Very Early Mobilization After Stroke Fast-Tracks Return to Walking: Further Results From the Phase II AVERT Randomized Controlled Trial
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Background and Purpose—: Regaining functional independence is an important goal for people who have experienced stroke. We hypothesized that introducing earlier and more intensive out-of-bed activity after stroke would reduce time to unassisted walking and improve independence in activities of daily living. Methods—: A Very Early Rehabilitation Trial (AVERT) was a phase II randomized controlled trial. Patients with confirmed stroke (infarct or hemorrhage) admitted <24 hours after stroke and who met physiological safety criteria were eligible. Patients randomized to the very early and intensive mobilization group were mobilized within 24 hours of stroke and at regular intervals thereafter. Control patients received standard stroke unit care. The primary outcome for this analysis was the number of days required to return to walking 50 m unassisted. Secondary outcomes were the Barthel Index and Rivermead Motor Assessment at 3 and 12 months after stroke. Results—: Seventy-one stroke patients with a mean age of 74.7 years were recruited from 2 hospitals. Adjusted Cox regression indicated that very early and intensive mobilization group patients returned to walking significantly faster than did standard stroke unit care controls ( P =0.032; median 3.5 vs 7.0 days). Multivariable regression revealed that exposure to very early and intensive mobilization was independently associated with good functional outcome on the Barthel Index at 3 months ( P =0.008) and on the Rivermead Motor Assessment at 3 ( P =0.050) and 12 ( P =0.024) months. Conclusions—: Earlier and more intensive mobilization after stroke may fast-track return to unassisted walking and improve functional recovery. Clinical Trial Registration—: This trial was not registered because enrollment began before July 2005.
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The phase 2 study of AVERT provided preliminary evidence that very early mobilisation started within 24 h of stroke onset and continued frequently thereafter was feasible, likely to be safe, with promising improvements in walking recovery, and could be cost effective.
“The phase 2 study of AVERT provided preliminary evidence that very early mobilisation started within 24 h of stroke onset and continued frequently thereafter was feasible, likely to be safe 12 with promising improvements in walking recovery, 13 and could be cost effective. 14”
From Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial (2015) · cites this paper as [13]
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Measurements of acute cerebral infarction: a clinical examination scale.
Brott, T. G., Adams, H. P., Olinger, C. P., Marler, J. R., Barsan, W. G., Biller, J., Spilker, J. A., Holleran, R. S., EBERLE, R. W., & Hertzberg, V. (1989) · Stroke · doi:10.1161/01.str.20.7.864 · Cited by 5,918 · see citing works
The Barthel ADL Index: A reliability study
Collin, C., Wade, D. T., Davies, S., & Horne, V. (1988) · International Disability Studies · doi:10.3109/09638288809164103 · Cited by 2,740 · see citing works
Recovery of walking function in stroke patients: The copenhagen stroke study
Jørgensen, H. S., Nakayama, H., Raaschou, H. O., & Olsen, T. S. (1995) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(95)80038-7 · Cited by 1,165 · see citing works
Effects of Augmented Exercise Therapy Time After Stroke: A Meta-Analysis
Kwakkel, G., van Peppen, R., Wagenaar, R. C., Wood Dauphinee, S., Richards, C., Ashburn, A., Miller, K., Lincoln, N., Partridge, C., Wellwood, I., et al. (2004) · Stroke · doi:10.1161/01.str.0000143153.76460.7d · Cited by 1,081 · see citing works
Functional abilities after stroke: measurement, natural history and prognosis.
Wade, D. T., & Hewer, R. L. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.2.177 · Cited by 896 · see citing works
Bamford, J., Sandercock, P. A., Dennis, M. S., Burn, J., & Warlow, C. (1990) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.53.1.16 · Cited by 811 · see citing works
Mobility after stroke: Reliability of measures of impairment and disability
Collen, F. M., Wade, D. T., & Bradshaw, C. M. (1990) · International Disability Studies · doi:10.3109/03790799009166594 · Cited by 668 · see citing works
Bernhardt (2004) · doi:10.1161/01.str.0000120727.40792.40 · Cited by 593 · see citing works
Self-citationBed rest: a potentially harmful treatment needing more careful evaluation
Allen, C., Glasziou, P., & Mar, C. D. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10063-6 · Cited by 480 · see citing works
Benefit of a stroke unit: a randomized controlled trial.
