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Cited by 25Blood Pressure and Hypertension StudiesProtein Tyrosine PhosphatasesDiabetes, Cardiovascular Risks, and Lipoproteins

Increasing Peripheral Insulin Sensitivity by Protein Tyrosine Phosphatase 1B Deletion Improves Control of Blood Pressure in Obesity

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de Chantemèle, Eric J. Belin, Ali, Mohammed Irfan, Mintz, James D., Rainey, William E., Tremblay, Michel L., Fulton, David J., Stepp, David W.·2012·Hypertension
DOI 10.1161/hypertensionaha.112.196295PMC PMC3475734
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Abstract

Obesity is a major risk factor for hypertension. The copresentation of hypertension and insulin resistance (IR) suggests a role for IR in blood pressure (BP) dysregulation. To test this hypothesis, peripheral IR has been genetically subtracted in a model of obesity by crossing leptin receptor mutant mice (K db H PTP ) with mice lacking protein tyrosine phosphatase 1B (insulin desensitizer, H db K PTP ) to generate obese insulin-sensitive mice (K db K PTP ). BP was recorded in lean (H db H PTP , H db K PTP ) and obese (K db H PTP , K db K PTP ) mice via telemetry, and a frequency analysis of the recording was performed to determine BP variability. Correction of IR in obese mice normalized BP values to baseline levels (H db H PTP : 116±2 mm Hg; K db H PTP : 129±4 mm Hg; K db K PTP : 114±5 mm Hg) and restored BP variability by decreasing its standard deviation and the frequency of BP values over the upper autoregulatory limit of the kidneys. However, although IR-induced increases in proteinuria (versus 53±13 μg/d, H db H PTP ) were corrected in K db K PTP (112±39 versus 422±159 μg/d, K db H PTP ), glomerular hypertrophy was not. IR reduced plasma aldosterone levels ruling out a role for mineralocorticoids in the development of hypertension. Taken together, these data indicate that correction of IR prevents hypertension, BP variability, and microalbuminuria in obese mice. Although the mechanism remains to be fully determined, increases in aldosterone or sympathoactivation of the cardiovascular system seem to be less likely contributors.

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  • Obesity is associated with several other changes in the kidney that promote the development of hypertension as well as chronic kidney disease and end-stage renal disease.

    “Obesity is associated with several other changes in the kidney that promote the development of hypertension as well as chronic kidney disease and end-stage renal disease.”

    From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [64]

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Authors
de Chantemèle, E. J. B., Ali, M. I., Mintz, J. D., Rainey, W. E., Tremblay, M. L., Fulton, D. J., & Stepp, D. W.
Affiliations
  • From the Vascular Biology Center (E.J.B.d.C., M.I.A., J.D.M., D.J.F., D.W.S), Department of Physiology (E.J.B.d.C., W.E.R., D.W.S.), and Department of Pharmacology (D.J.F.), Georgia Health Sciences University, Augusta, GA; Goodman Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec, Canada (M.L.T.).
  • McGill University (CA)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-11
Volume
60
Issue
5
Pages
1273-1279
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.112.196295
PMC
PMC3475734
OpenAlex
W2156496741
Cited by
25
References
49
Citations by year
2026: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 3
FWCI
2.47
Type
journal article
Language
en
Open access
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL092446)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
PTP1B, insulin resistance, obesity, blood pressure variability, microalbuminuria, proteinuria, glomerular hypertrophy, aldosterone, renal autoregulation
MeSH terms
Albuminuria, Aldosterone, Animals, Blood Pressure, Dose-Response Relationship, Drug, Female, Ganglionic Blockers, Heart Rate, Hypertension, Hypertrophy, Insulin Resistance, Kidney Glomerulus, Male, Mecamylamine, Mesenteric Arteries, Mice, Inbred C57BL, Obesity, Phenylephrine, Sympathetic Nervous System, Vasoconstriction, Mice, Knockout, Mice, Receptors, Leptin, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Adrenergic alpha-1 Receptor Agonists, In Vitro Techniques

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