The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Sympathetic and Baroreflex Cardiovascular Control in Hypertension-Related Left Ventricular Dysfunction
Abstract
The sympathetic overdrive that characterizes essential hypertension is potentiated when left ventricular hypertrophy or congestive heart failure is detected. No information exists, however, on whether this is the case also for left ventricular diastolic dysfunction. In 17 untreated hypertensive subjects with left ventricular diastolic dysfunction (age: 47.7±2.9 years, mean±SEM), we measured sympathetic nerve traffic (microneurography), heart rate (ECG), and beat-to-beat arterial blood pressure (Finapres) at rest and during baroreceptor deactivation and stimulation. Data were compared with those collected in 20 age-matched normotensive and 20 hypertensive subjects without a diastolic function impairment. Muscle sympathetic nerve traffic values were markedly and significantly greater in the 2 hypertensive groups than in the normotensive one (55.3±1.2 and 71.2±1.6 versus 41.7±1.0 bursts per 100 heartbeats, respectively; P <0.01 for both). For a similar blood pressure elevation, however, the sympathetic nerve traffic increase was significantly greater in patients with than without left ventricular diastolic dysfunction (+28.9%; P <0.05). In the population as a whole, muscle sympathetic nerve traffic was significantly and inversely related to various echocardiographic indices of diastolic function. Although baroreflex-heart rate control was significantly attenuated in the 2 hypertensive groups, baroreflex-sympathetic modulation was impaired only in those with diastolic dysfunction. These data provide the first evidence that, in hypertension, activation of the sympathetic nervous system may contribute not only at the blood pressure elevation but also at the development of left ventricular diastolic dysfunction. The sympathetic overactivity, which is likely to be related to the baroreflex impairment, may account for the increased cardiovascular risk characterizing diastolic dysfunction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Adrenergic neural factors may also contribute to the development and progression of target organ damage, as documented by the pronounced increase in sympathetic nerve traffic and cardiac norepinephrine spillover rate in patients in which hypertension is complicated by left ventricular hypertrophy or left ventricular diastolic dysfunction40,42,44,45.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [45]
Experimental — accuracy not yet measuredIn the citing paper
“As far as the second issue is concerned, microneurographic studies almost universally shown that sympathetic nerve traffic is potentiated in established hypertension in middle age and in elderly as well as young patients38–46.”
From The Sympathetic Nervous System Alterations in Human Hypertension (2015) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,739
Self-citationRecommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430
2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,870
Self-citationEchocardiographic determination of left ventricular mass in man. Anatomic validation of the method.
Devereux, R. B., & Reichek, N. (1977) · Circulation · doi:10.1161/01.cir.55.4.613 · Cited by 4,499
Paulus, W. J., Tschöpe, C., Sanderson, J. E., Rusconi, C., Flachskampf, F. A., Rademakers, F. E., Marino, P. N., Smiseth, O. A., Keulenaer, G. W. D., Leite-Moreira, A. F., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm037 · Cited by 2,646
SIMONE, G. D., Devereux, R. B., Roman, M. J., Ganau, A., Saba, P. S., Alderman, M. H., & Laragh, J. H. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90390-5 · Cited by 604
Hjemdahl, P., Daleskog, M., & Kahan, T. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90384-9 · Cited by 564
Aurigemma, G. P., Gottdiener, J. S., Shemanski, L. R., Gardin, J. M., & Kitzman, D. W. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01110-x · Cited by 528
Baroreflex Control of Sympathetic Nerve Activity in Essential and Secondary Hypertension
