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Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study
Open accessAbstract
Background: We determined whether vascular and valvular calcification predicted incident major coronary heart disease, cardiovascular disease ( CVD ), and all‐cause mortality independent of Framingham risk factors in the community‐based Framingham Heart Study. Methods and Results: Coronary artery calcium ( CAC ), thoracic and abdominal aortic calcium, and mitral or aortic valve calcium were measured by cardiac computed tomography in participants free of CVD . Participants were followed for a median of 8 years. Multivariate Cox proportional hazards models were used to determine association of CAC , thoracic and abdominal aortic calcium, and mitral and aortic valve calcium with end points. Improvement in discrimination beyond risk factors was tested via the C‐statistic and net reclassification index. In this cohort of 3486 participants (mean age 50±10 years; 51% female), CAC was most strongly associated with major coronary heart disease, followed by major CVD , and all‐cause mortality independent of Framingham risk factors. Among noncoronary calcifications, mitral valve calcium was associated with major CVD and all‐cause mortality independent of Framingham risk factors and CAC . CAC significantly improved discriminatory value beyond risk factors for coronary heart disease (area under the curve 0.78–0.82; net reclassification index 32%, 95% CI 11–53) but not for CVD . CAC accurately reclassified 85% of the 261 patients who were at intermediate (5–10%) 10‐year risk for coronary heart disease based on Framingham risk factors to either low risk (n=172; no events observed) or high risk (n=53; observed event rate 8%). Conclusions: CAC improves discrimination and risk reclassification for major coronary heart disease and CVD beyond risk factors in asymptomatic community‐dwelling persons and accurately reclassifies two‐thirds of the intermediate‐risk population.
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“Persons with a calcium score of zero are at very low risk24, with increasing risk in the ordinal calcium score tiers identified by the deep learning system25–27.”
From Deep convolutional neural networks to predict cardiovascular risk from computed tomography (2021) · cites this paper as [25]
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2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491
Self-citationPencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493
Self-citation2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.005 · Cited by 4,945
Self-citationCoronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Detrano, R., Guerci, A. D., Carr, J. J., Bild, D. E., Burke, G., Folsom, A. R., Liu, K., Shea, S., Szklo, M., Bluemke, D. A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa072100 · Cited by 2,989
Pencina, M. J., & D’Agostino, R. B. (2004) · Statistics in Medicine · doi:10.1002/sim.1802 · Cited by 1,442
Self-citationGreenland, P. (2007) · Statistics in Medicine · doi:10.1002/sim.2976 · Cited by 1,300
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e318282ab8f · Cited by 1,294
Self-citationAssociation of Aortic-Valve Sclerosis with Cardiovascular Mortality and Morbidity in the Elderly
Otto, C. M., Lind, B. K., Kitzman, D. W., Gersh, B. J., & Siscovick, D. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907153410302 · Cited by 1,281
Coronary Artery Calcium Score and Risk Classification for Coronary Heart Disease Prediction
Polonsky, T. S. (2010) · JAMA · doi:10.1001/jama.2010.461 · Cited by 1,123
