Organokines in disease

Hye Soo Chung; Kyung Mook Choi

doi:10.1016/bs.acc.2019.07.012

Cited by 46Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Organokines in disease

Hye Soo Chung, Kyung Mook Choi·2020·Advances in clinical chemistry

DOI 10.1016/bs.acc.2019.07.012

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Abstract

Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease. As the socioeconomic burden for these diseases has grown signficantly with an increasing elderly population, new and alternative pharmacologic solutions for these cardiometabolic diseases are required. Adipose tissue, skeletal muscle and liver are central endocrine organs that regulate inflammation, energy and metabolic homeostasis, and the neuroendocrine axis through synthesis and secretion of adipokines, myokines, and hepatokines, respectively. These organokines affect each other and communicate through various endocrine, paracrine and autocrine pathways. The ultimate goal of this review is to provide a comprehensive understanding of organ crosstalk. This will include the roles of novel organokines in normal physiologic regulation and their pathophysiological effect in obesity, metabolic syndrome, type 2 diabetes, CVD, NAFLD and neurodegenerative disorders.

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IL-6 stimulates insulin release by increasing expression of GLP-1.
“It also stimulates insulin release by increasing the expression of the glucagon-1-like peptide (GLP-1) [11,59].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [59]
TNF-α and leptin seem to aggravate hypertension.
“These cytokines, especially TNF-α and leptin, seem to aggravate hypertension, which, together with visceral obesity, dyslipidemia, and hyperglycemia, configure the metabolic syndrome scenario [59,93].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [59]

1 retracted

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
Nieto-Vazquez, I., Fernández-Veledo, S., de Alvaro, C., & Lorenzo, M. (2008) · Diabetes · doi:10.2337/db07-1062 · Cited by 209 · see citing works
Retracted
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514 · see citing works
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176 · see citing works
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · see citing works
Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr
Janssen, I., Heymsfield, S. B., Wang, Z., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.81 · Cited by 3,087 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Adipose tissue, adipokines, and inflammation
Fantuzzi, G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.02.023 · Cited by 2,606 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327 · see citing works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works
Fibrosis stage is the strongest predictor for disease‐specific mortality in NAFLD after up to 33 years of follow‐up
Ekstedt, M., Hagström, H., Nasr, P., Fredrikson, M., Stål, P., Kechagias, S., & Hultcrantz, R. (2015) · Hepatology · doi:10.1002/hep.27368 · Cited by 2,287 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Novel Modulator for Endothelial Adhesion Molecules
Ouchi, N., Kihara, S., Arita, Y., Maeda, K., Kuriyama, H., Okamoto, Y., Hotta, K., Nishida, M., Takahashi, M., Nakamura, T., et al. (1999) · Circulation · doi:10.1161/01.cir.100.25.2473 · Cited by 2,139 · see citing works
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125 · see citing works
Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-s302 · Cited by 2,102 · see citing works
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway
Ouchi, N., Kihara, S., Arita, Y., Okamoto, Y., Maeda, K., Kuriyama, H., Hotta, K., Nishida, M., Takahashi, M., Muraguchi, M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.11.1296 · Cited by 1,730 · see citing works
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.
Xing, Z., Gauldie, J., Cox, G., Baumann, H., Jordana, M., Lei, X.-F., & Achong, M. K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1368 · Cited by 1,578 · see citing works
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,536 · see citing works
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495 · see citing works
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
The IDF consensus worldwide definition of the metabolic syndrome
- (2005) · Obesity and metabolism · doi:10.14341/2071-8713-4854 · Cited by 1,403 · see citing works
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L., & Cooper, G. J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17797 · Cited by 1,298 · see citing works
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
Xu, A., Wang, Y., Keshaw, H., Xu, L. Y., Lam, K. S. L., & Cooper, G. J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317797 · Cited by 1,298 · see citing works
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
Yokota, T., Oritani, K., Takahashi, I., Ishikawa, J., Matsuyama, A., Ouchi, N., Kihara, S., Funahashi, T., Tenner, A. J., Tomiyama, Y., et al. (2000) · Blood · doi:10.1182/blood.v96.5.1723 · Cited by 1,294 · see citing works
World health statistics
(2012) · Choice Reviews Online · doi:10.5860/choice.49-6620 · Cited by 1,283 · see citing works
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T., et al. (1997) · Nature Medicine · doi:10.1038/nm0997-1029 · Cited by 1,277 · see citing works
Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages
Ouchi, N., Kihara, S., Arita, Y., Nishida, M., Matsuyama, A., Okamoto, Y., Ishigami, M., Kuriyama, H., Kishida, K., Nishizawa, H., et al. (2001) · Circulation · doi:10.1161/01.cir.103.8.1057 · Cited by 1,275 · see citing works
Leptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · see citing works
Interleukin-6-deficient mice develop mature-onset obesity
