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Cited by 197Chronic Obstructive Pulmonary Disease (COPD) ResearchRespiratory Support and MechanismsInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Effect of aging alone on mechanical properties of the normal adult human lung

Knudson, R. J., Clark, D. F., Kennedy, T. C., Knudson, D. E.·1977·Journal of Applied Physiology
DOI 10.1152/jappl.1977.43.6.1054
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Abstract

For plethysmographic studies of respiratory mechanics, we selected, from a general population, 51 subjects, aged 25-75 yr, who had never smoked, had no present or past cardiorespiratory symptoms or disease, were alpha1-antitrypsin MM phenotypes, and were normal by physical examination, vectorcardiography, and chest roentgenography. Approximately equal numbers of men and women were represented in each of three age groups; 25-35, 36-64, and 65-75. Both sexes demonstrated loss of lung elastic recoil with age, most significant at high lung volumes, but the rate of loss was less than previously reported. Males had higher lung recoil than females of comparable age, but if lung size was taken into account, there were no sex differences in bulk elastic properties. Maximum expiratory flow diminished with age only at low volumes, suggesting that equal pressure points are more centrally located at low lung volumes in the elderly.

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  • In the group with emphysema score greater than 5, the extent of emphysema had a linear negative correlation with percent of predicted elastic recoil at 90% total lung capacity (r=-0.696, p<0.01).

    “In the group with an emphysema score greater than 5 we found a linear negative correlation between the extent of emphysema and percent of predicted elastic recoil at 90 O/% total lung capacity (r=-0-696, p<0 01).”

    From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7

  • Using Knudson predicted values, the greater than 5 emphysema group was statistically different from the trace-grade 5 emphysema group at all volumes examined (p<0.01).

    “By one-way analysis of variance,9 the elastic recoil was decreased in the trace-grade5group compared to the normal group (p<0-01) at all volumes studied and in the grade 5 or greater group was statistically different from normal and the trace-grade 5 group (p<0-01) at all volumes examined when using regression curves obtained from the data of Knudson et al,7 (table 2).”

    From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7

  • In the studied excised lungs, the percentage of predicted elastic recoil had a negative correlation with lung volume (r=-0.612, p<0.01).

    “We found a negative correlation between the percentage of predicted elastic recoil and the lung volume (r=-0-612, p<0 01).”

    From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7

  • In excised human lungs, both the emphysema group with score 5 or less and the group with score greater than 5 had a percentage of predicted elastic recoil significantly different from normal lungs.

    “A comparison of the percentage of predicted elastic recoil revealed that both emphysema groups were significantly different from normal lungs.”

    From Elastic recoil changes in early emphysema (1980) · cites this paper as Knudson et al.7

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Authors
Knudson, R. J., Clark, D. F., Kennedy, T. C., & Knudson, D. E.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1977-12-01
Volume
43
Issue
6
Pages
1054-1062
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1977.43.6.1054
OpenAlex
W2336497260
Cited by
197
References
0
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 5
FWCI
4.56
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
aging, lung elastic recoil, respiratory mechanics, plethysmography, maximal expiratory flow, lung volume, sex differences, older adults, alpha-1-antitrypsin
MeSH terms
Adult, Aged, Aging, Female, Humans, Lung, Lung Compliance, Male, Maximal Expiratory Flow Rate, Middle Aged, Sex Factors, Total Lung Capacity, Vital Capacity

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