Role of the Sympathetic Nervous System in Schlager Genetically Hypertensive Mice
Open accessAbstract
Early studies indicate that the hypertension observed in the Schlager inbred mouse strain may be attributed to a neurogenic mechanism. In this study, we examined the contribution of the sympathetic nervous system in maintaining hypertension in the BPH/2J mouse and used c-Fos immunohistochemistry to elucidate whether neuronal activation in specific brain regions was associated with waking blood pressure. Male hypertensive (BPH/2J; n=14), normotensive (BPN/3J; n=18), and C57/Bl6 (n=5) mice were implanted with telemetry devices, and after 10 days of recovery, recordings of blood pressure, heart rate, and locomotor activity were measured to determine circadian variation. Mean arterial pressure was higher in BPH/2J than in BPN/3J or C57/Bl6 mice ( P <0.001), and BPH/2J animals showed exaggerated day-night differences (17±2 versus 6±1 mm Hg in BPN/3J or +8±2 mm Hg in C57/Bl6 mice; P <0.001). Acute sympathetic blockade with pentolinium (7.5 mg/kg IP) during the active and inactive phases reduced blood pressure to comparable levels in BPH/2J and BPN/3J mice. The number of c-Fos–labeled cells was greater in the amygdala (+180%; P <0.01), paraventricular nucleus (+110%; P <0.001), and dorsomedial hypothalamus (+48%; P <0.001) in the active (hypertensive) phase in BPH/2J compared with BPN/3J mice. The level of neuronal activation was mostly similar in these regions in the inactive phase. Of all of the regions studied, neuronal activation in the medial amygdala, as detected by c-Fos, was highly correlated to mean arterial pressure ( r =0.98). These findings indicate that the hypertension is largely attributable to sympathetic nervous system activity, possibly generated through greater levels of arousal regulated by neurons located in the medial amygdala.
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BPH/2J mice are a genetic model of lifelong hypertension and show some cardinal features of essential hypertension, including neurohumoral dysfunction, sympathetic activation, cardiac hypertrophy, and kidney atrophy.
“BPH/2J mice are a model of lifelong hypertension on a genetic basis and manifest some of the cardinal features of essential hypertension, i.e., neurohumoral dysfunction, sympathetic activation, cardiac hypertrophy, and kidney atrophy (58,59).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [58]
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Feetham, C. H. (2015) · University of Liverpool · doi:10.17638/02007920
PAPEL DO SISTEMA SIMPÁTICO NA DISFUNÇÃO CARDIOVASCULAR DO CHOQUE SÉPTICO
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- Authors
- Davern, P. J., Nguyen-Huu, T.-P., La Greca, L., Abdelkader, A., & Head, G. A.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- From the Neuropharmacology Laboratory (P.J.D., T.-P.N.-H., L.L.G., G.A.H.), Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia; Department of Physiology (A.A.), Monash University, Melbourne, Victoria, Australia.
- Venue
- Hypertension
- Published
- 2009-10
- Volume
- 54
- Issue
- 4
- Pages
- 852-859
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1967487265
- Cited by
- 73
- References
- 32
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 7 · 2012: 4
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- sympathetic nervous system, neurogenic hypertension, c-Fos neuronal activation, medial amygdala, paraventricular nucleus, dorsomedial hypothalamus, circadian blood pressure variation, pentolinium, sympathetic nerve block, arousal, mean arterial pressure
- MeSH terms
- Amygdala, Animals, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Disease Models, Animal, Heart Rate, Hypertension, Hypothalamus, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Motor Activity, Paraventricular Hypothalamic Nucleus, Pentolinium Tartrate, Sympathetic Nervous System, Proto-Oncogene Proteins c-fos, Mice
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