Renal Denervation Attenuates the Sodium Retention and Hypertension Associated With Obesity
Abstract
Abstract Recent studies have indicated that obesity is associated with hypertension, sodium retention, and increased sympathetic nervous system activity. The purpose of this study was to determine the role of renal nerves in mediating the sodium retention and hypertension associated with obesity. We determined the hemodynamic and renal excretory responses to a high-fat diet in control (n=6) and bilaterally renal-denervated (n=7) chronically instrumented dogs. After a control period of 8 days, dogs were placed on a high-fat diet for 5 weeks. In response to a high-fat diet, body weight increased from 19.9±2.2 to 29.9±2.4 kg in the control group and from 21.1±2.0 to 32.4±1.9 kg in the bilaterally renal-denervated group. Heart rate increased from 81±8 to 113±7 beats per minute in the control group and from 79±7 to 103±8 beats per minute in the bilaterally renal-denervated group. Arterial pressure increased significantly from 95±2 to 109±4 mm Hg in the control group. In contrast, 5 weeks of a high-fat diet in the bilaterally renal-denervated group did not significantly increase arterial pressure (which went from 87±3 to 90±4 mm Hg). Furthermore, the decrease in sodium excretion in response to the high-fat diet was significantly greater in the control group than in the bilaterally renal-denervated group. After 5 weeks of a high-fat diet, cumulative sodium retention was 455±85 mmol in the control group and only 252±47 mmol in the bilaterally renal-denervated group. Similar increases in glomerular filtration rate and renal plasma flow occurred in both groups in response to the high-fat diet. The results of this study indicate that the renal nerves play an important role in mediating the sodium retention and hypertension associated with obesity in dogs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Renal dysfunction may drive arterial pressure elevation in obesity.
“Longitudinal studies have shown that alterations in renal excretory function occur prior to the onset of obesity hypertension in animal models and humans (61;62) indicating that renal dysfunction may drive arterial pressure elevation in obesity.”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [62]
Alterations in renal excretory function occur prior to the onset of obesity hypertension in animal models and humans.
“Longitudinal studies have shown that alterations in renal excretory function occur prior to the onset of obesity hypertension in animal models and humans (61;62) indicating that renal dysfunction may drive arterial pressure elevation in obesity.”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [62]
Cites
The Kidney: Physiology and Pathophysiology
(1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-6-544_3 · Cited by 1,681 · see citing works
Obesity-induced hypertension. Renal function and systemic hemodynamics.
Hall, J. E., Brands, M. W., Dixon, W. N., & Smith, M. J. (1993) · Hypertension · doi:10.1161/01.hyp.22.3.292 · Cited by 328 · see citing works
Self-citationLouis K. Dahl Memorial Lecture. Renal and cardiovascular mechanisms of hypertension in obesity.
Hall, J. E. (1994) · Hypertension · doi:10.1161/01.hyp.23.3.381 · Cited by 204 · see citing works
Self-citationKidneys and fluids in pressure regulation. Small volume but large pressure changes.
Guyton, A. C. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i2 · Cited by 164 · see citing works
Role of the Sympathetic Nervous System in Blood Pressure Maintenance in Obesity
SOWERS, J. R., WHITFIELD, L. A., CATANIA, R. A., STERN, N., TUCK, M. L., DORNFELD, L., & MAXWELL, M. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-6-1181 · Cited by 162 · see citing works
Moyer, T. P., & Jiang, N. (1978) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)95496-7 · Cited by 144 · see citing works
Effect of dietary fat on sympathetic nervous system activity in the rat.
Schwartz, J. H., Young, J. B., & Landsberg, L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110976 · Cited by 133 · see citing works
A single-injection method for measuring glomerular filtration rate
Hall, J. E., Guyton, A. C., & Farr, B. M. (1977) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1977.232.1.f72 · Cited by 119 · see citing works
Self-citationPathogenesis of weight-related changes in blood pressure in dogs.
