Cited by 135Aortic Disease and Treatment ApproachesNitric Oxide and Endothelin EffectsAortic aneurysm repair treatments

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

NOX1 Deficiency Protects From Aortic Dissection in Response to Angiotensin II

Open access

Gavazzi, Gaetan, Deffert, Christine, Trocme, Candice, Schäppi, Michela, Herrmann, François R., Krause, Karl-Heinz·2007·Hypertension

DOI 10.1161/hypertensionaha.107.089706

Open this paper in CoChat — free account

Abstract

Oxidative stress leads to vascular damage and participates in the pathomechanisms of aortic dissection and aneurysm formation. Here we study aortic dissection in mice deficient in the superoxide-generating reduced nicotinamide-adenine dinucleotide phosphate oxidase NOX1. Seven days of treatment with the hypertensive agent angiotensin II (3 mg/kg per day) led to aortic dissection in 23% of wild-type C57BL/6J mice but in only 4% of NOX1-deficient mice ( P =0.05). In contrast, treatment of wild-type C57BL/6J mice with the hypertensive agent norepinephrine (12 mg/kg per day), did not lead to aortic dissection or sudden death, suggesting that hypertension is not sufficient to cause aortic dissection. Interestingly, norepinephrine-dependent blood pressure elevations were conserved in NOX1-deficient mice, demonstrating that, different from angiotensin II, it acts through NOX1-independent hypertensive mechanisms. The resistance of NOX1-deficient mice to angiotensin II-induced aortic dissection suggests a role for NOX1-dependent alterations of the vascular wall. We, therefore, studied gene expression and protease/inhibitor equilibrium. cDNA array analysis demonstrated differential effects of angiotensin II on gene expression in wild-type and NOX1-deficient mice. Tissue inhibitor of metalloproteinase 1 was increased both on the mRNA and the protein level in aortas from NOX1-deficient mice. Thus, our results demonstrate that NOX1 is involved in the mechanisms of angiotensin II-dependent aortic dissection. As one underlying mechanism, we have identified NOX1-dependent suppression of tissue inhibitor of metalloproteinase 1 expression, which could lead to tissue damage through an altered protease/inhibitor balance.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.107.089706