Indredavik, B., Bakke, F., Solberg, R., Rokseth, R., Haaheim, L. L., & Holme, I. (1991) · Stroke · doi:10.1161/01.str.22.8.1026 · Cited by 462 · see citing works
The Clinical Meaning of Rankin ‘Handicap’ Grades After Stroke
de Haan, R. J., Limburg, M., Bossuyt, P. M., van der Meulen, J., & Aaronson, N. K. (1995) · Stroke · doi:10.1161/01.str.26.11.2027 · Cited by 450 · see citing works
Treatment in a Combined Acute and Rehabilitation Stroke Unit: Which Aspects Are Most Important?
Indredavik, B., Bakke, F., Slørdahl, S. A., Rokseth, R., & Håheim, L. L. (1999) · Stroke · doi:10.1161/01.str.30.5.917 · Cited by 368 · see citing works
A Very Early Rehabilitation Trial for Stroke (AVERT): Phase II Safety and Feasibility
Bernhardt, J., Dewey, H., Thrift, A., Collier, J., & Donnan, G. (2008) · Stroke · doi:10.1161/strokeaha.107.492363 · Cited by 366 · see citing works
Self-citationAssessment of motor function in stroke patients.
Lincoln, N. B., & Leadbitter, D. (1979) · PubMed · Cited by 343 · see citing works
Predicting functional outcome and survival after acute ischemic stroke
Weimar, C., Ziegler, A., König, I. R., & Diener, H.-C. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0755-8 · Cited by 320 · see citing works
Prediction of rehabilitation outcomes with disability measures
Heinemann, A. W., Linacre, J. M., Wright, B. D., Hamilton, B. B., & Granger, C. V. (1994) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/0003-9993(94)90385-9 · Cited by 305 · see citing works
Predictors of stroke outcome using objective measurement scales.
Loewen, S. C., & Anderson, B. A. (1990) · Stroke · doi:10.1161/01.str.21.1.78 · Cited by 291 · see citing works
A patient-centred study of the consequences of stroke
Pound, P., Gompertz, P., & Ebrahim, S. B. J. (1998) · Clinical Rehabilitation · doi:10.1191/026921598677661555 · Cited by 259 · see citing works
Long-Term Functional Recovery After First Ischemic Stroke
Dhamoon, M. S., Moon, Y. P., Paik, M. C., Boden-Albala, B. M., Rundek, T., Sacco, R. L., & Elkind, M. S. V. (2009) · Stroke · doi:10.1161/strokeaha.109.549576 · Cited by 245 · see citing works
Fugl‐Meyer, A. R., Hellström, K., Lindmark, B., & Vahlberg, B. M. (2003) · Journal of Rehabilitation Medicine · doi:10.1080/16501970310000836 · Cited by 211 · see citing works
Stroke Incidence on the East Coast of Australia
Thrift, A. G., Dewey, H. M., Macdonell, R. A. L., McNeil, J. J., & Donnan, G. A. (2000) · Stroke · doi:10.1161/01.str.31.9.2087 · Cited by 198 · see citing works
Self-citationRate, degree, and predictors of recovery from disability following ischemic stroke
Hankey, G. J., Spiesser, J., Hakimi, Z., Bego, G., Carità, P., & Gabriel, S. (2007) · Neurology · doi:10.1212/01.wnl.0000260967.77422.97 · Cited by 179 · see citing works
Prediction of adolescent injury risk awareness
Heinemann, A. W., Lehmkuhl, D. I., Garvin, L., Graves, D. E., & Kelker, D. (1994) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/0003-9993(94)90219-4 · Cited by 101 · see citing works
RECOVERY TIME OF INDEPENDENT FUNCTION POST-STROKE
Mayo, N. E., Korner-Bitensky, N. A., & Becker, R. (1991) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-199102000-00003 · Cited by 92 · see citing works
Lesion Characteristics, NIH Stroke Scale, and Functional Recovery After Stroke
Glymour, M. M., Berkman, L. F., Ertel, K. A., Fay, M. E., Glass, T. A., & Furie, K. L. (2007) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0b013e31813e0a32 · Cited by 59 · see citing works
The Mobility Scale for Acute Stroke Patients: concurrent validity
Simondson, J., Goldie, P. A., & Greenwood, K. M. (2003) · Clinical Rehabilitation · doi:10.1191/0269215503cr650oa · Cited by 48 · see citing works
Bonetti, D., & Johnston, M. (2008) · British Journal of Health Psychology · doi:10.1348/135910707x216648 · Cited by 44 · see citing works
Exploring rating scale responsiveness
O’Connor, R. J., Cano, S., Thompson, A. J., & Hobart, J. C. (2004) · Neurology · doi:10.1212/01.wnl.0000116136.22922.d6 · Cited by 40 · see citing works
The verbal administration of the gross function scale of the Rivermead Motor Assessment
Sackley, C. M., & Lincoln, N. (1990) · Clinical Rehabilitation · doi:10.1177/026921559000400409 · Cited by 19 · see citing works
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- [28]28. Bernhardt J, Dewey HM, Thrift AG, Collier JM, Lindley RI, Moodie M, Donnan GA. Lancet protocol review: protocol 06PRT/5424: A Very Early Rehabilitation Trial (AVERT): phase III. Published on-line Lancet. July 2007. http://www.thelancet.com/journals/lancet/misc/protocol/ 06PRT-5424.