Rocchini, A. P., Moorehead, C., DeRemer, S. J., & Bondie, D. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.922 · Cited by 110 · see citing works
Obesity-induced hypertension in the dog.
Rocchini, A. P., Moorehead, C., Wentz, E., & DeRemer, S. J. (1987) · Hypertension · doi:10.1161/01.hyp.9.6_pt_2.iii64 · Cited by 90 · see citing works
Obesity-associated hypertension. Hyperinsulinemia and renal mechanisms.
Hall, J. E., Brands, M. W., Hildebrandt, D. A., & Mizelle, H. L. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i45 · Cited by 76 · see citing works
Self-citationYoung, J. K., & Landsberg, L. (1982) · Journal of Chronic Diseases · doi:10.1016/0021-9681(82)90118-7 · Cited by 75 · see citing works
Hyperinsulinemia: A link between obesity and hypertension?
Hall, J. E. (1993) · Kidney International · doi:10.1038/ki.1993.197 · Cited by 73 · see citing works
Self-citationEliasson, K., Ryttig, K. R., Hylander, B., & ssner, S. R. (1992) · Journal of Hypertension · doi:10.1097/00004872-199202000-00014 · Cited by 59 · see citing works
Abnormal pressure natriuresis in the dog model of obesity-induced hypertension.
Granger, J. P., West, D., & Scott, J. (1994) · Hypertension · doi:10.1161/01.hyp.23.1_suppl.i8 · Cited by 56 · see citing works
Self-citationLandsberg, L. (1992) · Journal of Hypertension · doi:10.1097/00004872-199212000-00022 · Cited by 39 · see citing works
The Influence of Obesity in Hypertension
Rocchini, A. P. (1990) · Physiology · doi:10.1152/physiologyonline.1990.5.6.245 · Cited by 30 · see citing works
Role of renal nerves in compensatory adaptation to chronic reductions in sodium intake
Mizelle, H. L., Hall, J. E., Woods, L. L., Montani, J. P., Dzielak, D. J., & Pan, Y. (1987) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1987.252.2.f291 · Cited by 26 · see citing works
Self-citationJanssen, B. J., & Smits, J. F. M. (1989) · PubMed · Cited by 25 · see citing works
Blunted natriuretic response to an acute sodium load in obese hypertensive dogs.
West, D. B., Wehberg, K. E., Kieswetter, K. M., & Granger, J. P. (1992) · Hypertension · doi:10.1161/01.hyp.19.1_suppl.i96 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880 · see citing works
Influence of Weight Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Neter, J. E., Stam, B. E., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2003) · Hypertension · doi:10.1161/01.hyp.0000094221.86888.ae · Cited by 1,391 · see citing works
The Kidney, Hypertension, and Obesity
Hall, J. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000052314.95497.78 · Cited by 868 · see citing works
Self-citationSympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 696 · see citing works
The pathophysiology of hypertension in patients with obesity
DeMarco, V. G., Aroor, A. R., & Sowers, J. R. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.44 · Cited by 545 · see citing works
Obesity, Sleep Apnea, and Hypertension
Wolk, R., Shamsuzzaman, A. S. M., & Somers, V. K. (2003) · Hypertension · doi:10.1161/01.hyp.0000101686.98973.a3 · Cited by 532 · see citing works
Obesity, hypertension, and chronic kidney disease
Hall, J., Juncos, L., Wang, Z., Hall, M., do Carmo, J., & da Silva, A. (2014) · International Journal of Nephrology and Renovascular Disease · doi:10.2147/ijnrd.s39739 · Cited by 520 · see citing works
Self-citationPathophysiology of obesity and its associated diseases
Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C. G., & Jiang, T. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.012 · Cited by 552 · see citing works
The sympathetic system and hypertension*1
ESLER, M. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)00225-9 · Cited by 479 · see citing works
Modulation of Blood Pressure by Central Melanocortinergic Pathways
Greenfield, J. R., Miller, J. W., Keogh, J. M., Henning, E., Satterwhite, J. H., Cameron, G. S., Astruc, B., Mayer, J. P., Brage, S., See, T. C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0803085 · Cited by 477 · see citing works