Wallenius, V., Wallenius, K., Ahrén, B., Rudling, M., Carlsten, H., Dickson, S. L., Ohlsson, C., & Jansson, J.-O. (2002) · Nature Medicine · doi:10.1038/nm0102-75 · Cited by 1,213 · see citing works
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Caro, J. F., Kolaczynski, J. W., Nyce, M. R., Ohannesian, J. P., Opentanova, I., Goldman, W. H., Lynn, R. B., Zhang, P.-L., Sinha, M. K., & Considine, R. V. (1996) · The Lancet · doi:10.1016/s0140-6736(96)03173-x · Cited by 1,175 · see citing works
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
Elumalai, A., & Jain, S. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061321 · Cited by 1,172 · see citing works
Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
Pajvani, U. B., Hawkins, M., Combs, T. P., Rajala, M. W., Doebber, T., Berger, J. P., Wagner, J. A., Wu, M., Knopps, A., Xiang, A. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311113200 · Cited by 1,163 · see citing works
A leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158 · see citing works
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151 · see citing works
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
(2012) · The Lancet · doi:10.1016/s0140-6736(12)60110-x · Cited by 1,146 · see citing works
Adiponectin and protection against type 2 diabetes mellitus
Spranger, J., Kroke, A., Möhlig, M., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12255-6 · Cited by 1,120 · see citing works
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105 · see citing works
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works
Interleukin-6, a Major Cytokine in the Central Nervous System
Erta, M., Quintana, A., & Hidalgo, J. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4679 · Cited by 1,093 · see citing works
FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Adiponectin Levels and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis
Li, S., Shin, H. J., Ding, E. L., & van Dam, R. M. (2009) · JAMA · doi:10.1001/jama.2009.976 · Cited by 991 · see citing works
Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients
Targher, G., Bertolini, L., Padovani, R., Rodella, S., Tessari, R., Zenari, L., Day, C. P., & Arcaro, G. (2007) · Diabetes Care · doi:10.2337/dc06-2247 · Cited by 990 · see citing works
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works
Adiponectin and AdipoR1 Regulate PGC-1α and Mitochondria by Ca2+ and AMPK/SIRT1
Iwabu, M., Yamauchi, T., Okada-Iwabu, M., Sato, K., Nakagawa, T., Funata, M., Yamaguchi, M., Namiki, S., Nakayama, R., Tabata, M., et al. (2010) · Nature · doi:10.1038/nature08991 · Cited by 971 · see citing works
Beyond insulin resistance in NASH: TNF-α or adiponectin?
Hui, J. M., Hodge, A., Farrell, G. C., Kench, J. G., Kriketos, A., & George, J. (2004) · Hepatology · doi:10.1002/hep.20280 · Cited by 942 · see citing works
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922 · see citing works
The serum protein α2–Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
Schäfer, C., Heiss, A., Schwarz, A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17202 · Cited by 919 · see citing works
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908 · see citing works
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works
The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885 · see citing works
IL-6 pathway in the liver: From physiopathology to therapy
Schmidt-Arras, D., & Rose-John, S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.004 · Cited by 881 · see citing works
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
Hug, C., Wang, J., Ahmad, N. S., Bogan, J. S., Tsao, T., & Lodish, H. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403382101 · Cited by 861 · see citing works
Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients
Mogi, M., Harada, M., Kondo, T., Riederer, P., Inagaki, H., Minami, M., & Nagatsu, T. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90508-8 · Cited by 855 · see citing works
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
Morino, K., Petersen, K. F., & Shulman, G. I. (2006) · Diabetes · doi:10.2337/db06-s002 · Cited by 853 · see citing works
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
Nishimura, T., Nakatake, Y., Konishi, M., & Itoh, N. (2000) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00067-1 · Cited by 847 · see citing works
Intracellular signalling pathways activated by leptin
Frühbeck, G. (2005) · Biochemical Journal · doi:10.1042/bj20051578 · Cited by 833 · see citing works
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823 · see citing works
Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802 · see citing works
Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works
Interleukin 6 and its receptor: ten years later
Hirano, T. (1998) · International Reviews of Immunology · doi:10.3109/08830189809042997 · Cited by 788 · see citing works
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 785 · see citing works
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7001 · Cited by 766 · see citing works
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works
Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
Kurosu, H., Choi, M., Ogawa, Y., Dickson, A. S., Goetz, R., Eliseenkova, A. V., Mohammadi, M., Rosenblatt, K. P., Kliewer, S. A., & Kuro-o, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704165200 · Cited by 748 · see citing works
Intracellular signalling pathways activated by leptin
Frühbeck, G. (. (2006) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 745 · see citing works
Adipokines: The missing link between insulin resistance and obesity
Antuna-Puente, B., Fève, B., Fellahi, S., & Bastard, J. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.09.004 · Cited by 738 · see citing works
Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · see citing works
Effects of parabiosis of obese with diabetes and normal mice.