Cited by
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Guidelines for the Management of Spontaneous Intracerebral Hemorrhage
Hemphill, J. C., Greenberg, S. M., Anderson, C. S., Becker, K. J., Bendok, B. R., Cushman, M., Fung, G. L., Goldstein, J. N., Macdonald, R. L., Mitchell, P. H., et al. (2015) · Stroke · doi:10.1161/str.0000000000000069 · Cited by 3,992 · see citing works
Winstein, C. J., Stein, J., Arena, R., Bates, B., Cherney, L. R., Cramer, S. C., Deruyter, F., Eng, J. J., Fisher, B., Harvey, R. L., et al. (2016) · Stroke · doi:10.1161/str.0000000000000098 · Cited by 3,293 · see citing works
Billinger, S. A., Arena, R., Bernhardt, J., Eng, J. J., Franklin, B. A., Johnson, C. M., MacKay-Lyons, M., Macko, R. F., Mead, G. E., Roth, E. J., et al. (2014) · Stroke · doi:10.1161/str.0000000000000022 · Cited by 1,529 · see citing works
Self-citationGuidelines for the Management of Spontaneous Intracerebral Hemorrhage
Morgenstern, L. B., Hemphill, J. C., Anderson, C. S., Becker, K. J., Broderick, J. P., Connolly, E. S., Greenberg, S. M., Huang, J. N., Macdonald, R. L., Messe, S. R., et al. (2010) · Stroke · doi:10.1161/str.0b013e3181ec611b · Cited by 1,486 · see citing works
Dose and timing in neurorehabilitation
Lang, C. E., Lohse, K. R., & Birkenmeier, R. L. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000256 · Cited by 278 · see citing works
Outcomes of inpatient mobilization: a literature review
Kalisch, B. J., Lee, S., & Dabney, B. W. (2013) · Journal of Clinical Nursing · doi:10.1111/jocn.12315 · Cited by 216 · see citing works
Stroke and the Connectome: How Connectivity Guides Therapeutic Intervention
Silasi, G., & Murphy, T. H. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.052 · Cited by 214 · see citing works
Impact of Early Mobilization Protocol on the Medical-Surgical Inpatient Population
Pashikanti, L., & Ah, D. M. V. (2012) · Clinical Nurse Specialist · doi:10.1097/nur.0b013e31824590e6 · Cited by 206 · see citing works
Gallacher, K., Morrison, D., Jani, B., Macdonald, S., May, C. R., Montori, V. M., Erwin, P. J., Batty, G. D., Eton, D. T., Langhorne, P., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001473 · Cited by 194 · see citing works
Langhorne, P., Wu, O., Rodgers, H., Ashburn, A., & Bernhardt, J. A. (2017) · Health Technology Assessment · doi:10.3310/hta21540 · Cited by 193 · see citing works
Self-citationImpact of Rehabilitation on Outcomes in Patients With Ischemic Stroke
Yagi, M., Yasunaga, H., Matsui, H., Morita, K., Fushimi, K., Fujimoto, M., Koyama, T., & Fujitani, J. (2017) · Stroke · doi:10.1161/strokeaha.116.015147 · Cited by 171 · see citing works
Selves, C., Stoquart, G. G., & Lejeune, T. M. (2020) · Acta Neurologica Belgica · doi:10.1007/s13760-020-01320-7 · Cited by 166 · see citing works
Cerebrolysin and Recovery After Stroke (CARS)
Muresanu, D. F., Heiss, W., Hoemberg, V., Bajenaru, O. A., Popescu, C. D., Vester, J., Rahlfs, V. W., Doppler, E., Meier, D., Moessler, H., et al. (2015) · Stroke · doi:10.1161/strokeaha.115.009416 · Cited by 165 · see citing works
Does Aerobic Exercise and the FITT Principle Fit into Stroke Recovery?