Grassi, G., Cattaneo, B. M., Seravalle, G., Lanfranchi, A., & Mancia, G. (1998) · Hypertension · doi:10.1161/01.hyp.31.1.68 · Cited by 526
Self-citation
Cited by
Sorted by citations
The Sympathetic Nervous System in Heart Failure
Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., & Butler, J. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.015 · Cited by 978
The Autonomic Nervous System and Hypertension
Mancia, G., & Grassi, G. (2014) · Circulation Research · doi:10.1161/circresaha.114.302524 · Cited by 627
Self-citationThe Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616
Self-citationThe Autonomic Nervous System and Heart Failure
Florea, V. G., & Cohn, J. N. (2014) · Circulation Research · doi:10.1161/circresaha.114.302589 · Cited by 587
Hering, D., Lambert, E. A., Marusic, P., Walton, A. S., Krum, H., Lambert, G. W., Esler, M. D., & Schlaich, M. P. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00194 · Cited by 356
Assessment of Sympathetic Cardiovascular Drive in Human Hypertension
Grassi, G. M. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.119883 · Cited by 340
Self-citationLambert, É. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00052 · Cited by 243
Heart failure as an autonomic nervous system dysfunction
Kishi, T. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.12.006 · Cited by 242
Sympathetic Neural Activity in Hypertension and Related Diseases
Grassi, G. M. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.154 · Cited by 225
Self-citationLambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.155663 · Cited by 209
The Sympathetic Nervous System and Heart Failure
Zhang, D. Y., & Anderson, A. S. (2013) · Cardiology Clinics · doi:10.1016/j.ccl.2013.09.010 · Cited by 199
Evidence for a critical role of the sympathetic nervous system in hypertension
Grassi, G. M., & Ram, V. S. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.02.015 · Cited by 193
Self-citationThe ‘neuroadrenergic hypothesis’ in hypertension: current evidence
Grassi, G. M., Seravalle, G., & Quarti‐Trevano, F. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.047381 · Cited by 156
Self-citationSympathetic Nerve Traffic Activation in Essential Hypertension and Its Correlates
Grassi, G. M., Pisano, A., Bolignano, D., Seravalle, G., D’Arrigo, G., Quarti‐Trevano, F., Mallamaci, F., Zoccali, C., & Mancia, G. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11038 · Cited by 142
Self-citationSympathetic nervous system: role in hypertension and in chronic kidney disease
Grassi, G., Bertoli, S., & Seravalle, G. (2012) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32834db45d · Cited by 118
Self-citationFloras, J. S. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.05.003 · Cited by 108
Carotid baroreflex activation therapy for resistant hypertension
Victor, R. G. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.96 · Cited by 98
Cholinergic Activity as a New Target in Diseases of the Heart
Roy, A., Guatimosim, S., Prado, V. F., Gros, R., & Prado, M. A. M. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00125 · Cited by 102
Sympathetic overactivity, hypertension and cardiovascular disease: state of the art
Grassi, G. M., & Drager, L. F. (2024) · Current Medical Research and Opinion · doi:10.1080/03007995.2024.2305248 · Cited by 101
Self-citationGeorgakopoulos, D., Little, W. C., Abraham, W. T., Weaver, F. A., & Zile, M. R. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.09.004 · Cited by 90
Grassi, G. M., Bombelli, M., Brambilla, G., Trevano, F. Q., Dell’Oro, R., & Mancia, G. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0273-8 · Cited by 89
Self-citationAutonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans
Tran, N. T., Asad, Z. U. A., Elkholey, K., Scherlag, B. J., Po, S. S., & Stavrakis, S. (2018) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-018-9853-6 · Cited by 91
Hypertension‐induced remodelling: on the interactions of cardiac risk factors
Tomek, J., & Bub, G. (2017) · The Journal of Physiology · doi:10.1113/jp273043 · Cited by 88
Despas, F., Lambert, É., Vaccaro, A., Labrunée, M., Franchitto, N., Lebrin, M., Galinier, M., Sénard, J., Lambert, G. W., Esler, M., et al. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328350136c · Cited by 82
