The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease.
Abstract
The purpose of this study was to assess whether expiratory flow limitation (FL), as measured by applying negative pressure at the mouth during tidal expiration, is a better predictor of dyspnea than routine spirometry measurements. The study population consisted of 117 ambulatory patients with COPD. Dyspnea was assessed according to the ATS-DLD respiratory Questionnaire. Expiratory flow limitation was measured in supine and sitting positions, and expressed as a percentage of the expired control tidal volume affected by flow limitation (FL, % VT). Using Spearman's rank correlation (rs), we found that the correlation of dyspnea scale with FL was stronger (rs > 0.5) than with FVC (rs < -0.3) or FEV1 (rs < -0.4) in both positions. In a multiple regression analysis FL remained the best predictor of dyspnea scale even after adjustment for FEV1 (% pred). Finally, FL was almost as sensitive as FEV1 (% pred) but much more specific in assessing the severity of dyspnea scale. These findings suggest that expiratory flow limitation as measured by the negative expiratory pressure technique may be more useful in the evaluation of dyspnea in patients with COPD than spirometry measurements.
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Citations
Cites
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Standardization of Spirometry — 1987 Update
Buist, A. S. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.5.1073 · Cited by 3,266
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O'Donnell, D. E., & Webb, K. A. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1351 · Cited by 543
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A simple method to detect expiratory flow limitation during spontaneous breathing
Koulouris, N., Valta, P., Lavoie, A., Corbeil, C., Chasse, M., Braidy, J., & Milic-Emili, J. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08020306 · Cited by 251
Self-citationPride, N. B., & Macklem, P. T. (1986) · Comprehensive Physiology · doi:10.1002/cphy.cp030337 · Cited by 188
Intrinsic PEEP and Arterial PCO2 in Stable Patients with Chronic Obstructive Pulmonary Disease
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Self-citationDetection of expiratory flow limitation during mechanical ventilation.
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Interpretative strategies for lung function tests
Pellegrino, R., Viegi, G., Brusasco, V., Crapo, R. O., Burgos, F., Casaburi, R., Coates, A., van der Grinten, C. P. M., Gustafsson, P., Hankinson, J., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00035205 · Cited by 5,945
Garcia-Aymerich, J., Lange, P., Benet, M., Schnohr, P., & Anto, J. M. (2006) · Thorax · doi:10.1136/thx.2006.060145 · Cited by 1,113
Disorders of the Respiratory Muscles
Laghi, F., & Tobin, M. J. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2206020 · Cited by 687
Puhan, M. A., Garcia-Aymerich, J., Frey, M., ter Riet, G., Antó, J. M., Agustí, A. G., Gómez, F. P., Rodríguez-Roisín, R., Moons, K. G., Kessels, A. G., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61301-5 · Cited by 521
Metadata
- Authors
- Eltayara, L., Becklake, M. R., Volta, C. A., & Milic-Emili, J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-12
- Volume
- 154
- Issue
- 6
- Pages
- 1726-1734
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2036984641
- Cited by
- 277
- References
- 20
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease. https://app.cochat.ai/papers/10.1164/ajrccm.154.6.8970362
- The paper
- Eltayara, L., Becklake, M. R., Volta, C. A., & Milic-Emili, J. (1996). Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.154.6.8970362
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