Billinger, S. A., Boyne, P., Coughenour, E., Dunning, K. K., & Mattlage, A. E. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0519-8 · Cited by 154 · see citing works
Austin, M. W., Ploughman, M., Glynn, L., & Corbett, D. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.06.007 · Cited by 153 · see citing works
Madden, L. K., Hill, M., May, T., Human, T., Guanci, M. M., Jacobi, J., Moreda, M. V., & Badjatia, N. (2017) · Neurocritical Care · doi:10.1007/s12028-017-0469-5 · Cited by 146 · see citing works
Very early versus delayed mobilisation after stroke
Bernhardt, J., Thuy, M. N., Collier, J. M., & Legg, L. A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006187.pub2 · Cited by 134 · see citing works
Self-citationAlbert, S. J., & Kesselring, J. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6247-y · Cited by 129 · see citing works
Spontaneous Intracerebral Hemorrhage: Management
Kim, J. Y., & Bae, H. (2017) · Journal of Stroke · doi:10.5853/jos.2016.01935 · Cited by 127 · see citing works
Rehabilitation and early mobilization in the critical patient: systematic review
Arias-Fernández, P., Romero‐Martín, M., Gómez-Salgado, J. C., & Fernández-García, D. (2018) · Journal of Physical Therapy Science · doi:10.1589/jpts.30.1193 · Cited by 123 · see citing works
Early Mobilization After Stroke: Early Adoption but Limited Evidence
Bernhardt, J., English, C., Johnson, L., & Cumming, T. B. (2015) · Stroke · doi:10.1161/strokeaha.114.007434 · Cited by 117 · see citing works
Self-citationInterventions to Mobilize Elderly Patients and Reduce Length of Hospital Stay
Surkan, M., & Gibson, W. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.04.033 · Cited by 115 · see citing works
Wearable devices for patient monitoring in the early postoperative period: a literature review
Amin, T., Mobbs, R. J., Mostafa, N., Sy, L. W., & Choy, W. J. (2021) · mHealth · doi:10.21037/mhealth-20-131 · Cited by 109 · see citing works
Rehabilitation is Initiated Early After Stroke, but Most Motor Rehabilitation Trials Are Not
Stinear, C. M., Ackerley, S. J., & Byblow, W. D. (2013) · Stroke · doi:10.1161/strokeaha.113.000968 · Cited by 106 · see citing works
Very early versus delayed mobilisation after stroke
Langhorne, P., Collier, J. M., Bate, P. J., Thuy, M. N. T., & Bernhardt, J. A. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006187.pub3 · Cited by 103 · see citing works
Self-citationKnecht, S., Hesse, S., & Oster, P. (2011) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2011.0600 · Cited by 100 · see citing works
Assisted Early Mobility for Hospitalized Older Veterans: Preliminary Data from the STRIDE Program
Hastings, S. N., Sloane, R. J., Morey, M. C., Pavon, J. M., & Hoenig, H. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13095 · Cited by 99 · see citing works
AMOBES (Active Mobility Very Early After Stroke)
Yelnik, A. P., Quintaine, V., Andriantsifanetra, C., Wannepain, M., Reiner, P., Marnef, H., Evrard, M., Meseguer, E., Devailly, J. P., Lozano, M., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.014803 · Cited by 98 · see citing works
Randomized Controlled Trial of Early Rehabilitation After Intracerebral Hemorrhage Stroke
Liu, N., Cadilhac, D. A.-M., Andrew, N. E., Zeng, L., Li, Z., Li, J., Li, Y., Yu, X., Mi, B., Li, Z., et al. (2014) · Stroke · doi:10.1161/strokeaha.114.005661 · Cited by 96 · see citing works
Pulmonary and Physical Rehabilitation in Critically Ill Patients
Jang, M. H., Shin, M., & Shin, Y. B. (2019) · Acute and Critical Care · doi:10.4266/acc.2019.00444 · Cited by 95 · see citing works
Diserens, K., Moreira, T., Hirt, L., Faouzi, M., Grujic, J., Bieler, G., Vuadens, P., & Michel, P. (2011) · Clinical Rehabilitation · doi:10.1177/0269215511425541 · Cited by 93 · see citing works
