Omega-3 Polyunsaturated Fatty Acid Supplementation Confers Long-Term Neuroprotection Against Neonatal Hypoxic–Ischemic Brain Injury Through Anti-Inflammatory Actions
Open accessAbstract
Background and Purpose— Current available therapies for neonatal hypoxia/ischemia (H/I) brain injury are rather limited. Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H/I in neonates. Methods— Female rats were treated with or without an omega-3 polyunsaturated fatty acids-enriched diet from the second day of pregnancy until 14 days after parturition. Seven-day-old neonates were subjected to H/I and euthanized 5 weeks later for evaluation of tissue loss. Neurological impairment was assessed progressively for 5 weeks after H/I by grid walking, foot fault, and Morris water maze. Activation of microglia and production of inflammatory mediators were examined up to 7 days after H/I. Results— Omega-3 polyunsaturated fatty acid supplementation significantly reduced brain damage and improved long-term neurological outcomes up to 5 weeks after neonatal H/I injury. Omega-3 polyunsaturated fatty acids exerted an anti-inflammatory effect in microglia both in an in vivo model of H/I and in in vitro microglial cultures subjected to inflammatory stimuli by inhibiting NF-κB activation and subsequent release of inflammatory mediators. Conclusions— Our results suggest that omega-3 polyunsaturated fatty acids confer potent neuroprotection against neonatal H/I brain injury through, at least partially, suppressing a microglial-mediated inflammatory response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
n-3 polyunsaturated fatty acids reduce the inflammatory response, limiting the production of pro-inflammatory mediators by microglial cells following ischemic insults, and enhance glutathione-related antioxidant pathways.
“Moreover, n-3 PUFAs reduce the inflammatory response, limiting the production of pro-inflammatory mediators by microglial cells following ischemic insults, and enhance glutathione-related antioxidant pathways [135, 136].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Direct transesterification of all classes of lipids in a one-step reaction.
Lepage, G., & ROY, C. C. (1986) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38861-1 · Cited by 2,385 · see citing works
Dietary (n-3) Fatty Acids and Brain Development1
Innis, S. M. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.4.855 · Cited by 906 · see citing works
Graham, E. M., Ruis, K. A., Hartman, A. L., Northington, F. J., & Fox, H. E. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.06.094 · Cited by 530 · see citing works
Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
Hudert, C. A., Weylandt, K. H., Lü, Y., Wang, J., Hong, S., Dignass, A. U., Serhan, C. N., & Kang, J. X. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601280103 · Cited by 379 · see citing works
Chemokine and Inflammatory Cell Response to Hypoxia-Ischemia in Immature Rats
Bona, E., Andersson, A.-L., Blomgren, K., Gilland, E., Puka‐Sundvall, M., Gustafson, K., & Hagberg, H. (1999) · Pediatric Research · doi:10.1203/00006450-199904010-00008 · Cited by 338 · see citing works
Interleukin-18 Involvement in Hypoxic–Ischemic Brain Injury
Hedtjärn, M., Leverin, A., Eriksson, K., Blomgren, K., Mallard, C. E., & Hagberg, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05910.2002 · Cited by 290 · see citing works
Bazan, N. G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800068-jlr200 · Cited by 256 · see citing works
Belayev, L., Khoutorova, L., Atkins, K. D., & Bazan, N. G. (2009) · Stroke · doi:10.1161/strokeaha.109.555979 · Cited by 170 · see citing works
Neuronal PPARγ Deficiency Increases Susceptibility to Brain Damage after Cerebral Ischemia
Zhao, X., Strong, R., Zhang, J., Sun, G., Tsien, J. Z., Cui, Z., Grotta, J. C., & Aronowski, J. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5857-08.2009 · Cited by 164 · see citing works
Turner, N. A., Else, P. L., & Hulbert, A. J. (2003) · Die Naturwissenschaften · doi:10.1007/s00114-003-0470-z · Cited by 151 · see citing works
Stetler, R. A., Cao, G., Gao, Y., Zhang, F., Wang, S., Weng, Z., Vosler, P. S., Zhang, L., Signore, A. P., Graham, S. H., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4407-08.2008 · Cited by 135 · see citing works
