The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.
Inhaled Bronchodilators Reduce Dynamic Hyperinflation During Exercise in Patients With Chronic Obstructive Pulmonary Disease
Abstract
Dynamic hyperinflation (DH) is a major pathophysiologic consequence of airflow limitation during exercise in patients with chronic obstructive pulmonary disease (COPD) and an important contributing factor to breathlessness. In this study we aimed to examine the effect of inhaled beta agonist therapy on DH during exercise in these patients and the relationship between changes in DH and breathlessness. In 13 COPD patients (mean age 65.1 +/- 2.0, FEV1 1.20 +/- 0.17, FEV1/FVC 40 +/- 3) we measured pulmonary function tests, exercise breathlessness by Borg score, and exercise flow volume and pressure volume loops on two separate days. Prior to testing, patients randomly received inhaled placebo or albuterol on the first test day and the alternative medication on the second test day. From measurements of exercise inspiratory capacity (IC), we calculated the end-expiratory and end-inspiratory lung volumes (EELV, EILV). We used esophageal pressure recordings to measure peak inspiratory esophageal pressure (Pesins) during exercise and this was related to the maximal capacity for pressure generation taking into account lung volume and airflow changes (Pcapi). Bronchodilator caused significant increase in both FEV1 and FVC (+0.23 and +0.51, p<0.01). Comparisons of breathlessness, exercise volumes, and pressures were made at the highest equivalent work load. There was a significant reduction in the peak exercise EELV/TLC (80 +/- 0.02% to 76 +/- 0.02%, p<0.05) while the peak EILV/TLC decreased by 2% (97 +/- 1% to 95 +/- 1%, p<0.05). The peak Pesins/Pcapi decreased (0.79 +/- 0.10 to 0.57 +/- 0.05, p<0.05), and the Pcapi - Pesins increased (7.4 +/- 3 to 13.0 +/- 3 cm H2O, p<0.05). There was significant improvement in neuroventilatory coupling for volume change (Pesins/Pcapi/VT/TLC 5.45 +/- 0.5 to 3.25 +/- 1.0, p<0.05). There was a significant reduction in breathlessness as measured by Borg score (4.5 +/- 0.7 to 3.1 +/- 0.5, p<0.05) and there was a significant correlation between delta Borg and delta EILV/TLC (r=0.771, p<0.01) with a trend for Pesins/Pcapi/VT/TLC (r=0.544, p=0.067). There was also a significant correlation between delta EELV/TLC and delta Pesins/Pcapi/VT/TLC (r=0.772, p<0.01). The relationships between delta Borg, delta resting volumes, and flow rates were not significant. We conclude that in patients with COPD, inhaled bronchodilator reduces exercise DH and improves inspiratory pressure reserve and neuroventilatory coupling. Changes in DH and neuroventilatory coupling were the main determinants of reduced breathlessness.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, interventions that deflate the lungs (ie, reduce EILV and EELV) and delay the onset of critical VT constraints consistently reduce dyspnea intensity in patients with COPD during exercise.45,46,55,56”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [55]
In the citing paper
“Pharmacological interventions that reduce operating lung volumes and delay the onset of ventilatory limitation consistently reduce the intensity of dyspnea during exercise in patients with COPD.46,55,56”
From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [55]
Citations
Cites
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580
Standardization of Spirometry — 1987 Update
Buist, A. S. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1073 · Cited by 3,256
O'Donnell, D. E., & Webb, K. A. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1351 · Cited by 543
The n-of-1 Randomized Controlled Trial: Clinical Usefulness
Guyatt, G., Keller, J. L., Jaeschke, R., Rosenbloom, D., Adachi, J. D., & Newhouse, M. T. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-4-293 · Cited by 320
Pulmonary mechanics during exercise in subjects with chronic airflow obstruction
Stubbing, D. G., Pengelly, L. D., Morse, J. L., & Jones, N. L. (1980) · Journal of Applied Physiology · doi:10.1152/jappl.1980.49.3.511 · Cited by 314
Potter, W. A., Ólafsson, S., & Hyatt, R. E. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106563 · Cited by 241
Murciano, D., Auclair, M.-H., Parienté, R., & Aubier, M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906083202304 · Cited by 223
Chest wall mechanics during exercise in patients with severe chronic air-flow obstruction.
