Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial
Open accessAbstract
IMPORTANCE: The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain. OBJECTIVE: To evaluate the effects of intensive (<120 mm Hg) compared with standard (<140 mm Hg) SBP targets in persons aged 75 years or older with hypertension but without diabetes. DESIGN, SETTING, AND PARTICIPANTS: A multicenter, randomized clinical trial of patients aged 75 years or older who participated in the Systolic Blood Pressure Intervention Trial (SPRINT). Recruitment began on October 20, 2010, and follow-up ended on August 20, 2015. INTERVENTIONS: Participants were randomized to an SBP target of less than 120 mm Hg (intensive treatment group, n = 1317) or an SBP target of less than 140 mm Hg (standard treatment group, n = 1319). MAIN OUTCOMES AND MEASURES: The primary cardiovascular disease outcome was a composite of nonfatal myocardial infarction, acute coronary syndrome not resulting in a myocardial infarction, nonfatal stroke, nonfatal acute decompensated heart failure, and death from cardiovascular causes. All-cause mortality was a secondary outcome. RESULTS: Among 2636 participants (mean age, 79.9 years; 37.9% women), 2510 (95.2%) provided complete follow-up data. At a median follow-up of 3.14 years, there was a significantly lower rate of the primary composite outcome (102 events in the intensive treatment group vs 148 events in the standard treatment group; hazard ratio [HR], 0.66 [95% CI, 0.51-0.85]) and all-cause mortality (73 deaths vs 107 deaths, respectively; HR, 0.67 [95% CI, 0.49-0.91]). The overall rate of serious adverse events was not different between treatment groups (48.4% in the intensive treatment group vs 48.3% in the standard treatment group; HR, 0.99 [95% CI, 0.89-1.11]). Absolute rates of hypotension were 2.4% in the intensive treatment group vs 1.4% in the standard treatment group (HR, 1.71 [95% CI, 0.97-3.09]), 3.0% vs 2.4%, respectively, for syncope (HR, 1.23 [95% CI, 0.76-2.00]), 4.0% vs 2.7% for electrolyte abnormalities (HR, 1.51 [95% CI, 0.99-2.33]), 5.5% vs 4.0% for acute kidney injury (HR, 1.41 [95% CI, 0.98-2.04]), and 4.9% vs 5.5% for injurious falls (HR, 0.91 [95% CI, 0.65-1.29]). CONCLUSIONS AND RELEVANCE: Among ambulatory adults aged 75 years or older, treating to an SBP target of less than 120 mm Hg compared with an SBP target of less than 140 mm Hg resulted in significantly lower rates of fatal and nonfatal major cardiovascular events and death from any cause. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01206062.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The SPRINT trial was stopped early because intensive blood pressure treatment produced significantly fewer cardiovascular events and deaths than standard treatment.
“The US and Puerto Rico Systolic Blood Pressure Intervention Trial (SPRINT) in 9361 hypertensive adults aged 50 years and older, was stopped early because of significantly fewer cardiovascular events and deaths occurring in the intensive treatment arm (aiming for systolic <120 mm Hg, n=4678) in comparison with standard treatment (systolic <140 mm Hg, n=4683).”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [78]
The Methods (Statistical Analysis) say the SPRINT intervention was stopped on August 20, 2015, and the Results (Clinical Outcomes) report significantly fewer cardiovascular composite events and deaths with intensive treatment. But this paper reports those outcomes for 2,636 participants aged 75 or older, not the cited sentence’s full trial of 9,361 adults aged 50 or older, and it does not explicitly say the outcome differences were the reason for stopping. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53221.x · Cited by 25,553 · see citing works
A Proportional Hazards Model for the Subdistribution of a Competing Risk