Zhou, L., Filiberti, A., Humphrey, M. B., Fleming, C. D., Scherlag, B. J., Po, S. S., & Stavrakis, S. (2018) · Experimental Physiology · doi:10.1113/ep087351 · Cited by 76
Mitsas, A. C., Elzawawi, M., Mavrogeni, S. I., Boekels, M., Khan, A. A., Eldawy, M., Stamatakis, I., Kouris, D., Daboul, B., Gunkel, O., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237041 · Cited by 77
Maniaci, A., Lavalle, S., Parisi, F. M., Barbanti, M., Cocuzza, S. G., Iannella, G., Magliulo, G., Pace, A., Lentini, M., Masiello, E., et al. (2024) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd11070204 · Cited by 71
Novel Interventional Therapies to Modulate the Autonomic Tone in Heart Failure
Chatterjee, N. A., & Singh, J. P. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.05.008 · Cited by 62
Esler, M., Lambert, G., Schlaich, M., Dixon, J., Sari, C. I., & Lambert, E. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.09790 · Cited by 60
Verloop, W. L., Beeftink, M. M. A., Santema, B. T., Bots, M. L., Blankestijn, P. J., Cramer, M. J., Doevendans, P. A., & Voskuil, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117332 · Cited by 58
Akoum, S. E., Lamontagne, V., Cloutier, I., & Tanguay, J. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-34 · Cited by 57
Lee, M. G. Y., Hemmes, R., Mynard, J. P., Lambert, É., Head, G. A., Cheung, M. M. H., Konstantinov, I. E., Brizard, C. P., Lambert, G. W., & d’Udekem, Y. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.05.075 · Cited by 57
Suri, J. S., Paul, S., Maindarkar, M. A., Puvvula, A., Saxena, S., Saba, L., Turk, M., Laird, J. R., Khanna, N. N., Višković, K., et al. (2022) · Metabolites · doi:10.3390/metabo12040312 · Cited by 60
Neuromodulation of the Failing Heart
Byku, M., & Mann, D. L. (2016) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2016.03.004 · Cited by 57
Bidirectional Relationship Between Cancer and Heart Failure: Old and New Issues in Cardio-oncology
Bertero, E., Ameri, P., & Maack, C. (2019) · Cardiac failure review · doi:10.15420/cfr.2019.1.2 · Cited by 56
Seravalle, G., Mancia, G., & Grassi, G. M. (2014) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-014-0056-1 · Cited by 53
Self-citationSympathetic Mechanisms, Organ Damage, and Antihypertensive Treatment
Grassi, G. M., Seravalle, G., Dell’Oro, R., & Mancia, G. (2011) · Current Hypertension Reports · doi:10.1007/s11906-011-0200-4 · Cited by 53
Self-citationSartipy, U., Savarese, G., Dahlström, U., Fu, M. L. X., & Lund, L. H. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1389 · Cited by 52
Sex and Heart Failure with Preserved Ejection Fraction: From Pathophysiology to Clinical Studies
Tadic, M. V., Cuspidi, C., Plein, S., Belyavskiy, E., Heinzel, F. R., & Galderisi, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060792 · Cited by 52
Calming the Nervous Heart: Autonomic Therapies in Heart Failure
Hanna, P., Shivkumar, K., & Ardell, J. L. (2018) · Cardiac failure review · doi:10.15420/cfr.2018.20.2 · Cited by 50
The Autonomic Nervous System and Cardiovascular Health and Disease
Merz, C. N. B., Elboudwarej, O., & Mehta, P. K. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2015.01.008 · Cited by 47
Verloop, W. L., Beeftink, M. M. A., Nap, A., Bots, M. L., Velthuis, B. K., Appelman, Y., Cramer, M. J., Agema, W. R. P., Scholtens, A. M., Doevendans, P. A., et al. (2013) · European Journal of Heart Failure · doi:10.1093/eurjhf/hft119 · Cited by 44
Cardiovascular Autonomic Disturbances in Heart Failure With Preserved Ejection Fraction
Badrov, M. B., Mak, S. S., & Floras, J. S. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.12.006 · Cited by 45
Berlier, C., Saxer, S., Lichtblau, M., Schneider, S., Schwarz, E. I., Furian, M., Bloch, K. E., Carta, A. F., & Ulrich, S. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.023839 · Cited by 43
The sympathetic nervous system in heart failure revisited
Triposkiadis, F. K., Briasoulis, Α., Kitai, T., Magouliotis, D. E., Athanasiou, T., Skoularigis, J. S., & Xanthopoulos, A. V. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10345-y · Cited by 42