Mechanisms of Sympathetic Activation in Obesity-Related Hypertension
Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443 · see citing works
Mechanisms of Obesity-Associated Cardiovascular and Renal Disease
Hall, J. E., Crook, E. D., Jones, D. W., Wofford, M. R., & Dubbert, P. M. (2002) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200209000-00003 · Cited by 373 · see citing works
Self-citationObesity hypertension: role of leptin and sympathetic nervous system
Hall, J. E. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02077-5 · Cited by 361 · see citing works
Self-citationLeptin Mediates the Increase in Blood Pressure Associated with Obesity
Simonds, S. E., Pryor, J. T., Ravussin, É., Greenway, F. L., Dileone, R., Allen, A. M., Bassi, J. K., Elmquist, J. K., Keogh, J. M., Henning, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.058 · Cited by 347 · see citing works
Sympathetic and Cardiorenal Actions of Leptin
Haynes, W. G., Sivitz, W. I., Morgan, D. A., Walsh, S. A., & Mark, A. L. (1997) · Hypertension · doi:10.1161/01.hyp.30.3.619 · Cited by 348 · see citing works
Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension
Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319 · see citing works
Chronic Cardiovascular and Renal Actions of Leptin: Role of Adrenergic Activity
Carlyle, M., Jones, O. B., Kuo, J. J., & Hall, J. E. (2002) · Hypertension · doi:10.1161/hy0202.104398 · Cited by 292 · see citing works
Self-citationMechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 277 · see citing works
Obesity, kidney dysfunction, and inflammation: interactions in hypertension
Hall, J. E., Mouton, A. J., da Silva, A. A., Omoto, A. C. M., Wang, Z., Li, X., & do Carmo, J. M. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa336 · Cited by 279 · see citing works
Self-citationIs obesity a major cause of chronic kidney disease?
Hall, J. E., Henegar, J. R., Dwyer, T. M., Liu, J., da Silva, A. A., Kuo, J. J., & Tallam, L. (2004) · Advances in Renal Replacement Therapy · doi:10.1053/j.arrt.2003.10.007 · Cited by 264 · see citing works
Self-citationCastrop, H., Höcherl, K., Kurtz, A., Schweda, F., Todorov, V., & Wagner, C. (2010) · Physiological Reviews · doi:10.1152/physrev.00011.2009 · Cited by 260 · see citing works
The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease
Odermatt, A. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00068.2011 · Cited by 255 · see citing works
Mark, A. L., Shaffer, R. A., Correia, M. L. G., Morgan, D. A., Sigmund, C. D., & Haynes, W. G. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917121-00026 · Cited by 254 · see citing works
Hypertension in Postmenopausal Women
Lima, R., Wofford, M. R., & Reckelhoff, J. F. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0260-0 · Cited by 256 · see citing works
DiBona, G. F. (2003) · Hypertension · doi:10.1161/01.hyp.0000047205.52509.8a · Cited by 250 · see citing works
Insulin Resistance as the Underlying Cause for the Metabolic Syndrome
Lann, D. E., & LeRoith, D. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.06.012 · Cited by 250 · see citing works
Renal Denervation as a Therapeutic Approach for Hypertension
Schlaich, M. P., Sobotka, P. A., Krum, H., Whitbourn, R., Walton, A. S., & Esler, M. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.138610 · Cited by 248 · see citing works
The Role of the Autonomic Nervous System in the Pathophysiology of Obesity
Guarino, D., Nannipieri, M., Iervasi, G., Taddei, S., & Bruno, R. M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00665 · Cited by 244 · see citing works
Sympathetic Nervous System and Hypertension
DiBona, G. F. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00633 · Cited by 238 · see citing works
Hypertension: Physiology and Pathophysiology
Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110058 · Cited by 232 · see citing works