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Items 101–200 of 239
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Sarma, A. A., Paniagua, S. M., Lau, E. S., Wang, D., Liu, E. E., Larson, M. G., Hamburg, N. M., Mitchell, G. F., Kizer, J. R., Psaty, B. M., et al. (2023) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2022.12.014 · Cited by 12
Immohr, M. B., Sugimura, Y., Kröpil, P., Aubin, H., Minol, J., Albert, A., Boeken, U., Lichtenberg, A., & Akhyari, P. (2021) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-021-01400-6 · Cited by 12
Zhang, X., Fujiyoshi, A., Kadota, A., Kondo, K., Torii, S., Okami, Y., Hisamatsu, T., Yano, Y., Barinas‐Mitchell, E., Magnani, J. W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24659-8 · Cited by 12
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Espinosa, E. V. P., Mato, E., Guzmán, D. M. S., & Khasawneh, F. T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13113179 · Cited by 14
Imaging Early Life Cardiovascular Phenotype
Varadarajan, V., Gidding, S. S., Wu, C. O., Carr, J. J., & Lima, J. A. C. (2023) · Circulation Research · doi:10.1161/circresaha.123.322054 · Cited by 11
Pinto‐Sietsma, S., Velthuis, B. K., Nurmohamed, N. S., Vliegenthart, R., & Martens, F. M. A. C. (2024) · Netherlands Heart Journal · doi:10.1007/s12471-024-01897-1 · Cited by 11
From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease
Mitsis, A., Khattab, E., Christodoulou, E., Myrianthopoulos, K., Myrianthefs, M. M., Tzikas, S., Ziakas, A., Fragakis, N., & Kassimis, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13216352 · Cited by 13
Otsuka, K., Ishikawa, H., Kono, Y., Oku, S., Yamaura, H., Shirasawa, K., Hirata, K., Shimada, K., Kasayuki, N., & Fukuda, D. (2022) · Coronary Artery Disease · doi:10.1097/mca.0000000000001171 · Cited by 11
Lee, J. E., Kim, N. Y., Kim, Y., Kwon, Y., Kim, S., Han, K., & Suh, Y. J. (2025) · American Journal of Roentgenology · doi:10.2214/ajr.25.32697 · Cited by 10
Menopause Per se Is Associated with Coronary Artery Calcium Score: Results from the ELSA-Brasil
Fonseca, M. I. H., de Almeida-Pititto, B., Bittencourt, M. S., Benseñor, I. M., Lotufo, P. A., & Ferreira, S. R. G. (2021) · Journal of Women s Health · doi:10.1089/jwh.2021.0182 · Cited by 10
Detection of cardiovascular calcifications: Is it a useful tool for nephrologists?
Bover, J., Górriz, J. L., Ureña, P., Lloret, M. J., Ruiz-García, C., daSilva, I., Chang, P., Rodríguez, M., & Ballarín, J. (2016) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2016.05.013 · Cited by 10
Chen, R., Xiang, F., Hu, J., Cao, X., Tan, X. L., Jia, P., Zhang, T., Song, N., Fang, Y., Ding, X., et al. (2017) · Renal Failure · doi:10.1080/0886022x.2017.1349672 · Cited by 10
Playford, D. A., Hamilton-Craig, C. R., Dwivedi, G., & Figtree, G. A. (2021) · Heart Lung and Circulation · doi:10.1016/j.hlc.2021.04.026 · Cited by 9
Li, Y.-F., Zheng, X., Gao, W.-L., Tao, F., & Chen, Y. (2022) · BMC Pediatrics · doi:10.1186/s12887-022-03688-2 · Cited by 9
Thoracic versus coronary calcification for atherosclerotic cardiovascular disease events prediction
Ichikawa, K., Wang, R., McClelland, R. L., Manubolu, V. S., Susarla, S., Lee, D., Pourafkari, L., Fazlalizadeh, H., Aldana-Bitar, J., Robin, R., et al. (2024) · Heart · doi:10.1136/heartjnl-2023-323838 · Cited by 9
Lysyl Oxidase in Ectopic Cardiovascular Calcification: Role of Oxidative Stress
Ballester‐Servera, C., Alonso, J., Cañes, L., Vázquez-Sufuentes, P., García‐Redondo, A. B., Rodrı́guez, C., & Martínez‐González, J. (2024) · Antioxidants · doi:10.3390/antiox13050523 · Cited by 9
Pedrosa, J. F., Brant, L. C. C., de Aquino, S. A., Ribeiro, A. L. P., & Barreto, S. M. (2021) · Cells · doi:10.3390/cells10051243 · Cited by 9
