Statin Use and Adverse Effects Among Adults >75 Years of Age: Insights From the Patient and Provider Assessment of Lipid Management (PALM) Registry
Open accessAbstract
Background: Current statin use and symptoms among older adults in routine community practice have not been well characterized since the release of the 2013 American College of Cardiology/American Heart Association guideline. Methods and Results: We compared statin use and dosing between adults >75 and ≤75 years old who were eligible for primary or secondary prevention statin use without considering guideline‐recommended age criteria. The patients were treated at 138 US practices in the Patient and Provider Assessment of Lipid Management (PALM) registry in 2015. Patient surveys also evaluated reported symptoms while taking statins. Multivariable logistic regression models examined the association between older age and statin use and dosing. Among 6717 people enrolled, 1704 (25%) were >75 years old. For primary prevention, use of any statin or high‐dose statin did not vary by age group: any statin, 62.6% in those >75 years old versus 63.1% in those ≤75 years old ( P =0.83); high‐dose statin, 10.2% versus 12.3% in the same groups ( P =0.14). For secondary prevention, older patients were slightly less likely to receive any statin (80.1% versus 84.2% [ P =0.003]; adjusted odds ratio, 0.81; 95% confidence interval, 0.66–1.01 [ P =0.06]), but were much less likely to receive a high‐intensity statin (23.5% versus 36.2% [ P <0.0001]; adjusted odds ratio, 0.54; 95% confidence interval, 0.45–0.65 [ P =0.0001]). Among current statin users, older patients were slightly less likely to report any symptoms (41.3% versus 46.6%; P =0.003) or myalgias (27.3% versus 33.3%; P <0.001). Conclusions: Overall use of statins was similar for primary prevention in those aged >75 years versus younger patients, yet older patients were less likely to receive high‐intensity statins for secondary prevention. Statins appear to be similarly tolerated in older and younger adults.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Bairey Merz, C. N., Blum, C. B., Eckel, R. H., Goldberg, A. C., Gordon, D., Levy, D., Lloyd-Jones, D. M., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437738.63853.7a · Cited by 7,081 · see citing works
Self-citationIntensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
Cannon, C. P., Braunwald, E., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040583 · Cited by 4,938 · see citing works
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Barter, P., Fruchart, J.-C., Gotto, A. M., Greten, H., Kastelein, J. J. P., Shepherd, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050461 · Cited by 3,489 · see citing works
Shepherd, J., Blauw, G. J., Murphy, M. B., Bollen, E. L., Buckley, B. M., Cobbe, S. M., Ford, I., Gaw, A., Hyland, M., Jukema, J. W., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11600-x · Cited by 3,378 · see citing works
Collaborators, C. T. T. (. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60367-5 · Cited by 2,833 · see citing works
Statins for the primary prevention of cardiovascular disease
Taylor, F., Huffman, M. D., Macedo, A. F., Moore, T. H., Burke, M., Davey Smith, G., Ward, K., Ebrahim, S., & Gay, H. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004816.pub5 · Cited by 1,934 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582 · see citing works
Heron, M. P., Hoyert, D. L., Murphy, S. L., Xu, J., Kochanek, K. D., & Tejada‐Vera, B. (2009) · PubMed · Cited by 909 · see citing works
Statin Use for the Primary Prevention of Cardiovascular Disease in Adults
US Preventive Services Task Force, Bibbins-Domingo, K. B., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W., García, F., Gillman, M. W., Kemper, A. R., Krist, A. H., et al. (2016) · JAMA · doi:10.1001/jama.2016.15450 · Cited by 590 · see citing works
Lipid-Lowering Therapy With Statins in High-Risk Elderly Patients
Ko, D. T., Mamdani, M., & Alter, D. A. (2004) · JAMA · doi:10.1001/jama.291.15.1864 · Cited by 411 · see citing works
Statins for the primary prevention of cardiovascular disease