Self-citationPathophysiology of an hypoxic–ischemic insult during the perinatal period
Calvert, J. W., & Zhang, J. H. (2005) · Neurological Research · doi:10.1179/016164105x25216 · Cited by 122 · see citing works
Basu, A., Lazović, J., Krady, J. K., Mauger, D. T., Rothstein, R. P., Smith, M. B. H., & Levison, S. W. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600002 · Cited by 118 · see citing works
Glial activation in white matter following ischemia in the neonatal P7 rat brain
Biran, V., Joly, L., Héron, A., Vernet, A., Véga, C., Mariani, J., Renolleau, S., & Charriaut‐Marlangue, C. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.037 · Cited by 81 · see citing works
Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration
Ebert, S., Weigelt, K., Walczak, Y., Drobnik, W., Mauerer, R., Hume, D. A., Weber, B. H. F., & Langmann, T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06286.x · Cited by 81 · see citing works
Shen, H., Hu, X., Liu, C., Wang, S., Zhang, W., Gao, H. Y., Stetler, R. A., Gao, Y., & Chen, J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.010 · Cited by 80 · see citing works
Self-citationBerman, D. R., Mozurkewich, E., Liu, Y., & Barks, J. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.01.020 · Cited by 59 · see citing works
Deleterious Effects of Plasminogen Activators in Neonatal Cerebral Hypoxia-Ischemia
Adhami, F., Yu, D., Yin, W., Schloemer, A. J., Burns, K. A., Liao, G., Degen, J. L., Chen, J., & Kuan, C.-Y. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070979 · Cited by 40 · see citing works
Self-citationZhang, D., Zhang, J., & Liu, G.-T. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.015 · Cited by 35 · see citing works
Chock, V. Y., & Giffard, R. G. (2005) · Pediatric Research · doi:10.1203/01.pdr.0000155758.79523.44 · Cited by 18 · see citing works
Berman, D. R., Mozurkewich, E., Liu, Y., & Barks, J. (2010) · Obstetric Anesthesia Digest · doi:10.1097/01.aoa.0000389604.63510.21 · Cited by 16 · see citing works
Glial activation in white matter injury following ischemia in the neonatal P7 rat brain
Biran, V., Joly, L., Mariani, J., Renolleau, S., & Charriaut‐Marlangue, C. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9591524.0252 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Layé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works
Sokoła-Wysoczańska, E., Wysoczański, T., Wagner, J., Czyż, K., Bodkowski, R., Lochyński, S., & Patkowska-Sokoła, B. (2018) · Nutrients · doi:10.3390/nu10101561 · Cited by 363 · see citing works
Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments
Allen, K. A., & Brandon, D. (2011) · Newborn and Infant Nursing Reviews · doi:10.1053/j.nainr.2011.07.004 · Cited by 296 · see citing works
Cai, W., Zhang, K., Li, P., Zhu, L., Xu, J., Yang, B., Hu, X., Lu, Z., & Chen, J. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.006 · Cited by 288 · see citing works
Self-citationCognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
Talukdar, S., Olefsky, J. M., & Osborn, O. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.04.004 · Cited by 241 · see citing works
Pascoe, M. C., Howells, D. W., Crewther, D. P., Constantinou, N., Carey, L. M., Rewell, S. S. J., Turchini, G. M., Kaur, G., & Crewther, S. G. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00014 · Cited by 211 · see citing works
Mennitti, L. V., de Oliveira, J. L., Morais, C. A., Estadella, D., Oyama, L. M., do Nascimento, C. M. O., & Pisani, L. P. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.001 · Cited by 208 · see citing works
Zhang, M., Wang, S., Mao, L., Leak, R. K., Shi, Y., Zhang, W., Hu, X., Sun, B., Cao, G., Gao, Y., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4043-13.2014 · Cited by 178 · see citing works
Self-citationn-3 PUFA supplementation benefits microglial responses to myelin pathology
Chen, S., Zhang, H., Pu, H., Wang, G., Li, W., Leak, R. K., Chen, J., Liou, A. K. F., & Hu, X. (2014) · Scientific Reports · doi:10.1038/srep07458 · Cited by 144 · see citing works
Self-citationOmega-3 Fatty acids and pregnancy.