Self-citationLeptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
Rahmouni, K., Fath, M. A., Seo, S., Thedens, D. R., Berry, C. J., Weiss, R. M., Nishimura, D. Y., & Sheffield, V. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32357 · Cited by 227 · see citing works
Neural control of the kidney: functionally specific renal sympathetic nerve fibers
DiBona, G. F. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.5.r1517 · Cited by 227 · see citing works
The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension
Engeli, S., & Sharma, A. M. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090000144 · Cited by 225 · see citing works
Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
Kalil, G. Z., & Haynes, W. G. (2011) · Hypertension Research · doi:10.1038/hr.2011.173 · Cited by 228 · see citing works
Mechanisms of Hypertension and Kidney Disease in Obesity
HALL, J. E., BRANDS, M. W., & HENEGAR, J. R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07788.x · Cited by 222 · see citing works
Self-citationMechanisms linking obesity to hypertension
Dorresteijn, J. A. N., Visseren, F. L. J., & Spiering, W. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00914.x · Cited by 220 · see citing works
Mechanisms of Abnormal Renal Sodium Handling in Obesity Hypertension
Hall, J. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00075-7 · Cited by 213 · see citing works
Self-citationSympathetic Hyperactivity in Chronic Renal Failure
Koomans, H. A., Blankestijn, P. J., & Joles, J. A. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000113320.57127.b9 · Cited by 203 · see citing works
Hypertension in Obese Zucker Rats: Role of Angiotensin II and Adrenergic Activity
Alonso-Galicia, M., Brands, M. W., Zappe, D. H., & Hall, J. E. (1996) · Hypertension · doi:10.1161/01.hyp.28.6.1047 · Cited by 200 · see citing works
Self-citationObesity-associated hypertension and kidney disease
Hall, J. E., Kuo, J. J., da Silva, A. A., de Paula, R. B., Liu, J., & Tallam, L. (2003) · Current Opinion in Nephrology and Hypertension · doi:10.1097/00041552-200303000-00011 · Cited by 187 · see citing works
Self-citationObesity-Induced Hypertension: New Concepts From the Emerging Biology of Obesity
Mark, A. L., Correia, M., Morgan, D. A., Shaffer, R. A., & Haynes, W. G. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.537 · Cited by 185 · see citing works
Yanes, L. L., & Reckelhoff, J. F. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.71 · Cited by 187 · see citing works
Pathophysiology of obesity hypertension
Hall, J. E. (2000) · Current Hypertension Reports · doi:10.1007/s11906-000-0073-4 · Cited by 185 · see citing works
Self-citationSympatho-renal axis in chronic disease
Sobotka, P. A., Mahfoud, F., Schlaich, M. P., Hoppe, U. C., Böhm, M., & Krum, H. (2011) · Clinical Research in Cardiology · doi:10.1007/s00392-011-0335-y · Cited by 178 · see citing works
The Renal Pathology of Obesity
Tsuboi, N., Okabayashi, Y., Shimizu, A., & Yokoo, T. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.01.007 · Cited by 153 · see citing works
Function of Renal Nerves in Kidney Physiology and Pathophysiology
Osborn, J. W., Tyshynsky, R., & Vulchanova, L. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-091656 · Cited by 171 · see citing works
The Role of Aldosterone in Obesity-Related Hypertension
Kawarazaki, W., & Fujita, T. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw003 · Cited by 167 · see citing works
Heart Rate Variability Predicts ESRD and CKD-Related Hospitalization
Brotman, D. J., Bash, L. D., Qayyum, R., Crews, D. C., Whitsel, E. A., Astor, B. C., & Coresh, J. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009111112 · Cited by 163 · see citing works
Obesity-related hypertension: possible pathophysiological mechanisms
Vaněčková, I., Maletı́nská, L., Behuliak, M., Pražienková, V., Zicha, J., & Kuneš, J. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0368 · Cited by 162 · see citing works