Klein, D. A., Katz, D. H., Beussink‐Nelson, L., Sanchez, C. L., Strzelczyk, T. A., & Shah, S. J. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.06.038 · Cited by 41
Holwerda, S. W., Carter, J. R., Yang, H., Wang, J., Pierce, G. L., & Fadel, P. J. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00704.2020 · Cited by 41
Souza, S. B., Rocha, J. A., Cuoco, M. A. R., Guerra, G. M., Ferreira‐Filho, J., Borile, S., Krieger, E. M., Bortolotto, L. A., & Consolim‐Colombo, F. M. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt032 · Cited by 40
Mental stress elicits sustained and reproducible increases in skin sympathetic nerve activity
Muller, M. D., Sauder, C. L., & Ray, C. A. (2013) · Physiological Reports · doi:10.1002/phy2.2 · Cited by 38
Autonomic Dysfunction in Diabetes: a Consequence of Cardiovascular Damage
Lefrandt, J. D., Smit, A. J., Zeebregts, C. J., Gans, R. O. B., & Hoogenberg, K. (2010) · Current Diabetes Reviews · doi:10.2174/157339910793499128 · Cited by 38
Aikawa, T., Naya, M., Obara, M., Manabe, O., Tomiyama, Y., Magota, K., Yamada, S., Katoh, C., Tamaki, N., & Tsutsui, H. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.178558 · Cited by 37
Tadić, M., Cuspidi, C., Frydas, A., & Grassi, G. M. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9698-8 · Cited by 36
Self-citationPotential Clinical Application of Recently Discovered Brain Mechanisms Involved in Hypertension
Hirooka, Y., Kishi, T., Ito, K., & Sunagawa, K. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00801 · Cited by 36
Baig, M., Moafi-Madani, M., Qureshi, R., Roberts, M. B., Allison, M., Manson, J. E., LaMonte, M. J., Liu, S., & Eaton, C. B. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276585 · Cited by 33
Baroreflex Sensitivity Impairment Is Associated With Cardiac Diastolic Dysfunction in Rats
Mostarda, C. T., Moraes-Silva, I. C., Moreira, É. D., Medeiros, A., Piratello, A. C., Consolim‐Colombo, F. M., Caldini, E. T. E. G., Brum, P. C., Krieger, E. M., & Irigoyen, M. C. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.02.007 · Cited by 33
The Role of Central Nervous System Mechanisms in Resistant Hypertension
Hering, D., & Schlaich, M. P. (2015) · Current Hypertension Reports · doi:10.1007/s11906-015-0570-0 · Cited by 32
Autonomic activation links CNS oxygen toxicity to acute cardiogenic pulmonary injury
It, D., Zhilyaev, S. Y., Moskvin, A. N., Piantadosi, C. A., & Allen, B. W. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00178.2010 · Cited by 32
Current Perspectives on Systemic Hypertension in Heart Failure with Preserved Ejection Fraction
Oktay, A. A., & Shah, S. J. (2014) · Current Cardiology Reports · doi:10.1007/s11886-014-0545-9 · Cited by 31
Heart Failure as a Disruption of Dynamic Circulatory Homeostasis Mediated by the Brain
Kishi, T. (2016) · International Heart Journal · doi:10.1536/ihj.15-517 · Cited by 29
Dorantes-Méndez, G., Aletti, F. M., Toschi, N., Canichella, A., Dauri, M., Coniglione, F., Guerrisi, M., Signorini, M. G., Cerutti, S., & Ferrario, M. (2013) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-012-9426-1 · Cited by 29
Grassi, G. M., Seravalle, G., Brambilla, G., & Mancia, G. (2012) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2011.11.005 · Cited by 27
Self-citationCardiac and pulmonary arterial remodeling after sinoaortic denervation in normotensive rats
Flues, K., Moraes-Silva, I. C., Mostarda, C. T., Souza, P. R. M., Diniz, G. P., Moreira, E. D., Piratello, A. C., de Chaves, M. L. M. B., Angelis, K. D., Salemi, V. M. C., et al. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.10.005 · Cited by 27
Aceros, H., Farah, G., Cobos-Puc, L. E., Stabile, A., Noiseux, N., & Mukaddam‐Daher, S. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01355.x · Cited by 25
Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure
Kishi, T., & Hirooka, Y. (2012) · Cardiology Research and Practice · doi:10.1155/2012/847172 · Cited by 26
Gimelli, A., Liga, R., Avogliero, F., Coceani, M. A., & Marzullo, P. (2016) · Journal of Nuclear Cardiology · doi:10.1007/s12350-016-0753-3 · Cited by 24
