The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Circadian Protein Period 1 Contributes to Blood Pressure Control and Coordinately Regulates Renal Sodium Transport Genes
Open accessAbstract
The circadian clock protein period 1 (Per1) contributes to the regulation of expression of the α subunit of the renal epithelial sodium channel at the basal level and in response to the mineralocorticoid hormone aldosterone. The goals of the present study were to define the role of Per1 in the regulation of additional renal sodium handling genes in cortical collecting duct cells and to evaluate blood pressure (BP) in mice lacking functional Per1. To determine whether Per1 regulates additional genes important in renal sodium handling, a candidate gene approach was used. Immortalized collecting duct cells were transfected with a nontarget small interfering RNA or a Per1-specific small interfering RNA. Expression of the genes for α-epithelial sodium channel and Fxyd5, a positive regulator of Na, K-ATPase activity, decreased in response to Per1 knockdown. Conversely, mRNA expression of caveolin 1, Ube2e3, and ET-1, all negative effectors of epithelial sodium channel, was induced after Per1 knockdown. These results led us to evaluate BP in Per1 KO mice. Mice lacking Per1 exhibit significantly reduced BP and elevated renal ET-1 levels compared with wild-type animals. Given the established role of renal ET-1 in epithelial sodium channel inhibition and BP control, elevated renal ET-1 is one possible explanation for the lower BP observed in Per1 KO mice. These data support a role for the circadian clock protein Per1 in the coordinate regulation of genes involved in renal sodium reabsorption. Importantly, the lower BP observed in Per1 KO mice compared with wild-type mice suggests a role for Per1 in BP control as well.
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“PER1 plays an important role in BP maintenance by regulating aldosterone levels and affecting sodium retention (71)(72)(73).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [73]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
Farré, D. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg605 · Cited by 1,057
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 905
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431
Regulation of Blood Pressure and Salt Homeostasis by Endothelin
Kohan, D. E., Rossi, N. F., Inscho, E. W., & Pollock, D. M. (2011) · Physiological Reviews · doi:10.1152/physrev.00060.2009 · Cited by 430
Circadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 408
Vascular Disease in Mice With a Dysfunctional Circadian Clock
Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 298
Bens, M., Vallet, V., Cluzeaud, F., Tallec, L. P.-L., Kahn, A., Rafestin-Oblin, M. E., Rossier, B. C., & Vandewalle, A. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v105923 · Cited by 286
Butz, G. M., & Davisson, R. L. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.2.89 · Cited by 282
Molecular clock is involved in predictive circadian adjustment of renal function
Zuber, A. M., Centeno, G., Pradervand, S., Nikolaeva, S., Maquelin, L., Cardinaux, L., Bonny, O., & Firsov, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904890106 · Cited by 274
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Salt Sensitivity of Blood Pressure: A Scientific Statement From the American Heart Association
Elijovich, F., Weinberger, M. H., Anderson, C. A. M., Appel, L. J., Bursztyn, M., Cook, N. R., Dart, R. A., Newton-Cheh, C. H., Sacks, F. M., & Laffer, C. L. (2016) · Hypertension · doi:10.1161/hyp.0000000000000047 · Cited by 482
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443
An Integrated View of Potassium Homeostasis
Gumz, M. L., Rabinowitz, L., & Wingo, C. S. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1313341 · Cited by 299
Self-citationHealth Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291
Circadian clock-mediated regulation of blood pressure
Douma, L. G., & Gumz, M. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.024 · Cited by 267
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Metadata
- Authors
- Stow, L. R., Richards, J., Cheng, K.-Y., Lynch, I. J., Jeffers, L. A., Greenlee, M. M., Cain, B. D., Wingo, C. S., & Gumz, M. L.
- Affiliations
- Emory University (US)
- Corresponding author
- Gumz, Michelle L.
- Venue
- Hypertension
- Published
- 2012-06
- Volume
- 59
- Issue
- 6
- Pages
- 1151-1156
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3366275
- OpenAlex
- W2099470856
- Cited by
- 146
- References
- 39
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 12 · 2017: 3 · 2016: 13 · 2015: 9 · 2014: 18 · 2013: 14 · 2012: 3
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health (UL1TR000064)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK082680, T32 DK07518, T32DK007518, R01DK082680, DK-085193, K01DK085193)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- circadian clock, blood pressure regulation, renal sodium transport, epithelial sodium channel, cortical collecting duct, endothelin-1, caveolin-1, FXYD5, Na+/K+-ATPase, aldosterone, gene expression regulation
- MeSH terms
- Animals, Blood Pressure, Cell Line, Cell Line, Transformed, Gene Expression Regulation, Kidney Tubules, Collecting, Male, Models, Genetic, Sodium, Blotting, Western, Ion Transport, Mice, Knockout, Endothelin-1, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference, Ubiquitin-Conjugating Enzymes, Caveolin 1, Mice, Epithelial Sodium Channels, Period Circadian Proteins, Mice, 129 Strain
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