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Vascular risks of asymptomatic carotid stenosis.
Open accessAbstract
We sought to determine the risks of stroke, myocardial ischemia, and vascular death in patients with asymptomatic carotid stenosis. Six hundred ninety-six patients with asymptomatic carotid stenosis referred to the Doppler laboratory were followed prospectively for a mean time of 41 months. These patients were studied both clinically and by carotid Doppler ultrasound, including evaluation of the effect of stroke risk factors. Transient ischemic attacks occurred in 75 patients and stroke in 29, while 132 had ischemic cardiac events. Five patients died from stroke and 59 from cardiac causes. Annual stroke rate was 1.3% in patients with carotid stenosis less than or equal to 75% and 3.3% in those with stenosis greater than 75%. Ipsilateral stroke rate was 2.5% in patients with greater than 75% carotid stenosis. Annual cardiac event rate was 8.3% and death rate 6.5% in patients with severe carotid stenosis. With carotid stenosis less than or equal to 75%, the stroke rate is negligible (1.3% annually) whereas the combined risk of cardiac ischemia and vascular death is as high as 9.9%. With stenosis greater than 75%, combined transient ischemic attack and stroke rate is 10.5% per year, with 75% of events ipsilateral to the stenosed artery.
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Citations
Cites
Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis
(1991) · New England Journal of Medicine · doi:10.1056/nejm199108153250701 · Cited by 8,368
Cited by
Silvestrini, M. (2000) · JAMA · doi:10.1001/jama.283.16.2122 · Cited by 587
de Weerd, M., Greving, J. P., Hedblad, B., Lorenz, M. W., Mathiesen, E. B., O'Leary, D. H., Rosvall, M., Sitzer, M., Buskens, E., & Bots, M. L. (2010) · Stroke · doi:10.1161/strokeaha.110.581058 · Cited by 435
Distribution of cardiac output to the brain across the adult lifespan
Xing, C.-Y., Tarumi, T., Liu, J., Zhang, Y., Turner, M., Riley, J., Tinajero, C. D., Yuan, L.-J., & Zhang, R. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16676826 · Cited by 160
Zhan, C., Shi, M., Yang, Y., Pang, H., Fei, S., Bai, L., Liu, B., Tu, J., Huo, Y., Ning, X., et al. (2016) · Scientific Reports · doi:10.1038/srep23870 · Cited by 41
Metadata
- Authors
- Norris, J. W., Zhu, C. Z., Bornstein, N. M., & Chambers, B. R.
- Venue
- Stroke
- Published
- 1991-12
- Volume
- 22
- Issue
- 12
- Pages
- 1485-1490
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2115076450
- Cited by
- 427
- References
- 1
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Norris, J. W., Zhu, C. Z., Bornstein, N. M., & Chambers, B. R. (1991). Vascular risks of asymptomatic carotid stenosis. Stroke. https://doi.org/10.1161/01.str.22.12.1485
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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