Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice
Open accessAbstract
Renal denervation (RDNX) lowers mean arterial pressure (MAP) in patients with resistant hypertension. Less well studied is the effect of celiac ganglionectomy (CGX), a procedure which involves the removal of the nerves innervating the splanchnic vascular bed. We hypothesized that RDNX and CGX would both lower MAP in genetically hypertensive Schlager (BPH/2J) mice through a reduction in sympathetic tone. Telemeters were implanted into the femoral artery in mice to monitor MAP before and after RDNX (n=5), CGX (n=6), or SHAM (n=6). MAP, systolic blood pressure, diastolic blood pressure, and heart rate were recorded for 14 days postoperatively. The MAP response to hexamethonium (10 mg/kg, IP) was measured on control day 3 and postoperative day 10 as a measure of global neurogenic pressor activity. The efficacy of denervation was assessed by measurement of tissue norepinephrine. Control MAP was similar among the 3 groups before surgical treatments (≈130 mm Hg). On postoperative day 14, MAP was significantly lower in RDNX (−11±2 mm Hg) and CGX (−11±1 mm Hg) groups compared with their predenervation values. This was not the case in SHAM mice (−5±3 mm Hg). The depressor response to hexamethonium in the RDNX group was significantly smaller on postoperative day 10 (−10±5 mm Hg) compared with baseline control (−25±10 mm Hg). This was not the case in mice in the SHAM (day 10; −28±5 mm Hg) or CGX (day 10; −34±7 mm Hg) group. In conclusion, both renal and splanchnic nerves contribute to hypertension in BPH/2J mice, but likely through different mechanisms.
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Multiple preclinical studies show that total renal denervation causes a significant and sustained fall in mean arterial blood pressure.
“Multiple preclinical studies have demonstrated that total RDN (TRDN, defined as ablation of the sympathetic efferent and sensory afferent nerves) causes a significant and sustained reduction in mean arterial blood pressure20,69–73.”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [69]
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Self-citation
- Authors
- Asirvatham-Jeyaraj, N., Gauthier, M. M., Banek, C. T., Ramesh, A., Garver, H., Fink, G. D., & Osborn, J. W.
- Affiliations
- From the Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (M.M.G., C.T.B., A.R., J.W.O.)
- University of Arizona (US)
- University of Minnesota (US)
- Michigan State University (US)
- Corresponding author
- Osborn, John W.
- ORCID
- Venue
- Hypertension
- Published
- 2021-02
- Volume
- 77
- Issue
- 2
- Pages
- 519-528
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC7803455
- OpenAlex
- W3118548285
- Cited by
- 24
- References
- 39
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 5
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Hypertension (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Michigan State University
- College of Engineering, Michigan State University
- National Heart, Lung, and Blood Institute (R01HL116476, R00HL141650)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- renal denervation, celiac ganglionectomy, resistant hypertension, mean arterial pressure, sympathetic nervous system, splanchnic nerve, hexamethonium, norepinephrine, blood pressure regulation
- MeSH terms
- Animals, Blood Pressure, Denervation, Heart Rate, Hypertension, Kidney, Male, Sympathetic Nervous System, Ganglionectomy, Mice, Arterial Pressure
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