The role of the sympathetic nervous system in obesity-related hypertension
da Silva, A. A., do Carmo, J. M., Dubinion, J. H., & Hall, J. E. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0036-3 · Cited by 156 · see citing works
Self-citationObesity-Related Hypertension in Children
Brady, T. M. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00197 · Cited by 161 · see citing works
Adipokines as a link between obesity and chronic kidney disease
Briffa, J. F., McAinch, A. J., Poronnik, P., & Hryciw, D. H. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00263.2013 · Cited by 153 · see citing works
The Sympathetic Nervous System and Hypertension
DiBona, G. F. (2004) · Hypertension · doi:10.1161/01.hyp.0000113047.47711.fa · Cited by 155 · see citing works
Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis
Rahmouni, K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.00920 · Cited by 150 · see citing works
Role of sympathetic nervous system and neuropeptides in obesity hypertension
Hall, J. E., BRANDS, M., Hildebrandt, D. A., Kuo, J. J., & Fitzgerald, S. M. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000000600001 · Cited by 149 · see citing works
Self-citationTallam, L. S., Stec, D. E., Willis, M. A., da Silva, A. A., & Hall, J. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000175474.99326.bf · Cited by 148 · see citing works
Self-citationNagae, A., Fujita, M., Kawarazaki, H., Matsui, H., Ando, K., & Fujita, T. (2009) · Circulation · doi:10.1161/circulationaha.108.824730 · Cited by 136 · see citing works
Is There a Rationale for Angiotensin Blockade in the Management of Obesity Hypertension?
Sharma, A. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000132568.71409.a2 · Cited by 136 · see citing works
Leptin and hypertension in obesity
Bravo, P. E., Morse, S., Borne, D. M., Aguilar, E. A., & Reisin, E. (2006) · Vascular Health and Risk Management · doi:10.2147/vhrm.2006.2.2.163 · Cited by 134 · see citing works
Programming of adult cardiovascular function after early maternal undernutrition in sheep
Gopalakrishnan, G. S., Gardner, D. S., Rhind, S. M., Rae, M. T., Kyle, C. E., Brooks, A. N., Walker, R. M., Ramsay, M., Keisler, D. H., Stephenson, T. J., et al. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00687.2003 · Cited by 134 · see citing works
Systemic and Renal-Specific Sympathoinhibition in Obesity Hypertension
Lohmeier, T. E., Iliescu, R., Liu, B., Henegar, J. R., Maric-Bilkan, C., & Irwin, E. D. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.185074 · Cited by 130 · see citing works
Obesity-hypertension: an ongoing pandemic
Francischetti, E. A., & Genelhu, V. A. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01262.x · Cited by 130 · see citing works
Interaction between leptin and sympathetic nervous system in hypertension
Haynes, W. G. (2000) · Current Hypertension Reports · doi:10.1007/s11906-000-0015-1 · Cited by 121 · see citing works
Altered renal sodium handling in men with abdominal adiposity: a link to hypertension
Strazzullo, P., Barba, G., Cappuccio, F. P., Siani, A., Trevisan, M., Farinaro, E., Pagano, E., Barbato, A., Iacone, R., & Galletti, F. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00007 · Cited by 123 · see citing works
Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance
DeLalio, L. J., Sved, A. F., & Stocker, S. D. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.03.003 · Cited by 126 · see citing works
Prolonged Activation of the Baroreflex Abolishes Obesity-Induced Hypertension
Lohmeier, T. E., Dwyer, T. M., Irwin, E. D., Rossing, M. A., & Kieval, R. S. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087874 · Cited by 118 · see citing works
Impact of the obesity epidemic on hypertension and renal disease
Hall, J. E., Jones, D. W., Kuo, J. J., da Silva, A. A., Tallam, L. S., & Liu, J. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0084-z · Cited by 106 · see citing works
