Cited by 73Blood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic ControlNeuroscience of respiration and sleep

Role of the Sympathetic Nervous System in Schlager Genetically Hypertensive Mice

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Davern, Pamela J., Nguyen-Huu, Thu-Phuc, La Greca, Luisa, Abdelkader, Amany, Head, Geoffrey A.·2009·Hypertension

Abstract

Early studies indicate that the hypertension observed in the Schlager inbred mouse strain may be attributed to a neurogenic mechanism. In this study, we examined the contribution of the sympathetic nervous system in maintaining hypertension in the BPH/2J mouse and used c-Fos immunohistochemistry to elucidate whether neuronal activation in specific brain regions was associated with waking blood pressure. Male hypertensive (BPH/2J; n=14), normotensive (BPN/3J; n=18), and C57/Bl6 (n=5) mice were implanted with telemetry devices, and after 10 days of recovery, recordings of blood pressure, heart rate, and locomotor activity were measured to determine circadian variation. Mean arterial pressure was higher in BPH/2J than in BPN/3J or C57/Bl6 mice ( P <0.001), and BPH/2J animals showed exaggerated day-night differences (17±2 versus 6±1 mm Hg in BPN/3J or +8±2 mm Hg in C57/Bl6 mice; P <0.001). Acute sympathetic blockade with pentolinium (7.5 mg/kg IP) during the active and inactive phases reduced blood pressure to comparable levels in BPH/2J and BPN/3J mice. The number of c-Fos–labeled cells was greater in the amygdala (+180%; P <0.01), paraventricular nucleus (+110%; P <0.001), and dorsomedial hypothalamus (+48%; P <0.001) in the active (hypertensive) phase in BPH/2J compared with BPN/3J mice. The level of neuronal activation was mostly similar in these regions in the inactive phase. Of all of the regions studied, neuronal activation in the medial amygdala, as detected by c-Fos, was highly correlated to mean arterial pressure ( r =0.98). These findings indicate that the hypertension is largely attributable to sympathetic nervous system activity, possibly generated through greater levels of arousal regulated by neurons located in the medial amygdala.

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Crossref · 10.1161/hypertensionaha.109.136069

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  • BPH/2J mice are a genetic model of lifelong hypertension and show some cardinal features of essential hypertension, including neurohumoral dysfunction, sympathetic activation, cardiac hypertrophy, and kidney atrophy.

    “BPH/2J mice are a model of lifelong hypertension on a genetic basis and manifest some of the cardinal features of essential hypertension, i.e., neurohumoral dysfunction, sympathetic activation, cardiac hypertrophy, and kidney atrophy (58,59).”

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  1. Snedecor GW, Cochran WG: Statistical Methods. Ames, IA: Iowa State University Press; 1980.

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Authors
Davern, P. J., Nguyen-Huu, T.-P., La Greca, L., Abdelkader, A., & Head, G. A.
Affiliations
  • Baker Heart and Diabetes Institute (AU)
  • From the Neuropharmacology Laboratory (P.J.D., T.-P.N.-H., L.L.G., G.A.H.), Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia; Department of Physiology (A.A.), Monash University, Melbourne, Victoria, Australia.
Venue
Hypertension
Published
2009-10
Volume
54
Issue
4
Pages
852-859
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W1967487265
Cited by
73
References
32
Citations by year
2025: 1 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 7 · 2012: 4
FWCI
3.02
Type
journal article
Language
en
Open access
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
sympathetic nervous system, neurogenic hypertension, c-Fos neuronal activation, medial amygdala, paraventricular nucleus, dorsomedial hypothalamus, circadian blood pressure variation, pentolinium, sympathetic nerve block, arousal, mean arterial pressure
MeSH terms
Amygdala, Animals, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Disease Models, Animal, Heart Rate, Hypertension, Hypothalamus, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Motor Activity, Paraventricular Hypothalamic Nucleus, Pentolinium Tartrate, Sympathetic Nervous System, Proto-Oncogene Proteins c-fos, Mice

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