Taylor, F. C., Ward, K. J., Moore, T. H., Burke, M., Smith, G. D., Casas, J. P., & Ebrahim, S. B. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004816.pub4 · Cited by 305 · see citing works
Deedwania, P., Stone, P. H., Bairey Merz, C. N., Cosin-Aguilar, J., Koylan, N., Luo, D., Ouyang, P., Piotrowicz, R., Schenck-Gustafsson, K., Sellier, P., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.654756 · Cited by 236 · see citing works
The Impact of the Aging Population on Coronary Heart Disease in the United States
Odden, M. C., Coxson, P. G., Moran, A., Lightwood, J. M., Goldman, L., & Bibbins-Domingo, K. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.010 · Cited by 235 · see citing works
Forman, D. E., Rich, M. W., Alexander, K. P., Zieman, S., Maurer, M. S., Najjar, S. S., Cleveland, J. C., Krumholz, H. M., & Wenger, N. K. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.014 · Cited by 228 · see citing works
Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults
Han, B. H., Sutin, D. G., Williamson, J. D., Davis, B. R., Piller, L. B., Pervin, H., Pressel, S., & Blaum, C. S. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.1442 · Cited by 178 · see citing works
Rodríguez, F., Maron, D. J., Knowles, J. W., Virani, S. S., Lin, S., & Heidenreich, P. A. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.4052 · Cited by 163 · see citing works
Self-citationMaycock, C. A. A., Muhlestein, J. B., Horne, B. D., Carlquist, J. F., Bair, T. L., Pearson, R. R., Li, Q., & Anderson, J. L. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02477-4 · Cited by 128 · see citing works
Odden, M. C., Pletcher, M. J., Coxson, P. G., Thekkethala, D., Guzman, D., Heller, D. J., Goldman, L., & Bibbins-Domingo, K. B. (2015) · Annals of Internal Medicine · doi:10.7326/m14-1430 · Cited by 119 · see citing works
Myopathy in older people receiving statin therapy: a systematic review and meta‐analysis
Iwere, R. B., & Hewitt, J. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12687 · Cited by 116 · see citing works
Statins for primary cardiovascular prevention in the elderly.
Pedro‐Botet, J., Climent, E., Chillarón, J. J., Toro, R., Benaiges, D., & Roux, J. A. F. (2015) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2015.04.016 · Cited by 53 · see citing works
Overcoming ???Ageism??? Bias in the Treatment of Hypercholesterolaemia
Jacobson, T. A. (2006) · Drug Safety · doi:10.2165/00002018-200629050-00005 · Cited by 51 · see citing works
Statins for primary cardiovascular prevention in the elderly
Juan, J., Pedro‐Botet, Elisenda, Climent, E., Chillarón, Rocío, Törö, David, Benaiges, Juana, et al. (2015) · 老年心脏病学杂志：英文版 · Cited by 48 · see citing works
Dodson, J. A., Geda, M. E., Krumholz, H. M., Lorenze, N. P., Murphy, T. E., Allore, H. G., Charpentier, P. A., Tsang, S. W., Acampora, D., Tinetti, M. E., et al. (2014) · BMC Health Services Research · doi:10.1186/s12913-014-0506-4 · Cited by 39 · see citing works
Secondary cardiovascular prevention in older adults: an evidence based review.
Damluji, A. A., Ramireddy, A., Otalvaro, L., & Forman, D. E. (2015) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2015.05.019 · Cited by 23 · see citing works
Design and rationale for the Patient and Provider Assessment of Lipid Management (PALM) registry
Návar, A. M., Wang, T. Y., Goldberg, A. C., Robinson, J. G., Roger, V. L., Wilson, P. W. F., Virani, S. S., Elassal, J., Lee, L. V., Webb, L. E., et al. (2015) · American Heart Journal · doi:10.1016/j.ahj.2015.08.002 · Cited by 21 · see citing works
Self-citation
Flagged first, then by citations
1 of the 27 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gencer, B., Marston, N. A., Im, K., Cannon, C. P., Sever, P., Keech, A., Braunwald, E., Giugliano, R. P., & Sabatine, M. S. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32332-1 · Cited by 318 · see citing works
Disorders of lipid metabolism. Clinical Guidelines 2023
Владиславович, Е. М., Kukharchuk, V. V., Сергиенко, И. В., Alieva, A. S., Antsiferov, M. B., Ansheles, A. A., Arabidze, G. G., Dm, A., Arutyunov, G. P., Ахмеджанов, Н. М., et al. (2023) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2023-5471 · Cited by 260 · see citing works