Coronary Artery Calcium for Risk Assessment in Young Adults
Haq, A., & Miedema, M. D. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01010-0 · Cited by 9
Serum levels of Dickkopf-1 are a potential negative biomarker of survival in geriatric patients
Dovjak, P., Heinze, G., Rainer, A., Sipos, W., & Pietschmann, P. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.002 · Cited by 9
Kwan, A. C., Aronis, K. N., Sandfort, V., Blumenthal, R. S., & Bluemke, D. A. (2017) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2017.1348228 · Cited by 9
Mitochondrial mutations associated with cardiac angina
Sazonova, M. A., Ryzhkova, A. I., Sinyov, V. V., Sazonova, M. D., Nikitina, N. N., Shkurat, T. P., Sobenin, I. A., & Orekhov, A. N. (2019) · Vessel Plus · doi:10.20517/2574-1209.2019.01 · Cited by 9
Polonskaya, Y. V., Kashtanova, E. V., Murashov, I. S., Кургузов, А. В., Sadovski, E. V., Maslatsov, N. A., Stakhneva, E. M., Chernyavskii, A. M., & Ragino, Y. I. (2020) · Diagnostics · doi:10.3390/diagnostics10121074 · Cited by 9
Coronary Calcification: Types, Morphology and Distribution
Morris, M. C., & Kreutz, R. P. (2025) · Interventional Cardiology Reviews Research Resources · doi:10.15420/icr.2024.03 · Cited by 8
Arita, Y., Nakayama, M., Matsukuma, Y., Yoshitomi, R., Seki, M., Fukui, A., Tsuda, S., Sonoda, Y., Imazu, R., Arakawa, K., et al. (2020) · BMC Nephrology · doi:10.1186/s12882-020-01864-z · Cited by 8
Klooster, C. C. V. ’., van der Graaf, Y., Nathoe, H. M., Bots, M. L., de Borst, G. J., Visseren, F. L. J., Leiner, T., the UCC-SMART-study group, Asselbergs, F. W., Nathoe, H. M., et al. (2021) · International journal of cardiac imaging · doi:10.1007/s10554-021-02164-9 · Cited by 8
Hyperphosphatemia-induced degradation of transcription factor EB exacerbates vascular calcification
Ishiwata, R., & Morimoto, Y. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166323 · Cited by 8
Asymptomatic Coronary Artery Calcifications in Men with Systemic Lupus Erythematosus
Romero‐Díaz, J., Acosta-Hernández, R. I., Críales-Vera, S., Kimura-Hayama, E., Domínguez-Quintana, M., Morán-Contla, R., Núñez‐Álvarez, C. A., Lara-Reyes, P., Aguilar-Salinas, C. A., & Sánchez‐Guerrero, J. (2018) · The Journal of Rheumatology · doi:10.3899/jrheum.170330 · Cited by 8
The Predictive Value of Aortic Calcification on Computed Tomography for Major Cardiovascular Events
Chlorogiannis, D., Pargaonkar, S., Apostolos, A., Vythoulkas-Biotis, N., Kokkinidis, D. G., & Nagraj, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144019 · Cited by 7
Weber, B., Biery, D. W., Petranović, M., Besser, S. A., Huck, D. M., Shiyovich, A., Cardoso, R. N., Berman, A. N., Blair, C. V., Trivedi, N., et al. (2025) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2025.08.020 · Cited by 7
Current status and future perspective of coronary artery calcium score in asymptomatic individuals
Kawaguchi, Y. O., Fujimoto, S., Nozaki, Y. O., Tomizawa, N., Daida, H., & Minamino, T. (2024) · Journal of Cardiology · doi:10.1016/j.jjcc.2024.11.008 · Cited by 7
Skovbo, J. S., Rasmussen, L. M., Kristensen, K. L., Dahl, M., & Lindholt, J. S. (2021) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2021.03.016 · Cited by 7
Castro‐Diehl, C., Song, R. J., Mitchell, G. F., McManus, D. D., Cheng, S. C., Vasan, R. S., & Xanthakis, V. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233321 · Cited by 7
Lee, J., Kiiskinen, T., Mars, N., Jukarainen, S., FinnGen Project, Ingelsson, E., Neale, B. M., Ripatti, S., Natarajan, P., & Ganna, A. (2021) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.120.003283 · Cited by 7
