The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease: A Randomized Double-Blind Pilot Trial
Open accessAbstract
Vitamin D receptor activation is associated with improved survival in patients with chronic kidney disease, but the mechanism of this benefit is unclear. To better understand the effects of vitamin D on endothelial function, blood pressure, albuminuria, and inflammation in patients with chronic kidney disease (2 patients stage 2, remaining stage 3), we conducted a pilot trial in 24 patients who were randomly allocated equally to 3 groups to receive 0, 1, or 2 μg of paricalcitol, a vitamin D analog, orally for 1 month. Placebo-corrected change in flow mediated dilatation with a 1-μg dose was 0.5% and 0.4% with a 2-μg dose ( P >0.2). At 1 month, the treatment:baseline ratio of high sensitivity C-reactive protein was 1.5 (95% CI: 1.1 to 2.1; P =0.02) with placebo, 0.8 (95% CI: 0.3 to 1.9; P =0.62) with a 1-μg dose, and 0.5 (95% CI: 0.3 to 0.9; P =0. 03) with a 2-μg dose of paricalcitol. At 1 month, the treatment:baseline ratio of 24-hour albumin excretion rate was 1.35 (95% CI: 1.08 to 1.69; P =0.01) with placebo, 0.52 (95% CI: 0.40 to 0.69; P <0.001) with a 1-μg dose, and 0.54 (95% CI: 0.35 to 0.83; P =0. 01) with a 2-μg dose ( P <0.001 for between group changes). No differences were observed in iothalamate clearance, 24-hour ambulatory blood pressure, or parathyroid hormone with treatment or on washout. Thus, paricalcitol-induced reduction in albuminuria and inflammation may be mediated independent of its effects on hemodynamics or parathyroid hormone suppression. Long-term randomized, controlled trials are required to confirm these benefits of vitamin D analogs.
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Self-citationVitamin D status and arterial hypertension: a systematic review
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Sepehrmanesh, Z., Kolahdooz, F., Abedi, F., Mazroii, N., Assarian, A., Asemi, Z., & Esmaillzadeh, A. (2016) · The Journal of Nutrition · doi:10.3945/jn.115.218883 · Cited by 143
Retracted
Metadata
- Authors
- Alborzi, P., Patel, N. A., Peterson, C., Bills, J. E., Bekele, D. M., Bunaye, Z., Light, R. P., & Agarwal, R.
- Venue
- Hypertension
- Published
- 2008-08
- Volume
- 52
- Issue
- 2
- Pages
- 249-255
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2162129240
- Cited by
- 331
- References
- 33
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease: A Randomized Double-Blind Pilot Trial. https://app.cochat.ai/papers/10.1161/hypertensionaha.108.113159
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- Alborzi, P., Patel, N. A., Peterson, C., Bills, J. E., Bekele, D. M., Bunaye, Z., Light, R. P., & Agarwal, R. (2008). Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease: A Randomized Double-Blind Pilot Trial. Hypertension. https://doi.org/10.1161/hypertensionaha.108.113159
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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