Sympathetic Nervous System Activity Is Associated With Obesity-Induced Subclinical Organ Damage in Young Adults
Open accessAbstract
Excess weight is established as a major risk factor for cardiovascular diseases, particularly in young individuals. To get a better understanding of the pathophysiology underlying increased cardiovascular disease risk, we evaluated early signs of organ damage and their possible relationship to sympathetic nervous activity. Eighteen lean (body mass index <25 kg/m 2 ) and 25 overweight or obese (body mass index >25 kg/m 2 ) healthy university students were included in the study. We comprehensively assessed subclinical target organ damage, including the following: (1) assessment of renal function; (2) left ventricular structure and systolic and diastolic function; and (3) endothelial function. Muscle sympathetic nervous activity was assessed by microneurography. Participants with excess weight had decreased endothelial function ( P <0.01), elevated creatinine clearance ( P <0.05), increased left ventricular mass index ( P <0.05), increased left ventricular wall thickness ( P <0.01), lower systolic and diastolic function ( P <0.01), and elevated muscle sympathetic nervous activity ( P <0.001) compared with lean individuals. In multiple regression analysis, endothelial function was inversely related to muscle sympathetic nervous activity ( R 2 =0.244; P <0.05), whereas creatinine clearance and left ventricular mass index were positively related to muscle sympathetic nervous activity, after adjustment for body mass index, sex, and blood pressure ( R 2 =0.318, P <0.01 and R 2 =0.312, P <0.05, respectively). Excess weight in young individuals is associated with subclinical alterations in renal and endothelial function, as well as in the structure of the heart, even in the absence of hypertension. Sympathetic activity is closely associated with cardiovascular and renal alterations observed in these subjects.
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Sympathetic overdrive is closely related to subclinical cardiovascular and renal alterations that develop in obese subjects even in the absence of hypertension.
“Interestingly, sympathetic overdrive was also found to be closely related to subclinical cardiovascular and renal alterations that develop in obese subjects even in the absence of hypertension (19).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [19]
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Self-citationSympathetic Nervous System Activation and Its Modulation: Role in Atrial Fibrillation
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Self-citationLambert, É., Straznicky, N. E., Sari, C. I., Eikelis, N., Hering, D., Head, G. A., Dixon, J. B., Esler, M., Schlaich, M. P., & Lambert, G. W. (2012) · American Journal of Hypertension · doi:10.1093/ajh/hps016 · Cited by 79 · see citing works
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Single‐unit muscle sympathetic nervous activity and its relation to cardiac noradrenaline spillover
Lambert, E. A., Schlaich, M. P., Dawood, T., Sari, C., Chopra, R., Barton, D. A., Kaye, D. M., Elam, M., Esler, M. D., & Lambert, G. W. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.205351 · Cited by 68 · see citing works
Self-citationObesity in anesthesia and intensive care
Huschak, G., Busch, T., & Kaisers, U. X. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.02.001 · Cited by 68 · see citing works
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Adrenal medullary dysfunction as a feature of obesity
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The impact of elevated blood pressure on exercise capacity in elite athletes
Mazic, S. D., Suzic-Lazić, J., Dekleva, M., Antić, M., Soldatović, I., Djelic, M. N., Nešić, D., Aćimović, T., Lazic, M., Lazović, B., et al. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.11.125 · Cited by 63 · see citing works
The Sympathetic Nervous System in Obesity Hypertension
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Obesity-induced increases in sympathetic nerve activity: Sex matters
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Chazova, I. E., & Schlaich, M. P. (2013) · International Journal of Hypertension · doi:10.1155/2013/541689 · Cited by 60 · see citing works
Self-citationObesity-Associated Organ Damage and Sympathetic Nervous Activity
Lambert, É., Esler, M., Schlaich, M. P., Dixon, J. B., Eikelis, N., & Lambert, G. W. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.11676 · Cited by 60 · see citing works
Self-citationSun, J., Xi, B., Yang, L., Zhao, M., Juonala, M., & Magnussen, C. G. (2020) · Obesity Reviews · doi:10.1111/obr.13138 · Cited by 56 · see citing works
Lee, M. G. Y., Hemmes, R., Mynard, J. P., Lambert, É., Head, G. A., Cheung, M. M. H., Konstantinov, I. E., Brizard, C. P., Lambert, G. W., & d’Udekem, Y. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.05.075 · Cited by 57 · see citing works
Self-citationObesity and hypertension in children and adolescents
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Relationships of Adrenoceptor Polymorphisms with Obesity
Masuo, K., & Lambert, G. W. (2011) · Journal of Obesity · doi:10.1155/2011/609485 · Cited by 51 · see citing works
Self-citationTowards an adiposity-related disease framework for the diagnosis and management of obesities
Perdomo, C. M., Avilés-Olmos, I., Dicker, D., & Frühbeck, G. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09797-2 · Cited by 51 · see citing works
Hypertension in obesity: is leptin the culprit?
