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Cited by 165Chronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory Support and MechanismsNeonatal Respiratory Health Research

Increase in Pulmonary Ventilation–Perfusion Inequality with Age in Healthy Individuals

CARDÚS, JAUME, BURGOS, FELIP, DIAZ, ORLANDO, ROCA, JOSEP, BARBERÁ, JOAN ALBERT, MARRADES, RAMÓN M., RODRIGUEZ-ROISIN, ROBERT, WAGNER, PETER D.·1997·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/ajrccm.156.2.9606016
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Abstract

Arterial oxygen tension (PaO2) is known to decrease with age, and this is accompanied by a number of changes in mechanical properties of the lungs, including loss of elastic recoil and increase in closing volume. The changes in respiratory mechanics with age could induce greater ventilation/perfusion (V̇a/Q̇) mismatch and thus explain the decrease in Pa O2. In 64 normal subjects aged 18 to 71 yr (lifetime nonsmokers with normal spirometry), we measured V̇a/Q̇ inequality and arterial respiratory blood gases (Pa O2 and PaCO2) at rest in the seated position. V̇a/Q̇ mismatch, represented by the second moments of the blood flow and ventilation distributions (log SDQ and log SDV) increased with age, but only slightly (mean log SDQ was 0.36 at age 20 yr and 0.47 at age 70 yr). Pa O2 fell by a correspondingly small amount of 6 mm Hg. Previously established upper 95% confidence limits for log SDQ (0.60) and log SDV (0.65) in subjects at age 20 yr were confirmed. At age 70 yr, the upper limits of reference for log SDQ are 0.70 and for log SDV 0.75. The study shows that an increased alveolar– arterial O2 gradient with age is due to V̇a/Q̇ inequality rather than to shunting.

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Crossref · 10.1164/ajrccm.156.2.9606016

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  • Reduced alveolar-capillary density and changes to pulmonary vasculature result in a gradual decrease in pulmonary capillary blood volume with aging.

    “Reduced alveolar-capillary density as well as changes to pulmonary vasculature result in a gradual decrease in pulmonary capillary blood volume with aging (24–28).”

    From Aging and Lung Disease (2020) · cites this paper as [26]

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Authors
CARDÚS, J., BURGOS, F., DIAZ, O., ROCA, J., BARBERÁ, J. A., MARRADES, R. M., RODRIGUEZ-ROISIN, R., & WAGNER, P. D.
Affiliations
  • University of California San Diego (US)
  • Departament de Medicina, Hospital Cinic, Universitat de Barcelona, Barcelona, Spain; and Department of Medicine, University of California, San Diego, La Jolla, California
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
1997-08-01
Volume
156
Issue
2
Pages
648-653
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/ajrccm.156.2.9606016
OpenAlex
W1984119045
Cited by
165
References
19
Citations by year
2026: 7 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 4 · 2014: 3 · 2013: 9 · 2012: 10
FWCI
4.77
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (P01HL017731, HL17731)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords
ventilation-perfusion inequality, VA/Q mismatch, aging, arterial oxygen tension, alveolar-arterial oxygen gradient, respiratory mechanics, lung elastic recoil, closing volume, shunting, reference limits
MeSH terms
Adult, Aged, Aging, Anthropometry, Cardiac Output, Female, Humans, Male, Middle Aged, Oxygen, Partial Pressure, Reference Values, Respiratory Function Tests, Ventilation-Perfusion Ratio

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