The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Clinical Features of 8295 Patients With Resistant Hypertension Classified on the Basis of Ambulatory Blood Pressure Monitoring
Abstract
We aimed to estimate the prevalence of resistant hypertension through both office and ambulatory blood pressure monitoring in a large cohort of treated hypertensive patients from the Spanish Ambulatory Blood Pressure Monitoring Registry. In addition, we also compared clinical features of patients with true or white-coat–resistant hypertension. In December 2009, we identified 68 045 treated patients with complete information for this analysis. Among them, 8295 (12.2% of the database) had resistant hypertension (office blood pressure ≥140 and/or 90 mm Hg while being treated with ≥3 antihypertensive drugs, 1 of them being a diuretic). After ambulatory blood pressure monitoring, 62.5% of patients were classified as true resistant hypertensives, the remaining 37.5% having white-coat resistance. The former group was younger, more frequently men, with a longer duration of hypertension and a worse cardiovascular risk profile. The group included larger proportions of smokers, diabetics, target organ damage (including left ventricular hypertrophy, impaired renal function, and microalbuminuria), and documented cardiovascular disease. Moreover, true resistant hypertensives exhibited in a greater proportion a riser pattern (22% versus 18%; P <0.001). In conclusion, this study first reports the prevalence of resistant hypertension in a large cohort of patients in usual daily practice. Resistant hypertension is present in 12% of the treated hypertensive population, but among them more than one third have normal ambulatory blood pressure. A worse risk profile is associated with true resistant hypertension, but this association is weak, thus making it necessary to assess ambulatory blood pressure monitoring for a correct diagnosis and management.
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“Among treated adults with hypertension, prevalent aTRH occurs in ≈12% to 15% of population-based13–16 and 15% to 18% of clinic-based reports.17–20”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [18]
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2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,870
Self-citationPickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Circulation · doi:10.1161/01.cir.0000154900.76284.f6 · Cited by 3,985
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,240
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000150859.47929.8e · Cited by 2,051
Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension.
Verdecchia, P., Porcellati, C., Schillaci, G., Borgioni, C., Ciucci, A., Battistelli, M., Guerrieri, M., Gatteschi, C., Zampi, I., Santucci, A., et al. (1994) · Hypertension · doi:10.1161/01.hyp.24.6.793 · Cited by 1,671
O'Brien, E., Asmar, R., Beilin, L., Imai, Y., Mallion, J.-M., Mancia, G., Mengden, T., Myers, M., Padfield, P., Palatini, P., et al. (2003) · Journal of Hypertension · doi:10.1097/00004872-200305000-00001 · Cited by 1,655
Staessen, J. A. (1999) · JAMA · doi:10.1001/jama.282.6.539 · Cited by 1,592
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,416
Dolan, E., Stanton, A., Thijs, L., Hinedi, K., Atkins, N., McClory, S., Hond, E. D., McCormack, P., Staessen, J. A., & O’Brien, E. (2005) · Hypertension · doi:10.1161/01.hyp.0000170138.56903.7a · Cited by 1,227
Ohkubo, T., Hozawa, A., Yamaguchi, J., Kikuya, M., Ohmori, K., Michimata, M., Matsubara, M., Hashimoto, J., Hoshi, H., Araki, T., et al. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00017 · Cited by 1,053
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Evaluación de la hipertensión resistente
Bargalló, E. V., & Bacardit, N. S. (2026) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2025.09.008
Phenotype-Guided Renal Denervation: the Key to Therapeutic Response
Shahverdi, E., Herda, L. R., Shahi, S., Lange, M., & Schneider, C. (2026) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-026-00809-1
Palomo‐Piñón, S., Alcocer, L., Álvarez‐López, H., Enciso‐Muñoz, J. M., Galván‐Oseguera, H., Chávez‐Mendoza, A., Díaz‐Díaz, E., Muñoz, E. G. C., & Rosas-Peralta, M. (2026) · Annals of Clinical Hypertension · doi:10.29328/journal.ach.1001044
Perceptions and practices of primary care physicians in the management of resistant hypertension
Wong, C. W. K., Lee, R., Lee, J., Leong, E. K. F., Ramani, N. V., Tan, N. C., Puar, T. H. K., & Parameswaran, R. (2026) · Singapore Medical Journal · doi:10.4103/singaporemedj.smj-2025-248
Choudhary, A. K., Hait, A., & Baladaniya, M. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1958980
Finerenone-Empagliflozin Combination Therapy in Apparent Resistant Hypertension
Agarwal, R., Navaneethan, S. D., Correa‐Rotter, R., Estrella, M. M., Heerspink, H. J., McGill, J. B., Mottl, A. K., Nangaku, M., Rosenstock, J., Rossing, P., et al. (2026) · JACC Advances · doi:10.1016/j.jacadv.2026.103388
Tocci, G., Burnier, M., de la Sierra, A., Grassi, G. M., Narkiewicz, K., Kreutz, R. H., Tsioufis, K. P., & Volpe, M. (2026) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-026-00824-2
Kardiovaskuläres Risiko besser abschätzen
Lüders, S. (2014) · Pädiatrie · doi:10.1007/s15014-014-0478-1
Metadata
- Authors
- de la Sierra, A., Segura, J., Banegas, J. R., Gorostidi, M., de la Cruz, J. J., Armario, P., Oliveras, A., & Ruilope, L. M.
- Affiliations
- From the Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona (A.d.l.S.), Hypertension Unit (J.S., L.M.R.), Hospital 12 de Octubre, Madrid, Spain; Department of Preventive Medicine and Public Health (J.R.B., J.J.d.l.C.), Autonomous University, Madrid, Spain; Department of Nephrology (M.G.), Hospital Universitario Central de Asturias, Oviedo, Spain; Department of Internal Medicine (P.A.), Hospital General de L'Hospitalet, Barcelona, Spain; Hypertension Unit (A.O.),...
- Universitat Autònoma de Barcelona (ES)
- Venue
- Hypertension
- Published
- 2011-05
- Volume
- 57
- Issue
- 5
- Pages
- 898-902
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2113750355
- Cited by
- 809
- References
- 32
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 32 · 2023: 33 · 2022: 34 · 2021: 25 · 2020: 35 · 2019: 49 · 2018: 41 · 2017: 48 · 2016: 88 · 2015: 68 · 2014: 115 · 2013: 130 · 2012: 63
- FWCI
- 73.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- resistant hypertension, white coat hypertension, ambulatory blood pressure monitoring, prevalence, cardiovascular risk profile, target organ damage, left ventricular hypertrophy, microalbuminuria, renal dysfunction, cardiovascular disease, duration of hypertension, smoking, diabetes mellitus, antihypertensive therapy
- MeSH terms
- Age Factors, Aged, Antihypertensive Agents, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Registries, Risk, Sex Factors, Smoking, Spain, Prevalence, Chi-Square Distribution, Blood Pressure Monitoring, Ambulatory, Statistics, Nonparametric
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