Coleman, D. L. (1973) · Diabetologia · doi:10.1007/bf01221857 · Cited by 729 · see citing works
Treatment of Obesity with Celastrol
Liu, J., Lee, J., Salazar Hernandez, M. A., Mazitschek, R., & Ozcan, U. (2015) · Cell · doi:10.1016/j.cell.2015.05.011 · Cited by 726 · see citing works
Acute stimulation of glucose metabolism in mice by leptin treatment
Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., & Charron, M. J. (1997) · Nature · doi:10.1038/38717 · Cited by 708 · see citing works
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
Potthoff, M. J., Inagaki, T., Satapati, S., Ding, X., He, T., Goetz, R., Mohammadi, M., Finck, B. N., Mangelsdorf, D. J., Kliewer, S. A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904187106 · Cited by 704 · see citing works
Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
Fon Tacer, K., Bookout, A. L., Ding, X., Kurosu, H., John, G. B., Wang, L., Goetz, R., Mohammadi, M., Kuro-o, M., Mangelsdorf, D. J., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0142 · Cited by 700 · see citing works
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
Lin, Z., Tian, H., Lam, K. S. L., Lin, S., Hoo, R. C. L., Konishi, M., Itoh, N., Wang, Y., Bornstein, S. R., Xu, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.005 · Cited by 691 · see citing works
A Randomized Controlled Trial of Metformin versus Vitamin E or Prescriptive Diet in Nonalcoholic Fatty Liver Disease
Bugianesi, E., Gentilcore, E., Manini, R., Natale, S., Vanni, E., Villanova, N., David, E., Rizzetto, M., & Marchesini, G. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.41583.x · Cited by 683 · see citing works
Physical activity and risk of cardiovascular disease—a meta-analysis of prospective cohort studies
Li, J., & Siegrist, J. (2012) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph9020391 · Cited by 674 · see citing works
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673 · see citing works
Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673 · see citing works
Muscles and their myokines
Pedersen, B. K. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048074 · Cited by 668 · see citing works
Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin
Kobayashi, H., Ouchi, N., Kihara, S., Walsh, K., Kumada, M., Abe, Y., Funahashi, T., & Matsuzawa, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000119921.86460.37 · Cited by 658 · see citing works
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
Wong, V. W.-S., Wong, G. L., Choi, P. C. L., Chan, A. W. H., Li, M. K.-P., Chan, H.-Y., Chim, A. M.-L., Yu, J. Q., Sung, J. J. �., & Chan, H. L. (2010) · Gut · doi:10.1136/gut.2009.205088 · Cited by 648 · see citing works
Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion
Vozarova, B., Weyer, C., Hanson, K. A., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2001) · Obesity Research · doi:10.1038/oby.2001.54 · Cited by 638 · see citing works
The Epidemic of Obesity
Stein, C. J., & Colditz, G. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0288 · Cited by 635 · see citing works
Update on Adipocyte Hormones
Havel, P. J. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s143 · Cited by 625 · see citing works
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
Hondares, E., Iglesias, R., Giralt, A., Gonzalez, F. J., Giralt, M., Mampel, T., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.215889 · Cited by 623 · see citing works
Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease
Dushay, J., Chui, P. C., Gopalakrishnan, G. S., Varela–Rey, M., Crawley, M., Fisher, F. M., Badman, M. K., Martinez–Chantar, M. L., & Maratos–Flier, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.04.054 · Cited by 607 · see citing works
Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis
Wieckowska, A., Papouchado, B. G., Li, Z., Lopez, R., Zein, N. N., & Feldstein, A. E. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01774.x · Cited by 597 · see citing works
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works
Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes
Kim, T. N., Park, M. S., Yang, S. J., Yoo, H. J., Kang, H. J., Song, W., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2010) · Diabetes Care · doi:10.2337/dc09-2310 · Cited by 585 · see citing works
Self-citation
Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P., & Spiegelman, B. M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.001 · Cited by 568 · see citing works
Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization
Combs, T. P., Wagner, J. A., Berger, J. P., Doebber, T. W., Wang, W., Zhang, B. B., Tanen, M. R. L., Berg, A. H., O’Rahilly, S., Savage, D. B., et al. (2002) · Endocrinology · doi:10.1210/endo.143.3.8662 · Cited by 565 · see citing works
The effects of acute and chronic exercise on <scp>PGC</scp> ‐1α, irisin and browning of subcutaneous adipose tissue in humans
Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works
Leptin Signaling in the Central Nervous System and the Periphery
Bjørbæk, C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.305 · Cited by 550 · see citing works
Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
Mogi, M., Harada, M., Narabayashi, H., Inagaki, H., Minami, M., & Nagatsu, T. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12706-3 · Cited by 545 · see citing works
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works
Circulating irisin in relation to insulin resistance and the metabolic syndrome.