High-Risk Coronary Atherosclerosis
Maehara, A., & Stone, G. W. (2017) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.117.007116 · Cited by 7
A Cardiovascular Disease Risk Score Model Based on High Contribution Characteristics
Peng, M., Hou, F. F., Cheng, Z.-X., Shen, T., Liu, K., Zhao, C., & Zheng, W. (2023) · Applied Sciences · doi:10.3390/app13020893 · Cited by 6
Osawa, K., Nakanishi, R., & Budoff, M. J. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.01.007 · Cited by 6
Reference distributions of aortic calcification and association with Framingham risk score
Horbal, S. R., Derstine, B. A., Brown, E., Su, G. L., Wang, S. C., & Holcombe, S. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-36565-8 · Cited by 6
Wernly, B., Langthaler, P. B., Fixl, B., Kiesslich, T., Kedenko, L., Frey, V., Trinka, E., Iglseder, B., Flamm, M., Aigner, E. S., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf206 · Cited by 6
Gać, P., Martuszewski, A., Paluszkiewicz, P., Poręba, M., Mazur, G. J., & Poręba, R. (2021) · Cardiovascular Toxicology · doi:10.1007/s12012-021-09677-8 · Cited by 5
Neisius, U., Zhou, G., Ward, R. E., Ellison, R. C., Gaziano, J. M., & Djoussé, L. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.02.112 · Cited by 5
Braun, F. M., Risch, F., Decker, J. A., Woźnicki, P., Bette, S. J., Becker, J., Rippel, K., Scheurig‐Muenkler, C., Kröncke, T. J., & Schwarz, F. (2023) · Diagnostics · doi:10.3390/diagnostics13223402 · Cited by 5
Mahajan, H., Choo, J., Masaki, K., Fujiyoshi, A., Guo, J. S., Evans, R., Shangguan, S., Willcox, B. J., Barinas‐Mitchell, E., Kadota, A., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.04.011 · Cited by 5
Markers of Subclinical Atherosclerosis in Severe Obesity and One Year after Bariatric Surgery
Kovac, N., Grymyr, L. M. D., Gerdts, E., Nadirpour, S., Nedrebø, B. G., Hjertaas, J. J., Matre, K., & Cramariuc, D. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11082237 · Cited by 5
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Rodrigues, I. G., Pinho, C. P. S., Filho, D. C. S., Leão, A. P. D., Oliveira, M. C. M., Barbosa, G. P., de Siqueira, A. A., & Bandeira, F. A. F. (2021) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.67.01.20200388 · Cited by 5
Tsai, J., Kuo, R., Sun, J.-Y., Yun, C., Sung, K.-T., Liu, C.-C., Kuo, J., Hung, C., Wu, T., Lin, J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0207089 · Cited by 5
Anderson, J. L., Knight, S., Li, D., May, H. T., Le, V. T., Bair, T. L., & Knowlton, K. U. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13092569 · Cited by 4
Koutroumpakis, E., Venkatesh, N., Aparicio, A. M., Song, J., Panaretakis, T., Deswal, A. M., Logothetis, C. J., Frigo, D. E., & Hahn, A. W. (2024) · The Oncologist · doi:10.1093/oncolo/oyae308 · Cited by 4
Opportunistic Cardiovascular Risk Assessment Using Routine Head CT in the Emergency Department
Zhang, X., Acosta, J., Dogra, S., Silva, E. N., Basu, S., Krumholz, H. M., Khera, R., Rajpurkar, P., & Kim, D. A. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.02.5095 · Cited by 5
Szulc, P., Planckaert, C., Foesser, D., Patsch, J., & Chapurlat, R. D. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315289 · Cited by 4
Edy, E., Rankin, A. J., Lees, J. S., Barrientos, P. H., Woodward, R. A., Stoumpos, S., Koktzoglou, I., Edelman, R. R., Radjenovic, A., Mark, P. B., et al. (2021) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-021-00769-6 · Cited by 4
Foldyna, B., Basmagi, S., Zangeneh, F. A., Wagner, M. W., Doktorov, K., Matveeva, A., Denecke, T., Gohmann, R. F., Lücke, C., Gutberlet, M., et al. (2023) · Clinical Imaging · doi:10.1016/j.clinimag.2023.109980 · Cited by 4