Self-citationCARDIOVASCULAR CONSEQUENCES OF OBESITY: ROLE OF LEPTIN
Haynes, W. G., Morgan, D. A., Walsh, S. A., Sivitz, W. I., & Mark, A. L. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02147.x · Cited by 101 · see citing works
Packer, M. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13229 · Cited by 101 · see citing works
Altered Renal Handling of Sodium in Human Hypertension
Strazzullo, P., Galletti, F., & Barba, G. (2003) · Hypertension · doi:10.1161/01.hyp.0000066844.63035.3a · Cited by 98 · see citing works
Clonidine Prevents Insulin Resistance and Hypertension in Obese Dogs
Rocchini, A. P., Mao, H. Z., Babu, K., Marker, P. H., & Rocchini, A. J. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.548 · Cited by 98 · see citing works
Sustained Activation of the Central Baroreceptor Pathway in Angiotensin Hypertension
Lohmeier, T. E., Lohmeier, J. R., Warren, S., May, P. J., & Cunningham, J. T. (2002) · Hypertension · doi:10.1161/hy0202.103003 · Cited by 97 · see citing works
Hsueh, W. A., & Buchanan, T. A. (1994) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30105-1 · Cited by 91 · see citing works
Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs
Henegar, J. R., Zhang, Y., Rama, R. D., Hata, C., Hall, M. E., & Hall, J. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu048 · Cited by 89 · see citing works
Self-citationMechanisms mediating renal sympathetic activation to leptin in obesity
Morgan, D. A., Thedens, D. R., Weiss, R., & Rahmouni, K. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90324.2008 · Cited by 89 · see citing works
New developments in the pathogenesis of obesity-induced hypertension
Kotsis, V., Nilsson, P. M., Grassi, G. M., Mancia, G., Redón, J., Luft, F., Schmieder, R. E., Engeli, S., Stabouli, S., Antza, C., et al. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000645 · Cited by 89 · see citing works
Mechanisms and treatment of obesity-related hypertension—Part 1: Mechanisms
Parvanova, A. I., Reseghetti, E., Abbate, M., & Ruggenenti, P. L. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad282 · Cited by 98 · see citing works
Leptin and mechanisms of endothelial dysfunction and cardiovascular disease
Knudson, J. D., Payne, G. A., Borbouse, L., & Tune, J. D. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0082-2 · Cited by 88 · see citing works
Nondiabetic consequences of obesity on kidney
Srivastava, T. (2006) · Pediatric Nephrology · doi:10.1007/s00467-006-0027-4 · Cited by 88 · see citing works
Hypertension and the Metabolic Syndrome
Morse, S. A., Zhang, R., Thakur, V., & Reisin, E. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00008 · Cited by 88 · see citing works
Mechanisms of hypertension in the cardiometabolic syndrome
Redón, J., Cífková, R., Laurent, S., Nilsson, P. M., Narkiewicz, K., Erdine, S. E., & Mancia, G. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32831e13e5 · Cited by 84 · see citing works
Xiong, X.-Q., Chen, W.-W., Han, Y., Zhou, Y.-B., Zhang, F., Gao, X.-Y., & Zhu, G.-Q. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.198002 · Cited by 85 · see citing works
Catheter-Based Radiofrequency Renal Denervation: Location Effects on Renal Norepinephrine
Henegar, J. R., Zhang, Y., Hata, C., Narciso, I., Hall, M. E., & Hall, J. E. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpu258 · Cited by 83 · see citing works
Self-citationObesity as a premature aging phenotype — implications for sarcopenic obesity
Nunan, E. L., Wright, C. L., Semola, O. A., Subramanian, M., Balasubramanian, P., Lovern, P. C., Fancher, I. S., & Butcher, J. T. (2022) · GeroScience · doi:10.1007/s11357-022-00567-7 · Cited by 83 · see citing works
Osborn, J. W., Fink, G. D., & Kuroki, M. T. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0188-9 · Cited by 80 · see citing works
