The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes
Open accessAbstract
The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal level and in response to the mineralocorticoid hormone aldosterone. The goals of the present study were to define the role of Per1 in the regulation of additional renal sodium handling genes in cortical collecting duct cells and to evaluate blood pressure (BP) in mice lacking functional Per1. To determine whether Per1 regulates additional genes important in renal sodium handling, a candidate gene approach was used. Immortalized collecting duct cells were transfected with a nontarget small interfering RNA or a Per1-specific small interfering RNA. Expression of the genes for α-epithelial sodium channel and Fxyd5, a positive regulator of Na, K-ATPase activity, decreased in response to Per1 knockdown. Conversely, mRNA expression of caveolin 1, Ube2e3, and ET-1, all negative effectors of epithelial sodium channel, was induced after Per1 knockdown. These results led us to evaluate BP in Per1 KO mice. Mice lacking Per1 exhibit significantly reduced BP and elevated renal ET-1 levels compared with wild-type animals. Given the established role of renal ET-1 in epithelial sodium channel inhibition and BP control, elevated renal ET-1 is one possible explanation for the lower BP observed in Per1 KO mice. These data support a role for the circadian clock protein Per1 in the coordinate regulation of genes involved in renal sodium reabsorption. Importantly, the lower BP observed in Per1 KO mice compared with wild-type mice suggests a role for Per1 in BP control as well.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“PER1 plays an important role in BP maintenance by regulating aldosterone levels and affecting sodium retention (71)(72)(73).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [73]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
Farré, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg605 · Cited by 1,057
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 905
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431
Regulation of Blood Pressure and Salt Homeostasis by Endothelin
Kohan, D. E., Rossi, N. F., Inscho, E. W., & Pollock, D. M. (2011) · Physiological Reviews · doi:10.1152/physrev.00060.2009 · Cited by 430
Circadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 408
Vascular Disease in Mice With a Dysfunctional Circadian Clock
Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 298
Bens, M., Vallet, V., Cluzeaud, F., Tallec, L. P.-L., Kahn, A., Rafestin-Oblin, M. E., Rossier, B. C., & Vandewalle, A. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v105923 · Cited by 286
Butz, G. M., & Davisson, R. L. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.2.89 · Cited by 282
Molecular clock is involved in predictive circadian adjustment of renal function
Zuber, A. M., Centeno, G., Pradervand, S., Nikolaeva, S., Maquelin, L., Cardinaux, L., Bonny, O., & Firsov, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904890106 · Cited by 274
Collecting duct–specific knockout of endothelin-1 causes hypertension and sodium retention
Ahn, D., Ge, Y., Stricklett, P. K., Gill, P. S., Taylor, D., Hughes, A. K., Yanagisawa, M., Miller, L., Nelson, R. D., & Kohan, D. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21064 · Cited by 262
Stow, L. R., Jacobs, M. E., Wingo, C. S., & Cain, B. D. (2010) · The FASEB Journal · doi:10.1096/fj.10-161612 · Cited by 253
Self-citationAlbrecht, U., & Gregor Eichele, C. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00055-8 · Cited by 239
Circadian variation of blood pressure: The basis for the chronotherapy of hypertension
Hermida, R. C., Ayala, D. E., & Portaluppi, F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.08.003 · Cited by 224
Gumz, M. L., Stow, L. R., Lynch, I. J., Greenlee, M. M., Rudin, A., Cain, B. D., Weaver, D. R., & Wingo, C. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36908 · Cited by 216
Self-citationMetabolic Syndrome in Permanent Night Workers
Biggi, N., Consonni, D., Galluzzo, V., Sogliani, M., & Costa, G. (2008) · Chronobiology International · doi:10.1080/07420520802114193 · Cited by 213
Robert-Nicoud, M., Flahaut, M., Elalouf, J., Nicod, M., Salinas, M., Bens, M., Doucet, A., Wincker, P., Artiguenave, F., Horisberger, J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051603198 · Cited by 212
Badura, L., Swanson, T., Adamowicz, W., Adams, J., Cianfrogna, J., Fisher, K., Holland, J., Kleiman, R., Nelson, F., Reynolds, L., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.122846 · Cited by 176
The Circadian Clock in the Kidney
Stow, L. R., & Gumz, M. L. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010080803 · Cited by 147
Self-citationHatanaka, F., Matsubara, C., Myung, J., Yoritaka, T., Kamimura, N., Tsutsumi, S., Kanai, A., Suzuki, Y., Sassone‐Corsi, P., Aburatani, H., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00781-10 · Cited by 140
Hartner, A. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg299 · Cited by 138
Early Aldosterone-Induced Gene Product Regulates the Epithelial Sodium Channel by Deubiquitylation
Fakitsas, P., Adam, G., Daidie[Combining Acute Accent], D. A. A., van Bemmelen, M. X., Fouladkou, F., Patrignani, A., Wagner, U., Warth, R., Camargo, S. M. R., Staub, O., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080902 · Cited by 136
Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line
Gumz, M. L., Popp, M. P., Wingo, C. S., & Cain, B. D. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00353.2002 · Cited by 123