Fine, J. P., & Gray, R. J. (1999) · Journal of the American Statistical Association · doi:10.1080/01621459.1999.10474144 · Cited by 14,290 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
James, P. A., Oparil, S., Carter, B. L., Cushman, W. C., Dennison-Himmelfarb, C., Handler, J., Lackland, D. T., LeFevre, M. L., MacKenzie, T. D., Ogedegbe, O., et al. (2014) · JAMA · doi:10.1001/jama.2013.284427 · Cited by 7,950 · see citing works
Self-citationA Randomized Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511939 · Cited by 6,325 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Self-citationHEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595 · see citing works
Effects of intensive blood-pressure control in type 2 diabetes mellitus
(2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001286 · Cited by 3,598 · see citing works
Treatment of hypertension in patients 80 years of age or older
Beckett, N. S., Peters, R., Fletcher, A. E., Staessen, J. A., Liu, L., Dumitrascu, D., Stoyanovsky, V., Antikainen, R. L., Nikitin, Y., Anderson, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0801369 · Cited by 3,092 · see citing works
Abellan Van Kan, G., Rolland, Y., Andrieu, S., Bauer, J., Beauchet, O., Bonnefoy, M., Cesari, M., Donini, L. M., Gillette-Guyonnet, S., Inzitari, M., et al. (2009) · The Journal of nutrition, health and aging · doi:10.1007/s12603-009-0246-z · Cited by 2,003 · see citing works
The J-Curve Phenomenon in Hypertension
Kang, Y., & Wang, J. (2016) · Pulse · doi:10.1159/000446922 · Cited by 1,548 · see citing works
On the regression analysis of multivariate failure time data
Prentice, R., Williams, B., & Peterson, A. V. (1981) · Biometrika · doi:10.1093/biomet/68.2.373 · Cited by 1,362 · see citing works
Confidence intervals for the number needed to treat.
Altman, D. G. (1998) · BMJ · doi:10.1136/bmj.317.7168.1309 · Cited by 938 · see citing works
Bakris, G. L., & Weir, M. R. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.5.685 · Cited by 823 · see citing works
Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial
* (2013) · The Lancet · doi:10.1016/s0140-6736(13)60852-1 · Cited by 751 · see citing works
A Randomized Trial of Intensive versus Standard Blood-Pressure Control
Bangalore, S., Rimoldi, S., & Messerli, F. H. (2016) · New England Journal of Medicine · doi:10.1056/nejmc1602668 · Cited by 652 · see citing works
Ambrosius, W. T., Sink, K. M., Foy, C. G., Berlowitz, D. R., Cheung, A. K., Cushman, W. C., Fine, L. J., Goff, D. C., Johnson, K., Killeen, A. A., et al. (2014) · Clinical Trials · doi:10.1177/1740774514537404 · Cited by 544 · see citing works
Self-citationFrailty in NHANES: Comparing the frailty index and phenotype
Blodgett, J. M., Theou, O., Kirkland, S., Andreou, P., & Rockwood, K. J. (2015) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.01.016 · Cited by 430 · see citing works
Warwick, J., Falaschetti, E., Rockwood, K. J., Mitnitski, A., Thijs, L., Beckett, N. S., Bulpitt, C. J., & Peters, R. K. (2015) · BMC Medicine · doi:10.1186/s12916-015-0328-1 · Cited by 329 · see citing works
Gangavati, A., Hajjar, I. M., Quach, L., Jones, R. N., Kiely, D. K., Gagnon, P., & Lipsitz, L. A. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03317.x · Cited by 328 · see citing works
Wright, J. T., Fine, L. J., Lackland, D. T., Ogedegbe, G. G., & Himmelfarb, C. D. (2014) · Annals of Internal Medicine · doi:10.7326/m13-2981 · Cited by 317 · see citing works
Self-citationFerrucci, L. (1997) · JAMA · doi:10.1001/jama.1997.03540330050034 · Cited by 279 · see citing works
Self‐Reported Causes of Physical Disability in Older People: The Cardiovascular Health Study
Ettinger, W. H., Fried, L. P., Harris, T. B., Shemanski, L. R., Schulz, R., & Robbins, J. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06206.x · Cited by 275 · see citing works
Validation of an index to estimate the prevalence of frailty among community-dwelling seniors.
Hoover, M., Rotermann, M., Sanmartin, C., & Bernier, J. (2013) · PubMed · Cited by 251 · see citing works
Ooi, W. L. (1997) · JAMA · doi:10.1001/jama.1997.03540400049030 · Cited by 228 · see citing works
Apperloo, A. J., de Zeeuw, D., & de Jong, P. E. (1997) · Kidney International · doi:10.1038/ki.1997.111 · Cited by 202 · see citing works
Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial
Pajewski, N. M., Williamson, J. D., Applegate, W. B., Berlowitz, D. R., Bolin, L. P., Chertow, G. M., Krousel-Wood, M. A., Barrera, N. L., Powell, J. R., Roumie, C. L., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv228 · Cited by 187 · see citing works
Self-citationGeneralizability of SPRINT Results to the U.S. Adult Population
Bress, A. P., Tanner, R. M., Hess, R., Colantonio, L. D., Shimbo, D., & Muntner, P. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.037 · Cited by 144 · see citing works
Updated National and International Hypertension Guidelines: A Review of Current Recommendations
Kjeldsen, S. E., Feldman, R. D., Lisheng, L., Mourad, J., Chiang, C., Zhang, W., Wu, Z., Li, W., & Williams, B. (2014) · Drugs · doi:10.1007/s40265-014-0306-5 · Cited by 123 · see citing works
Dong, H., Robison, L. L., Leisenring, W. M., Martin, L. J., Armstrong, G. T., & Yasui, Y. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwu289 · Cited by 106 · see citing works
On the Regression Analysis of Multivariate Failure Time Data
PRENTICE, R. L., Williams, B. J., & Peterson, A. V. (1981) · Biometrika · doi:10.2307/2335582 · Cited by 91 · see citing works
Using Benefit-Based Tailored Treatment to Improve the Use of Antihypertensive Medications
Sussman, J. B., Vijan, S. S., & Hayward, R. A. (2013) · Circulation · doi:10.1161/circulationaha.113.002290 · Cited by 84 · see citing works
Margolis, K. L., Palermo, L., Vittinghoff, E., Evans, G. W., Atkinson, H. H., Hamilton, B. P., Josse, R. G., O’Connor, P. J., Simmons, D. L., Tiktin, M., et al. (2014) · Journal of General Internal Medicine · doi:10.1007/s11606-014-2961-3 · Cited by 75 · see citing works
Systolic and Diastolic Blood Pressure, Incident Cardiovascular Events, and Death in Elderly Persons
Peralta, C. A., Katz, R., Newman, A. B., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03831 · Cited by 64 · see citing works
High Blood Pressure, Physical and Cognitive Function, and Risk of Stroke in the Oldest Old
Sabayan, B., van Vliet, P., de Ruijter, W., Gussekloo, J., de Craen, A. J. M., & Westendorp, R. G. J. (2012) · Stroke · doi:10.1161/strokeaha.112.663062 · Cited by 61 · see citing works
Functional Status and Antihypertensive Therapy in Older Adults: A New Perspective on Old Data
Charlesworth, C. J., Peralta, C. A., & Odden, M. C. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv177 · Cited by 46 · see citing works
Ooi, W. L. (1997) · JAMA · doi:10.1001/jama.277.16.1299 · Cited by 35 · see citing works
Ferrucci, L. (1997) · JAMA · doi:10.1001/jama.277.9.728 · Cited by 33 · see citing works
Windham, B. G., Griswold, M. E., Lirette, S. T., Kucharska‐Newton, A., Foraker, R. E., Rosamond, W. D., Coresh, J., Kritchevsky, S. B., & Mosley, T. H. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv162 · Cited by 27 · see citing works
Do subclinical vascular abnormalities precede impaired physical ability and ADL disability?
den Ouden, M. E. M., Schuurmans, M. J., Mueller‐Schotte, S., Bots, M. L., & van der Schouw, Y. T. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.06.002 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30367-6 · Cited by 10,430 · see citing works
Retracted2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286 · see citing works
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391 · see citing works
Self-citation2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz425 · Cited by 7,166 · see citing works
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485 · see citing works
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000066 · Cited by 4,347 · see citing works
Self-citationMancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473 · see citing works
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000509 · Cited by 3,109 · see citing works
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885 · see citing works
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862 · see citing works
Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015
Forouzanfar, M. H., Liu, P., Roth, G. A., Ng, M., Biryukov, S., Marczak, L., Alexander, L., Estep, K., Hassen Abate, K., Akinyemiju, T. F., et al. (2017) · JAMA · doi:10.1001/jama.2016.19043 · Cited by 2,381 · see citing works
2024 ESC Guidelines for the management of elevated blood pressure and hypertension
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae178 · Cited by 2,298 · see citing works
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922 · see citing works
High blood pressure and cardiovascular disease
Fuchs, F. D., & Whelton, P. K. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14240 · Cited by 1,948 · see citing works
Self-citationGlobal Vascular Guidelines on the management of chronic limb-threatening ischemia.
Conte, M. S., Bradbury, A. W., Kolh, P., White, J. V., Dick, F., Fitridge, R., Mills, J. L., Ricco, J.-B., Suresh, K. R., Murad, M. H., et al. (2019) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2019.02.016 · Cited by 2,015 · see citing works
Global vascular guidelines on the management of chronic limb-threatening ischemia
Conte, M. S., Bradbury, A. W., Kolh, P., White, J. V., Dick, F., Fitridge, R., Mills, J. L., Ricco, J.-B., Suresh, K. R., Murad, M. H., et al. (2019) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2019.05.006 · Cited by 1,582 · see citing works
Williamson (2019) · doi:10.1001/jama.2018.21442 · Cited by 1,246 · see citing works
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000596 · Cited by 1,127 · see citing works
Self-citationEzekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676 · see citing works
The Aging Cardiovascular System
Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618 · see citing works
Jones, D. W., Ferdinand, K. C., Taler, S. J., Johnson, H. M., Shimbo, D., Abdalla, M., Altieri, M. M., Bansal, N., Bello, N. A., Bress, A. P., et al. (2025) · JACC · doi:10.1016/j.jacc.2025.05.007 · Cited by 280 · see citing works
Self-citationGerdts (2022) · doi:10.1093/eurheartj/ehac470 · Cited by 241 · see citing works
Reverse Causality in Cardiovascular Epidemiological Research: More Common Than Imagined?
Sattar, N., & Preiss, D. (2017) · Circulation · doi:10.1161/circulationaha.117.028307 · Cited by 211 · see citing works
Atrial Fibrillation and Hypertension
Dzeshka, M. S., Shantsila, A., Shantsila, E., & Lip, G. Y. H. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.08934 · Cited by 148 · see citing works
Agarwal, R. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004536 · Cited by 144 · see citing works
Beddhu, S., Greene, T., Boucher, R., Cushman, W. C., Wei, G., Stoddard, G., Ix, J. H., Chonchol, M., Kramer, H., Cheung, A. K., et al. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30099-8 · Cited by 128 · see citing works
Self-citationUpadhya, B., Rocco, M., Lewis, C. E., Oparil, S., Lovato, L. C., Cushman, W. C., Bates, J. T., Bello, N. A., Aurigemma, G., Fine, L. J., et al. (2017) · Circulation: Heart Failure · doi:10.1161/circheartfailure.116.003613 · Cited by 118 · see citing works
Self-citationSink, K. M., Evans, G. W., Shorr, R. I., Bates, J. T., Berlowitz, D., Conroy, M. B., Felton, D. M., Gure, T., Johnson, K. C., Kitzman, D., et al. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15236 · Cited by 92 · see citing works
Self-citationNguyen, T. N., Harris, K., Woodward, M., Chalmers, J., Cooper, M., Hamet, P., Harrap, S., Heller, S., MacMahon, S., Mancia, G., et al. (2021) · Diabetes Care · doi:10.2337/dc20-2664 · Cited by 72 · see citing works
Prevention of cognitive impairment with intensive systolic blood pressure control
Yaffe, K. (2019) · JAMA · doi:10.1001/jama.2019.0008 · Cited by 43 · see citing works
Teramoto, K., Nadruz Junior, W., Matsushita, K., Claggett, B., John, J. E., Skali, H., Solomon, S., Cheng, S., & Shah, A. M. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14833 · Cited by 36 · see citing works
More Versus Less Blood Pressure Lowering: An Update
Atkins, E. R., & Rodgers, A. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.08.007 · Cited by 12 · see citing works
- Authors
- Williamson, J. D., Supiano, M. A., Applegate, W. B., Berlowitz, D. R., Campbell, R. C., Chertow, G. M., Fine, L. J., Haley, W. E., Hawfield, A. T., Ix, J. H., Kitzman, D. W., Kostis, J. B., Krousel-Wood, M. A., Launer, L. J., Oparil, S., Rodriguez, C. J., Roumie, C. L., Shorr, R. I., Sink, K. M., Wadley, V. G., Whelton, P. K., Whittle, J., Woolard, N. F., Wright, J. T., Pajewski, N. M., & for the SPRINT Research Group
- Affiliations
- Wake Forest University (US)
- University of Utah (US)
- Boston University (US)
- Medical University of South Carolina (US)
- Stanford Medicine (US)
- National Heart, Lung, and Blood Institute (US)
- Mayo Clinic in Florida (US)
- Wake Forest University Health Sciences (US)
- University of California San Diego (US)
- Rutgers, The State University of New Jersey (US)
- Tulane University (US)
- National Institutes of Health (US)
- University of Alabama (US)
- Division of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina
- Vanderbilt University (US)
- University of Florida (US)
- University of Alabama at Birmingham (US)
- Department of Medicine, Medical College of Wisconsin, Milwaukee29Primary Care Division, Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin
- Case Western Reserve University (US)
- Corresponding author
- Williamson, Jeff D.
- ORCID
- Williamson, Jeff D.
- Supiano, Mark A.
- Applegate, William B.
- Berlowitz, Dan R.
- Campbell, Ruth C.
- Chertow, Glenn M.
- Haley, William E.
- Hawfield, Amret T.
- Ix, Joachim H.
- Kitzman, Dalane W.
- Kostis, John B.
- Krousel-Wood, Marie A.
- Launer, Lenore J.
- Oparil, Suzanne
- Roumie, Christianne L.
- Shorr, Ronald I.
- Sink, Kaycee M.
- Wadley, Virginia G.
- Whelton, Paul K.
- Woolard, Nancy F.
- Wright, Jackson T.
- Pajewski, Nicholas M.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2016-06-28
- Volume
- 315
- Issue
- 24
- Pages
- 2673
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC4988796
- OpenAlex
- W2402203869
- Cited by
- 1,261
- References
- 40
- Citations by year
- 2026: 62 · 2025: 93 · 2024: 101 · 2023: 106 · 2022: 112 · 2021: 112 · 2020: 122 · 2019: 155 · 2018: 150 · 2017: 187 · 2016: 59
- FWCI
- 150.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (UL1TR000093, UL1TR000050, UL1TR001427, UL1TR000073, UL1TR001064, UL1TR001085, UL1TR000002, UL1TR001070, UL1TR000075, UL1TR000064, UL1TR000005, UL1TR000433, UL1TR000003, UL1TR000445, UL1TR000439, UL1TR000105)
- U.S. Public Health Service (HHSN268200900040C, HHSN268200900049C, HHSN268200900046C, HHSN268200900047C, HHSN268200900048C)
- National Institute on Aging (P30AG021332)
- National Heart, Lung, and Blood Institute (R01HL107257, HHSN268200900040C, A-HL-13-002-001, HHSN268200900049C, R01HL107241, HHSN268200900048C, HHSN268200900047C, R01HL130500, 01-HL10741, HHSN268200900046C)
- National Institute of General Medical Sciences (P30GM103337)
- National Center for Research Resources (UL1RR025755, UL1RR024134, UL1RR025752, UL1RR025771)
- National Center for Advancing Translational Sciences (9U54TR000017‐06)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Keywords
- intensive blood pressure control, systolic blood pressure target, hypertension, older adults, cardiovascular outcomes, all-cause mortality, acute coronary syndrome, stroke, heart failure, hypotension, SPRINT trial, antihypertensive therapy, serious adverse events, cardiovascular risk reduction, antihypertensive drugs, anticoagulation, antithrombotic therapy, antihypertensive drug discontinuation, antihypertensive drug switching
- MeSH terms
- Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Blood Pressure Determination, Cause of Death, Female, Heart Failure, Humans, Hypertension, Male, Myocardial Infarction, Acute Coronary Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