Qu, H., Guo, M., Chai, H., Wang, W., Gao, Z., & Shi, D. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009835 · Cited by 178 · see citing works
“induced myopathy reported from studies adversely affects the cardiovascular disease benefits of statins.(23) The present”
BackgroundStatin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy
Vinci, P., Panizon, E., Tosoni, L. M., Cerrato, C., Pellicori, F., Mearelli, F., Biasinutto, C., Fiotti, N., Girolamo, F. G. D., & Biolo, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111687 · Cited by 180 · see citing works
Sandhu, A. T., Rodriguez, F., Ngo, S., Patel, B. N., Mastrodicasa, D., Eng, D., Khandwala, N., Balla, S., Sousa, D., & Maron, D. J. (2023) · Circulation · doi:10.1161/circulationaha.122.062746 · Cited by 174 · see citing works
Effect of Statin Therapy on Cognitive Decline and Incident Dementia in Older Adults
Zhou, Z., Ryan, J. L., Ernst, M. E., Zoungas, S., Tonkin, A. M., Woods, R. L., McNeil, J. J., Reid, C. M., Curtis, A. J., Wolfe, R. S., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.04.075 · Cited by 109 · see citing works
Joseph, J., Pajewski, N. M., Dolor, R. J., Sellers, M. A., Perdue, L., Peeples, S. R., Henrie, A. M., Woolard, N., Jones, W. S., Benziger, C. P., et al. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18312 · Cited by 90 · see citing works
Role of Statin Therapy in Primary Prevention of Cardiovascular Disease in Elderly Patients
Strandberg, T. E. (2019) · Current Atherosclerosis Reports · doi:10.1007/s11883-019-0793-7 · Cited by 78 · see citing works
Management of Coronary Artery Disease in Older Adults: Recent Advances and Gaps in Evidence
Cacciatore, S., Spadafora, L., Bernardi, M., Galli, M., Betti, M., Perone, F., Nicolaio, G., Marzetti, E., Martone, A. M., Landi, F., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165233 · Cited by 70 · see citing works
Zhou, Z., Ofori‐Asenso, R., Curtis, A. J., Breslin, M. C., Wolfe, R. S., McNeil, J. J., Murray, A. M., Ernst, M. E., Reid, C. M., Lockery, J. E., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.05.016 · Cited by 65 · see citing works
Návar, A. M., Kolkailah, A. A., Gupta, A., Gillard, K. K., Israel, M. K., Wang, Y., & Peterson, E. D. (2023) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.122.009787 · Cited by 65 · see citing works
Self-citationThe Accuracy of Cardiovascular Pooled Cohort Risk Estimates in U.S. Older Adults
Nanna, M. G., Peterson, E. D., WOJDYLA, D. M., & Návar, A. M. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-05361-4 · Cited by 63 · see citing works
Self-citationStatins and cognition: Modifying factors and possible underlying mechanisms
Jamshidnejad-Tosaramandani, T., Kashanian, S., Al-Sabri, M. H., Kročianová, D., Clemensson, L. E., Gentreau, M., & Schiöth, H. B. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.968039 · Cited by 59 · see citing works
Benefits and Risks Associated With Statin Therapy for Primary Prevention in Old and Very Old Adults
Xu, W., Lee, A. L., Lam, C. L. K., Danaei, G., & Wan, E. Y. F. (2024) · Annals of Internal Medicine · doi:10.7326/m24-0004 · Cited by 37 · see citing works
Ma, Q., Wu, S., Yang, L., Wei, Y., He, C., Wang, W., Zhao, Y., Wang, Z., Yang, S., Shi, D., et al. (2022) · Advanced Science · doi:10.1002/advs.202202416 · Cited by 36 · see citing works
Usman, O., Baig, M. M. M., Ikram, M., Iqbal, T., Islam, S., Syed, W., Al-Rawi, M. B. A., & Naseem, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-61920-8 · Cited by 34 · see citing works
Statin Therapy in Very Old Patients: Lights and Shadows
Cobos-Palacios, L., Sanz‐Cánovas, J., Muñoz-Úbeda, M., Lopez-Carmona, M. D., Perez-Belmonte, L. M., Sampalo, A. L., Gómez-Huelgas, R., & Bernal-López, M. R. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.779044 · Cited by 28 · see citing works
Nanna, M. G., Návar, A. M., Wang, T. Y., Li, S., Virani, S. S., Li, Z., Robinson, J. G., Roger, V. L., Wilson, P. W. F., Goldberg, A. C., et al. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.05.009 · Cited by 27 · see citing works
