomechanisms of essential and obesity-associated hypertension in adolescents
Baráth, Á., Túri, S., Németh, I., Bereczki, C., Gellén, B., Haszon, I., & Monostori, P. B. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0215-2 · Cited by 16
da Silva, A. A., Hall, J. E., & do Carmo, J. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184805 · Cited by 16
Self-citationChronic central nervous system hyperinsulinemia and regulation of arterial pressure and food intake
Liu, J., da Silva, A. A., Tallam, L. S., & Hall, J. E. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000234120.71142.6c · Cited by 16
Self-citationBeall, C., Hanna, L., & Ellacott, K. L. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160045 · Cited by 16
Berenson, G. S., Patel, D. A., Wang, H., Srinivasan, S. R., & Chen, W. (2008) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2007.08.007 · Cited by 15
Factors influencing blood pressure control in children and adolescents
Koulouridis, E., Georgalidis, K., Kostimpa, I., Kalantzi, M., Ntouto, P., Koulouridis, I., Mandyla, M., Krokida, A., & Boulgari, N. (2008) · International Urology and Nephrology · doi:10.1007/s11255-008-9340-0 · Cited by 13
Obesity, Leptin, and Incident Heart Failure
Deswal, A. M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.030 · Cited by 14
Pedroso, J. A. B., da Silva, I. B., Zampieri, T. T., Totola, L. T., Moreira, T. S., Taniguti, A. P. T., Diniz, G. P., Barreto‐Chaves, M. L. M., & Donato, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126484 · Cited by 13
Impact of hyperleptinemia during placental ischemia-induced hypertension in pregnant rats
Palei, A. C., Martin, H. L., Wilson, B. A., Anderson, C. D., Granger, J. P., & Spradley, F. T. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00724.2019 · Cited by 13
Pathophysiology of Primary Hypertension
Carey, R. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374530-9.00020-6 · Cited by 13
Barzel, B., Lim, K., Davern, P. J., Burke, S. L., Armitage, J. A., & Head, G. A. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000811 · Cited by 13
Role of autonomic nervous system in chronic CNS-mediated antidiabetic action of leptin
da Silva, A. A., Hall, J. E., Moak, S. P., Browning, J. R., Houghton, H. J., Micheloni, G. C., & do Carmo, J. M. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00301.2016 · Cited by 13
Self-citationLeptin, Blood Pressure, and Aerobic Capacity in Women
Sabatier, M. J., McCully, K. K., Marinik, E. L., Schwark, E. H., Haddow, S., Cortez‐Cooper, M. Y., Bergeron, M. F., Sloan, G. J., & Cannon, J. G. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.254 · Cited by 13
Paleczny, B., Siennicka, A. E., Zacharski, M., Jankowska, E. A., Ponikowska, B., & Ponikowski, P. P. (2016) · Clinical Autonomic Research · doi:10.1007/s10286-015-0338-2 · Cited by 12
do Carmo, J. M., da Silva, A. A., Freeman, J. N., Wang, Z., Moak, S. P., Hankins, M. W., Drummond, H. A., & Hall, J. E. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11127 · Cited by 11
Self-citationRenal outcomes of bariatric surgery in obese adults with diabetic kidney disease
Rao, B. B., Bhattacharya, A., & Agrawal, V. (2014) · Journal of Nephrology · doi:10.1007/s40620-014-0078-8 · Cited by 11
Sun, L., Zhu, M., Wang, M., Hao, Y., Hao, Y., Jing, X., Yu, H., Shi, Y., Zhang, X., Wang, S., et al. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110693 · Cited by 11
Adejumo, E. N., Adejumo, O. A., Azenabor, A., Ekun, A. O., Enitan, S. S., Adebola, O. K., & Ogundahunsi, O. A. (2019) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2019.04.008 · Cited by 11
Sharma, S., Colangelo, L. A., Allison, M., Lima, J. A. C., Ambale‐Venkatesh, B., Kishi, S., Liu, K., & Greenland, P. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.068 · Cited by 11
