Synthesis and degradation of a tri-component copolymer derived from glycolide, L-lactide, and ε-caprolactone

Abstract

A series of tri-component copolymers was synthesized by ring opening copolymerization of cyclic lactones, i.e. glycolide, L-lactide, and caprolactone, using stannous octoate as a catalyst. Various techniques, including FT-IR, 1H NMR, DSC, X-ray diffraction, tensile strength, and contact angle measurements, were used to elucidate structural characteristics, thermal behavior, mechanical properties, and hydrophilicity of the resulting copolymers. Data showed that the properties of these copolymers could be modulated by adjusting the composition of the copolymers. The DSC and X-ray analysis demonstrated amorphous structures for most of the PGLC copolyesters. The degradation behavior of these PGLC copolymers had been studied in vitro, i.e. in 0.10 M pH 7.4 phosphate buffer solution (PBS). The degradation was monitored by intrinsic viscosity and weight loss measurements. SEM and GPC were also used to monitor the morphology and molecular weight change during degradation. The PGLC copolymers were shown to have variable degradation rates, and most of them could disappear within a few months due to their amorphous structure and low glass transition temperature.