Dodd, D., Brancatisano, T. P., & Engel, L. A. (1984) · PubMed · doi:10.1164/arrd.1984.129.1.33 · Cited by 195
Effect of mild-to-moderate airflow limitation on exercise capacity
Babb, T. G., Viggiano, R. W., Hurley, B. F., Staats, B., & RODARTE, J. R. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.1.223 · Cited by 195
Dose response relation to oral theophylline in severe chronic obstructive airways disease.
Chrystyn, H., Mulley, B. A., & Peake, M. D. (1988) · BMJ · doi:10.1136/bmj.297.6662.1506 · Cited by 164
Cited by
Sorted by citations
Items 201–300 of 401
Lung hyperinflation in COPD: the impact of pharmacotherapy
O’Donnell, D. E., & Laveneziana, P. (2006) · European Respiratory Review · doi:10.1183/09059180.00010006 · Cited by 16
Kitaguchi, Y., Fujimoto, K., Komatsu, Y., Hanaoka, M., Honda, T., & Kubo, K. (2012) · Respiratory Medicine · doi:10.1016/j.rmed.2012.11.013 · Cited by 16
Gelb, A., Taylor, C., Cassino, C., Shinar, C. M., Schein, M. J., & Zamel, N. (2009) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2008.12.018 · Cited by 19
Laveneziana, P., Galarducci, A., Binazzi, B., Stendardi, L., Duranti, R., & Scano, G. (2007) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2007.02.003 · Cited by 16
Parasternal Muscle Activity Decreases in Severe COPD With Salmeterol-Fluticasone Propionate
Easton, P. A., Hawes, H. G., Doig, C. J., Johnson, M. W., Yokoba, M., & Wilde, E. R. (2009) · CHEST Journal · doi:10.1378/chest.09-0197 · Cited by 16
Rescue! Therapy and the paradox of the Barcalounger
Rennard, S. I., & CALVERLEY, P. M. A. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00111602 · Cited by 16
Lung function improvements with once-daily tiotropium in chronic obstructive pulmonary disease.
Casaburi, R., & Conoscenti, C. (2004) · American Journal of Medicine · doi:10.1016/j.amjmed.2004.10.019 · Cited by 16
Levy, M. L., Quanjer, P. H., Booker, R., Cooper, B. G., Holmes, S. J., & Small, I. R. (2009) · Cited by 15
Advantages of Endurance Treadmill Walking Compared With Cycling To Assess Bronchodilator Therapy
Zhang, X., Waterman, L. A., Ward, J., Baird, J. C., & Mahler, D. A. (2009) · CHEST Journal · doi:10.1378/chest.09-2470 · Cited by 15
Clinical Effects of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease
Jones, P. (2004) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200402-012ms · Cited by 15
Vogelmeier, C. F., MAGNUSSEN, H., LaForce, C., Owen, R. J., & Krämer, B. (2011) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465811410100 · Cited by 14
Measuring quality of life in patients with sleep apnoea: whose life is it anyway?
Flemons, W. W. (2004) · Thorax · doi:10.1136/thx.2003.016774 · Cited by 14
Rodrigues, F. (2004) · Revista Portuguesa de Pneumologia · doi:10.1016/s0873-2159(15)30556-0 · Cited by 14
Husereau, D., Shukla, V., Boucher, M., Mensinkai, S., & Dales, R. (2004) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-4-7 · Cited by 12
Chuang, M.-L., Lin, I., Huang, S.-F., & Hsieh, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-11189-x · Cited by 14
Bourbeau, J., Gagnon, S., & Ross, B. A. (2020) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2020.06.003 · Cited by 3
Perception of bronchoconstriction in smokers with airflow limitation
Ottanelli, R., Rosi, E., Ronchi, M. C., GRAZZINI, M., Lanini, B., Stendardi, L., Romagnoli, P., Bertini, S., Duranti, R., & Scano, G. (2001) · Clinical Science · doi:10.1042/cs1010515 · Cited by 13
Mineshita, M., Matsuoka, S., & Miyazawa, T. (2013) · Respiration · doi:10.1159/000350228 · Cited by 12