Park, K., Zaichenko, L., Brinkoetter, M. T., Thakkar, B., Sahin-Efe, A., Joung, K., Tsoukas, M. A., Geladari, E., Huh, J., Dinçer, F., et al. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-2373 · Cited by 527 · see citing works
Interleukin-6 and Diabetes
Kristiansen, O. P., & Mandrup-Poulsen, T. R. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s114 · Cited by 525 · see citing works
A clinical perspective of obesity, metabolic syndrome and cardiovascular disease
Han, T. S., & Lean, M. E. (2016) · JRSM Cardiovascular Disease · doi:10.1177/2048004016633371 · Cited by 500 · see citing works
A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects
Talukdar, S., Zhou, Y., Li, D., Rossulek, M., Dong, J., Somayaji, V., Weng, Y., Clark, R., Lanba, A., Owen, B. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.001 · Cited by 496 · see citing works
Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population
YAMAMOTO, Y., Hirose, H., Saito, I., Tomita, M., Taniyama, M., Matsubara, K., Okazaki, Y., Ishii, T., Nishikai, K., & Saruta, T. (2002) · Clinical Science · doi:10.1042/cs1030137 · Cited by 490 · see citing works
α2-Heremans-Schmid Glycoprotein/ Fetuin-A Is Associated With Insulin Resistance and Fat Accumulation in the Liver in Humans
Stefan, N., Hennige, A. M., Staiger, H., Machann, J., Schick, F., Kröber, S. M., Machicao, F. E., Fritsche, A., & Häring, H. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-1938 · Cited by 475 · see citing works
Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and Atherosclerotic Progression: Mechanisms and Perspectives
Yanai, H., & Yoshida, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051190 · Cited by 471 · see citing works
Adiponectin Cardioprotection After Myocardial Ischemia/Reperfusion Involves the Reduction of Oxidative/Nitrative Stress
Tao, L., Gao, E., Jiao, X., Yuan, Y., Li, S., Christopher, T. A., Lopez, B. L., Koch, W. J., Chan, L., Goldstein, B. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.666941 · Cited by 453 · see citing works
Lower circulating irisin is associated with type 2 diabetes mellitus
Liu, J., Wong, M. D. S., Toy, W. C., Tan, C., Liu, S., Ng, X. W., Subramaniam, T., Sum, C. F., & Lim, S. C. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.03.002 · Cited by 446 · see citing works
Interleukin‐6 production in contracting human skeletal muscle is influenced by pre‐exercise muscle glycogen content
Steensberg, A., Febbraio, M. A., Osada, T., Schjerling, P., van Hall, G., Saltin, B., & Pedersen, B. K. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00633.x · Cited by 444 · see citing works
Adipokines and cytokines in non‐alcoholic fatty liver disease
Jarrar, M. H., Baranova, A. V., Collantes, R. S., Ranard, B. L., Stepanova, M., Bennett, C., Fang, Y. H., Elariny, H. A., Goodman, Z. D., Chandhoke, V., et al. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03586.x · Cited by 430 · see citing works
Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging
Lieb, W. (2009) · JAMA · doi:10.1001/jama.2009.1836 · Cited by 428 · see citing works
Serum irisin levels in new-onset type 2 diabetes
Choi, Y., Kim, M. K., Bae, K.-H., Seo, H.-A., Jeong, J.-Y., Lee, W.-K., Kim, J., Lee, I., & Park, K. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.01.007 · Cited by 422 · see citing works
Cerebral Interleukin-6 is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat
Loddick, S. A., Turnbull, A. V., & Rothwell, N. J. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199802000-00008 · Cited by 418 · see citing works
Leptin Expression in Human Mammary Epithelial Cells and Breast Milk
Kirwin, S. M., O’Connor, D. M., Johnston, J. J., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4952 · Cited by 415 · see citing works
Plasma Adiponectin in Nonalcoholic Fatty Liver Is Related to Hepatic Insulin Resistance and Hepatic Fat Content, Not to Liver Disease Severity
Bugianesi, E., Pagotto, U., Manini, R., Vanni, E., Gastaldelli, A., IASIO, R. D., Gentilcore, E., Natale, S., Cassader, M., Rizzetto, M., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2240 · Cited by 409 · see citing works
Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?