Arefi, R., Namazi, M. H., Safi, M., Saadat, H., Vakili, H., Pishgahi, M., & Parsa, S. A. (2020) · Galen Medical Journal · doi:10.31661/gmj.v9i0.1443 · Cited by 4
Mehta, A., Blaha, M. J., Miller, J. C., & Joshi, P. H. (2017) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-017-9431-3 · Cited by 4
Revisiting Coronary Artery Calcium and Incident Dementia
Lu, M. T. (2017) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.117.006365 · Cited by 4
Abe, T., Yan, F., Olanipekun, T. O., Blaha, M. J., Effoe, V. S., Udongwo, N., Mentz, R. J., Oshunbade, A. A., Terry, J. G., Ghali, J. K., et al. (2024) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.124.016775 · Cited by 3
Hayashida, S., Haruyama, N., Hayashida, H., Fukui, A., Ohta, O., Yoshitomi, R., & Nakayama, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-21517-1 · Cited by 3
Huynh, T. N., Yamazaki, F., Kishimoto, I., Tanaka, A., Son, Y., Ozaki, Y., Takehana, K., & Tanizaki, H. (2023) · Diagnostics · doi:10.3390/diagnostics13020274 · Cited by 3
Bansah, E. C., Ejiri, K., Kim, E., Mok, Y., Cainzos‐Achirica, M., Tanaka, H., Howard, C. M., Butler, K. R., Hughes, T. M., Hof, J. V., et al. (2025) · European Heart Journal Open · doi:10.1093/ehjopen/oeaf133 · Cited by 3
Should vascular wall 18F-FDG uptake be adjusted for the extent of atherosclerotic burden?
Lensen, K. D. F., Voskuyl, A. E., Comans, E. F. I., van der Laken, C. J., Boellaard, R., & Smulders, Y. M. (2020) · International journal of cardiac imaging · doi:10.1007/s10554-019-01744-0 · Cited by 3
Aortic arch calcification: A simple but powerful marker of subclinical cardiovascular disease
Qazi, S., & Chuang, M. L. (2022) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2022.100500 · Cited by 3
Chin, J. C. (2022) · Federal Practitioner · doi:10.12788/fp.0318 · Cited by 3
Liu, P., Xu, X., Wang, Y., Long, X., Li, X., & Peng, H. (2023) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.14029 · Cited by 3
Marcos-Mangas, M., Revilla, A., Sevilla, T., González-Bartol, E., Lite, I. S., Martínez-Urueña, N., Arnold, R. J., Gómez, I., & Román, J. A. S. (2023) · European Radiology · doi:10.1007/s00330-023-10229-7 · Cited by 3
Li, Y., Zou, K., Wang, Y., Zhang, Y., Zhong, J., Wu, Z., Tang, F., Lu, P., Liu, X., & Deng, L. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2517403 · Cited by 3
Non-coronary cardiac calcifications and outcomes in patients with heart failure
Topaz, G., Yehezkel, E., Benchetrit, S., Korzets, Z., Arnson, Y., Kitay‐Cohen, Y., Pereg, D., & Cohen‐Hagai, K. (2020) · Journal of Cardiology · doi:10.1016/j.jjcc.2020.07.019 · Cited by 3
Kaoud, R. M., Heikal, E. J., & Gad, S. (2022) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2022v14i3.44072 · Cited by 3
Chen, L. Q., Weber, J., Christian, T. F., Guerci, A. D., & Cao, J. J. (2021) · Coronary Artery Disease · doi:10.1097/mca.0000000000001017 · Cited by 3
Harlianto, N. I., Hoesein, F. A. A. M., Mali, W. P. T. M., Hol, M. E., Hazenberg, C. E. V. B., van Herwaarden, J. A., Foppen, W., de Jong, P. A., & UCC-SMART-Studygroup (2025) · The International Journal of Cardiovascular Imaging · doi:10.1007/s10554-025-03435-5 · Cited by 2
Calcification of the elastic component: the impact on the cardiovascular system
Lofaro, F. D., Mazzilli, A., Bonacorsi, S., Quaglino, D., & Boraldi, F. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1636812 · Cited by 2
Peri-aortic fat to assess cardiovascular aging using an AI-driven radiomic biomarker
Lebowitz, M., Modanwal, G., Singh, A., Dhamdhere, R., Diwan, S. G., Suleiman, T. A., Al-Shakhshir, H., Gilkey, M., Shofer, S. L., Sirasapalli, S. K., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag498 · Cited by 2