An Integrative Approach to the Interpretation of Cardiopulmonary Exercise Testing
Weisman, I. M., & Zeballos, R. J. (2002) · KARGER eBooks · doi:10.1159/000062225 · Cited by 12
Bronchodilator response to adrenergic β2 -agonists: Relationship to symptoms in an adult community
Lehmann, S., Bakke, P. S., Eide, G. E., & Gulsvik, A. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.11.007 · Cited by 12
Airflow Limitation and Breathing Strategy in Congestive Heart Failure Patients during Exercise
Schroeder, C. A., Balfe, D. L., Khan, S. S., & Mohsenifar, Z. (2003) · Respiration · doi:10.1159/000070059 · Cited by 12
de Miguel‐Díez, J., Alonso, J. L. I., París, J. M., Cano, J. M. B., González-Moro, J. M. R., & Ramos, P. D. L. (2005) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(06)60399-6 · Cited by 12
Inspiratroy Capacity and Exercise Tolerance in Chronic Obstructive Pulmonary Disease
Milic‐Emili, J. (2000) · Canadian Respiratory Journal · doi:10.1155/2000/745686 · Cited by 12
Valores de referencia de la capacidad inspiratoria en sujetos sanos no fumadores mayores de 50 años
Lisboa, C., Leiva, A., Ramón Pinochet, U., Repetto, P. B., Borzone, G. R., & Orlando Díaz, P. (2007) · Archivos de Bronconeumología · doi:10.1157/13109468 · Cited by 12
RODRIGUES, R., Jr., & Pereira, C. A. D. C. (2001) · Jornal de Pneumologia · doi:10.1590/s0102-35862001000100007 · Cited by 12
O'Donnell, D., & Webb, K. (2005) · Lung biology in health and disease · doi:10.1201/b14111-4 · Cited by 24
Azevedo, K. S., Luiz, R., Rocco, P., & Conde, M. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-49 · Cited by 10
Sukisaki, T., Senjyu, H., Oishi, K., Rikitomi, N., & Ariyoshi, K. (2008) · Physiotherapy Theory and Practice · doi:10.1080/09593980701686815 · Cited by 11
European Respiratory Society Monograph
Jensen, D., Pattinson, K., & Jolley, C. (2016) · European Respiratory Society eBooks · doi:10.1183/2312508x.10011715 · Cited by 12
Effects of exercise and β2-agonists on lung function in chronic obstructive pulmonary disease
Corsico, A. G., Fulgoni, P., Beccaria, M., Zoia, M. C., Barisione, G., Pellegrino, R., Brusasco, V., & Cerveri, I. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00490.2002 · Cited by 11
Approaches to Improving Health Status in Chronic Obstructive Pulmonary Disease: One or Several?
Wouters, E. F. �. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200511-118sf · Cited by 11
Breathlessness during exercise in COPD: how do the drugs work?
Calverley, P. M. (2004) · Thorax · doi:10.1136/thx.2004.023150 · Cited by 11
Comparison of bronchodilatory properties of transdermal and inhaled long-acting beta 2-agonists.
Yamagata, T., Hirano, T., Sugiura, H., Yanagisawa, S., Ichikawa, T., Ueshima, K., Akamatsu, K., Nakanishi, M., Matsunaga, K., Minakata, Y., et al. (2008) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2007.05.004 · Cited by 11
Fujimoto, K., Yamazaki, H., Ura, M., & Kitaguchi, Y. (2017) · International Journal of COPD · doi:10.2147/copd.s149054 · Cited by 10
Jo, Y. S., Kim, S. K., Park, S. J., Um, S., Park, Y. B., Jung, K., Kim, D. K., & Yoo, K. H. (2019) · International Journal of COPD · doi:10.2147/copd.s189384 · Cited by 10
Responses to progressive exercise in subjects with chronic dyspnea and inspiratory muscle weakness
Berton, D. C., Gass, R., Feldmann, B., Plachi, F., Hütten, D. O., Mendes, N. B. S., Schroeder, E., Balzan, F. M., Peyré‐Tartaruga, L. A., & Gazzana, M. B. (2020) · The Clinical Respiratory Journal · doi:10.1111/crj.13265 · Cited by 9