Licastro, F., Pedrini, S., Caputo, L., Annoni, G., Davis, L. J., Ferri, C., Casadei, V. M., & Grimaldi, L. M. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00226-x · Cited by 400 · see citing works
Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
Li, H., Fang, Q., Gao, F., Fan, J., Zhou, J., Wang, X., Zhang, H., Pan, X., Bao, Y., Xiang, K., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.018 · Cited by 400 · see citing works
Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
Chavez, A. O., Molina-Carrion, M., Abdul-Ghani, M. A., Folli, F., DeFronzo, R. A., & Tripathy, D. (2009) · Diabetes Care · doi:10.2337/dc09-0684 · Cited by 390 · see citing works
Running is the neurogenic and neurotrophic stimulus in environmental enrichment
Kobilo, T., Liu, Q.-R., Gandhi, K., Mughal, M., Shaham, Y., & van Praag, H. (2011) · Learning & Memory · doi:10.1101/lm.2283011 · Cited by 385 · see citing works
Relationship Between Sarcopenia and Nonalcoholic Fatty Liver Disease: The Korean Sarcopenic Obesity Study
Hong, H. C., Hwang, S. Y., Choi, H. Y., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2014) · Hepatology · doi:10.1002/hep.26716 · Cited by 385 · see citing works
Self-citation
Leptin Gene Expression in the Brain and Pituitary Gland
Morash, B. A., Li, A., Murphy, P. R., Wilkinson, M., & Ur, E. (1999) · Endocrinology · doi:10.1210/endo.140.12.7288 · Cited by 384 · see citing works
Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis
Huby, A.-C., Antonova, G., Groenendyk, J., Gomez-Sanchez, C. E., Bollag, W. B., Filosa, J. A., & de Chantemèle, E. J. B. (2015) · Circulation · doi:10.1161/circulationaha.115.018226 · Cited by 376 · see citing works
Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
Planavila, A., Redondo‐Angulo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L., Sitges, M., Giralt, M., van Bilsen, M., et al. (2013) · Nature Communications · doi:10.1038/ncomms3019 · Cited by 371 · see citing works
Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation
Huh, J. Y., Mougios, V., Kabasakalis, A., Fatouros, I., Siopi, A., Douroudos, I. I., Filippaios, A., Panagiotou, G., Park, K. H., & Mantzoros, C. S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1437 · Cited by 363 · see citing works
Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis
Badman, M. K., Koester, A., Flier, J. S., Kharitonenkov, A., & Maratos-Flier, E. (2009) · Endocrinology · doi:10.1210/en.2009-0532 · Cited by 362 · see citing works
Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis
Anstey, K. J., Ashby-Mitchell, K., & Peters, R. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160826 · Cited by 360 · see citing works
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Liu, T.-Y., Shi, C.-X., Gao, R., Sun, H.-J., Xiong, X.-Q., Ding, L., Chen, Q., Li, Y.-H., Wang, J.-J., Kang, Y.-M., et al. (2015) · Clinical science · doi:10.1042/cs20150009 · Cited by 352 · see citing works
Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population
Stepanova, M., & Younossi, Z. M. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2011.12.039 · Cited by 352 · see citing works
AMP-Activated Protein Kinase Protects Cardiomyocytes against Hypoxic Injury through Attenuation of Endoplasmic Reticulum Stress
Terai, K., Hiramoto, Y., Masaki, M., Sugiyama, S., Kuroda, T., Hori, M., Kawase, I., & Hirota, H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9554-9575.2005 · Cited by 351 · see citing works
Irisin – a myth rather than an exercise-inducible myokine
Albrecht, E., Norheim, F., Thiede, B., Holen, T., Ohashi, T., Schering, L., Lee-Ødegård, S., Brenmoehl, J., Thomas, S., Drevon, C. A., et al. (2015) · Scientific Reports · doi:10.1038/srep08889 · Cited by 346 · see citing works
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
Mathews, S. T., Singh, G. P., Ranalletta, M., Cintrón, V. J., Qiang, X., Goustin, A. S., Jen, K. C., Charron, M. J., Jahnen‐Dechent, W., & Grunberger, G. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2450 · Cited by 343 · see citing works
Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling
Imajo, K., Fujita, K., Yoneda, M., Nozaki, Y., Ogawa, Y., Shinohara, Y., Kato, S., Mawatari, H., Shibata, W., Kitani, H., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.012 · Cited by 341 · see citing works
Nonalcoholic Fatty Liver Disease: The Pathogenetic Roles of Insulin Resistance and Adipocytokines
Pοlyzos, S. A., Kountouras, J., & Zavos, C. (2009) · Current Molecular Medicine · doi:10.2174/156652409787847191 · Cited by 336 · see citing works
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1865-y · Cited by 334 · see citing works
Endocrine Functions of Adipose Tissue
Waki, H., & Tontonoz, P. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.2.010506.091859 · Cited by 334 · see citing works
Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, and Outcomes
Ahmed, A., Wong, R. J., & Harrison, S. A. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.029 · Cited by 330 · see citing works
Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development
Ahima, R. S., Bjørbæk, C., Osei, S. Y., & Flier, J. S. (1999) · Endocrinology · doi:10.1210/endo.140.6.6774 · Cited by 327 · see citing works
Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis
Wu, S., Wu, F., Ding, Y., Hou, J., Bi, J., & Zhang, Z. (2016) · Scientific Reports · doi:10.1038/srep33386 · Cited by 318 · see citing works
Association Between Human Fetuin-A and the Metabolic Syndrome
Ix, J. H., Shlipak, M. G., Brandenburg, V. M., Ali, S., Ketteler, M., & Whooley, M. A. (2006) · Circulation · doi:10.1161/circulationaha.105.588723 · Cited by 316 · see citing works
Effects of leptin on memory processing
Farr, S. A., Banks, W. A., & Morley, J. E. (2005) · Peptides · doi:10.1016/j.peptides.2005.10.006 · Cited by 314 · see citing works
Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke
Weikert, C., Stefan, N., Schulze, M. B., Pischon, T., Berger, K., Joost, H., Häring, H., Boeing, H., & Fritsche, A. (2008) · Circulation · doi:10.1161/circulationaha.108.814418 · Cited by 310 · see citing works
Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis
Pοlyzos, S. A., Toulis, K. A., Goulis, D. G., Zavos, C., & Kountouras, J. (2010) · Metabolism · doi:10.1016/j.metabol.2010.09.003 · Cited by 310 · see citing works
Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans
Huh, J. Y., Dincer, F., Mesfum, E., & Mantzoros, C. S. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.42 · Cited by 309 · see citing works
The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia
Li, D., Li, Y., Yuan, H., Qu, L., & Wang, P. (2016) · Metabolism · doi:10.1016/j.metabol.2016.12.003 · Cited by 308 · see citing works
Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease
Puchades, M. A., Hansson, S., Nilsson, C. L., Andreasen, N., Blennow, K., & Davidsson, P. (2003) · Molecular Brain Research · doi:10.1016/j.molbrainres.2003.08.005 · Cited by 306 · see citing works
Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical perspectives
Woo, Y. C., Xu, A., Wang, Y., & Lam, K. S. L. (2012) · Clinical Endocrinology · doi:10.1111/cen.12095 · Cited by 302 · see citing works
Mitochondrial myopathy induces a starvation-like response
Tyynismaa, H., Carroll, C. J., Raimundo, N., Ahola-Erkkilä, S., Wenz, T., Ruhanen, H., Guse, K., Hemminki, A., Peltola-Mjøsund, K. E., Tulkki, V., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq310 · Cited by 300 · see citing works
Adipose Fibroblast Growth Factor 21 Is Up-Regulated by Peroxisome Proliferator-Activated Receptor γ and Altered Metabolic States
Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., & Wong, K. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.044826 · Cited by 294 · see citing works
Chronic Cardiovascular and Renal Actions of Leptin: Role of Adrenergic Activity
Carlyle, M., Jones, O. B., Kuo, J. J., & Hall, J. E. (2002) · Hypertension · doi:10.1161/hy0202.104398 · Cited by 292 · see citing works
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.
Kelly, M., Keller, C., Avilucea, P. R., Keller, P., Luo, Z., Xiang, X., Giralt, M., Hidalgo, J., Saha, A. K., Pedersen, B. K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.188 · Cited by 289 · see citing works
Fetuin-A Induces Cytokine Expression and Suppresses Adiponectin Production
Hennige, A. M., Staiger, H., Wicke, C., Machicao, F., Fritsche, A., Häring, H.-U., & Stefan, N. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001765 · Cited by 282 · see citing works
Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
Li, Y., Wong, K., Giles, A. J., Jiang, J., Lee, J. W., Adams, A. C., Kharitonenkov, A., Yang, Q., Gao, B., Guarente, L., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.059 · Cited by 281 · see citing works
The fasting polypeptide FGF21 can enter brain from blood
Hsuchou, H., Pan, W., & Kastin, A. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.10.007 · Cited by 280 · see citing works
Predictors for incidence and remission of NAFLD in the general population during a seven-year prospective follow-up
Zelber‐Sagi, S., Lotan, R., Shlomai, A., Webb, M., Harrari, G., Buch, A., Nitzan, D., Halpern, Z., & Oren, R. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.011 · Cited by 274 · see citing works
Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
Lin, Z., Pan, X., Wu, F., Ye, D., Zhang, Y., Wang, Y., Jin, L., Lian, Q., Huang, Y., Ding, H., et al. (2015) · Circulation · doi:10.1161/circulationaha.115.015308 · Cited by 271 · see citing works
Three new players in energy regulation: preptin, adropin and irisin.