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Sari, C. I., Eikelis, N., Head, G. A., Schlaich, M. P., Meikle, P. J., Lambert, G. W., & Lambert, É. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01162 · Cited by 44 · see citing works
Self-citationBody mass index contributes to sympathovagal imbalance in prehypertensives
Pal, G. K., Chandrasekaran, A., Hariharan, A. P., Dutta, T. K., Pal, P., Nanda, N., & Venugopal, L. (2012) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-12-54 · Cited by 44 · see citing works
Lambert, É., Rice, T., Eikelis, N., Straznicky, N. E., Lambert, G. W., Head, G. A., Hensman, C., Schlaich, M. P., & Dixon, J. B. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu050 · Cited by 43 · see citing works
Self-citationSušić, D., & Varagić, J. (2016) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.008 · Cited by 43 · see citing works
Meta-inflammation and cardiometabolic disease in obesity: Can heat therapy help?
Ely, B. R., Clayton, Z. S., McCurdy, C. E., Pfeiffer, J. D., & Minson, C. T. (2017) · Temperature · doi:10.1080/23328940.2017.1384089 · Cited by 43 · see citing works
Obesity related complications in surgery
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Obesity and atrial fibrillation
Abed, H. S., & Wittert, G. (2013) · Obesity Reviews · doi:10.1111/obr.12056 · Cited by 41 · see citing works
A sympathetic view of human obesity
Lambert, É., Straznicky, N. E., & Lambert, G. W. (2012) · Clinical Autonomic Research · doi:10.1007/s10286-012-0169-3 · Cited by 38 · see citing works
Self-citationAlternative Quantitative Tools in the Assessment of Diabetic Peripheral and Autonomic Neuropathy
Vinik, A. I., CASELLINI, C. M., & Névoret, M. L. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.03.010 · Cited by 37 · see citing works
Shi, Z., Wong, J., & Brooks, V. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00286-8 · Cited by 37 · see citing works
Wang, Y., Rijal, B., Xu, M., Li, Z., An, Y., Zhang, F., & Lu, C. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01532-6 · Cited by 37 · see citing works
McCully, B. H., Hasan, W., Streiff, C. T., Houle, J. C., Woodward, W. R., Giraud, G. D., Brooks, V. L., & Habecker, B. A. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00196.2013 · Cited by 37 · see citing works
Central Nervous System Dysfunction in Obesity-Induced Hypertension
Head, G. A., Lim, K., Barzel, B., Burke, S. L., & Davern, P. J. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0466-4 · Cited by 36 · see citing works
Self-citationGui, J., & Wang, R. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.03.018 · Cited by 35 · see citing works
Lucini, D., de Giacomi, G., Tosi, F., Malacarne, M., Respizzi, S., & Pagani, M. (2012) · Heart · doi:10.1136/heartjnl-2012-302616 · Cited by 34 · see citing works
Leptin increasing sympathetic nerve outflow in obesity
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Garafová, A., Penesová, A., Cizmárová, E., Marko, A., Vlček, M., & Ježová, D. (2014) · Physiological Research · doi:10.33549/physiolres.932931 · Cited by 32 · see citing works
Targeting Features of the Metabolic Syndrome Through Sympatholytic Effects of SGLT2 Inhibition
Herat, L. Y., Matthews, J. R., Azzam, O., Schlaich, M. P., & Matthews, V. B. (2022) · Current Hypertension Reports · doi:10.1007/s11906-022-01170-z · Cited by 30 · see citing works
Self-citationYu, L., Wang, Y., Zhou, X., Huang, B. S., Wang, M., Li, X., Meng, G., Yuan, S., Xia, H., & Jiang, H. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.12.003 · Cited by 29 · see citing works
Sympathetic activity in obesity: a brief review of methods and supportive data
Lambert, G. W., Schlaich, M. P., Eikelis, N., & Lambert, É. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14140 · Cited by 30 · see citing works
Self-citationCentral mechanisms in sympathetic nervous dysregulation in obesity
Patel, M., Braun, J., Lambert, G. W., Kameneva, T., Keatch, C., & Lambert, É. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00254.2023 · Cited by 33 · see citing works
Self-citationSympathovagal Imbalance in Prehypertensive Offspring of Two Parents versus One Parent Hypertensive
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Zhou, R., Li, F., Chen, G., Fu, Q. J., Gu, S., & Wu, X. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13075 · Cited by 29 · see citing works
Sympathoexcitation Associated with Renin‐Angiotensin System in Metabolic Syndrome