Physical Activity Early after Stroke and Its Association to Functional Outcome 3 Months Later
Askim, T., Bernhardt, J., Salvesen, Ø., & Indredavik, B. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2013.12.011 · Cited by 91 · see citing works
Self-citationOlkowski, B. F., Devine, M. A., Slotnick, L. E., Veznedaroglu, E., Liebman, K. M., Arcaro, M. L., & Binning, M. J. (2012) · Physical Therapy · doi:10.2522/ptj.20110334 · Cited by 88 · see citing works
Resnick, B. M., & Boltz, M. P. (2019) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.01.003 · Cited by 87 · see citing works
To total amount of activity….. and beyond: perspectives on measuring physical behavior
Bussmann, J. B. J., & van den Berg-Emons, R. J. G. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00463 · Cited by 78 · see citing works
Activity level of hospital medical inpatients: An observational study
Kuys, S. S., Dolecka, U. E., & Guard, A. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.02.008 · Cited by 76 · see citing works
Chippala, P., & Sharma, R. (2015) · Clinical Rehabilitation · doi:10.1177/0269215515596054 · Cited by 76 · see citing works
Rehabilitation – a new approach. Part four: a new paradigm, and its implications
Wade, D. T. (2015) · Clinical Rehabilitation · doi:10.1177/0269215515601177 · Cited by 76 · see citing works
Early Mobilization in the Neuro-ICU: How Far Can We Go?
Olkowski, B. F., & Shah, S. O. (2016) · Neurocritical Care · doi:10.1007/s12028-016-0338-7 · Cited by 75 · see citing works
Fatigue in the acute phase after first stroke predicts poorer physical health 18 months later
Lerdal, A., & Gay, C. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a9f471 · Cited by 74 · see citing works
When Should Physical Rehabilitation Commence after Stroke: A Systematic Review
Lynch, E. A., Hillier, S., & Cadilhac, D. A.-M. (2014) · International Journal of Stroke · doi:10.1111/ijs.12262 · Cited by 73 · see citing works
Craig, L. E., Bernhardt, J., Langhorne, P., & Wu, O. (2010) · Stroke · doi:10.1161/strokeaha.110.588244 · Cited by 72 · see citing works
Self-citationUse of Accelerometers to Examine Sedentary Time on an Acute Stroke Unit
Mattlage, A. E., Redlin, S. A., Rippee, M. A., Abraham, M. G., Rymer, M. M., & Billinger, S. A. (2015) · Neurology Report · doi:10.1097/npt.0000000000000092 · Cited by 72 · see citing works
Clarkson, A. N., Parker, K., Nilsson, M., Walker, F. R., & Gowing, E. K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.33 · Cited by 71 · see citing works
Richards, C. L., Malouin, F., & Nadeau, S. M. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.01.003 · Cited by 70 · see citing works
Tong, Y., Cheng, Z., Rajah, G. B., Duan, H., Cai, L., Zhang, N., Du, H., Geng, X., & Ding, Y. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00113 · Cited by 69 · see citing works
Atashzar, S. F., Carriere, J., & Tavakoli, M. (2021) · Frontiers in Robotics and AI · doi:10.3389/frobt.2021.610529 · Cited by 67 · see citing works
Effects of Early Mobilization after Acute Stroke: A Meta-Analysis of Randomized Control Trials
Li, Z., Zhang, X., Wang, K., & Wen, J. (2018) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.12.021 · Cited by 67 · see citing works
Zhang, P., Zhang, Y., Zhang, J., Wu, Y., Jia, J., Wu, J., & Hu, Y. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036074 · Cited by 65 · see citing works
Factors associated with time to independent walking recovery post-stroke
Kennedy, C., Bernhardt, J. A., Churilov, L. P., Collier, J. M., Ellery, F., Rethnam, V., Carvalho, L. B., Donnan, G. A., & Hayward, K. S. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325125 · Cited by 62 · see citing works