Coletta, J. M., Bell, S. J., & Roman, A. S. (2010) · PubMed Central · Cited by 125 · see citing works
Pharmacologic Neuroprotective Strategies in Neonatal Brain Injury
Juul, S. E., & Ferriero, D. M. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2013.09.004 · Cited by 119 · see citing works
Strosznajder, A. K., Wójtowicz, S., Jeżyna, M. J., Sun, G. Y., & Strosznajder, J. B. (2020) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08629-9 · Cited by 117 · see citing works
Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines
Thuc, O. L., Stobbe, K., Cansell, C., Nahon, J., Blondeau, N., & Rovère, C. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00197 · Cited by 111 · see citing works
Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches
Arteaga, O., Alvarez, A. A., Revuelta, M., Santaolalla, F., Urtasun, A., & Hilario, E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020265 · Cited by 110 · see citing works
N-3 polyunsaturated fatty acids in animal models with neuroinflammation: An update
Trépanier, M., Hopperton, K. E., Orr, S. K., & Bazinet, R. P. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.045 · Cited by 109 · see citing works
Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target
Stetler, R. A., Leak, R. K., Gao, Y., & Chen, J. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.158 · Cited by 106 · see citing works
Self-citationPutative neuroprotective agents in neuropsychiatric disorders
Dodd, S., Maes, M. H. J., Anderson, G., Dean, O. M., Moylan, S., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.007 · Cited by 105 · see citing works
Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries
Fleiss, B., Steenwinckel, J. V., Bokobza, C., Shearer, I. K., Ross-Munro, E., & Gressèns, P. (2021) · Biomolecules · doi:10.3390/biom11010099 · Cited by 103 · see citing works
Wang, J., Shi, Y., Zhang, L., Zhang, F., Hu, X., Zhang, W., Leak, R. K., Gao, Y., Chen, L., & Chen, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.014 · Cited by 101 · see citing works
Self-citationFatting the brain: a brief of recent research
Hussain, G., Schmitt, F., Loeffler, J., & de Aguilar, J. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00144 · Cited by 97 · see citing works
Omega-3 polyunsaturated fatty acids in the brain: metabolism and neuroprotection
Zhang, W. (2011) · Frontiers in bioscience · doi:10.2741/3878 · Cited by 92 · see citing works
Self-citationLakshmi, D., Gopinath, K., Jayanthy, G., Anjum, S., Dharmalingam, P., & Sudhandiran, G. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0794-1 · Cited by 87 · see citing works
Zhang, W., Zhang, H., Mu, H., Zhu, W., Jiang, X., Hu, X., Shi, Y., Leak, R. K., Dong, Q., Chen, J., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.020 · Cited by 85 · see citing works
Self-citationDocosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia
Mayurasakorn, K., Williams, J. J., Ten, V. S., & Deckelbaum, R. J. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328342cba5 · Cited by 83 · see citing works
Shi, X.-D., Xu, L., Doycheva, D., Tang, J.-P., Yan, M., & Zhang, J. H. (2017) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x16656201 · Cited by 72 · see citing works
Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain Injury
Desai, A., Kevala, K., & Kim, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086472 · Cited by 78 · see citing works
Lu, Y., Zhao, L., Cao, D., & Gao, Y. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.03.003 · Cited by 77 · see citing works
Self-citationDesai, A., Park, T., Barnes, J., Kevala, K., Chen, H., & Kim, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0714-4 · Cited by 73 · see citing works
Fatty acid transporting proteins: Roles in brain development, aging, and stroke
Zhang, W., Chen, R., Yang, T., Xu, N., Chen, J., Gao, Y., & Stetler, R. A. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.04.004 · Cited by 74 · see citing works
Self-citationTranscriptomic characterization of microglia activation in a rat model of ischemic stroke
