Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase
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Rationale: The function of Nox4, a source of vascular H 2 O 2 , is unknown. Other Nox proteins were identified as mediators of endothelial dysfunction. Objective: We determined the function of Nox4 in situations of increased stress induced by ischemia or angiotensin II with global and tamoxifen-inducible Nox4 −/− mice. Methods and Results: Nox4 was highly expressed in the endothelium and contributed to H 2 O 2 formation. Nox4 −/− mice exhibited attenuated angiogenesis (femoral artery ligation) and PEG-catalase treatment in control mice had a similar effect. Tube formation in cultured Nox4 −/− lung endothelial cells (LECs) was attenuated and restored by low concentrations of H 2 O 2, whereas PEG-catalase attenuated tube formation in control LECs. Angiotensin II infusion was used as a model of oxidative stress. Compared to wild-type, aortas from inducible Nox4-deficient animals had development of increased inflammation, media hypertrophy, and endothelial dysfunction. Mechanistically, loss of Nox4 resulted in reduction of endothelial nitric oxide synthase expression, nitric oxide production, and heme oxygenase-1 (HO-1) expression, which was associated with apoptosis and inflammatory activation. HO-1 expression is controlled by Nrf-2. Accordingly, Nox4-deficient LECs exhibited reduced Nrf-2 protein level and deletion of Nox4 reduced Nrf-2 reporter gene activity. In vivo treatment with hemin, an inducer of HO-1, blocked the vascular hypertrophy induced by Nox4 deletion in the angiotensin II infusion model and carbon monoxide, the product of HO-1, blocked the Nox4-deletion-induced apoptosis in LECs. Conclusion: Endogenous Nox4 protects the vasculature during ischemic or inflammatory stress. Different from Nox1 and Nox2, this particular NADPH oxidase therefore may have a protective vascular function.
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Nitrated fatty acids are a class of electrophilic signaling molecules which have been shown to react with a number of cellular targets to mediate protective inflammatory and metabolic signaling.
“Nitrated fatty acids are a class of electrophilic signaling molecules which have been shown to react with a number of cellular targets to mediate protective inflammatory and metabolic signaling (830).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [830]
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- Authors
- Schröder, K., Zhang, M., Benkhoff, S., Mieth, A., Pliquett, R., Kosowski, J., Kruse, C., Luedike, P., Michaelis, U. R., Weissmann, N., Dimmeler, S., Shah, A. M., & Brandes, R. P.
- Affiliations
- Goethe University Frankfurt (DE)
- ORCID
- Venue
- Circulation Research
- Published
- 2012-04-27
- Volume
- 110
- Issue
- 9
- Pages
- 1217-1225
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2150459982
- Cited by
- 622
- References
- 44
- Citations by year
- 2026: 28 · 2025: 20 · 2024: 22 · 2023: 30 · 2022: 44 · 2021: 39 · 2020: 46 · 2019: 37 · 2018: 40 · 2017: 63 · 2016: 49 · 2015: 61 · 2014: 54 · 2013: 62 · 2012: 25
- FWCI
- 43.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- British Heart Foundation (RG/08/011/25922)
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- NOX4, NADPH oxidase, reactive oxygen species, hydrogen peroxide, endothelial dysfunction, angiogenesis, angiotensin II, oxidative stress, heme oxygenase-1, Nrf2, endothelial nitric oxide synthase, nitric oxide, endothelial cell apoptosis, vascular inflammation, carbon monoxide, hemin
- MeSH terms
- NADPH Oxidase 1, NADPH Oxidase 4, Angiotensin II, Animals, Antioxidants, Boranes, Carbon Dioxide, Carbonates, Catalase, Cells, Cultured, Disease Models, Animal, Hemin, Humans, Hydrogen Peroxide, Hypertension, Hypertrophy, Ischemia, Lung, Male, Membrane Proteins, Mice, Inbred C57BL, NADH, NADPH Oxidoreductases, Organometallic Compounds, Polyethylene Glycols, RNA, Messenger, Time Factors, Transfection, Apoptosis, Mice, Knockout, Oxidative Stress, Muscle, Skeletal, Neovascularization, Physiologic, NADPH Oxidases, Cytoprotection, Endothelial Cells, NF-E2-Related Factor 2, Mice, Heme Oxygenase-1, Nitric Oxide Synthase Type III, Human Umbilical Vein Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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