Sebastián, G. G., Güell, R., Valencia, A. G., Alfara, J. J. F., Saló, G. E., & González, C. L. (2007) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(07)60064-0 · Cited by 10
Matera, M. G., Sanduzzi, A., Ponticiello, A., Vatrella, A., Salzillo, A., & Cazzola, M. (2005) · Respiration · doi:10.1159/000087669 · Cited by 10
Sebastián, G. G., Güell, R., Valencia, A. G., Alfara, J. J. F., Saló, G. E., & González, C. L. (2007) · Archivos de Bronconeumología · doi:10.1157/13101952 · Cited by 10
Chronic Obstructive Pulmonary Disease in the Older Patient
Nazir, S. A., Alhamed, M., & Erbland, M. L. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2007.07.003 · Cited by 10
Reference Values for Inspiratory Capacity in Healthy Nonsmokers Over Age 50 Years
Lisboa, C., Leiva, A., Ramón Pinochet, U., Repetto, P. B., Borzone, G. R., & Orlando Díaz, P. (2007) · Archivos de Bronconeumología · doi:10.1016/s1579-2129(07)60112-8 · Cited by 10
Exercise testing in the evaluation of pharmacotherapy in COPD
O’Donnell, D. E., Elbehairy, A. F., Berton, D. C., Domnik, N. J., Webb, K. A., & Neder, J. A. (2018) · European Respiratory Society eBooks · doi:10.1183/2312508x.10012017 · Cited by 9
Gagliardi, E., Bruni, G. I., Presi, I., Gigliotti, F., & Scano, G. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.10.005 · Cited by 9
COPD management—a hospital physician's view
Wouters, E. F. �. (2005) · Respiratory Medicine COPD Update · doi:10.1016/j.rmedu.2004.12.003 · Cited by 9
Changes in Lung Volumes and Poor Perception of Bronchoconstriction-Induced Respiratory Symptoms
Catellier, P., Turcotte, H., Deschenes, F., & Boulet, L. (1998) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)63122-5 · Cited by 8
It's about time – directing our attention toward modifying the course of COPD
Cazzola, M., Hanania, N. A., Jones, P., Mahler, D. A., Make, B. J., Ohar, J. A., & Rennard, S. I. (2008) · Respiratory Medicine · doi:10.1016/s0954-6111(08)70006-4 · Cited by 8
Alterações espirométricas em doenças obstrutivas: afinal, o quanto é relevante?
Soares, A. L. P., Pereira, C. A. D. C., & Rodrigues, S. C. S. (2013) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37132013000100008 · Cited by 9
Li, Y., Li, Y.-H., Li, S., Luo, Y., Xiao, R., Huang, Y.-X., Huang, J.-L., Chen, Y.-T., Zhi, R.-C., & Chen, X. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.03.70 · Cited by 9
Nonpharmacological modulation of dynamic hyperinflation
Wouters, E. (2006) · European Respiratory Review · doi:10.1183/09059180.00010007 · Cited by 9
Terzano, C., Petroianni, A., Rícci, A., & Allegra, L. (2005) · PubMed · Cited by 8
Health Related Quality Of Life (Hrqol) In COPD
Gupta, B., & Kant, S. (2008) · The Internet Journal of Pulmonary Medicine · Cited by 8
Ventilation-limited exercise capacity in a 59-year-old athlete
Burtscher, M., Schocke, M. F. H., & Koch, R. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.10.003 · Cited by 8
Symptoms of asthma, bronchial responsiveness and atopy in immigrants and emigrants in Europe
Kalyoncu, A. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00305302 · Cited by 39
Can bronchodilators improve exercise tolerance in COPD patients without dynamic hyperinflation?
Scuarcialupi, M. E. A., Berton, D., Cordoni, P., Squassoni, S., Fiss, E., & Neder, J. (2014) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37132014000200003 · Cited by 8
Bronchodilator response in residual volume in irreversible airway obstruction.