van Rosendael, A. R., van den Hoogen, I. J., Bax, A. M., Alaref, S. J., Alawamlh, O. A. H., Larine, D., & Min, J. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816389-4.00004-9 · Cited by 2
Plaque-Charakterisierung und individualisierte Risikoeinschätzung
Brendel, J. M., Nikolaou, K., & Foldyna, B. (2024) · Die Radiologie · doi:10.1007/s00117-024-01385-y · Cited by 2
Tedeschi, S. K., Hayashi, K., Guan, H., Solomon, D. H., & Weber, B. (2024) · Lara D. Veeken · doi:10.1093/rheumatology/keae655 · Cited by 2
Conesa, A. E., Esteve‐Pastor, M. A., Roldán, V., Soler‐Espejo, E., Rivera‐Caravaca, J. M., Gil‐Pérez, P., Lozano, E. G., Arribas, J. M., López, S. J. C., Saura, D., et al. (2025) · Clinical Cardiology · doi:10.1002/clc.70172 · Cited by 2
Janjua, S., Massaro, J. M., Chuang, M. L., D’Agostino, R. B., Hoffmann, U., & O’Donnell, C. J. (2020) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2020.09.019 · Cited by 2
Self-citationWilliams, M. C., Weir-McCall, J. R., Moss, A. J., Schmitt, M., Stirrup, J., Holloway, B., Gopalan, D., Deshpande, A., Hughes, G. M., Agrawal, B., et al. (2022) · BJR|Open · doi:10.1259/bjro.20210057 · Cited by 2
The 2018 ACC/AHA Lipid Guidelines: A Little More or Less Canadian?
Thanassoulis, G., Grégoire, J. C., & Pearson, G. J. (2019) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2019.03.003 · Cited by 2
Dietary patterns and subclinical atherosclerosis incidence and progression: Results from ELSA-Brasil
Alves, M. D. A., Miranda, A. M., Cacau, L. T., Levy, J., Generoso, G., Bittencourt, M. S., Lotufo, P. A., Benseñor, I. M., & Marchioni, D. M. L. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.09.021 · Cited by 3
Santos, R. D. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.12.019 · Cited by 2
Zhang, J., Li, M., Wang, X., Wang, T., Tian, W., & Xu, H. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1459894 · Cited by 1
Rau, A., Michel, L., Reisert, M., Rospleszcz, S., Russe, M. F., Schlesinger, S., Peters, A., Bamberg, F., Schlett, C. L., Weiß, J., et al. (2025) · Academic Radiology · doi:10.1016/j.acra.2025.01.032 · Cited by 1
Cacau, L. T., Bittencourt, M. S., Santos, I. S., Lotufo, P. A., Benseñor, I. M., & Marchioni, D. M. L. (2025) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2025.104228 · Cited by 1
Zhou, L., Yu, P., Li, L., Zhang, J., Long, H., Yu, H., Gu, X., & Hua, H. (2026) · Journal of Investigative Medicine · doi:10.1177/10815589261425968 · Cited by 1
Zhou, S., Zheng, C., Li, W., & Jin, Z. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1890920 · Cited by 1
Coronary Calcium Scoring in 2017
Osawa, K., Nakanishi, R., & Budoff, M. J. (2016) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2016.0047 · Cited by 1
Polonskaya, Y. V., Kashtanova, E. V., Аникина, А. В., & Ragino, Y. I. (2020) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2020-1-172-179 · Cited by 1
Николаев, А. Е., Korkunova, O. A., Khutornoy, I. V., Pakhomov, P. V., Gavrilov, P. V., Petraikin, A. V., Suchilova, M. M., Shapiev, A. N., DАDАKINА, I. S., Serebryakova, I. V., et al. (2021) · Medical Visualization · doi:10.24835/1607-0763-1047 · Cited by 1
Foldyna, B., Lu, M. T., & Hoffmann, U. (2018) · Contemporary cardiology · doi:10.1007/978-3-319-97622-8_26 · Cited by 1
Self-citationPlayford, E., Stewart, S., Hoyne, G. F., Strange, G. A., Dwivedi, G., Hamilton-Craig, C. R., Figtree, G. A., & Playford, D. A. (2024) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2024.100493 · Cited by 1
Sheng, C., Xiong, Y., Yang, P., & Wang, W. (2025) · PLoS ONE · doi:10.1371/journal.pone.0317007 · Cited by 1