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Self-citation
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467
Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.
Rajagopalan, S., Meng, X. P., Ramasamy, S., Harrison, D. G., & Galis, Z. S. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119076 · Cited by 1,137
Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture
Newby, A. C. (2005) · Physiological Reviews · doi:10.1152/physrev.00048.2003 · Cited by 817
Robust estimators for expression analysis
Hubbell, E. A., Liu, W., & Mei, R. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.12.1585 · Cited by 603
Mouse Models of Abdominal Aortic Aneurysms
Daugherty, A., & Cassis, L. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000118013.72016.ea · Cited by 489
Nox1 Is Involved in Angiotensin II–Mediated Hypertension: A Study in Nox1-Deficient Mice
Matsuno, K., Yamada, H., Iwata, K., Jin, D., Katsuyama, M., Matsuki, M., Takai, S., Yamanishi, K., Miyazaki, M., Matsubara, H., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.573709 · Cited by 470
Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice
Dikalova, A., Clempus, R., Lassègue, B., Cheng, G., McCoy, J., Dikalov, S., Martin, A. S., Lyle, A., Weber, D. S., Weiss, D., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.538934 · Cited by 438
Analysis of high density expression microarrays with signed-rank call algorithms
Liu, W.-M., Mei, R., Di, X., Ryder, T. B., Hubbell, E. A., Dee, S., Webster, T. A., Harrington, C. A., Ho, M.-H., Baid, J., et al. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.12.1593 · Cited by 426
Redox Mechanisms in Blood Vessels
Mueller, C. F. H., Laude, K. M., McNally, J. S., & Harrison, D. G. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149143.04821.eb · Cited by 351
Role of Oxidative Stress in the Pathogenesis of Abdominal Aortic Aneurysms
McCormick, M. L., Gavrila, D., & Weintraub, N. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000257552.94483.14 · Cited by 349
Role of NADPH Oxidase in the Vascular Hypertrophic and Oxidative Stress Response to Angiotensin II in Mice
Wang, H. D., Xu, S., Johns, D. G., Du, Y., Quinn, M. T., Cayatte, A. J., & Cohen, R. A. (2001) · Circulation Research · doi:10.1161/hh0901.089987 · Cited by 342
Decreased blood pressure in NOX1‐deficient mice
Gavazzi, G., Banfi, B., Deffert, C., Fiette, L., Schappi, M., Herrmann, F., & Krause, K.-H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.049 · Cited by 321
Self-citation
Role of the Renin-Angiotensin System in Vascular Diseases
Ruiz‐Ortega, M., Lorenzo, Ó., Rupérez, M., Esteban, V., Suzuki, Y., Mezzano, S. A., Plaza, J. J. G., & Egido, J. (2001) · Hypertension · doi:10.1161/hy1201.100589 · Cited by 317
Antagonism of AT2 receptors augments Angiotensin II‐induced abdominal aortic aneurysms and atherosclerosis
Daugherty, A., Manning, M. W., & Cassis, L. A. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704331 · Cited by 290
NADPH oxidase and endothelial cell function
Ray, R., & Shah, A. M. (2005) · Clinical Science · doi:10.1042/cs20050067 · Cited by 280
Oxidative Stress in Human Abdominal Aortic Aneurysms
Miller, F. J., Sharp, W. J., Fang, X., Oberley, L. W., Oberley, T. D., & Weintraub, N. L. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013778.72404.30 · Cited by 277
Angiotensin receptors: distribution, signalling and function
Dinh, D. T., Frauman, A. G., Johnston, C. I., & Fabiani, M. E. (2001) · Clinical Science · doi:10.1042/cs1000481 · Cited by 268
Collagen Triple Helix Repeat Containing 1, a Novel Secreted Protein in Injured and Diseased Arteries, Inhibits Collagen Expression and Promotes Cell Migration
Pyagay, P., Héroult, M., Wang, Q., Lehnert, W., Belden, J. R., Liaw, L., Friesel, R. E., & Lindner, V. (2004) · Circulation Research · doi:10.1161/01.res.0000154262.07264.12 · Cited by 254
Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall
Wang, M., Zhao, D., Spinetti, G., Zhang, J., Jiang, L.-Q., Pintus, G., Monticone, R. E., & Lakatta, E. G. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000225777.58488.f2 · Cited by 252
Novel NAD(P)H oxidases in the cardiovascular system: Table 1
Griendling, K. K. (2004) · Heart · doi:10.1136/hrt.2003.029397 · Cited by 215
Deletion of p47 phox Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E–Deficient Mice
Thomas, M., Gavrila, D., McCormick, M. L., Miller, F. J., Daugherty, A., Cassis, L. A., Dellsperger, K. C., & Weintraub, N. L. (2006) · Circulation · doi:10.1161/circulationaha.105.607168 · Cited by 206
Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
Deem, T. L., & Cook‐Mills, J. M. (2004) · Blood · doi:10.1182/blood-2004-02-0665 · Cited by 200
Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms
Kadoglou, N. P. E., & Liapis, C. D. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904125003143 · Cited by 196
Reduced Atherosclerotic Plaque but Enhanced Aneurysm Formation in Mice With Inactivation of the Tissue Inhibitor of Metalloproteinase-1 ( TIMP-1 ) Gene
Silence, J., Collen, D., & LIJNEN, H. R. (2002) · Circulation Research · doi:10.1161/01.res.0000016501.56641.83 · Cited by 185
Urokinase-Type Plasminogen Activator Plays a Critical Role in Angiotensin II–Induced Abdominal Aortic Aneurysm