Balestra, A.-M., Bingisser, R., Chhajed, P., Tamm, M., & Leuppi, J. (2008) · Swiss medical weekly · doi:10.4414/smw.2008.11992 · Cited by 11
Kılıç, L., Önür, S. T., Dilektaşlı, A. G., Ulubay, G., & Balcı, A. (2023) · International Journal of COPD · doi:10.2147/copd.s384127 · Cited by 8
Miki, K., Tsujino, K., Fukui, M., Miki, M., Kitajima, T., Sumitani, H., Hashimoto, K., Yokoyama, M., Hashimoto, H., Nii, T., et al. (2023) · Thorax · doi:10.1136/thorax-2022-219755 · Cited by 7
Yıldız, Ö. A., Önen, Z. P., Demir, G., Gülbay, B. E., Saryal, S., & Karabıyıkoğlu, G. (2006) · PubMed · Cited by 7
Perez, T., Garcia, G., Roche, N., Bautin, N., Chambellan, A., Chaouat, A., Court‐Fortune, I., Delclaux, B., Guénard, H. J.-P., Jébrak, G., et al. (2014) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2013.11.007 · Cited by 8
Luo, Y., Qiu, Z., Wang, Y., He, B., Qin, H., Xiao, S., Luo, Y., Steier, J. S., Moxham, J., & Polkey, M. I. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00695.2018 · Cited by 7
Zuwallack, R. (2008) · Respiratory care · doi:10.4187/respcare.08531190 · Cited by 9
Guest, J. F., Varney, S. J., & Diggle, J. (2005) · Primary Care Respiratory Journal · doi:10.1016/j.pcrj.2005.07.003 · Cited by 7
Usefulness of inspiratory capacity measurement in COPD patients in the primary care setting
Martín, A. (2009) · International Journal of General Medicine · doi:10.2147/ijgm.s4824 · Cited by 7
Difference in breathing strategies during exercise between trained elderly men and women
Deruelle, F., Nourry, C., Mucci, P., Bart, F., Grosbois, J. M., Lensel, G. H., & Fabre, C. (2008) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2007.00641.x · Cited by 7
The clinical role of long-acting β2-agonists in COPD
KIPS, J. C. (2000) · Respiratory Medicine · doi:10.1016/s0954-6111(00)90154-9 · Cited by 7
Dynamische Lungenüberblähung: Implikationen für die klinische Praxis
Rothe, T. (2006) · Swiss Medical Forum ‒ Schweizerisches Medizin-Forum · doi:10.4414/smf.2006.05865 · Cited by 6
Modalities of Clinical Exercise Testing
Zeballos, R. J., & Weisman, I. M. (2002) · KARGER eBooks · doi:10.1159/000062229 · Cited by 6
The Role of Spirometry in Evaluating Therapeutic Responses in Advanced COPD
Laveneziana, P., & O'Donnell, D. (2007) · Disease Management & Health Outcomes · doi:10.2165/00115677-200715020-00004 · Cited by 3
Cutting edge of COPD therapy: current pharmacological therapy and future direction
Yamada, M., & Ichinose, M. (2015) · COPD Research and Practice · doi:10.1186/s40749-015-0009-7 · Cited by 6
Nichols, J. (2007) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.27.3.447 · Cited by 6
Pathophysiology of Chronic Obstructive Pulmonary Disease
Celli, B. R. (2002) · Springer eBooks · doi:10.1007/978-88-470-2916-3_19 · Cited by 6
Lipson, D. (2004) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200403020-00003 · Cited by 3
Xie, C., Yang, K., Tang, W. T., Zhang, H., Jin, H., Li, C., Gao, Z., Wei, Y., Yalikun, M., & Dong, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1834906 · Cited by 5
Tsujimura, Y., Hiramatsu, T., Kojima, E., & Tabira, K. (2019) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2019.1641866 · Cited by 5
New treatment strategies for COPD
Côté, C., & Celli, B. (2005) · Postgraduate medicine · doi:10.3810/pgm.2005.03.1594 · Cited by 5
Wedzicha, J. A. (2002) · Elsevier eBooks · doi:10.1016/b978-012079028-9/50143-5 · Cited by 5
Vincken, W. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.1.11 · Cited by 5
Deruelle, F., Nourry, C., Mucci, P., Bart, F., Grosbois, J., Lensel, G., & Fabre, C. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h05-023 · Cited by 5
Incorvaia, C., Riario-Sforza, G. G., Pravettoni, C., Dugnani, N., Paterniti, F., Pessina, L., & Fumagalli, M. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.07.008 · Cited by 5
Jorge Manríquez, H., Orlando Díaz, P., Gisella Borzone, T., & Carmen Lisboa, B. (2004) · Revista médica de Chile · doi:10.4067/s0034-98872004000700001 · Cited by 5
Asthma bronchiale und chronisch-obstruktive Lungenkrankheit (COPD)
Ullmer, E., & Solr, M. (1999) · Der Internist · doi:10.1007/s001080050408 · Cited by 5
Asthma and COPD: A Focus on β-Agonists – Past, Present and Future
Baker, J. G., & Shaw, D. E. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_679 · Cited by 4
COPD Anno 2011: Emphasis on Bronch(iol)odilation
Lahaije, A., Heijdra, Y. F., Willems, L. M., van Helvoort, H. A. C., & Dekhuijzen, P. N. R. (2012) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2011.0922 · Cited by 4
Reversibility of inspiratory lung function parameters after short-term bronchodilators in COPD.