Self-citationLiu, Y., Lu, K., Zhang, R., Hu, D., Yang, Z., Zeng, J., & Cai, W. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00574 · Cited by 24 · see citing works
Ma, M.-M., Xu, Y., Li-hua, S., Cui, W., Fan, M., Zhang, S., Liu, L., Wu, L.-Z., & Li, L. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s460305 · Cited by 24 · see citing works
Primary prevention statin therapy in older adults
Nanna, M. G., Abdullah, A., Mortensen, M. B., & Návar, A. M. (2022) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001003 · Cited by 21 · see citing works
Self-citationPalo, K. E. D., Feder, S. L., Baggenstos, Y. T., Cornelio, C. K., Forman, D. E., Goyal, P., Kwak, M. J., & McIlvennan, C. K. (2024) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/hcq.0000000000000131 · Cited by 20 · see citing works
Treatment of hypercholesterolaemia in older adults calls for a patient-centred approach
Kleipool, E. E. F., Dorresteijn, J. A. N., Smulders, Y. M., Visseren, F. L. J., Peters, M. J. L., & Muller, M. (2019) · Heart · doi:10.1136/heartjnl-2019-315600 · Cited by 20 · see citing works
Bittner, V., Linnebur, S. A., Dixon, D. L., Forman, D. E., Green, A. R., Jacobson, T. A., Orkaby, A. R., Saseen, J. J., & Virani, S. S. (2025) · Journal of clinical lipidology · doi:10.1016/j.jacl.2024.09.005 · Cited by 20 · see citing works
Self-citationStatin intolerance: an updated, narrative review mainly focusing on muscle adverse effects
Li, J., Liu, H.-H., Wu, N., Yeo, K. K., Tan, K. C. B., Ako, J., Krittayaphong, R., Tan, R., Aylward, P. E., Baek, S. H., et al. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2020.1802426 · Cited by 19 · see citing works
Kim, S. Y., Choi, H., & Won, C. W. (2020) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.20.0028 · Cited by 17 · see citing works
Tran, C., Vo, V., Taylor, P., Koehn, D. A., Virani, S. S., & Dixon, D. L. (2022) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2022.05.003 · Cited by 17 · see citing works
Self-citationBittner, V., Linnebur, S. A., Dixon, D. L., Forman, D. E., Green, A. R., Jacobson, T. A., Orkaby, A. R., Saseen, J. J., & Virani, S. S. (2025) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19398 · Cited by 15 · see citing works
Self-citationCholesterol Lowering in Older Adults: Should We Wait for Further Evidence?
Jamil, Y., Cohen, R., Alameddine, D., Deo, S. V., Kumar, M., & Orkaby, A. R. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01224-4 · Cited by 13 · see citing works
Xian, Y., Návar, A. M., Li, S., Li, Z., Robinson, J. G., Virani, S. S., Louie, M. J., Koren, A., Goldberg, A. C., Roger, V. L., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013229 · Cited by 13 · see citing works
Self-citationJung, H. N., Kim, M., Kim, H. S., Lee, W. J., Min, S. H., Kim, Y., & Jung, C. H. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024637 · Cited by 13 · see citing works
Statins in Primary Prevention in People Over 80 Years
Marcellaud, E., Jost, J., Tchalla, A. E., Magné, J., & Aboyans, V. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.10.015 · Cited by 13 · see citing works
Cuenca‐Bermejo, L., Prinetti, A., Kublickiene, K. R., Raparelli, V., Kautzky‐Willer, A., Norris, C. M., Pilote, L., & Herrero, M. T. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15834 · Cited by 13 · see citing works
Statin Use and All-Cause Mortality in Nursing Home Residents With and Without Dementia
O’Sullivan, J. L., Kohl, R., Lech, S., Romanescu, L., Schuster, J., Kuhlmey, A., Gellert, P. R., & Yaşar, S. (2024) · Neurology · doi:10.1212/wnl.0000000000209189 · Cited by 12 · see citing works
Statin Therapy for Primary and Secondary Prevention in Older Adults
Bao, A., & Karalis, D. G. (2024) · Current Atherosclerosis Reports · doi:10.1007/s11883-024-01257-9 · Cited by 12 · see citing works
Cha, J., Hong, S. J., Kim, J. H., Lim, S., Joo, H. J., Park, J. H., Yu, C. W., Lee, P. H., Lee, S., Lee, C. W., et al. (2023) · American Heart Journal · doi:10.1016/j.ahj.2023.03.002 · Cited by 12 · see citing works
Lipid‐lowering treatment among older patients with atherosclerotic cardiovascular disease
