Cellular and Molecular Mechanisms of Arterial Stiffness Associated With Obesity
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Multiple mechanisms, including sympathetic overdrive, inflammatory mediators, excessive reactive oxygen species production, and decreased nitric oxide bioactivity, may contribute to the deleterious effects of obesity on the vasculature.
“Multiple other mechanisms including sympathetic overdrive, inflammatory mediators, excessive reactive oxygen species production, decreased NO bioactivity may contribute to the deleterious effects of obesity on the vasculature (70;71;74;75).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [75]
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Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension
Kaess, B. M., Rong, J., Larson, M. G., Hamburg, N. M., Vita, J. A., Levy, D. A., Benjamin, E. J., Vasan, R. S., & Mitchell, G. F. (2012) · JAMA · doi:10.1001/2012.jama.10503 · Cited by 1,086 · see citing works
Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Weisbrod, R. M., Shiang, T., Al Sayah, L., Fry, J. L., Bajpai, S., Reinhart-King, C. A., Lob, H. E., Santhanam, L., Mitchell, G., Cohen, R. A., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01744 · Cited by 317 · see citing works
Salt overload damages the glycocalyx sodium barrier of vascular endothelium
Oberleithner, H., Peters, W., Kusche‐Vihrog, K., et al. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0999-1 · Cited by 235 · see citing works
Mortality, Health Outcomes, and Body Mass Index in the Overweight Range
Lewis, C. E., McTigue, K. M., Burke, L. E., Poirier, P., Eckel, R. H., Howard, B. V., Allison, D. B., Kumanyika, S., & Pi-Sunyer, X. (2009) · Circulation · doi:10.1161/circulationaha.109.192574 · Cited by 184 · see citing works
Hypertension and Vascular Dynamics in Men and Women With Metabolic Syndrome
Safar, M. E., Balkau, B., Lange, C., Protogerou, A. D., Czernichow, S., Blacher, J., Levy, B. I., & Smulyan, H. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.01.088 · Cited by 118 · see citing works
Mitchell, G. F., Verwoert, G. C., Tarasov, K. V., Isaacs, A. J., Smith, A. V., Yasmin, Y., Rietzschel, E. R., Tanaka, T., Liu, Y., Parsa, A., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.959817 · Cited by 108 · see citing works
Arterial Stiffness as Surrogate End Point
Laurent, S., Briet, M. B., & Boutouyrie, P. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.194456 · Cited by 105 · see citing works
Disturbance of macro- and microcirculation: relations with pulse pressure and cardiac organ damage
Safar, M. E., & Lacolley, P. J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00063.2007 · Cited by 92 · see citing works
Windham, B. G., Griswold, M. E., Farasat, S. M., Ling, S. M., Carlson, O., Egan, J. M., Ferrucci, L., & Najjar, S. S. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.8 · Cited by 86 · see citing works
Molecular mechanisms of arterial stiffness: new insights
Luft, F. C. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2012.10.004 · Cited by 53 · see citing works
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Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis
Rahmouni, K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.00920 · Cited by 150 · see citing works
- Authors
- Leopold, J. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Leopold, Jane A.
- ORCID
- Leopold, Jane A.
- Venue
- Hypertension
- Published
- 2013-12
- Volume
- 62
- Issue
- 6
- Pages
- 1003-1004
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3905983
- OpenAlex
- W2144336921
- Cited by
- 31
- References
- 10
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL105301, R01HL105301)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- arterial stiffness, obesity, vascular function, cellular mechanisms, molecular mechanisms
- MeSH terms
- Animals, Aorta, Diet, Hypertension, Obesity, Vascular Stiffness
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