The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Decreased Functional Connectivity by Aging Is Associated with Cognitive Decline
Abstract
Aging is related to cognitive decline, and it has been reported that aging disrupts some resting state brain networks. However, most studies have focused on the default mode network and ignored other resting state networks. In this study, we measured resting state activity using fMRI and explored whether cognitive decline with aging is related to disrupted resting state networks. Independent component analysis was used to evaluate functional connectivity. Notably, the connectivity within the salience network that consisted of the bilateral insula and the anterior cingulated cortex decreased with aging; the impairment of functional connectivity was correlated with measured decreases in individual cognitive abilities. Furthermore, certain internetwork connectivities (salience to auditory, default mode to visual, etc.) also decreased with aging. These results suggest that (1) aging affects not only the default mode network but also other networks, specifically the salience network; (2) aging affects internetwork connectivity; and (3) disruption of the salience network is related to cognitive decline in elderly people.
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MethodInfluentialA fast diffeomorphic image registration algorithm
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Consistent resting-state networks across healthy subjects
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Cited by
Betzel, R. F., Byrge, L., He, Y., Goñi, J., Zuo, X.-N., & Sporns, O. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.07.067 · Cited by 807
Reorganization of brain networks in aging: a review of functional connectivity studies
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The role of the medial prefrontal cortex in cognition, ageing and dementia
Jobson, D. D., Hase, Y., Clarkson, A. N., & Kalaria, R. N. (2021) · Brain Communications · doi:10.1093/braincomms/fcab125 · Cited by 338
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Bagarinao, E., Watanabe, H., Maesawa, S., Mori, D., Hara, K., Kawabata, K., Yoneyama, N., Ohdake, R., Imai, K., Masuda, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47922-x · Cited by 108
Metadata
- Authors
- Onoda, K., Ishihara, M., & Yamaguchi, S.
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press
- Published
- 2012-11-01
- Volume
- 24
- Issue
- 11
- Pages
- 2186-2198
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2133173194
- Cited by
- 316
- References
- 68
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