Self-citationEarly Physical Rehabilitation in the ICU: A Review for the Neurohospitalist
Méndez-Téllez, P. A., Nusr, R., Feldman, D. R., & Needham, D. M. (2012) · The Neurohospitalist · doi:10.1177/1941874412447631 · Cited by 62 · see citing works
Wu, W.-X., Zhou, C.-Y., Wang, Z., Chen, G.-Q., Chen, X., Jin, H.-M., & He, D.-R. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.104649 · Cited by 61 · see citing works
Kanai, M., Izawa, K. P., Kobayashi, M., Ōnishi, A., Kubo, H., Nozoe, M., Mase, K., & Shimada, S. (2018) · Clinical Rehabilitation · doi:10.1177/0269215518755841 · Cited by 61 · see citing works
Ueba, T., Hamada, O., Ogata, T., Inoue, T., Shiota, E., & Sankai, Y. (2013) · Neurologia medico-chirurgica · doi:10.2176/nmc.53.287 · Cited by 60 · see citing works
Recovery Potential After Acute Stroke
Seitz, R. J., & Donnan, G. A. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00238 · Cited by 56 · see citing works
Self-citationInterventions for reducing sedentary behaviour in people with stroke
Saunders, D. H., Mead, G. E., Fitzsimons, C., Kelly, P., van Wijck, F., Verschuren, O., Backx, K., & English, C. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012996.pub2 · Cited by 55 · see citing works
Measuring Activity Levels at an Acute Stroke Ward: Comparing Observations to a Device
Kramer, S. F., Cumming, T. B., Churilov, L. P., & Bernhardt, J. (2013) · BioMed Research International · doi:10.1155/2013/460482 · Cited by 55 · see citing works
Self-citationKumar, A., Adhikari, D., Karmarkar, A. M., Freburger, J. K., Gozalo, P. L., Mor, V., & Resnik, L. J. (2019) · Physical Therapy · doi:10.1093/ptj/pzz014 · Cited by 52 · see citing works
Clinical Practice Guideline for Stroke Rehabilitation in Korea 2016
Kim, D. Y., Kim, Y., Lee, J., Chang, W. H., Kim, M.-W., Pyun, S., Yoo, W., Ohn, S. H., Park, K. D., Oh, B., et al. (2017) · Brain & Neurorehabilitation · doi:10.12786/bn.2017.10.e11 · Cited by 52 · see citing works
Calabrò, R. S., Naro, A., Russo, M., Leo, A., Balletta, T., Saccá, I., Luca, R. D., & Bramanti, P. (2015) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-140475 · Cited by 52 · see citing works
Goffredo, M., on behalf of Italian EksoGait Study Group, Guanziroli, E., Pournajaf, S., Gaffuri, M., Gasperini, G., Filoni, S., Baratta, S., Damiani, C., Franceschini, M., et al. (2020) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.19.05574-6 · Cited by 52 · see citing works
An, K., Rybalko, N. V., Daminov, V. D., & Luft, A. R. (2013) · Stroke Research and Treatment · doi:10.1155/2013/946056 · Cited by 51 · see citing works
Poststroke Physical Activity Levels No Higher in Rehabilitation than in the Acute Hospital
Åstrand, A., Saxin, C., Sjöholm, A., Skarin, M., Linden, T. K. A., Stoker, A., Roshandel, S., Dedering, Å., Halvorsen, M., Bernhardt, J. A., et al. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.12.046 · Cited by 50 · see citing works
Self-citationWalters, R., Collier, J. M., Carvalho, L. B., Langhorne, P., Ali, N. A. M., Tan, D. M. L., Moodie, M., & Bernhardt, J. A. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-035850 · Cited by 50 · see citing works
Self-citationFleming, L. M., Zhao, X., DeVore, A. D., Heidenreich, P. A., Yancy, C. W., Fonarow, G. C., Hernandez, A. F., & Kociol, R. D. (2018) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004634 · Cited by 49 · see citing works
Update on Intravenous Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke
Fugate, J. E., & Rabinstein, A. A. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.03.001 · Cited by 48 · see citing works
Kjeverud, A., Østlie, K., Schanke, A., Gay, C., Thoresen, M., & Lerdal, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231709 · Cited by 47 · see citing works