Kishi, T., & Hirooka, Y. (2013) · International Journal of Hypertension · doi:10.1155/2013/406897 · Cited by 27 · see citing works
Sympathetic Activation in Obesity
Grassi, G. M., Seravalle, G., & Dell’Oro, R. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.156596 · Cited by 27 · see citing works
Zwack, C. C., McDonald, R. L., Tursunalieva, A., Lambert, G. W., & Lambert, É. (2022) · Journal of Intellectual Disability Research · doi:10.1111/jir.12917 · Cited by 26 · see citing works
Self-citationExercise Training Attenuates Sympathetic Activation and Oxidative Stress in Diet-Induced Obesity
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Sympathovagal Imbalance in Young Prehypertensives: Importance of Male-Female Difference
Pal, G. K., Pal, P., Lalitha, V., Dutta, T. K., Adithan, C., & Nanda, N. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31824ba080 · Cited by 25 · see citing works
Deep breathing improves blunted baroreflex sensitivity even after 30 years of type 1 diabetes
the FinnDiane Study Group, Rosengård‐Bärlund, M., Bernardi, L., Holmqvist, J., Debarbieri, G., Mäntysaari, M., af Björkesten, C.-G., Forsblom, C. M., & Groop, P. (2011) · Diabetologia · doi:10.1007/s00125-011-2164-y · Cited by 25 · see citing works
Antiobesogenic Role of Endothelial Nitric Oxide Synthase
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Diabesity in Elderly Cardiovascular Disease Patients: Mechanisms and Regulators
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Self-citationCircadian hemodynamics in men and women with high blood pressure
Sherwood, A., Hill, L. K., Blumenthal, J. A., & Hinderliter, A. L. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001533 · Cited by 23 · see citing works
Lambert, É., Phillips, S. E., Belski, R., Tursunalieva, A., Eikelis, N., Sari, C. I., Dixon, J. B., Straznicky, N. E., Grima, M. T., Head, G. A., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00876 · Cited by 23 · see citing works
Self-citationLeft ventricular diastolic dysfunction in patients with metabolic syndrome
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Risk of acute coronary syndrome in patients with cervical spondylosis
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The Emerging Epidemic of Hypertension in Asian Children and Adolescents
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Self-citationBone Loss in Obesity and Obstructive Sleep Apnea: A Review of Literature
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Autonomic Nervous System Dysregulation in Pediatric Hypertension
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Hypertension and Diabetes in Obesity
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Self-citationCharacterization of Perivascular Nerve Distribution in Rat Mesenteric Small Arteries
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The incidence of orthostatic intolerance after bariatric surgery
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- Authors
- Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., Straznicky, N., Esler, M., Schlaich, M., & Lambert, G.
- Affiliations
- From the Human Neurotransmitters (E.L., C.I.S., T.D., J.N., M.M., N.E., R.C., N.S., M.E., G.L.), Neurovascular Hypertension and Kidney Disease (M.S.), and Neuropharmacology (K.C., G.H.) Laboratories, Baker IDI Heart and Diabetes Institute, Heart Centre, Alfred Hospital (C.W.), and Faculty of Medicine, Nursing and Health Sciences (M.E., M.S., G.L.), and Departments of Physiology (E.L.) and Pharmacology (G.H.), Monash University, Melbourne, Victoria, Australia.
- Baker Heart and Diabetes Institute (AU)
- Venue
- Hypertension
- Published
- 2010-09
- Volume
- 56
- Issue
- 3
- Pages
- 351-358
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2156328907
- Cited by
- 209
- References
- 58
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 8 · 2017: 20 · 2016: 11 · 2015: 15 · 2014: 24 · 2013: 20 · 2012: 23
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart Foundation of Australia
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, sympathetic nervous system, muscle sympathetic nerve activity, subclinical organ damage, endothelial function, left ventricular hypertrophy, renal function, creatinine clearance, cardiovascular risk, young adults
- MeSH terms
- Adolescent, Adult, Endothelium, Vascular, Female, Heart, Humans, Hypertension, Kidney, Male, Obesity, Regression Analysis, Sympathetic Nervous System, Body Mass Index, Muscle, Skeletal, Statistics, Nonparametric, Overweight
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