Deng, W., Mandeville, E. T., Terasaki, Y., Li, W., Holder, J. C., Chuang, A. T., Ning, M., Arai, K., Lo, E. H., & Xing, C. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20932870 · Cited by 69 · see citing works
Docosahexaenoic acid confers enduring neuroprotection in experimental stroke
Hong, S., Belayev, L., Khoutorova, L., Obenaus, A., & Bazan, N. G. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.12.033 · Cited by 66 · see citing works
Chen, A. T., Chibnall, J. T., & Nasrallah, H. A. (2015) · Annals of Clinical Psychiatry · doi:10.1177/104012371502700408 · Cited by 64 · see citing works
Yang, T., Sun, Y., Mao, L., Zhang, M., Li, Q., Zhang, L., Shi, Y., Leak, R. K., Chen, J., & Zhang, F. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.001 · Cited by 63 · see citing works
Self-citationZhang, W., Liu, J., Hu, X., Li, P., Leak, R. K., Gao, Y., & Chen, J. (2015) · Stroke · doi:10.1161/strokeaha.115.010815 · Cited by 62 · see citing works
Self-citationLipotoxicity of Palmitic Acid on Neural Progenitor Cells and Hippocampal Neurogenesis
Park, H. R., Kim, J., Park, K.-Y., & Lee, J. (2011) · Toxicological Research · doi:10.5487/tr.2011.27.2.103 · Cited by 62 · see citing works
Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice
Zhao, J., Song, J., Pan, S., & Wang, K. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1904-2 · Cited by 61 · see citing works
Wang, J., Xia, J., Zhang, F., Shi, Y., Wu, Y., Pu, H., Liou, A. K. F., Leak, R. K., Yu, X., Chen, L., et al. (2015) · Scientific Reports · doi:10.1038/srep09621 · Cited by 59 · see citing works
Self-citationZhang, W., Wang, H., Zhang, H., Leak, R. K., Shi, Y., Hu, X., Gao, Y., & Chen, J. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.005 · Cited by 57 · see citing works
Self-citationLei, X., Zhang, W., Liu, T., Xiao, H., Liang, W., Xia, W., & Zhang, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070645 · Cited by 53 · see citing works
Self-citationCai, M., Zhang, W., Weng, Z., Stetler, R. A., Jiang, X., Shi, Y., Gao, Y., & Chen, J. (2017) · Aging and Disease · doi:10.14336/ad.2017.0520 · Cited by 49 · see citing works
Self-citationYang, T., Sun, Y., Li, Q., Li, S., Shi, Y., Leak, R. K., Chen, J., & Zhang, F. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113142 · Cited by 49 · see citing works
Self-citationNew Antioxidant Drugs for Neonatal Brain Injury
Tataranno, M. L., Perrone, S., Longini, M., & Buonocore, G. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/108251 · Cited by 48 · see citing works
Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury
Luo, C., Ren, H., Wan, J., Yao, X., Zhang, X., He, C., So, K., Kang, J. X., Pei, Z., & Su, H. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m046466 · Cited by 47 · see citing works
Bourourou, M., Heurteaux, C., & Blondeau, N. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.040 · Cited by 46 · see citing works
Tüzün, F., Kumral, A., Dilek, M., Özbal, S., Ergür, B. U., Yeşilırmak, D. C., Duman, N., Yılmaz, O., & Özkan, H. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2011.587917 · Cited by 40 · see citing works
Chauveau, F., Cho, T., Perez, M., Guichardant, M., Riou, A., Aguettaz, P., Picq, M., Lagarde, M., Berthezène, Y., Nighoghossian, N., et al. (2011) · Current Neurovascular Research · doi:10.2174/156720211795495349 · Cited by 39 · see citing works
Gao, H. Y., Yan, P., Zhang, S., Huang, H., Huang, F., Sun, T., Deng, Q., Huang, Q., Chen, S., Ye, K., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9393-x · Cited by 38 · see citing works
Morais, C. A., Oyama, L. M., de Oliveira, J. L., Garcia, M. C., de Rosso, V. V., Amigo, L. S. M., do Nascimento, C. M. O., & Pisani, L. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/987927 · Cited by 37 · see citing works
Calle, D., Negri, V., Ballesteros, P., & Cerdán, S. (2015) · Theranostics · doi:10.7150/thno.10069 · Cited by 36 · see citing works
Andraka, J. M., Sharma, N., & Marchalant, Y. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.08.001 · Cited by 36 · see citing works