Left Ventricular Diastolic Dysfunction in Ischemic Stroke: Functional and Vascular Outcomes
Park, H., Kim, B. J., Yoon, C., Yang, M., Han, M., & Bae, H. (2016) · Journal of Stroke · doi:10.5853/jos.2015.01697 · Cited by 46 · see citing works
Geng, H., Min, L., Tang, J. Y., Lv, Q., Li, R., & Wang, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810508 · Cited by 44 · see citing works
Lerdal, A., & Gay, C. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.11.130 · Cited by 44 · see citing works
Ekechukwu, E. N. D., Olowoyo, P., Nwankwo, K. O., Olaleye, O. A., Ogbodo, V. E., Hamzat, T. K., & Owolabi, M. O. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00337 · Cited by 44 · see citing works
Novel Score Predicting Gastrostomy Tube Placement in Intracerebral Hemorrhage
Faigle, R., Marsh, E. B., Llinas, R. H., Urrutia, V., & Gottesman, R. F. (2014) · Stroke · doi:10.1161/strokeaha.114.006891 · Cited by 42 · see citing works
Imura, T., Nagasawa, Y., Fukuyama, H., Imada, N., Oki, S., & Araki, O. (2017) · Disability and Rehabilitation · doi:10.1080/09638288.2017.1300337 · Cited by 42 · see citing works
Goffredo, M., Iacovelli, C., Russo, E. F., Pournajaf, S., Blasi, C. D., Galafate, D., Pellicciari, L., Agosti, M., Filoni, S., Aprile, I. G., et al. (2019) · Applied Sciences · doi:10.3390/app9132627 · Cited by 42 · see citing works
Yen, H.-C., Chuang, H., Hsiao, W.-L., Tsai, Y.-C., Hsu, P.-M., Chen, W., & Han, Y. (2024) · Critical Care · doi:10.1186/s13054-024-04940-0 · Cited by 40 · see citing works
Norvang, O. P., Hokstad, A., Taraldsen, K., Tan, X., Lydersen, S., Indredavik, B., & Askim, T. (2018) · BMC Neurology · doi:10.1186/s12883-018-1134-0 · Cited by 40 · see citing works
When Should Rehabilitation Begin after Stroke?
Bernhardt, J. A., Indredavik, B., & Langhorne, P. (2012) · International Journal of Stroke · doi:10.1111/ijs.12020 · Cited by 39 · see citing works
Self-citationKono, Y., Izawa, H., Aoyagi, Y., Ishikawa, A. W., Sugiura, T., Mori, E., Yanohara, R., Ishiguro, T., Yamada, R., Okumura, S., et al. (2019) · Heart and Vessels · doi:10.1007/s00380-019-01517-8 · Cited by 39 · see citing works
Hellweg, S. (2012) · Critical Care Research and Practice · doi:10.1155/2012/768456 · Cited by 39 · see citing works
Venturelli, P. M., Arima, H., Lavados, P. M., Brunser, A. M., Peng, B., Cui, L., Song, L., Billot, L., Boaden, E., Hackett, M. L., et al. (2015) · Trials · doi:10.1186/s13063-015-0767-1 · Cited by 38 · see citing works
Early rehabilitation in patients with acute aneurysmal subarachnoid hemorrhage
Karic, T., Sorteberg, A. G., Nordenmark, T. H., Becker, F., & Røe, C. (2014) · Disability and Rehabilitation · doi:10.3109/09638288.2014.966162 · Cited by 38 · see citing works
Factors influencing implementation of aerobic exercise after stroke: a systematic review
Gaskins, N. J., Bray, E. P., Hill, J. E., Doherty, P., Harrison, A. S., & Connell, L. (2019) · Disability and Rehabilitation · doi:10.1080/09638288.2019.1704075 · Cited by 37 · see citing works
Aries, M. J. H., Elting, J. W. J., Stewart, R. E., Keyser, J. D., Kremer, B. P. H., & Vroomen, P. C. A. J. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002960 · Cited by 37 · see citing works
Lou, Y., Liu, Z., Ji, Y., Cheng, J., Zhao, C., & Li, L. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1423517 · Cited by 36 · see citing works
The immediate effects of fitting and tuning solid ankle–foot orthoses in early stroke rehabilitation
Carse, B., Bowers, R. J., Meadows, B. C., & Rowe, P. J. (2014) · Prosthetics and Orthotics International · doi:10.1177/0309364614538090 · Cited by 36 · see citing works
Patients with severe acquired brain injury show increased arousal in tilt-table training.
