Cited by 34Physical Activity and HealthAcute Ischemic Stroke ManagementCardiovascular and exercise physiology

Trajectories in leisure-time physical activity and risk of stroke in women in the California Teachers Study

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Willey, Joshua Z., Voutsinas, Jenna, Sherzai, Ayesha, Ma, Huiyan, Bernstein, Leslie, Elkind, Mitchell S.V., Cheung, Ying K., Wang, Sophia S.·2017·Stroke

Abstract

Background and Purpose—: Whether changes in leisure-time physical activity (LTPA) over time are associated with lower risk of stroke is not well established. We examined the association between changes in self-reported LTPA 10 years apart, with risk of incident stroke in the CTS (California Teachers Study). We hypothesized that the risk of stroke would be lowest among those who remained active. Methods—: Sixty-one thousand two hundred and fifty-six CTS participants reported LTPA at 2 intensity levels (moderate and strenuous activity) at 2 time points (baseline 1995–96; 10-year follow-up 2005–2006). LTPA at each intensity level was categorized based on American Heart Association (AHA) recommendations (moderate, >150 minutes/week; strenuous, >75 minutes/week). Changes in LTPA were summarized as follows: (1) not meeting recommendations at both time points; (2) meeting recommendations only at follow-up; (3) meeting recommendations only at baseline; and (4) meeting recommendations at both time points. Incident strokes were identified through California state hospitalization records. Using multivariable Cox models, we examined the associations between changes in LTPA with incident stroke. Results—: Nine hundred and eighty-seven women were diagnosed with stroke who completed both questionnaires. Meeting AHA recommendations at both the time points was associated with a lower risk of all stroke (adjusted hazard ratio, 0.84; 95% confidence interval, 0.72–0.98). The protective effects for stroke were driven by meeting AHA recommendations for moderate activity and largely observed for ischemic strokes (adjusted hazard ratio, 0.70; 95% confidence interval, 0.55–0.88). Conclusions—: Meeting AHA recommendations for moderate activity had a protective effect for reducing ischemic stroke risk. Participants who met AHA recommendations at baseline but not at follow-up, however, were not afforded reduced stroke risk.

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Authors
Willey, J. Z., Voutsinas, J., Sherzai, A., Ma, H., Bernstein, L., Elkind, M. S. V., Cheung, Y. K., & Wang, S. S.
Affiliations
Cedars-Sinai Medical Center (US)
Venue
Stroke
Published
2017-09
Volume
48
Issue
9
Pages
2346-2352
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
OpenAlex
W2743908248
Cited by
34
References
29
Citations by year
2026: 3 · 2025: 3 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 2
FWCI
1.82
Type
journal article
Language
en
Open access
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01HL111195)
  • National Institute of Neurological Disorders and Stroke (K23NS073104)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
leisure-time physical activity, stroke risk, ischemic stroke, physical activity trajectories, moderate physical activity, women, California Teachers Study, incident stroke
MeSH terms
School Teachers, Adult, Aged, Aged, 80 and over, American Heart Association, California, Female, Follow-Up Studies, Humans, Leisure Activities, Middle Aged, Surveys and Questionnaires, Risk, United States, Exercise, Incidence, Multivariate Analysis, Proportional Hazards Models, Guideline Adherence, Stroke, Self Report

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