Gao, H. Y., Yan, P., Zhang, S., Nie, S., Huang, F., Han, H., Deng, Q., Huang, Q., Yang, W. Q., Wu, H., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.012 · Cited by 34 · see citing works
Self-citationXu, M., Wang, Y., Wei, P., Gao, Y., & Zhang, W. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13102 · Cited by 30 · see citing works
Self-citationMicroglia‐leucocyte axis in cerebral ischaemia and inflammation in the developing brain
Rayasam, A., Fukuzaki, Y., & Vexler, Z. S. (2021) · Acta Physiologica · doi:10.1111/apha.13674 · Cited by 31 · see citing works
Arteaga, O., Revuelta, M., Urigüen, L., Martínez‐Millán, L., Hilario, E., & Alvarez, A. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0221-8 · Cited by 28 · see citing works
Docosahexaenoic Acid Augments Hypothermic Neuroprotection in a Neonatal Rat Asphyxia Model
Berman, D. R., Mozurkewich, E., Liu, Y., Shangguan, Y., Barks, J., & Silverstein, F. S. (2013) · Neonatology · doi:10.1159/000351011 · Cited by 28 · see citing works
Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations
Poblete, R. A., Yaceczko, S., Aliakbar, R., Saini, P., Hazany, S., Breit, H., Louie, S. G., Lyden, P. D., & Partikian, A. (2023) · Biomedicines · doi:10.3390/biomedicines11092551 · Cited by 27 · see citing works
Castillo, R. L., Zepeda, A. B., Short, S., Figueroa, E., Bustos‐Obregón, E., & Farías, J. G. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-015-0112-8 · Cited by 26 · see citing works
Reyes‐Corral, M., Idígora, N. S., la Puerta, R. D., Montaner, J., & Ybot‐González, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052524 · Cited by 25 · see citing works
Mucci, D. D. B., Fernandes, F. S., Souza, A. D. S., Sardinha, F. L. D. C., Soares-Mota, M., & do Carmo, M. D. G. T. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.03.001 · Cited by 24 · see citing works
Mondal, K., Takahashi, H., Cole, J., Mar, N. A. D., Li, C., Stephenson, D., Allegood, J. C., Cowart, L. A., Chalfant, C. E., Reiner, A. J., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02501-y · Cited by 24 · see citing works
Ren, H., Yang, Z., Luo, C., Zeng, H., Li, P., Kang, J. X., Wan, J., He, C., & Su, H. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9931-1 · Cited by 24 · see citing works
Bacarin, C. C., Mori, M., Ferreira, E. D. F., Romanini, C. V., de Oliveira, R. M. W., & Milani, H. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.06.001 · Cited by 24 · see citing works
Ahmed, O. A. A., Fahmy, U. A., Bakhaidar, R. B., El‐Moselhy, M. A., Okbazghi, S. Z., Ahmed, A. F., Hammad, A. S. A., & Alhakamy, N. A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020140 · Cited by 23 · see citing works
RetractedTüzün, F., Kumral, A., Özbal, S., Dilek, M., Tuğyan, K., Duman, N., & Özkan, H. (2012) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2012.01.007 · Cited by 23 · see citing works
Shi, Z., Wu, D., Yao, J., Yao, X., Huang, Z., Li, P., Wan, J., He, C., & Su, H. (2016) · Nutrients · doi:10.3390/nu8010041 · Cited by 23 · see citing works
Tarui, T., Rasool, A., & O’Tierney-Ginn, P. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113910 · Cited by 20 · see citing works
Grundy, T., Toben, C. G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00399 · Cited by 20 · see citing works
Emerging targets in lipid-based therapy
Tucker, S. C., & Honn, K. V. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.028 · Cited by 18 · see citing works
Ahmed, A. O., & Bhat, I. (2014) · CNS Drugs · doi:10.1007/s40263-014-0146-6 · Cited by 19 · see citing works
Yang, B., Ren, X.-L., Huang, H. L., Guo, X., Ma, A., & Li, D. (2017) · Oncotarget · doi:10.18632/oncotarget.19530 · Cited by 19 · see citing works
Pregnancy as a valuable period for preventing hypoxia‐ischemia brain damage
Netto, C. A., Sanches, E. F., Odorcyk, F. K., Durán‐Carabali, L. E., & Sizonenko, S. V. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.06.004 · Cited by 19 · see citing works
