The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Low Risk of Ipsilateral Stroke in Patients With Asymptomatic Carotid Stenosis on Best Medical Treatment: A Prospective, Population-Based Study
Open accessAbstract
Background and Purpose— The annual risk of ischemic stroke distal to ≥50% asymptomatic carotid stenoses was ≈2% to 3% in early cohort studies and subsequent randomized trials of endarterectomy. This risk might have fallen in recent years owing to improvements in medical treatment, but there are no published prognostic data from studies initiated within the last 10 years. Methods— In a population-based study of all patients with transient ischemic attack (TIA) or stroke in the Oxford Vascular Study, we studied the risk of TIA and stroke in patients with ≥50% contralateral asymptomatic carotid stenoses recruited consecutively from 2002 to 2009 and given intensive contemporary medical treatment. Results— Of 1153 consecutively imaged patients presenting with stroke or TIA, 101 (8.8%) had ≥50% asymptomatic carotid stenoses (mean age, 75 years; 39% women; 40% age ≥80 years). During 301 patient-years of follow-up (mean, 3 years), there were 6 ischemic events in the territory of an asymptomatic stenosis, 1 minor stroke (initially 50% to 69% stenosis), and 5 TIAs (2 initially 50% to 69% stenosis; 3 to 70% to 99% stenosis), 3 of which led to subsequent endarterectomy. The average annual event rates on medical treatment were 0.34% (95% CI, 0.01 to 1.87) for any ipsilateral ischemic stroke, 0% (95% CI, 0.00 to 0.99) for disabling ipsilateral stroke, and 1.78% (95% CI, 0.58 to 4.16) for ipsilateral TIA. Conclusions— In the first study of the prognosis of ≥50% asymptomatic carotid stenosis to be initiated in the last 10 years, the risk of stroke on intensive contemporary medical treatment was low. Larger studies are required to determine whether this apparent improvement in prognosis is generalizable.
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Citations
Cites
Endarterectomy for Asymptomatic Carotid Artery Stenosis
Walker, M. D. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03520420037035 · Cited by 4,403
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061894 · Cited by 2,887
Rothwell, P., Eliasziw, M., Gutnikov, S., Fox, A., Taylor, D., Mayberg, M., Warlow, C., & Barnett, H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12228-3 · Cited by 1,696
Self-citationRothwell, P., Coull, A., Giles, M., Howard, S., Silver, L., Bull, L., Gutnikov, S., Edwards, P., Mant, D., Sackley, C., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16405-2 · Cited by 1,094
Self-citationVascular risks of asymptomatic carotid stenosis.
Norris, J. W., Zhu, C. Z., Bornstein, N. M., & Chambers, B. R. (1991) · Stroke · doi:10.1161/01.str.22.12.1485 · Cited by 427
Rothwell, P. M., Gibson, R., & Warlow, C. P. (2000) · Stroke · doi:10.1161/01.str.31.3.615 · Cited by 392
Self-citation
Cited by
Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., et al. (2014) · Stroke · doi:10.1161/str.0000000000000046 · Cited by 2,650
Goldstein, L. B., Bushnell, C. D., Adams, R. J., Appel, L. J., Braun, L. T., Chaturvedi, S., Creager, M. A., Culebras, A., Eckel, R. H., Hart, R. G., et al. (2011) · Stroke · doi:10.1161/str.0b013e3181fcb238 · Cited by 1,306
Lackland, D. T., Roccella, E. J., Deutsch, A. F., Fornage, M., George, M. G., Howard, G., Kissela, B. M., Kittner, S. J., Lichtman, J. H., Lisabeth, L. D., et al. (2014) · Stroke · doi:10.1161/01.str.0000437068.30550.cf · Cited by 815
Powers, W. J., Clarke, W. R., Grubb, R. L., Videen, T. O., Adams, H. P., Derdeyn, C. P., & COSS Investigators, F. T. (2011) · JAMA · doi:10.1001/jama.2011.1610 · Cited by 803
Randomized Trial of Stent versus Surgery for Asymptomatic Carotid Stenosis
Rosenfield, K., Matsumura, J. S., Chaturvedi, S., Riles, T., Ansel, G. M., Metzger, D. C., Wechsler, L., Jaff, M. R., & Gray, W. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1515706 · Cited by 629
Metadata
- Authors
- Marquardt, L., Geraghty, O. C., Mehta, Z., & Rothwell, P. M.
- Venue
- Stroke
- Published
- 2010-01
- Volume
- 41
- Issue
- 1
- Pages
- e11-7
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W1993165079
- Cited by
- 454
- References
- 30
- FWCI
- 36.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Low Risk of Ipsilateral Stroke in Patients With Asymptomatic Carotid Stenosis on Best Medical Treatment: A Prospective, Population-Based Study. https://app.cochat.ai/papers/10.1161/strokeaha.109.561837
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- Marquardt, L., Geraghty, O. C., Mehta, Z., & Rothwell, P. M. (2010). Low Risk of Ipsilateral Stroke in Patients With Asymptomatic Carotid Stenosis on Best Medical Treatment: A Prospective, Population-Based Study. Stroke. https://doi.org/10.1161/strokeaha.109.561837
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