Fouillioux, C., Contreras, F., Lares, M., Cano, R., Leal, E., Arráiz, N., Bermúdez, V., & Velasco, M. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318169bca8 · Cited by 11
Kim, E. J., Cho, S. W., Kang, J., Choi, T., & Park, Y. K. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720440 · Cited by 12
Leptin is an independent marker of metabolic syndrome in elderly adults with type 2 diabetes
Hsu, B., Tseng, P.-W., Wu, D., & Hou, J.-S. (2017) · Tzu Chi Medical Journal · doi:10.4103/tcmj.tcmj_31_17 · Cited by 11
Gijón‐Conde, T., Graciani, A., Guallar‐Castillón, P., Aguilera, M. T., Rodríguez‐Artalejo, F., & Banegas, J. R. (2015) · Revista Española de Cardiología · doi:10.1016/j.recesp.2014.08.015 · Cited by 10
Shebl, T., Azeem, N. E. D., Younis, H. A. E. K., Soliman, A., Ashmawy, A. M., & Ali, M. N. (2017) · Journal of Current Medical Research and Practice · doi:10.4103/jcmrp.jcmrp_33_16 · Cited by 10
Chronic CNS-mediated cardiometabolic actions of leptin: potential role of sex differences
da Silva, A. A., Pinkerton, M., Spradley, F. T., Palei, A. C., Hall, J. E., & do Carmo, J. M. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00027.2020 · Cited by 10
Self-citationPublisher, B. S. P. B. S. (2006) · Current Vascular Pharmacology · doi:10.2174/157016106778521599 · Cited by 9
Morais, R. L., Hilzendeger, A. M., Visniauskas, B., Todiraş, M., Alenina, N. V., Mori, M. A., Araújo, R. C., Nakaie, C. R., Chagas, J. R., Carmona, A. K., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00485.2016 · Cited by 10
Short-term physiological hyperleptinemia decreases arterial blood pressure
Knight, W. D., Seth, R., Boron, J., & Overton, J. M. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.02.001 · Cited by 10
Leptin, Fetal Nutrition, and Long-Term Outcomes for Adult Hypertension
Symonds, M. E., Budge, H., Stephenson, T. J., & Gardner, D. S. (2005) · Endothelium · doi:10.1080/10623320590933860 · Cited by 10
Cardiovascular Side Effects of Antiobesity Drugs
Mark, A. L. (2009) · Circulation · doi:10.1161/circulationaha.109.888529 · Cited by 10
DIFFERENTIAL CONTROL OF THE SYMPATHETIC NERVOUS SYSTEM BY LEPTIN: IMPLICATIONS FOR OBESITY
Rahmouni, K. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04760.x · Cited by 9
Role of the Melanocortin System in the Central Regulation of Cardiovascular Functions
Copperi, F., Kim, J. D., & Diano, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.725709 · Cited by 9
Renal Dysfunction in Hypertension and Obesity
Elmarakby, A. A., Pollock, D. M., & Imig, J. D. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00187-5 · Cited by 9
Metadata
- Authors
- Carlyle, M., Jones, O. B., Kuo, J. J., & Hall, J. E.
- Affiliations
- University of Mississippi Medical Center (US)
- Venue
- Hypertension
- Published
- 2002-02
- Volume
- 39
- Issue
- 2
- Pages
- 496-501
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2072436009
- Cited by
- 292
- References
- 22
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 13 · 2021: 11 · 2020: 8 · 2019: 13 · 2018: 4 · 2017: 21 · 2016: 21 · 2015: 13 · 2014: 18 · 2013: 10 · 2012: 16
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- National Heart, Lung, and Blood Institute (P01-HL-51971, P01HL051971)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, adrenergic activity, alpha-blockers, beta-blockers, terazosin, propranolol, blood pressure, heart rate, dietary intake, insulin, glucose regulation, glomerular filtration rate, obesity, sympathetic nervous system
- MeSH terms
- Adrenergic Agonists, Animals, Blood Pressure, Disease Models, Animal, Drug Interactions, Eating, Heart Rate, Hormones, Kidney, Kidney Function Tests, Male, Pressoreceptors, Receptors, Adrenergic, Tachycardia, Rats, Sprague-Dawley, Adrenergic Antagonists, Leptin, Rats
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