Nanna, M. G., Nelson, A. J., Haynes, K., Shambhu, S., Eapen, Z. J., Cziraky, M. J., Calvert, S. B., Pagidipati, N. J., & Granger, C. B. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18172 · Cited by 11 · see citing works
Self-citationAssociation of cardiovascular diseases with cognitive performance in older adults
Park, D. Y., Jamil, Y., Babapour, G., Kim, J., Campbell, G., Akman, Z., Kochar, A., Sen, S., Samsky, M. D., Sikand, N. V., et al. (2024) · American Heart Journal · doi:10.1016/j.ahj.2024.03.016 · Cited by 11 · see citing works
Self-citationLipid-Lowering Therapy and Cardiovascular Prevention in Elderly
Baratta, F., Moscucci, F., Lospinuso, I., Cocomello, N., Colantoni, A., Costanzo, A. D., Tramontano, D., D’Erasmo, L., Pastori, D., Ettorre, E., et al. (2025) · Drugs · doi:10.1007/s40265-025-02182-0 · Cited by 11 · see citing works
Cha, J., Kim, J. H., Hong, S. J., Lim, S., Joo, H. J., Park, J. H., Yu, C. W., Lee, P. H., Lee, S., Lee, C. W., et al. (2024) · Journal of Internal Medicine · doi:10.1111/joim.20029 · Cited by 10 · see citing works
Sarraju, A., Spencer‐Bonilla, G., Chung, S., Gomez, S. E., Li, J., Heidenreich, P. A., Palaniappan, L. P., & Rodríguez, F. (2021) · Journal of General Internal Medicine · doi:10.1007/s11606-021-07107-7 · Cited by 9 · see citing works
Park, D. Y., Hanna, J. M., Kadian, S., Kadian, M., Jones, W. S., Damluji, A. A., Kochar, A., Curtis, J. P., & Nanna, M. G. (2022) · PubMed Central · doi:10.11909/j.issn.1671-5411.2022.09.006 · Cited by 9 · see citing works
Self-citationOkunrintemi, V., Benson, E.-M. A., Derbal, O., Miedema, M. D., Blumenthal, R. S., Tibuakuu, M., Ogunmoroti, O., Khan, S. U., Mamas, M. A., Gulati, M., et al. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100083 · Cited by 9 · see citing works
Jhaveri, A., Sibley, R. A., Spatz, E. S., & Dodson, J. A. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01499-y · Cited by 9 · see citing works
Management of dyslipidaemias in the elderly population—A narrative review
Anagnostis, P. G., Vaitsi, K., Veneti, S., Georgiou, T., Paschou, S. Α., Lambrinoudaki, I. V., & Goulis, D. G. (2019) · Maturitas · doi:10.1016/j.maturitas.2019.03.011 · Cited by 8 · see citing works
Yashima, F., Hara, M., Inohara, T., Jinzaki, M., Shimizu, H., Fukuda, K., Tanaka, M., Yamamoto, M., Watanabe, Y., Naganuma, T., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-044319 · Cited by 8 · see citing works
Viscogliosi, G., Donfrancesco, C., Noce, C. L., Vanuzzo, D., Carle, F., Giampaoli, S., & Palmieri, L. (2020) · Rejuvenation Research · doi:10.1089/rej.2019.2268 · Cited by 8 · see citing works
Wettermark, B., Kalantaripour, C., Forslund, T., & Hjemdahl, P. (2024) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-024-03724-3 · Cited by 8 · see citing works
Impact of Guideline-Directed Statin Intervention for Primary Prevention in Patients With Diabetes
Muluk, P., Zhu, J., Thoma, F. W., Hay, E., Marroquin, O. C., Makani, A., Aiyer, A., Nasir, K., Gulati, M., Shapiro, M. D., et al. (2023) · Diabetes Care · doi:10.2337/dc23-0816 · Cited by 6 · see citing works
Walker, A. J., Zhu, J., Thoma, F. W., Marroquin, O. C., Makani, A., Gulati, M., Gianos, E., Virani, S. S., Rodríguez, F., Reís, S. E., et al. (2024) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2024.100664 · Cited by 8 · see citing works
Self-citationMosher, C. L., Osazuwa‐Peters, O. L., Nanna, M. G., MacIntyre, N. R., Que, L. G., Jones, S., Palmer, S. M., & O'Brien, E. C. (2024) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202401-017oc · Cited by 6 · see citing works
Self-citationTreating Hypercholesterolemia in Older Adults for Primary Prevention of Cardiovascular Events
Al-Ani, A., Jamil, Y., & Orkaby, A. R. (2024) · Drugs & Aging · doi:10.1007/s40266-024-01139-4 · Cited by 6 · see citing works
Chronic Coronary Disease in Older Adults
Ambrosini, A. P., Fishman, E. S., Damluji, A. A., & Nanna, M. G. (2024) · Medical Clinics of North America · doi:10.1016/j.mcna.2023.12.004 · Cited by 5 · see citing works
Self-citationKim, S. Y., Choi, H., & Won, C. W. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104644 · Cited by 5 · see citing works
Should we treat high LDL cholesterol in ‘healthy’ elderly individuals?