Ramlal, S., Visser, F., Hop, W., Dekhuijzen, P., & Heijdra, Y. (2010) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2010.06.007 · Cited by 7
Fadaii, A., Sohrabpour, H., Taherkhanchi, B., & Bagheri, B. (2011) · Europe PMC (PubMed Central) · Cited by 4
An update on the use of indacaterol in patients with COPD
Brienza, N. S., Amor-Carro, Ó., & Ramos-Barbón, D. (2011) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465810387810 · Cited by 5
Evankovich, J. W., Nouraie, M. S., & Sciurba, F. C. (2022) · Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · doi:10.15326/jcopdf.2022.0354 · Cited by 3
Performance enhancement in chronic obstructive pulmonary disease
Fuld, J. P., & Cotton, M. M. (2004) · Chronic Respiratory Disease · doi:10.1191/1479972304cd001oa · Cited by 4
JorgeJorquera, A., OrlandoDíaz, P., & CarmenLisboa, B. (2003) · Revista médica de Chile · doi:10.4067/s0034-98872003000600003 · Cited by 4
Pathogenese, Diagnostik und Therapie der COPD
Ullmer, E., Solèr, M., Hamm, H., & Perruchoud, A. P. (2000) · Pneumologie · doi:10.1055/s-2000-9079 · Cited by 4
Reasons for Exercise Intolerance in Patients with Chronic Obstructive Pulmonary Disease
Kealy, S., Hussey, J., & Lane, S. (2003) · Physical Therapy Reviews · doi:10.1179/108331903225001372 · Cited by 3
Nici, L. L., Donner, C. F., Wouters, E. F. �., ZuWallack, R., Ambrosino, N., Bourbeau, J., Carone, M., Celli, B. R., ENGELEN, M. P. K. J., Fahy, B. F., et al. (2006) · Cited by 3
Approaches to Improving Health Status in Chronic Obstructive Pulmonary Disease
Wouters, E. F. �. (2012) · Proceedings of the American Thoracic Society · Cited by 3
Lack of protective effect of tiotropium vs induced dynamic hyperinflation in moderate COPD.
Gelb, A., Fraser, C., & Zamel, N. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2010.11.020 · Cited by 2
Palo, V. A. D. (2004) · Journal of the American Podiatric Medical Association · doi:10.7547/87507315-94-2-157 · Cited by 3
Health Status Measurement in COPD
Jones, P. (2003) · Lung biology in health and disease · doi:10.1201/9780203913406.ch10 · Cited by 3
Wedzicha, J. A. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374001-4.00067-5 · Cited by 3
Laveneziana, P., & Paolo, M. D. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00526.2019 · Cited by 4
Exercise Limitations and Cardiopulmonary Exercise Testing in COPD
Morris, N. R., Adams, L., Johnson, B. D., & Weisman, I. M. (2007) · doi:10.1002/9780470755976.ch4 · Cited by 3
Carmen Lisboa, B., Gisella Borzone, T., & Orlando Díaz, P. (2004) · Revista chilena de enfermedades respiratorias · doi:10.4067/s0717-73482004000100002 · Cited by 3
Metadata
- Authors
- Belman, M. J., Botnick, W. C., & Shin, J. W.
- Affiliations
- Cedars-Sinai Medical Center (US)
- ORCID
- Shin, J W
- Venue
- American journal of respiratory and critical care medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-03-01
- Volume
- 153
- Issue
- 3
- Pages
- 967-975
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2007810665
- Cited by
- 402
- References
- 21
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 8 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 10
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- dynamic hyperinflation, chronic obstructive pulmonary disease, inhaled beta-agonists, salbutamol, esophageal pressure, end-expiratory lung volume, inspiratory capacity, pressure-volume loops, inspiratory muscle strength, inspiratory muscle endurance, inspiratory muscle training
- MeSH terms
- Administration, Inhalation, Adrenergic beta-Agonists, Aged, Albuterol, Bronchodilator Agents, Dyspnea, Esophagus, Physical Exertion, Female, Forced Expiratory Volume, Humans, Inspiratory Capacity, Lung, Lung Diseases, Obstructive, Male, Middle Aged, Peak Expiratory Flow Rate, Pressure, Pulmonary Ventilation, Total Lung Capacity, Vital Capacity, Respiratory Mechanics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