Riberholt, C. G., Thorlund, J. B., Mehlsen, J., & Nordenbo, A. M. (2013) · PubMed · Cited by 36 · see citing works
Neurorehabilitation: Motor recovery after stroke as an example
Ganguly, K., Byl, N. N., & Abrams, G. (2013) · Annals of Neurology · doi:10.1002/ana.23994 · Cited by 36 · see citing works
The next revolution in stroke care
Teasell, R. W., Rice, D. B., Richardson, M., Campbell, N., Madady, M., Hussein, N., Murie-Fernández, M., & Page, S. J. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.968130 · Cited by 35 · see citing works
Mobile Phone-Connected Wearable Motion Sensors to Assess Postoperative Mobilization
Appelboom, G., Taylor, B. E. S., Bruce, E. M., Bassile, C. C., Malakidis, C., Yang, A., Youngerman, B., D’Amico, R. S., Bruce, S., Bruyère, O., et al. (2015) · JMIR mhealth and uhealth · doi:10.2196/mhealth.3785 · Cited by 35 · see citing works
Clinical Practice Guideline for Stroke Rehabilitation in Korea
Kim, Y., Han, T. R., Jung, H. Y., Chun, M. H., Lee, J., Kim, D. Y., Paik, N., Park, S.-W., Kim, M.-W., Pyun, S., et al. (2009) · Brain & Neurorehabilitation · doi:10.12786/bn.2009.2.1.1 · Cited by 35 · see citing works
Fukuda, H., Samura, K., Hamada, O., Saita, K., Ogata, T., Shiota, E., Sankai, Y., & Inoue, T. (2015) · Neurologia medico-chirurgica · doi:10.2176/nmc.oa.2014-0431 · Cited by 34 · see citing works
Early Progressive Mobilization of Patients with External Ventricular Drains: Safety and Feasibility
Yataco, R. A., Arnold, S. M., Brown, S. M., Freeman, W. D., Cononie, C., Heckman, M. G., Partridge, L. W., Stucky, C. M., Mellon, L. N., Birst, J., et al. (2018) · Neurocritical Care · doi:10.1007/s12028-018-0632-7 · Cited by 33 · see citing works
Interventions for reducing sedentary behaviour in people with stroke
Saunders, D. H., Mead, G. E., Fitzsimons, C. F., Kelly, P., van Wijck, F., Verschuren, O. W., & English, C. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012996 · Cited by 32 · see citing works
How to increase activity level in the acute phase after stroke
van de Port, I. G. L., Valkenet, K., Schuurmans, M. J., & Visser‐Meily, J. M. A. (2012) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2012.04249.x · Cited by 31 · see citing works
Cusack, T. J., Carhuapoma, J. R., & Ziai, W. (2018) · Current Treatment Options in Neurology · doi:10.1007/s11940-018-0486-5 · Cited by 30 · see citing works
Logan, A., Freeman, J. A., Kent, B., Pooler, J., Creanor, S., Vickery, J., Enki, D. G., Barton, A., & Marsden, J. F. (2018) · Pilot and Feasibility Studies · doi:10.1186/s40814-018-0254-z · Cited by 30 · see citing works
Arnold, S. M., Dinkins, M., Mooney, L. H., Freeman, W. D., Rawal, B., Heckman, M. G., & Davis, O. (2015) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2015.01.007 · Cited by 30 · see citing works
Feasibility and Efficacy of Function-Focused Care for Orthopedic Trauma Patients
Resnick, B. M., Wells, C. L., Galik, E. M., Holtzman, L., Zhu, S., Gamertsfelder, E., Laidlow, T., & Boltz, M. P. (2016) · Journal of Trauma Nursing · doi:10.1097/jtn.0000000000000203 · Cited by 29 · see citing works
Hancock, N., Shepstone, L., Winterbotham, W., & Pomeroy, V. M. (2011) · International Journal of Stroke · doi:10.1111/j.1747-4949.2011.00728.x · Cited by 28 · see citing works
- Authors
- Cumming, T. B., Thrift, A. G., Collier, J. M., Churilov, L., Dewey, H. M., Donnan, G. A., & Bernhardt, J.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- ORCID
- Venue
- Stroke
- Published
- 2011-01
- Volume
- 42
- Issue
- 1
- Pages
- 153-158
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2123996033
- Cited by
- 281
- References
- 29
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 12 · 2023: 10 · 2022: 21 · 2021: 15 · 2020: 28 · 2019: 17 · 2018: 18 · 2017: 16 · 2016: 17 · 2015: 29 · 2014: 28 · 2013: 25 · 2012: 19
- FWCI
- 18.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
- Keywords
- early mobilization, functional recovery, activities of daily living, stroke rehabilitation, Barthel Index, stroke unit care
- MeSH terms
- Aged, Aged, 80 and over, Early Ambulation, Female, Humans, Male, Prospective Studies, Time Factors, Multivariate Analysis, Walking, Intracranial Hemorrhages, Brain Infarction
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