Tachycardia: The hidden cardiovascular risk factor in uncomplicated arterial hypertension
Cierpka‐Kmieć, K., & Hering, D. (2019) · Cardiology Journal · doi:10.5603/cj.a2019.0021 · Cited by 27
Triposkiadis, F. K., Sarafidis, P. A., Briasoulis, Α., Magouliotis, D. E., Athanasiou, T., Skoularigis, J. S., & Xanthopoulos, A. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12155090 · Cited by 27
Khanna, N. N., Maindarkar, M. A., Saxena, A. K., Ahluwalia, P., Paul, S., Srivastava, S. K., Cuadrado‐Godia, E., Sharma, A., Omerzu, T., Saba, L., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12051249 · Cited by 24
van Lill, L., Malan, L., Rooyen, J. V., Steyn, F., Reimann, M., & Ziemssen, T. (2011) · Blood Pressure · doi:10.3109/08037051.2011.580529 · Cited by 23
Schulz, A., & Schuster, A. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104369 · Cited by 22
Angiotensin II–Mediated Left Ventricular Abnormalities in Chronic Kidney Disease
Raizada, V., Hillerson, D., Amaram, J. S., & SKIPPER, B. J. (2012) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e318250b101 · Cited by 21
Volpe, M., Tocci, G., de la Sierra, A., Kreutz, R. H., Laurent, S., Manolis, A. J., & Tsioufis, K. (2017) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-017-0239-7 · Cited by 20
Tokuhisa, H., Murai, H., Okabe, Y., Hamaoka, T., Sugimoto, H., Mukai, Y., Inoue, O., Takashima, S., Kato, T., Usui, S., et al. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.006 · Cited by 20
Dofetilide Promotes Repolarization Abnormalities in Perfused Guinea-pig Heart
Osadchii, O. E. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6405-1 · Cited by 20
Iliocaval Venous Obstruction, Cardiac Preload Reserve and Exercise Limitation
Morris, R. I., Sobotka, P. A., Balmforth, P., Stöhr, E. J., McDonnell, B. J., Spencer, D., O’Sullivan, G. J., & Black, S. A. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-09963-w · Cited by 20
Obstructive sleep apnea syndrome, continuous positive airway pressure and treatment of hypertension
Floras, J. S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.024 · Cited by 22
Cardiometabolic-based chronic disease: adiposity and dysglycemia drivers of heart failure
Correia, E. T. D. O., Mechanick, J. I., Barbetta, L. M. D. S., Jorge, A. J. L., & Mesquita, E. T. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10233-x · Cited by 22
Evaluation and treatment of patients with cardiac disease undergoing bariatric surgery
Katkhouda, N., Mason, R. J., Wu, B., Takla, F. S., Keenan, R. M., & Zehetner, J. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.01.012 · Cited by 19
Baroreflex activation therapy systems: current status and future prospects
Seravalle, G., Dell’Oro, R., & Grassi, G. M. (2019) · Expert Review of Medical Devices · doi:10.1080/17434440.2019.1697230 · Cited by 18
Self-citationStavres, J., Aultman, R. A., Brandner, C. F., Newsome, T. A., Vallecillo‐Bustos, A., Wise, H. L., Henderson, A., Stanfield, D., Mannozzi, J. T., & Graybeal, A. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1212775 · Cited by 18
Deep and future insights into neuromodulation therapies for heart failure
Kishi, T. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.05.010 · Cited by 17
Ahmadi, A., Renaud, J. M., Promislow, S., Burwash, I. G., Dwivedi, G., Klein, R., Zelt, J. G. E., deKemp, R. A., Beanlands, R. S., & Mielniczuk, L. M. (2020) · Journal of Nuclear Cardiology · doi:10.1007/s12350-020-02144-x · Cited by 17
Harada, D., Asanoi, H., Noto, T., & Takagawa, J. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.05.001 · Cited by 17
Kouidi, E. J., Καλτσάτου, Α., Anifanti, M., & Deligiannis, A. P. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136974 · Cited by 17
Sympathetic nerve activity in women 40 years after a hypertensive pregnancy
Collén, A.-C., Manhem, K., & Sverrisdóttir, Y. B. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283531ed2 · Cited by 17
Nammas, W., Koistinen, J. M., Paana, T., & Karjalainen, P. P. (2017) · Annals of Medicine · doi:10.1080/07853890.2017.1282168 · Cited by 17
The Sympathetic Nervous System in Hypertensive Heart Failure with Preserved LVEF
