The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization.
Abstract
Eosinophils play a central role in the inflammatory response associated with bronchial asthma. We studied the involvement of eosinophils in the development of airway hyperresponsiveness (AHR) in a mouse model of allergic airway sensitization. Sensitization of BALB/c mice to OVA via the airways induced allergen-specific T-cell responses, IgE production, immediate cutaneous hypersensitivity (ICH), and increased airway reactivity. Airway sensitization was associated with eosinophil infiltration of the airways and increased production of interleukin-5 (IL-5) in cultures of peribronchial lymph node cells. Treatment of OVA-challenged animals with anti-IL-5 antibody during the sensitization protocol completely abolished the infiltration of eosinophils into the lung tissue and prevented the development of AHR without affecting levels of allergen-specific IgE, cutaneous hypersensitivity and allergen-specific T cell responses. These findings demonstrate that infiltration of lung tissue by eosinophils, triggered by increased IL-5 production, is a major factor in the development of AHR in this mouse model of airway sensitization.
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Cites
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Mucosal Inflammation in Asthma
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Recombinant human interleukin 5 is a selective activator of human eosinophil function.
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Self-citationT cells and eosinophils in the pathogenesis of asthma
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Cited by
Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356
Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
HAMELMANN, E., SCHWARZE, J., TAKEDA, K., OSHIBA, A., LARSEN, G. L., IRVIN, C. G., & GELFAND, E. W. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.3.9606031 · Cited by 1,286
Self-citationThe Biology of IgE and the Basis of Allergic Disease
Gould, H. J., Sutton, B. J., Beavil, A. J., Beavil, R. L., McCloskey, N., Coker, H. A., Fear, D., & Smurthwaite, L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141103 · Cited by 685
Bischoff, S. C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2018 · Cited by 620
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Metadata
- Authors
- Hamelmann, E., Oshiba, A., Loader, J., Larsen, G. L., Gleich, G., Lee, J., & Gelfand, E. W.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-03
- Volume
- 155
- Issue
- 3
- Pages
- 819-825
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2021184075
- Cited by
- 260
- References
- 26
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamelmann, E., Oshiba, A., Loader, J., Larsen, G. L., Gleich, G., Lee, J., & Gelfand, E. W. (1997). Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.155.3.9117011
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