Self-citationInteraction with the Na,K-ATPase and Tissue Distribution of FXYD5 (Related to Ion Channel)
Lubarski, I., Pihakaski‐Maunsbach, K., KARLISH, S. J. D., Maunsbach, A. B., & Garty, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506397200 · Cited by 102
Regulation of the epithelial Na + channel by endothelin-1 in rat collecting duct
Bugaj, V., Pochynyuk, O. M., Mironova, E., Vandewalle, A., Medina, J., & Stockand, J. D. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90321.2008 · Cited by 101
Su, T., Lin, L., Baker, D. B., Schnall, P. L., Chen, M.-F., Hwang, W., Chen, C., & Wang, J. (2008) · Journal of Occupational Health · doi:10.1539/joh.l7056 · Cited by 92
The mammalian circadian clock: a network of gene expression
Albrecht, U. (2004) · Frontiers in bioscience · doi:10.2741/1196 · Cited by 87
Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms
Vukolic, A., Antic, V., Vliet, B. N. V., Yang, Z., Albrecht, U., & Montani, J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00404.2009 · Cited by 85
Identification of mPer1 Phosphorylation Sites Responsible for the Nuclear Entry
Takano, A., Isojima, Y., & Nagai, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403433200 · Cited by 79
Regulation of amiloride-sensitive Na+ channels by endothelin-1 in distal nephron cells
Gallego, M. S., & Ling, B. N. (1996) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1996.271.2.f451 · Cited by 76
Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCDc14 cells
Gumz, M. L., Cheng, K., Lynch, I. J., Stow, L. R., Greenlee, M. M., Cain, B. D., & Wingo, C. S. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.09.003 · Cited by 70
Self-citationCollecting duct-specific endothelin B receptor knockout increases ENaC activity
Bugaj, V., Mironova, E., Kohan, D. E., & Stockand, J. D. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00301.2011 · Cited by 63
Lee, I., Campbell, C. R., Song, S., Day, M. L., Kumar, S., Cook, D. I., & Dinudom, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809737200 · Cited by 58
Aldosterone Modulates Steroid Receptor Binding to the Endothelin-1 Gene (edn1)
Stow, L. R., Gumz, M. L., Lynch, I. J., Greenlee, M. M., Rudin, A., Cain, B. D., & Wingo, C. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030718 · Cited by 58
Self-citationRegulation of Epithelial Na+ Transport by Soluble Adenylyl Cyclase in Kidney Collecting Duct Cells
Hallows, K. R., Wang, H., Edinger, R. S., Butterworth, M. B., Oyster, N. M., Li, H., Buck, J., Levin, L. R., Johnson, J. P., & Pastor‐Soler, N. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805501200 · Cited by 51
Debonneville, C., & Staub, O. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2397-2409.2004 · Cited by 35
Bose, S. K., & Boockfor, F. R. (2010) · Endocrinology · doi:10.1210/en.2009-1252 · Cited by 32
Sprouse, J. S., Reynolds, L. S., Swanson, T. A., & Engwall, M. J. A. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1503-x · Cited by 31
Chang, C., Wu, M.-S., Tian, Y., Chen, K.-H., Yu, C.-C., Liao, C., Hung, C.-C., & Yang, C. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl668 · Cited by 23
Flagged first, then by citations
Research works printed but not linked: 1
- 10.1172/JCI200421064 · DOI
Cited by
Sorted by citations
Salt Sensitivity of Blood Pressure: A Scientific Statement From the American Heart Association
Elijovich, F., Weinberger, M. H., Anderson, C. A. M., Appel, L. J., Bursztyn, M., Cook, N. R., Dart, R. A., Newton-Cheh, C. H., Sacks, F. M., & Laffer, C. L. (2016) · Hypertension · doi:10.1161/hyp.0000000000000047 · Cited by 482
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443
An Integrated View of Potassium Homeostasis
Gumz, M. L., Rabinowitz, L., & Wingo, C. S. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1313341 · Cited by 299
Self-citationHealth Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291
Circadian clock-mediated regulation of blood pressure
Douma, L. G., & Gumz, M. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.024 · Cited by 267
Self-citation
Metadata
- Authors
- Stow, L. R., Richards, J., Cheng, K.-Y., Lynch, I. J., Jeffers, L. A., Greenlee, M. M., Cain, B. D., Wingo, C. S., & Gumz, M. L.
- Affiliations
- Emory University (US)
- Corresponding author
- Gumz, Michelle L.
- Venue
- Hypertension
- Published
- 2012-06
- Volume
- 59
- Issue
- 6
- Pages
- 1151-1156
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3366275
- OpenAlex
- W2099470856
- Cited by
- 146
- References
- 39
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 12 · 2017: 3 · 2016: 13 · 2015: 9 · 2014: 18 · 2013: 14 · 2012: 3
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health (UL1TR000064)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK082680, T32 DK07518, T32DK007518, R01DK082680, DK-085193, K01DK085193)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- circadian clock, blood pressure regulation, renal sodium transport, epithelial sodium channel, cortical collecting duct, endothelin-1, caveolin-1, FXYD5, Na+/K+-ATPase, aldosterone, gene expression regulation
- MeSH terms
- Animals, Blood Pressure, Cell Line, Cell Line, Transformed, Gene Expression Regulation, Kidney Tubules, Collecting, Male, Models, Genetic, Sodium, Blotting, Western, Ion Transport, Mice, Knockout, Endothelin-1, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference, Ubiquitin-Conjugating Enzymes, Caveolin 1, Mice, Epithelial Sodium Channels, Period Circadian Proteins, Mice, 129 Strain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
