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The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes
Open accessAbstract
The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal level and in response to the mineralocorticoid hormone aldosterone. The goals of the present study were to define the role of Per1 in the regulation of additional renal sodium handling genes in cortical collecting duct cells and to evaluate blood pressure (BP) in mice lacking functional Per1. To determine whether Per1 regulates additional genes important in renal sodium handling, a candidate gene approach was used. Immortalized collecting duct cells were transfected with a nontarget small interfering RNA or a Per1-specific small interfering RNA. Expression of the genes for α-epithelial sodium channel and Fxyd5, a positive regulator of Na, K-ATPase activity, decreased in response to Per1 knockdown. Conversely, mRNA expression of caveolin 1, Ube2e3, and ET-1, all negative effectors of epithelial sodium channel, was induced after Per1 knockdown. These results led us to evaluate BP in Per1 KO mice. Mice lacking Per1 exhibit significantly reduced BP and elevated renal ET-1 levels compared with wild-type animals. Given the established role of renal ET-1 in epithelial sodium channel inhibition and BP control, elevated renal ET-1 is one possible explanation for the lower BP observed in Per1 KO mice. These data support a role for the circadian clock protein Per1 in the coordinate regulation of genes involved in renal sodium reabsorption. Importantly, the lower BP observed in Per1 KO mice compared with wild-type mice suggests a role for Per1 in BP control as well.
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“PER1 plays an important role in BP maintenance by regulating aldosterone levels and affecting sodium retention (71)(72)(73).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [73]
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Metadata
- Authors
- Stow, L. R., Richards, J., Cheng, K.-Y., Lynch, I. J., Jeffers, L. A., Greenlee, M. M., Cain, B. D., Wingo, C. S., & Gumz, M. L.
- Affiliations
- Emory University (US)
- Corresponding author
- Gumz, Michelle L.
- Venue
- Hypertension
- Published
- 2012-06
- Volume
- 59
- Issue
- 6
- Pages
- 1151-1156
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3366275
- OpenAlex
- W2099470856
- Cited by
- 146
- References
- 39
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 12 · 2017: 3 · 2016: 13 · 2015: 9 · 2014: 18 · 2013: 14 · 2012: 3
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health (UL1TR000064)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK082680, T32 DK07518, T32DK007518, R01DK082680, DK-085193, K01DK085193)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- circadian clock, blood pressure regulation, renal sodium transport, epithelial sodium channel, cortical collecting duct, endothelin-1, caveolin-1, FXYD5, Na+/K+-ATPase, aldosterone, gene expression regulation
- MeSH terms
- Animals, Blood Pressure, Cell Line, Cell Line, Transformed, Gene Expression Regulation, Kidney Tubules, Collecting, Male, Models, Genetic, Sodium, Blotting, Western, Ion Transport, Mice, Knockout, Endothelin-1, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference, Ubiquitin-Conjugating Enzymes, Caveolin 1, Mice, Epithelial Sodium Channels, Period Circadian Proteins, Mice, 129 Strain
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