Triposkiadis, F. K., Briasoulis, Α., Sarafidis, P. A., Magouliotis, D. E., Athanasiou, T., PARASKEVAIDIS, I. A., Skoularigis, J. S., & Xanthopoulos, A. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12206486 · Cited by 18
Why is functional capacity decreased in hypertensive patients? From mechanisms to clinical studies
Tadić, M., & Ivanović, B. (2014) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000050 · Cited by 17
Torto, A. D., Guaricci, A. I., Pomarico, F., Guglielmo, M., Fusini, L., Monitillo, F., Santoro, D., Vannini, M., Rossi, A., Muscogiuri, G., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.758975 · Cited by 16
The central sympathetic nervous system in hypertension
Mancia, G., & Grassi, G. M. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00026-2 · Cited by 14
Self-citationFranchitto, N., Despas, F., Labrunée, M., Vaccaro, A., Lambert, É., Lambert, G. W., Galinier, M., Sénard, J., & Pathak, A. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.023 · Cited by 15
Abubakar, M., Saleem, A., Hajjaj, M., Faiz, H., Pragya, A., Jamil, R., Salim, S. S., Lateef, I. K., Singla, D. K., Ramar, R., et al. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10369-4 · Cited by 16
Premise, Promise, and Potential Limitations of Invasive Devices to Treat Hypertension
Martin, E. A., & Victor, R. G. (2010) · Current Cardiology Reports · doi:10.1007/s11886-010-0156-z · Cited by 14
Acute Decompensated Heart Failure
Hammond, D. A., Smith, M. N., Lee, K. C., Honein, D., & Miller, A. D. (2016) · Journal of Intensive Care Medicine · doi:10.1177/0885066616669494 · Cited by 15
Muller, M. D., Mast, J. L., Patel, H. M., & Sinoway, L. I. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01165.2012 · Cited by 15
PPAR Gamma at the Crossroads of Health and Disease: A Masterchef in Metabolic Homeostasis
Akoum, S. E. (2014) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000126 · Cited by 13
Cardiac function in women with preeclampsia
Dennis, A. T. (2010) · Minerva Access (University of Melbourne) · Cited by 13
Effects of Baroreflex Activation Therapy on Cardiac Function and Morphology
Schäfer, A.-K. C., Wallbach, M., Schroer, C., Lehnig, L.-Y., Lüders, S., Hasenfuss, G., Wachter, R., & Koziolek, M. J. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14940 · Cited by 10
Timing and Efficacy of Alternative Methods of Sympathetic Blockade
Briasoulis, Α., & Bakris, G. L. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0294-3 · Cited by 11
Clemmer, J. S., & Pruett, W. A. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00329.2022 · Cited by 10
Metadata
- Authors
- Grassi, G., Seravalle, G., Quarti-Trevano, F., Dell'Oro, R., Arenare, F., Spaziani, D., & Mancia, G.
- Affiliations
- IRCCS Istituto Auxologico Italiano (IT)
- From the Clinica Medica (G.G., F.Q-T., R.D., F.A., G.M.), Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano-Bicocca, Ospedale San Gerardo, Milan, Italy; Istituto Auxologico Italiano (G.G., G.S., G.M.), Milan, Italy; and the Divisione di Cardiologia (D.S.), Ospedale di Legnano, Legnano, Italy.
- Venue
- Hypertension
- Published
- 2009-02
- Volume
- 53
- Issue
- 2
- Pages
- 205-209
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2122749049
- Cited by
- 194
- References
- 40
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 13 · 2023: 11 · 2022: 10 · 2021: 3 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 11 · 2016: 16 · 2015: 10 · 2014: 11 · 2013: 13 · 2012: 20
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- essential hypertension, left ventricular diastolic dysfunction, sympathetic nervous system, baroreflex, muscle sympathetic nerve activity, baroreflex sensitivity, rate control, cardiovascular risk, sympathetic hyperactivity
- MeSH terms
- Adult, Blood Pressure, Cardiac Output, Cardiovascular Physiological Phenomena, Heart Rate, Heart Ventricles, Humans, Hypertension, Male, Middle Aged, Stroke Volume, Sympathetic Nervous System, Echocardiography, Doppler, Case-Control Studies, Baroreflex, Ventricular Dysfunction, Left
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