Aydin, S. (2014) · Peptides · doi:10.1016/j.peptides.2014.03.021 · Cited by 269 · see citing works
Effects of canagliflozin versus glimepiride on adipokines and inflammatory biomarkers in type 2 diabetes
Garvey, W. T., Gaal, L. V., Leiter, L. A., Vijapurkar, U., List, J. F., Cuddihy, R. M., Ren, J., & Davies, M. J. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.002 · Cited by 261 · see citing works
Preventing Alzheimer's disease and cognitive decline.
(2010) · PubMed Central · Cited by 259 · see citing works
Cardioprotection by Adiponectin
Ouchi, N., Shibata, R., & Walsh, K. X. (2006) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2006.03.001 · Cited by 257 · see citing works
Adiponectin Inhibits Endothelial Synthesis of Interleukin-8
Kobashi, C., Urakaze, M., Kishida, M., Kibayashi, E., Kobayashi, H., Kihara, S., Funahashi, T., Takata, M., Temaru, R., Sato, A., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000194328.57164.36 · Cited by 252 · see citing works
Mitochondrial uncoupling protein‐2 protects the immature brain from excitotoxic neuronal death
Sullivan, P. G., Dubé, C. M., Dorenbos, K., Steward, O., & Baram, T. Z. (2003) · Annals of Neurology · doi:10.1002/ana.10543 · Cited by 251 · see citing works
Irisin and exercise training in humans – Results from a randomized controlled training trial
Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., Kaestner, L., & Meyer, T. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-235 · Cited by 250 · see citing works
Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway
Xin, C., Liu, J., Zhang, J., Zhu, D., Wang, H., Xiong, L., Lee, Y., Ye, J., Lian, K., Xu, C., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.199 · Cited by 248 · see citing works
Circulating leptin in non-alcoholic fatty liver disease: A systematic review and meta-analysis
Polyzos, S. A., Aronis, K. N., Kountouras, J., Raptis, D. D., Vasiloglou, M. F., & Mantzoros, C. S. (2016) · Diabetologia · doi:10.1007/s00125-015-3769-3 · Cited by 248 · see citing works
Non-invasive diagnosis of non-alcoholic steatohepatitis by combined serum biomarkers
Shen, J., Chan, H. L., Wong, G. L., Choi, P. C., Chan, A. W. H., Chan, H., Chim, A. M., Yeung, D. K., Chan, F. K. L., Woo, J., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.025 · Cited by 247 · see citing works
Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease
Gu, Y., Luchsinger, J. A., Stern, Y., & Scarmeas, N. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100897 · Cited by 244 · see citing works
Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
Srinivas, P. R., Wagner, A. S., Reddy, L. V. K., Deutsch, D. D., Leon, M. A., Goustin, A. S., & Grunberger, G. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.11.7906861 · Cited by 243 · see citing works
Leptin and Leptin Receptor Expression in Rat and Mouse Pituitary Cells1
Jin, L., Zhang, S., Burguera, B. G., Couce, M., OSAMURA, R. Y., Kulig, E., & Lloyd, R. V. (2000) · Endocrinology · doi:10.1210/endo.141.1.7260 · Cited by 242 · see citing works
Adiposity indices and dementia
Gustafson, D. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70526-9 · Cited by 237 · see citing works
Leptin in nonalcoholic fatty liver disease: A narrative review
Polyzos, S. A., Kountouras, J., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2014.10.012 · Cited by 235 · see citing works
AMP-Activated Protein Kinase Activates p38 Mitogen-Activated Protein Kinase by Increasing Recruitment of p38 MAPK to TAB1 in the Ischemic Heart
Li, J., Miller, E. J., Ninomiya‐Tsuji, J., Russell, R. R., & Young, L. H. (2005) · Circulation Research · doi:10.1161/01.res.0000187458.77026.10 · Cited by 234 · see citing works
A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues
Aydin, S., Kuloglu, T., Aydin, S., Kalayci, M., Yilmaz, M., Cakmak, T., Albayrak, S., Gungor, S., Colakoglu, N., & Ozercan, İ. H. (2014) · Peptides · doi:10.1016/j.peptides.2014.09.014 · Cited by 233 · see citing works
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling
Timper, K., Denson, J. L., Steculorum, S. M., Heilinger, C., Engström, L., Wunderlich, C. M., Rose‐John, S., Wunderlich, F. T., & Brüning, J. C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.043 · Cited by 233 · see citing works
Exercise Increases Adiponectin Levels and Insulin Sensitivity in Humans
Kriketos, A. D., Gan, S. K., Poynten, A. M., Furler, S. M., Chisholm, D. J., & Campbell, L. V. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.629 · Cited by 227 · see citing works
Serum leptin level and cognition in the elderly: Findings from the Health ABC Study
Holden, K. F., Lindquist, K. J., Tylavsky, F. A., Rosano, C., Harris, T. B., & Yaffe, K. S. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.024 · Cited by 227 · see citing works
The implications of sarcopenia and sarcopenic obesity on cardiometabolic disease
Kim, T. N., & Choi, K. M. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25077 · Cited by 225 · see citing works
Self-citation
High Plasma Immunoreactive Leptin Level in Essential Hypertension
Agata, J. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00310-5 · Cited by 222 · see citing works
Immunohistochemical Localization of Leptin and Uncoupling Protein in White and Brown Adipose Tissue1
Cinti, S., Frederich, R. C., Zingaretti, M. C., Matteis, R. D., Flier, J. S., & Lowell, B. B. (1997) · Endocrinology · doi:10.1210/endo.138.2.4908 · Cited by 221 · see citing works
Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK
Lee, H. J., Lee, J. O., Kim, N., Kim, J. K., Kim, H. I., Lee, Y. W., Kim, S. J., Choi, J., Oh, Y., Kim, J. H., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1353 · Cited by 219 · see citing works
Making insulin-deficient type 1 diabetic rodents thrive without insulin
Yu, X., Park, B.-H., Wang, M.-Y., Wang, Z. V., & Unger, R. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806993105 · Cited by 219 · see citing works
Obesity and dementia: Adipokines interact with the brain
Arnoldussen, I. A. C., Kiliaan, A. J., & Gustafson, D. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.002 · Cited by 219 · see citing works
Leptin signaling in brain: A link between nutrition and cognition?
Morrison, C. D. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.004 · Cited by 218 · see citing works
Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
Pardo, M., Crujeiras, A. B., Amil, M., Agüera, Z., Jiménez‐Múrcia, S., Baños, R., Botella, C., de la Torre, R., Estivill, X., Fagundo, A. B., et al. (2014) · International Journal of Endocrinology · doi:10.1155/2014/857270 · Cited by 216 · see citing works
Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.
Burguera, B. G., Couce, M., Curran, G. L., Jensen, M. D., Lloyd, R. V., Cleary, M. P., & Poduslo, J. F. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1219 · Cited by 216 · see citing works
NASH Predicts Plasma Inflammatory Biomarkers Independently of Visceral Fat in Men
Targher, G., Bertolini, L., Rodella, S., Lippi, G., Franchini, M., Zoppini, G., Muggeo, M., & Day, C. P. (2008) · Obesity · doi:10.1038/oby.2008.64 · Cited by 214 · see citing works
The glucoregulatory actions of leptin
D'souza, A. M., Neumann, U. H., Glavas, M. M., & Kieffer, T. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.011 · Cited by 214 · see citing works
Association of Serum Fetuin-A With Insulin Resistance in Type 2 Diabetic and Nondiabetic Subjects
Mori, K., Emoto, M., Yokoyama, H., Araki, T., Teramura, M., Koyama, H., Shoji, T., Inaba, M., & Nishizawà, Y. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1484 · Cited by 213 · see citing works

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Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
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Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
Barbalho, S. M., Flato, U. A. P., Tofano, R. J., Goulart, R. D. A., Guiguer, E. L., Detregiachi, C. R. P., Buchaim, D. V., Araújo, A. C., Buchaim, R. L., Reina, F. T. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103607 · Cited by 156 · see citing works

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Prevalence and pattern of diabetic dyslipidemia in Indian type 2 diabetic patients
Parikh, R. M., Joshi, S., Menon, P. S. N., & Shah, N. S. (2009) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2009.04.005 · Cited by 42 · see citing works
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Adipokines in pulmonary hypertension: angels or demons?
Jia, Q., Ouyang, Y., Yang, Y., Yao, S., Chen, X., & Hu, Z. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22482 · Cited by 8 · see citing works

Authors: Chung, H. S., & Choi, K. M.
Affiliations: Hallym University (KR)
Korea University (KR)
Corresponding author: Kyung Mook Choi
ORCID: Hye Soo Chung
Kyung Mook Choi
Venue: Advances in clinical chemistry
Publisher: Elsevier
Published: 2020
Volume: 94
Pages: 261-321
ISSN: 0065-2423 (ISSN-L)
DOI: 10.1016/bs.acc.2019.07.012
OpenAlex: W2967080190
Cited by: 46
References: 411
Citations by year: 2026: 5 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 3
FWCI: 17.66
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Advances in clinical chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Korea University
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adipokines, myokines, hepatokines, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, dementia, neurodegenerative diseases, low-grade inflammation, oxidative stress, organ crosstalk, insulin resistance, adipose tissue, skeletal muscle, liver, cardiometabolic disease
MeSH terms: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Obesity, Neurodegenerative Diseases, Metabolic Syndrome, Adipokines

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