Stock, J. K. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.11.029 · Cited by 5 · see citing works
Bitter taste receptor agonists induce vasorelaxation in porcine coronary arteries
Tsai, C., Li, Y., Chang, L.-C., & Huang, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1578913 · Cited by 3 · see citing works
Jering, K., Claggett, B. L., Amir, O., Čikeš, M., Claeys, M. J., Pasquale, C. G. D., Granger, C. B., Køber, L., Landmesser, U., Lewis, E. F., et al. (2025) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2025.07.032 · Cited by 3 · see citing works
Clinical impact of statin intensity according to age in patients with acute myocardial infarction
Lee, K., Lee, M., Kim, D., Kim, J., Lim, S., Choo, E. H., Kim, C. J., Park, C. S., Kim, H.-Y., Yoo, K., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269301 · Cited by 3 · see citing works
Ijaz, S. H., Minhas, A. M. K., Jain, V., Rifai, M. A., Sharma, G. V., Mehta, A., Dani, S. S., Fudim, M., Al-Kindi, S. G., Sperling, L. S., et al. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.104930 · Cited by 3 · see citing works
Self-citationTamblyn, R. M., Moraga, T., Girard, N., Chan, F. K. I., Habib, B., & Boulet, J. R. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04429-5 · Cited by 3 · see citing works
Patterns of Statin Therapy Use and Associated Outcomes in Older Veterans Across Kidney Function
Gjyriqi, G., Gross, A., Burns, E. A., Gianos, E., Sidhu, M. S., & Mathew, R. O. (2024) · The American Journal of Medicine · doi:10.1016/j.amjmed.2024.03.016 · Cited by 3 · see citing works
Li, Y., Yang, X., Zou, Y., Li, J., Sun, Q., Jing, X., Yang, M. J., Wang, S., & Dong, B. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1305-8 · Cited by 3 · see citing works
Cummings, D. M., Jones, S. B., Bushnell, C., Halladay, J. R., Hart, S. L., Kinlaw, A. C., Psioda, M., Wen, F., Sissine, M. E., & Duncan, P. W. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18318 · Cited by 2 · see citing works
Chaitoff, A. M., Haff, N., Lauffenburger, J. C., & Choudhry, N. K. (2023) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18368 · Cited by 2 · see citing works
Bolden, D. M., Wogu, A. F., Peterson, P. N., Ross, E., Hogan, S. E., Matsushita, K., Criqui, M. H., & Allison, M. (2024) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.11.030 · Cited by 1 · see citing works
Statin-Associated Myalgia, Myopathy, and Myositis
Starkweather, A. R., & Patel, P. (2024) · Topics in Pain Management · doi:10.1097/01.tpm.0001024936.09562.71 · Cited by 1 · see citing works
Frailty and Cardiovascular Risk
Evans, N. R., Bhakta, S., Zeicu, C., Todd, O. M., Nguyen, T. N., & Hewitt, J. (2026) · European Cardiology Review · doi:10.15420/ecr.2026.09 · Cited by 1 · see citing works
Moon, I. T., Kang, S., Lee, W., Cho, Y., Park, J. J., Yoon, Y. E., Oh, I., Yoon, C., Suh, J., Youn, T., et al. (2021) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2021.08.005 · Cited by 1 · see citing works
Effect of lipid-lowering therapy on carotid plaque burden in older adults
Iankov, S., Sikand, A., Chowdhury, J. R., Spence, J. D., Arsang‐Jang, S., Sohrevardi, S. M., Hackam, D. G., & Azarpazhooh, M. R. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.123023 · Cited by 1 · see citing works
Park, D. Y., Jamil, Y., Frampton, J., Damluji, A. A., & Nanna, M. G. (2024) · JACC Advances · doi:10.1016/j.jacadv.2024.101091 · Cited by 1 · see citing works
Self-citationTrends in high intensity statin use among secondary prevention patients 76 years and older