Deng, G. G., Martin-McNulty, B., Sukovich, D. A., Freay, A. D., Halks‐Miller, M., Thinnes, T. C., Loskutoff, D. J., Carmeliet, P., Dole, W. P., & Wang, Y. (2003) · Circulation Research · doi:10.1161/01.res.0000061571.49375.e1 · Cited by 182
The Reactive Adventitia
Rey, F. E., & Pagano, P. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000043452.30772.18 · Cited by 177
Vitamin E Inhibits Abdominal Aortic Aneurysm Formation in Angiotensin II–Infused Apolipoprotein E–Deficient Mice
Gavrila, D., Li, W. G., McCormick, M. L., Thomas, M., Daugherty, A., Cassis, L. A., Miller, F. J., Oberley, L. W., Dellsperger, K. C., & Weintraub, N. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000172631.50972.0f · Cited by 172
Models of Experimental Hypertension in Mice
Johns, C. A., Gavras, I., Handy, D. E., Salomão, A., & Gavras, H. P. (1996) · Hypertension · doi:10.1161/01.hyp.28.6.1064 · Cited by 170
Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection
Ishii, T., & Asuwa, N. (2000) · Human Pathology · doi:10.1053/hupa.2000.7642 · Cited by 146
Hypertension Does Not Account for the Accelerated Atherosclerosis and Development of Aneurysms in Male Apolipoprotein E/Endothelial Nitric Oxide Synthase Double Knockout Mice
Chen, J., Kuhlencordt, P., Astern, J., Gyurko, R., & Huang, P. L. (2001) · Circulation · doi:10.1161/hc4501.099729 · Cited by 144
Oxidative stress in the pathogenesis of thoracic aortic aneurysm Protective role of statin and angiotensin II type 1 receptor blocker
Ejiri, J. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00523-6 · Cited by 144
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology
BENGTSSON, S. H. M., Gulluyan, L. M., Dusting, G. J., & Drummond, G. R. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03929.x · Cited by 136
Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes
McCarthy, J. J., Parker, A., Salem, R., Moliterno, D. J., Wang, Q., Plow, E. F., Rao, S., Shen, G., Rogers, W. J., Newby, L. K., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.016584 · Cited by 130
Angiotensin II-Mediated Development of Vascular Diseases
Daugherty, A. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.01.002 · Cited by 121
Angiotensin II induces MMP-2 in a p47phox-dependent manner
Luchtefeld, M., Grote, K., Grothusen, C., Bley, S., Bandlow, N., Selle, T., Strüber, M., Haverich, A., Bavendiek, U., Drexler, H., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.152 · Cited by 119
Increased Medial Degradation With Pseudo-Aneurysm Formation in Apolipoprotein E–Knockout Mice Deficient in Tissue Inhibitor of Metalloproteinases-1
Lemaître, V., Soloway, P. D., & D'Armiento, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000044915.37074.5c · Cited by 118
Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms
Ogata, T., Shibamura, H., Tromp, G. C., Sinha, M., Goddard, K. A. B., Sakalihasan, N., Limet, R., MacKean, G. L., Arthur, C., Sueda, T., et al. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.02.020 · Cited by 117
Thrombospondin-4 Binds Specifically to Both Collagenous and Non-collagenous Extracellular Matrix Proteins via Its C-terminal Domains
Narouz-Ott, L., Maurer, P., Nitsche, D. P., Smyth, N. R., & Paulsson, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007223200 · Cited by 97
Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: A study of the transcription profile with complementary DNA microarray
Yajima, N., Masuda, M., Miyazaki, M., Nakajima, N., Chien, S., & Shyy, J. Y.-J. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.124366 · Cited by 89
Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events
Sundström, J., & Vasan, R. S. (2006) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000203891.34890.b5 · Cited by 87
Enhanced abdominal aortic aneurysm in TIMP-1-deficient mice1
Eskandari, M. K., Vijungco, J. D., Flores, A., Borensztajn, J., Shively, V. P., & Pearce, W. H. (2004) · Journal of Surgical Research · doi:10.1016/j.jss.2004.07.247 · Cited by 87
Angiotensin II-mediated signal transduction pathways
Saito, Y., & Berk, B. C. (2002) · Current Hypertension Reports · doi:10.1007/s11906-002-0042-1 · Cited by 67
Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction
Wessel, J., Topol, E. J., Ji, M. H., Meyer, J. M., & McCarthy, J. J. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.12.013 · Cited by 58
Coronary artery disease and the thrombospondin single nucleotide polymorphisms
Stenina‐Adognravi, O., Byzova, T. V., Adams, J. C., McCarthy, J. J., Topol, E. J., & Plow, E. F. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.005 · Cited by 45
Angiotensin in atherosclerosis
Kon, V., & Jabs, K. L. (2004) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200405000-00005 · Cited by 42
Aortic Aneurysms
Miller, F. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000047947.37203.82 · Cited by 25
TIMP-1/MMP-9 imbalance in an EBV-immortalized B lymphocyte cellular model: evidence for TIMP-1 multifunctional properties
Gaudin, P., Trocmé, C., Berthier, S., Kieffer‐Jaquinod, S., Boutonnât, J., Lamy, C., Surla, A., Garin, J., & Morel, F. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00084-7 · Cited by 22
Thrombospondins and Premature Coronary Artery Disease
Hamsten, A., & Eriksson, P. O. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000051871.32874.6a · Cited by 5