Willis, B. L., Radford, N. B., Barlow, C. E., Leonard, D. S., Franklin, B. A., & DeFina, L. F. (2020) · American Heart Journal · doi:10.1016/j.ahj.2020.11.007 · Cited by 1
Coulibaly, M., Samaké, D., Sonfo, B., Lamine, S., Diawara, M., Barry, M., Sagara, V., Traoré, B., Guindo, O., Maiga, B., et al. (2021) · World Journal of Cardiovascular Diseases · doi:10.4236/wjcd.2021.113019 · Cited by 1
Arefi, R., Namazi, M. H., Safi, M., Saadat, H., Vakili, H., Pishgahi, M., & Parsa, S. A. (2020) · Galen Medical Journal · doi:10.31661/gmj.v9i.1443 · Cited by 1
Biomarkers: Population Screening and Risk-Stratification
Ratjen, I., Vasan, R. S., & Lieb, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.64154-6 · Cited by 1
Nollet, L., Lefthériotis, G., & Vanakker, O. M. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1820272 · Cited by 1
OBSOLETE: Biomarkers: Population Screening and Risk-Stratification
Lieb, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64154-5
Ferencik, M., & Udelson, J. E. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.05.008
Syed, M. B. J., Kaczynski, J., & Newby, D. E. (2019) · Springer eBooks · doi:10.1007/978-3-030-23577-2_11
Clinical Value of Cardiovascular Calcifications on Non-Enhanced, Non-ECG-Gated Chest CT
Choi, T. S., Yong, H. S., Kim, C., & Suh, Y. J. (2020) · Journal of the Korean Society of Radiology · doi:10.3348/jksr.2020.81.2.324
Oral anticoagulants as double-edged swords
Petrus, V. G. R. H. (2020) · Research Publications (Maastricht University) · doi:10.26481/dis.20200708rg
Metadata
- Authors
- Hoffmann, U., Massaro, J. M., D'Agostino, R. B., Kathiresan, S., Fox, C. S., & O'Donnell, C. J.
- Affiliations
- Harvard University (US)
- Boston University (US)
- Department of Mathematics, Boston University, Boston, MA
- Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
- Corresponding author
- Hoffmann, Udo
- Venue
- Journal of the American Heart Association
- Published
- 2016-02-23
- Volume
- 5
- Issue
- 2
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC4802453
- OpenAlex
- W2290600783
- Cited by
- 239
- References
- 32
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 26 · 2023: 20 · 2022: 26 · 2021: 40 · 2020: 30 · 2019: 21 · 2018: 13 · 2017: 20 · 2016: 5
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- School of Medicine, Boston University
- National Institutes of Health (n01hc25195-41-0-1, 5r01hl080124-05)
- National Institute on Aging (R01AG028321, AG-028321)
- National Heart, Lung, and Blood Institute (R01-HL080124, HL-076784, N01‐HC25195, HL107385, HL 080124, HL077447, R01HL077447, R01HL107385, R01HL076784, HL070100, HL 060040, R01HL070100, HL071039, R01HL060040, R01HL071039)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- coronary artery calcium, aortic calcification, valve calcification, mitral valve calcification, aortic valve calcification, cardiovascular risk reclassification, cardiovascular event prediction, coronary artery disease, all-cause mortality, cardiovascular disease, Framingham risk factors, risk discrimination, intermediate-risk patients
- MeSH terms
- Adult, Aorta, Abdominal, Aorta, Thoracic, Aortic Diseases, Aortic Valve, Aortography, Calcinosis, Coronary Artery Disease, Coronary Vessels, Female, Heart Valve Diseases, Humans, Male, Massachusetts, Middle Aged, Mitral Valve, Predictive Value of Tests, Prospective Studies, Risk Factors, Time Factors, Prevalence, Multivariate Analysis, Proportional Hazards Models, Coronary Angiography, Risk Assessment, Kaplan-Meier Estimate, Vascular Calcification, Multidetector Computed Tomography
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