Wood, M., Delate, T., Stadler, S. L., Denham, A. M., Ruppe, L. K., Hornak, R., & Olson, K. L. (2019) · Pharmacy Practice · doi:10.18549/pharmpract.2019.2.1402 · Cited by 1 · see citing works
Tratamiento con estatinas en los pacientes de más edad en 2018: cuándo, cómo y por qué
Lozano-Montoya, I., & Formiga, F. (2019) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2019.06.001
LDL-C–lowering therapies reduce major vascular events in patients aged ≥75 y
Elgendy, I. Y., & Elshazly, M. B. (2021) · Annals of Internal Medicine · doi:10.7326/acpj202104200-038
[Prosthetic fitting in the geriatric leg amputee (author's transl)].
Allgulander, S., & Mattsson, S. (1978) · PubMed
Vadhariya, A., Sharma, M., Abughosh, S., Birtcher, K. K., Chen, H., Mohan, A., & Johnson, M. L. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900221128850
Park, G., Lee, Y., Kim, B., & Kim, J. (2024) · Journal of Cardiovascular Intervention · doi:10.54912/jci.2024.0016
Pan, C., Zhou, X., Wang, Y., Wu, Y. Z., Han, Q., & Cui, X. (2025) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2025.2449986
Lipitension today — disaster tomorrow: focus on elderly comorbid patients
Скотников, А. С., Дмитриевич, З. В., Гвоздева, А. Д., & Бектемирова, Л. Г. (2025) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6340
Tamblyn, R., Moraga, T., Girard, N., Chan, F. K. I., Habib, B., & Boulet, J. (2023) · Figshare · doi:10.6084/m9.figshare.24597745
Gavina, C., Araújo, F., Luz, A. R., Jácome, C. I. O., Ruivo, J., & Teixeira, C. (2026) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2026.15.1.138
Nanna, M. G., Rossi, R., Anderson, T. S., Orkaby, A. R., Damluji, A. A., & Alexander, K. P. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2026.03.062
Self-citationBelyaeva, О. D., Беркович, О. А., & Zhdanova, О. N. (2026) · Новые Санкт-Петербургские врачебные ведомости. · doi:10.24884/1609-2201-2026-105-2-11-18
- Authors
- Nanna, M. G., Navar, A. M., Wang, T. Y., Mi, X., Virani, S. S., Louie, M. J., Lee, L. V., Goldberg, A. C., Roger, V. L., Robinson, J., & Peterson, E. D.
- Affiliations
- Duke Medical Center (US)
- Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC
- Duke University (US)
- Baylor College of Medicine (US)
- Regeneron (United States) (US)
- Sanofi (United States) (US)
- Washington University in St. Louis (US)
- Mayo Clinic (US)
- University of Iowa (US)
- Corresponding author
- Nanna, Michael G.
- ORCID
- Venue
- Journal of the American Heart Association
- Published
- 2018-05-15
- Volume
- 7
- Issue
- 10
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC6015311
- OpenAlex
- W2800388256
- Cited by
- 82
- References
- 27
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 21 · 2023: 12 · 2022: 12 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 1
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
- eCommons - AKU (Aga Khan University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Heart Association
- Amgen
- National Heart, Lung, and Blood Institute (K01HL133416)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Keywords
- statins, older adults, high-intensity statin therapy, statin adverse effects, myalgia, lipid-lowering therapy, secondary prevention, primary prevention, statin dosing, guideline adherence, community practice, patient-reported symptoms, hypercholesterolemia, cardiovascular risk reduction, statin intolerance
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Female, Humans, Lipids, Male, Middle Aged, Primary Prevention, Registries, Risk Factors, United States, Biomarkers, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Dyslipidemias, Healthcare Disparities, Secondary Prevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