Research works printed but not linked: 4

10.1161/hyp.38.6.1382 · DOI
10.1161/res.88.9.947 · DOI
10.1161/hyp.28.6.1064 · DOI
10.1161/circ.104.20.2391 · DOI

Sorted by citations

Reactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Forrester, S. J., Booz, G. W., Sigmund, C. D., Coffman, T. M., Kawai, T., Rizzo, V., Scalia, R. G., & Eguchi, S. (2018) · Physiological Reviews · doi:10.1152/physrev.00038.2017 · Cited by 1,135
Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899
Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
Lassegue, B. P., Martín, A. S., & Griendling, K. K. (2012) · Circulation Research · doi:10.1161/circresaha.111.243972 · Cited by 780
Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.267054 · Cited by 622

See all 135

Authors: Gavazzi, G., Deffert, C., Trocme, C., Schäppi, M., Herrmann, F. R., & Krause, K.-H.
Affiliations: Centre National de la Recherche Scientifique (FR)
From the Department of Geriatrics (G.G.) and Groupe de Recherche et d’Etude du Processus Inflammatoire Techniques de I’Ingénierie Médicale et de la Complexité-Imag Unité Mixtede Recherche-Centre National de la Recherche Scientifique 5525 (G.G., C.T.), University Hospital of Grenoble, Grenoble, France; and the Departments of Pathology, Immunology, and Clinical Pathology (C.D., M.S., K-H.K.), Pediatrics (C.D.), and Rehabilitation and Geriatrics (F.R.H.), Geneva Medical Faculty, Geneva, Switzerland.
ORCID: Gavazzi, Gaetan
Deffert, Christine
Krause, Karl-Heinz
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2007-07
Volume: 50
Issue: 1
Pages: 189-196
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.107.089706
OpenAlex: W2140545013
Cited by: 135
References: 50
Citations by year: 2026: 1 · 2025: 3 · 2024: 9 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 10 · 2015: 8 · 2014: 7 · 2013: 11 · 2012: 8
FWCI: 8.93
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Aortic Disease and Treatment Approaches
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Surgery › Aortic aneurysm repair treatments
Keywords: NOX1, aortic dissection, angiotensin II, oxidative stress, NADPH oxidase, norepinephrine, TIMP-1, protease-inhibitor balance, vascular wall damage, gene expression, sudden death
MeSH terms: NADPH Oxidase 1, Aortic Dissection, Angiotensin II, Animals, Aorta, Thoracic, Aortic Aneurysm, Blood Pressure, Disease Susceptibility, Gene Expression Regulation, Hypertension, Male, Mice, Inbred C57BL, Norepinephrine, RNA, Messenger, Vasoconstrictor Agents, Mice, Knockout, NADPH Oxidases, Tissue Inhibitor of Metalloproteinase-1, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NOX1 Deficiency Protects From Aortic Dissection in Response to Angiotensin II

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks