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Lifetime Risk for Sudden Cardiac Death in the Community
Open accessAbstract
Background: Sudden cardiac death ( SCD ) is a leading cause of death in the United States and often occurs without previous cardiac symptoms. Lifetime risk for SCD and the influence of established risk factors on lifetime risks for SCD have not been estimated previously. Methods and Results: We followed Framingham Heart Study participants who were free of cardiovascular disease before their earliest examination. SCD was defined as death attributed to coronary heart disease within 1 hour of symptom onset without another probable cause of death, as adjudicated by a panel of 3 physicians. Lifetime risk for SCD was estimated to 85 years of age for men and women, with death attributed to other causes as the competing risk, and stratified by risk factor levels. We followed 2294 men and 2785 women for 160 396 person‐years; 375 experienced SCD . At 45 years of age, lifetime risks were 10.9% (95% CI , 9.4–12.5) for men and 2.8% (95% CI , 2.1–3.5) for women. Greater aggregate burden of established risk factors was associated with a higher lifetime risk for SCD . Categorizing men and women solely by blood pressure levels resulted in a clear stratification of lifetime risk curves. Conclusions: We present the first lifetime risk estimates for SCD . Greater aggregate risk factor burden, or blood pressure level alone, is associated with higher lifetime risks for SCD . This high risk of premature death attributed to SCD (approximately 1 in 9 men and 1 in 30 women) should serve as a motivator of public health efforts in preventing and responding to SCD .
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“Older patients and those with multi-morbidities are at a risk of high acuity events such as cardiac arrest [22].”
From Making the invisible visible: a place for utilizing activity theory within in situ simulation to drive healthcare organizational development? (2020) · cites this paper as [22]
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Self-citationLifetime Risk for Developing Congestive Heart Failure
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Self-citationLifetime risks of cardiovascular disease
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Self-citationAN APPROACH TO LONGITUDINAL STUDIES IN A COMMUNITY: THE FRAMINGHAM STUDY
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Self-citationLifetime Risk for Heart Failure Among White and Black Americans
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Risk Stratification for Arrhythmic Sudden Cardiac Death
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Metadata
- Authors
- Bogle, B. M., Ning, H., Mehrotra, S., Goldberger, J. J., & Lloyd‐Jones, D. M.
- Affiliations
- Department of Preventive Medicine, Feinberg School of Medicine, Chicago, IL
- Northwestern University (US)
- Department of Medicine, Feinberg School of Medicine, Chicago, IL
- Corresponding author
- Lloyd‐Jones, Donald M.
- Venue
- Journal of the American Heart Association
- Published
- 2016-07-06
- Volume
- 5
- Issue
- 7
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC5015355
- OpenAlex
- W2468092841
- Cited by
- 121
- References
- 21
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 21 · 2023: 16 · 2022: 13 · 2021: 15 · 2020: 17 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 2
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Foundation (0824162)
- National Institutes of Health (UL1TR001422)
- National Heart, Lung, and Blood Institute
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Keywords
- sudden cardiac death, lifetime risk, cardiovascular risk factors, blood pressure, sex differences, competing risks, coronary artery disease, Framingham Heart Study, premature mortality
- MeSH terms
- Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Female, Humans, Hypertension, Male, Middle Aged, Risk Factors, United States, Death, Sudden, Cardiac, Independent Living
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