Kumar, J., Khan, S., Mandotra, S. K., Dhar, P., Tayade, A. B., Verma, S., Toppo, K., Arora, R., Upreti, D. K., & Chaurasia, O. P. (2019) · Scientific Reports · doi:10.1038/s41598-018-35595-x · Cited by 19 · see citing works
Manlapaz‐Mann, A., Cai, C. L., Bodkin, D., Mustafa, G., Aranda, J. V., & Beharry, K. D. A. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10120 · Cited by 18 · see citing works
Exploiting drug delivery systems for oral route in the peptic ulcer disease treatment
Spósito, L., Fortunato, G. C., de Camargo, B. A. F., Ramos, M. A. D. S., de Souza, M. P. C., Meneguin, A. B., Bauab, T. M., & Chorilli, M. (2021) · Journal of drug targeting · doi:10.1080/1061186x.2021.1904249 · Cited by 18 · see citing works
Bie, N., Li, J., Li, C., Lian, R., Qin, L., & Wang, C. (2021) · Food & Function · doi:10.1039/d1fo01922h · Cited by 18 · see citing works
Gestational exposure to a ketogenic diet increases sociability in CD-1 mice.
Arqoub, A. M. S., Flynn, K. G., & Martinez, L. A. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000368 · Cited by 17 · see citing works
Mancilla, L. E. F., Hernández-González, M., Guevara, M. A., Benavides‐Haro, D. E., & Martínez-Arteaga, P. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.02.023 · Cited by 16 · see citing works
Shysh, A., Nagibin, V., Kaplinskii, S. P., & Dosenko, V. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.06.013 · Cited by 18 · see citing works
Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities
FRAJEWICKI, A., Laštůvka, Z., Borbélyová, V., Khan, S., Jandová, K., Janisova, K., Otáhal, J., Mysliveček, J., & RILJAK, V. (2021) · Physiological Research · doi:10.33549/physiolres.934595 · Cited by 16 · see citing works
Omega-3 Fatty Acids: Possible Neuroprotective Mechanisms in the Model of Global Ischemia in Rats
Nobre, M. E. P., Correia, A. O., Mendonça, F. N. M., Uchôa, L. R. A., Vasconcelos, J. T. N., de Araújo, C. N. A., Brito, G. A. D. C., Siqueira, R. M. P., Cerqueira, G. S., Neves, K. R. T., et al. (2016) · Journal of Nutrition and Metabolism · doi:10.1155/2016/6462120 · Cited by 16 · see citing works
Chumak, T., Lecuyer, M., Nilsson, A., Faustino, J. V., Ardalan, M., Svedin, P., Sjöbom, U., Ek, C. J., Obenaus, A., Vexler, Z. S., et al. (2021) · Translational Stroke Research · doi:10.1007/s12975-021-00947-9 · Cited by 14 · see citing works
Maternal high-fat diet influences outcomes after neonatal hypoxic-ischemic brain injury in rodents
Barks, J., Liu, Y., Shangguan, Y., Djurić, Z., Ren, J., & Silverstein, F. S. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15624934 · Cited by 13 · see citing works
Rathod, R. S., Khaire, A. A., Kale, A. A., & Joshi, S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.018 · Cited by 12 · see citing works
Yu, J.-F., Yang, H., Fang, B., Zhang, Z., Wang, Y., & Dai, Y. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24096 · Cited by 11 · see citing works
Shati, A. A., & El-kott, A. F. (2021) · Human & Experimental Toxicology · doi:10.1177/09603271211038739 · Cited by 11 · see citing works
Perinatal stroke: a case-based review
Sehgal, A. (2011) · European Journal of Pediatrics · doi:10.1007/s00431-011-1509-3 · Cited by 11 · see citing works
Long, C., Yin, X., Sheng, X., Wang, X., Xiao, L., & Qi, X. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104252 · Cited by 10 · see citing works
Comparative Analysis of the Antioxidant and Anti-Inflammatory Effects of Krill and Fish Oil
Sarıyer, E. T., Baş, M., & Yüksel, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157360 · Cited by 10 · see citing works
Huţanu, A., Iancu, M., Dobreanu, M., Oprea, O. R., Barbu, Ș., Maier, S., Tero-Vescan, A., Bajkó, Z., & Bălașa, R. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.89302 · Cited by 10 · see citing works
Drozd, A., Kotlęga, D., Nowacki, P., Ciećwież, S. M., Trochanowski, T., & Szczuko, M. (2022) · Biomedicines · doi:10.3390/biomedicines10092200 · Cited by 10 · see citing works
Positive and negative conditioning in the neonatal brain.