El-Atat, F. A., Aneja, A., McFarlane, S. I., & Sowers, J. R. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00070-7 · Cited by 82 · see citing works
The obese gene product, leptin
Hirose, H., Saito, I., Tsujioka, M., Mori, M., Kawabe, H., & Saruta, T. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816121-00023 · Cited by 80 · see citing works
Aghamohammadzadeh, R., & Heagerty, A. M. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.663928 · Cited by 78 · see citing works
Zhang, X., Miao, J., Hu, B. X., Liu, H., Zhang, H., & Ma, Z. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9641-x · Cited by 78 · see citing works
Neurons of the Rostral Ventrolateral Medulla Contribute to Obesity-Induced Hypertension in Rats
Stocker, S. D., Meador, R., & Adams, J. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000254828.71253.dc · Cited by 77 · see citing works
Renal sympathetic denervation: applications in hypertension and beyond
Böhm, M., Linz, D., Urban, D., Mahfoud, F., & Ukena, C. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.89 · Cited by 75 · see citing works
Salt-Sensitive Hypertension and the Kidney
Nishimoto, M., Griffin, K. A., Wynne, B. M., & Fujita, T. (2024) · Hypertension · doi:10.1161/hypertensionaha.123.21369 · Cited by 80 · see citing works
Verwaerde, P., Sénard, J., Galinier, M., Rougé, P., MASSABUAU, P., Galitzky, J., Berlan, M., Lafontan, M., & Montastruc, J. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917080-00013 · Cited by 76 · see citing works
Kidney and epigenetic mechanisms of salt-sensitive hypertension
Kawarazaki, W., & Fujita, T. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00399-2 · Cited by 73 · see citing works
Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome?
Moreira, M. C. D. S., Pinto, I. S. D. J., Mourão, A. A., Fajemiroye, J. O., Colombari, E., Reis, Â. A. D. S., Freiria-Oliveira, A. H., Neto, M. L. F., & Pedrino, G. R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00234 · Cited by 72 · see citing works
Device-Based Neuromodulation for Resistant Hypertension Therapy
Lohmeier, T. E., & Hall, J. E. (2019) · Circulation Research · doi:10.1161/circresaha.118.313221 · Cited by 71 · see citing works
Self-citationRole of Adrenergic Activity in Pressor Responses to Chronic Melanocortin Receptor Activation
Kuo, J. J., da Silva, A. A., Tallam, L. S., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000111836.54204.93 · Cited by 68 · see citing works
Self-citationRenal Denervation and Hypertension
Schlaich, M. P., Krum, H., Sobotka, P. A., & Esler, M. D. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.35 · Cited by 65 · see citing works
Barba, G., Galletti, F., Cappuccio, F. P., Siani, A., Venezia, A., Versiero, M., Valle, E. D., Sorrentino, P., Tarantino, G., Farinaro, E., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281139ebd · Cited by 64 · see citing works
- Authors
- Kassab, S., Kato, T., Wilkins, F. C., Chen, R., Hall, J. E., & Granger, J. P.
- Affiliations
- University of Mississippi Medical Center (US)
- Venue
- Hypertension
- Published
- 1995-04
- Volume
- 25
- Issue
- 4
- Pages
- 893-897
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2162085427
- Cited by
- 307
- References
- 20
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 14 · 2016: 11 · 2015: 17 · 2014: 21 · 2013: 22 · 2012: 15
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r23hl033947-01, 5r01hl023502-13)
- National Heart, Lung, and Blood Institute (HL-23502, HL33947, HL‐51971, P01HL051971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- renal denervation, obesity, sodium retention, renal nerves, sympathetic nervous system, high-fat diet, sodium excretion, glomerular filtration rate, renal plasma flow, heart rate, dogs
- MeSH terms
- Animals, Denervation, Dietary Fats, Dogs, Hemodynamics, Hypertension, Kidney, Natriuresis, Obesity, Renal Circulation, Renin, Sodium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