Vexler, Z. S., Mallard, C. E., & Hagberg, H. (2018) · PubMed · Cited by 10 · see citing works
Reyes‐Corral, M., Gil-González, L., González-Díaz, Á., Luzón., J. T., Ayuso, M. I., Lao, M., Montaner, J., de la Puerta, R., Fernández‐Torres, R., & Ybot‐González, P. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241270237 · Cited by 9 · see citing works
Wei, G., Zhang, Z., Fu, D., Zhang, Y., Zhang, W., Zu, Y., Zhang, L., & Zhang, Z. (2021) · Journal of Oleo Science · doi:10.5650/jos.ess21040 · Cited by 8 · see citing works
Self-citationFan, C., Sun, W., Fu, H., Dong, H., Xia, L., Lu, Y., Deckelbaum, R. J., & Qi, K. (2015) · PubMed · doi:10.3305/nh.2015.32.3.9259 · Cited by 8 · see citing works
White Matter Injury in Preterm Infants
Kotey, F. O., & Spatz, D. L. (2013) · Advances in Neonatal Care · doi:10.1097/anc.0b013e31827bfead · Cited by 8 · see citing works
Decker, M. J., Jones, K. A., Keating, G. L., Damato, E. G., & Darrah, R. J. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.05.007 · Cited by 8 · see citing works
Dyall, S. C., Nessel, I., Sharpe, J. A., Yip, P. K., Michael-Titus, A. T., & Shah, D. K. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1231743 · Cited by 7 · see citing works
Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?
Morozan, V.-P., Ionescu, M.-I., Zahiu, C. D. M., Catrina, A. M., Racoviță, A., Chirilă, A.-T., Dogaru, I.-A., Ciotei, C., Pîrcălăbioru, G. G., & Zăgrean, A. (2025) · Antioxidants · doi:10.3390/antiox14091134 · Cited by 7 · see citing works
- Authors
- Zhang, W., Hu, X., Yang, W., Gao, Y., & Chen, J.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Stroke
- Published
- 2010-10
- Volume
- 41
- Issue
- 10
- Pages
- 2341-2347
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC3021248
- OpenAlex
- W2107189849
- Cited by
- 127
- References
- 21
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 13 · 2020: 6 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 10 · 2012: 6
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 45048, NS-036736, R01NS056118, R01NS045048, R01NS036736, NS056118.)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- omega-3 polyunsaturated fatty acids, neonatal hypoxic-ischemic brain injury, neuroprotection, microglia, neuroinflammation, NF-κB signaling, anti-inflammatory activity, dietary supplementation, perinatal nutrition, rat model
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Brain, Female, Maternal-Fetal Exchange, Pregnancy, Prenatal Exposure Delayed Effects, Time, Fatty Acids, Omega-3, Rats, Sprague-Dawley, Microglia, Neuroprotective Agents, Maze Learning, Reverse Transcriptase Polymerase Chain Reaction, Hypoxia-Ischemia, Brain, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review